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01.12.2014 | Translational Research and Biomarkers | Sonderheft 4/2014

Annals of Surgical Oncology 4/2014

Prognostic Impact of Major Receptor Tyrosine Kinase Expression in Gastric Cancer

Zeitschrift:
Annals of Surgical Oncology > Sonderheft 4/2014
Autoren:
MD Yukinori Kurokawa, MD Nariaki Matsuura, MD Ryohei Kawabata, MD Kazuhiro Nishikawa, MD Chikara Ebisui, PhD Yuhki Yokoyama, MD Mohammed Nouri Shaker, MD Takuya Hamakawa, MD Tsuyoshi Takahashi, MD Shuji Takiguchi, MD, FACS Masaki Mori, MD Yuichiro Doki

Abstract

Background

Various kinds of molecular targeted drugs to inhibit receptor tyrosine kinases (RTKs) have been recently developed. The relationship between the expression status of major RTKs and prognosis in gastric cancer remains unclear. We conducted a multicenter study to evaluate the prognostic impact of the expression of epidermal growth factor receptor (EGFR), c-Met, platelet-derived growth factor receptor (PDGFR), and c-Kit in gastric cancer.

Methods

This study included 153 gastric cancer patients who underwent gastrectomy at 9 institutions between 2000 and 2006. Expression status of EGFR, c-Met, PDGFR, and c-Kit were evaluated with immunohistochemistry (IHC) centrally. Overall survival based on RTK expression status was statistically compared. Cox multivariate analysis was conducted to adjust for potentially confounding factors.

Results

The positive rates for EGFR, c-Met, PDGFR, and c-Kit were 14.4, 24.8, 41.2, and 11.1 %, respectively. Significant interactions with expression status were observed for pathological N stage with EGFR; HER2-status with c-Met; tumor location, histology, and pathological N stage with PDGFR; and no examined variables with c-Kit. Concomitant HER2 positivity was observed for 0.7 % of tumors positive for EGFR, 3.9 % for c-Met, 4.6 % for PDGFR, and 1.3 % for c-Kit. There were some differences in overall survival between patients with or without RTK expression, but only c-Kit expression showed a significant survival difference in Cox multivariate analysis (P = 0.046).

Conclusions

Our multicenter study indicated that IHC expression of 4 RTKs had some prognostic impact and that c-Kit–positive status may be a significant indicator of good prognosis in gastric cancer patients.

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