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Semin Neurol 2007; 27(1): 007-021
DOI: 10.1055/s-2006-956751
Copyright © 2007 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Neuropsychology of Cortical versus Subcortical Dementia Syndromes

David P. Salmon1 , J. Vincent Filoteo2
  • 1Department of Neurosciences, University of California, San Diego
  • 2Department of Psychiatry, University of California, San Diego, and Psychology Service, San Diego Veterans Affairs Medical Center, La Jolla, California
Further Information

Publication History

Publication Date:
17 January 2007 (online)

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ABSTRACT

Neuropsychological studies have shown that there are several prominent differences in the patterns of cognitive deficits that occur in neurodegenerative disorders that have their primary etiology in either cortical or subcortical brain dysfunction. Quantitative and qualitative differences are apparent across many cognitive domains, including memory (in all its aspects), attention, executive functions, language and semantic knowledge, and visuospatial abilities. These distinct patterns of deficits have been broadly characterized as forming cortical and subcortical dementia syndromes. Differentiating between cortical and subcortical dementia provides a heuristically useful model for understanding brain-behavior relationships in neurodegenerative diseases and may improve the ability to clinically distinguish among various dementing disorders.

KEYWORDS

Dementia - Alzheimer's disease - Huntington's disease - cognition - memory

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David P SalmonPh.D. 

Department of Neurosciences (0948), University of California, San Diego

9500 Gilman Drive, La Jolla, CA 92093-0948

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