Background
Methods
Patients
Analysis of sugical procedures
Statistical analysis
Results
Patients
Characteristics | n/N | % | |
---|---|---|---|
Age | Mean 56.6 y (range, 21–86 y) | ||
FIGO stage | |||
III | 277/301 | 92.0% | |
IV | 24/301 | 8.0% | |
Histology | |||
Serous | 148/301 | 49.2% | |
Undifferentiated | 116/301 | 38.5% | |
Endometrioid | 17/301 | 5.6% | |
Mucinous | 15/301 | 5.0% | |
Others | 5/301 | 1.7% | |
Tumor grade | |||
G1 | 27/301 | 9.0% | |
G2 | 66/301 | 21.9% | |
G3 | 208/301 | 69.1% | |
Ascites > 500 ml | 62/301 | 20.6% | |
Primary Cytoreductive Surgery | 240/301 | 79.7% | |
Interval Debulking Surgery | 61/301 | 20.3% | |
Residual Disease after surgery | |||
R0 | 209/301 | 69.4% | |
R < 0.5 | 35/301 | 11.6% | |
R2 | 57/301 | 19% | |
R0 in G3 | 130/208 | 62.5% | |
R0 in G1-2 | 79/93 | 84.9% |
Treatment results
Bowel Resection | 116/301 | 38.5% |
Rectosigmoidectomy Only | 81/116 | 69,8% |
Upper Bowel Surgery Only | 17/116 | 14,7% |
Rectosigmoidectomy and Upper Bowel Surgery | 18/116 | 15,5% |
Pelvic Peritonectomy Only | 133/301 | 44,2% |
Upper Abdominal Procedurs Only | 13/301 | 4,3% |
Pelvic Peritonectomy and Upper Abdominal Procedures | 69/301 | 22,9% |
Upper Abdominal Procedures | 82/301 | 27.2% |
Diaphragmatic Peritoneum Stripping | 45/82 | 54,9% |
Splenectomy | 31/82 | 37,8% |
Colecystectomy | 16/82 | 19,5% |
Liver Metastasectomy | 5/82 | 6,1% |
Partial Gastrectomy | 3/82 | 3,6% |
Distal Pancreatectomy | 3/82 | 3,6% |
Diaphragmatic Full-Thickness Resection | 2/82 | 2.4% |
Hepatic Hilum Lymphadenectomy | 1/82 | 1.4% |
Celiac Lymphadenectomy | 1/82 | 1.4% |
Retroperitoneal Lymphadenectomy | 196/301 | 65.1% |
Pelvic Lymphadenectomy | 188/196 | 95.9% |
Aortic Lymphadenectomy | 149/196 | 74.5% |
Complications
Total (n = 301) | Bowel resection group (n = 116) | No resection group (n = 185) | p | |
---|---|---|---|---|
Intraoperative complications
| ||||
Vessel injuries
| 8 (2.7%) | 3 (2.6%) | 5 (2.7%) | NS |
Bladder lesions
| 24 (8.0%) | 14 (12.1%) | 10 (5.4%) | <0.05 |
Diaphragm perforations
| 12 (4.0%) | 8 (6.9%) | 4 (2.2%) | <0.05 |
Estimated blood loss ≥ 1000 mL | 65 (21.6%) | 37 (31.9%) | 28 (15.1%) | <0.05 |
Perioperative complications
| ||||
Wound infection
| 5 (1.7%) | 4 (3.4%) | 1 (0.5%) | NS |
Pleuric effusion
| 5 (1.7%) | 4 (3.4%) | 1 (0.5%) | NS |
Post-operative hemorrhage
| 4 (1.3%) | 3 (2.6%) | 1 (0.5%) | NS |
Enteric fistula
| 10 (3.3%) | 5 (4.3%) | 5 (2.7%) | NS |
Pulmonary embolism
| 3 (1.0%) | 3 (2.6%) | 0 | <0.05 |
Pelvic Infection
| 4 (1.3%) | 3 (2.6%) | 1 (0.5%) | NS |
Survival analysis
Regression Coefficient (B) PFS | PFS(p) | PFS HR | Regression Coefficient (B) OS | OS(p) | OS HR | |
---|---|---|---|---|---|---|
Infiltration of Mucosa or Muscolar layer vs. Infiltration of Serosa
|
-,502
|
,234
|
,605
|
-,271
|
,458
|
,763
|
Intestinal Resection vs. No Intestinal Resection
|
-,152
|
,942
|
,859
|
-,404
|
,184
|
,668
|
Grading G 1&2 vs 3
|
,974
|
,000
|
2,648
|
,784
|
,004
|
2,189
|
Upper Abdominal Procedures vs. No Upper Abdominal Procedures
|
-,499
|
,119
|
,607
|
-,409
|
,127
|
,664
|
Age
|
,005
|
,335
|
1,005
|
,039
|
,000
|
1,040
|
Primary Cytoreduction vs. Interval Debulking Surgery
|
1,277
|
,000
|
3,586
|
1,280
|
,000
|
3,596
|