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01.12.2011 | Case report | Ausgabe 1/2011 Open Access

Journal of Medical Case Reports 1/2011

Prognosis of West Nile virus associated acute flaccid paralysis: a case series

Zeitschrift:
Journal of Medical Case Reports > Ausgabe 1/2011
Autoren:
Jennie Johnstone, Steven E Hanna, Lindsay E Nicolle, Michael A Drebot, Binod Neupane, James B Mahony, Mark B Loeb
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

JJ drafted the manuscript. SH participated in its design and helped draft the initial manuscript. LN helped conceive the study and design, helped coordinate the study and critically revised the manuscript. MD performed the West Nile virus testing and critically revised the manuscript. BN critically revised the manuscript. JM performed West Nile virus testing and critically revised the manuscript. ML conceived the study and design, acquired the data, critically revised the manuscript and gave final approval of the version to be published.

Abstract

Introduction

Little is known about the long-term health related quality of life outcomes in patients with West Nile virus associated acute flaccid paralysis. We describe the quality of life scores of seven patients with acute flaccid paralysis who presented to hospital between 2003 and 2006, and were followed for up to two years.

Case presentations

Between 2003 and 2006, 157 symptomatic patients with West Nile virus were enrolled in a longitudinal cohort study of West Nile virus in Canada. Seven patients (4%) had acute flaccid paralysis. The first patient was a 55-year-old man who presented with left upper extremity weakness. The second patient was a 54-year-old man who presented with bilateral upper extremity weakness. The third patient was a 66-year-old woman who developed bilateral upper and lower extremity weakness. The fourth patient was a 67-year-old man who presented with right lower extremity weakness. The fifth patient was a 60-year-old woman who developed bilateral lower extremity weakness. The sixth patient was a 71-year-old man with a history of Parkinson's disease and acute onset bilateral lower extremity weakness. The seventh patient was a 52-year-old man who presented with right lower extremity weakness. All were Caucasian. Patients were followed for a mean of 1.1 years. At the end of follow-up the mean score on the Physical Component Summary of the Short-Form 36 scale had only slightly increased to 39. In contrast, mean score on the Mental Component Summary of the Short-Form 36 scale at the end of follow-up had normalized to 50.

Conclusion

Despite the poor physical prognosis for patients with acute flaccid paralysis, the mental health outcomes are generally favorable.

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Literatur
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