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01.12.2012 | Research | Ausgabe 1/2012 Open Access

World Journal of Surgical Oncology 1/2012

Prognosis significance of HER-2/neu overexpression/amplification in Chinese patients with curatively resected gastric cancer after the ToGA clinical trial

Zeitschrift:
World Journal of Surgical Oncology > Ausgabe 1/2012
Autoren:
Fei Zhou, Ning Li, Weihua Jiang, Zhaolai Hua, Lin Xia, Qingyi Wei, Liwei Wang
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-10-274) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

FZ carried out the experiment and data acquisition, and drafted the manuscript. NL helped with the experiment and data acquisition. WJ helped with the literature research. ZH and LX participated in collecting the samples. QW helped with writing, discussion of and editing the manuscript. LW designed the study, and read and revised the manuscript. All authors read and approved the final manuscript.

Abstract

Background

HER-2/neu-targeted therapy has been successfully used in advanced gastric cancer, but the role of HER-2/neu in the prognosis of gastric cancer is not yet clear. In this study, we investigated the correlation between HER-2/neu expression and amplification as well as their association with clinic outcomes in patients with curatively resected gastric cancer.

Methods

We constructed tissue microarray blocks containing >70% of gastric cancer tissue and matched adjacent normal gastric tissue for 227 patients. Expression of the HER-2/neu protein in these specimens was analyzed using immunohistochemical staining. Amplification of HER-2/neu was also analyzed for the same samples using fluorescence in situ hybridization. Data on clinicopathological features and relevant prognostic factors in these patients were analyzed.

Results

Of the 227 gastric cancer samples, 11.89% were positive for HER-2/neu overexpression/amplification under the new scoring system. HER-2/neu overexpression/amplification was closely correlated to the Lauren type, degree of differentiation, tumor size and lymph node metastasis. HER-2/neu overexpression/amplification predicted poor survival in univariate analysis but not in a Cox proportional hazards model.

Conclusion

HER-2/neu overexpression/amplification was not an independent predictor for survival in patients with curatively resected gastric cancer.
Zusatzmaterial
Authors’ original file for figure 1
12957_2012_1232_MOESM1_ESM.pdf
Authors’ original file for figure 2
12957_2012_1232_MOESM2_ESM.pdf
Literatur
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