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Planta Med 1997; 63(4): 352-355
DOI: 10.1055/s-2006-957699
Papers
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Isolation of Angiotensin Converting Enzyme (ACE) Inhibiting Triterpenes from Schinus molle

Kjartan Olafsson, Jerzy W. Jaroszewski, Ulla Wagner Smitt, Ulf Nyman
  • Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen, Denmark
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Publication History

1996

1996

Publication Date:
04 January 2007 (online)

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Abstract

Bioactivity-guided fractionation of extracts of Schinus molle leaves, using an in vitro assay, led to the isolation of ACE-inhibitory steroidal triterpenes of the euphane type, identified by means of NMR spectroscopic methods. One of the triterpenes was isolated as an equilibrium mixture of epimeric aldehydes. The triterpenes showed moderate ACE-inhibitory activity (IC50 about 250 µM).

Key words

Schinus molle - Anacardiaceae - euphane triterpenes - epimerisation - NMR spectroscopy - angiotensin converting enzyme - ACE inhibitors

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