Introduction
Materials and methods
Patients and tissue samples
Parameters | N | NRP-1 expression (n, %) | P | |
---|---|---|---|---|
High | Low | |||
Age
| ||||
< 48 | 100 | 63 (63.00) | 37 (37.00) | NS |
≥ 48 | 166 | 113 (68.07) | 53 (31.93) | |
Gender
| ||||
Male | 166 | 106 (63.86) | 60 (36.14) | NS |
Female | 100 | 70 (70.00) | 30 (30.00) | |
Clinical stage
| ||||
I ~ II | 68 | 30 (44.12) | 38 (55.88) | 0.02 |
III ~ IV | 198 | 146 (73.74) | 52 (27.26) | |
T-stage
| ||||
T1 ~ T2 | 90 | 55 (61.11) | 35 (38.89) | NS |
T3 ~ T4 | 176 | 121 (68.75) | 55 (31.25) | |
N-stage
| ||||
N0 | 78 | 50 (64.10) | 28 (35.90) | NS |
N1 ~ N3 | 188 | 126 (67.02) | 62 (32.98) | |
WHO histological type
| ||||
II | 76 | 50 (65.79) | 26 (34.21) | NS |
III | 190 | 136 (71.58) | 54 (28.42) | |
Recurrence
| ||||
No | 196 | 116 (59.18) | 80 (40.92) | 0.001 |
Yes | 70 | 60 (85.71) | 10 (14.29) | |
Metastasis
| ||||
No | 211 | 128 (60.66) | 63 (39.34) | 0.001 |
Yes | 55 | 48 (87.27) | 7 (12.73) |
Immunohistochemistry analysis
Statistical analysis
Results
Upregulation of NRP-1 in human NPCs
Association of NRP-1 protein expression with the clinicopathological characteristics of human NPCs
Association of NRP-1 protein expression with the prognosis of human NPCs
Variables | Subset | Hazard ratio (HR) | 95% confidence interval [CI] | P |
---|---|---|---|---|
Patient gender
| Male vs. Female | 1.987 | 0.608 ~ 4.092 | NS |
Patient age
| < 48 vs. ≥ 48 | 1.566 | 0.465 ~ 3.853 | NS |
Clinical stage
| I ~ II vs. III ~ IV | 7.382 | 1.031-16.613 | 0.002 |
T-stage
| T1 ~ T2 vs. T3 ~ T4 | 2.380 | 0.738 ~ 5.046 | NS |
N-stage
| N0 vs N1 ~ N3 | 1.778 | 0.732 ~ 4.028 | NS |
WHO histological type
| II vs. III | 1.458 | 0.689 ~ 3.076 | NS |
Recurrence
| No vs. Yes | 8.892 | 1.021-18.656 | 0.001 |
Metastasis
| No vs. Yes | 8.788 | 1.042-19.052 | 0.001 |
NRP-1
| Low vs. High | 16.926 | 1.833-38.132 | < 0.001 |
Variables | Subset | Hazard ratio (HR) | 95% confidence interval [CI] | P |
---|---|---|---|---|
Clinical stage
| I ~ II vs. III ~ IV | 6.193 | 1.011-13.392 | 0.006 |
Recurrence
| No vs. Yes | 6.928 | 0.922-13.556 | 0.005 |
Metastasis
| No vs. Yes | 6.893 | 1.023-13.528 | 0.005 |
NRP-1
| Low vs. High | 8.631 | 1.392-18.288 | 0.001 |