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Erschienen in: Heart and Vessels 8/2022

18.02.2022 | Original Article

Prognostic role of diuretic failure in determining mortality for patients hospitalized with acute decompensated heart failure

verfasst von: Salmaan Mumtaz, Mehul Sharma, Maggie P. Fu, Abhinav Sharma, Junaid Mir, Aisha Rehman, Michael N. Vranian

Erschienen in: Heart and Vessels | Ausgabe 8/2022

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Abstract

Background

Worsening heart failure (WHF) is defined as persistent or worsening symptoms of heart failure that require an escalation in intravenous therapy or initiation of mechanical and ventilatory support during hospitalization. We assessed a simplified version of WHF called diuretic failure (DF), defined as an escalation of loop diuretic dosing after 48 h, and assessed its effects on mortality and rehospitalizations at 60-days.

Methods

We conducted a multicenter retrospective study between December 1, 2017 and January 1, 2020. We identified 1389 patients of which 6.4% experienced DF.

Results

There was a significant relationship between DF and cumulative rates of 60-day mortality and 60-day rehospitalizations (p = 0.0002 and p = 0.0214). After multivariate adjustment, DF was associated with longer hospital stay (p < 0.0001), increased rate of 60-day mortality (p = 0.026), 60-day rehospitalizations (p = 0.036), and a composite outcome of 60-day mortality and 60-day cardiac rehospitalizations (p = 0.018).

Conclusions

DF has a strong relationship with adverse heart failure outcomes suggesting it is a simple yet robust prognostic indicator which can be used in real time to identify high-risk patients during hospitalization and beyond.
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Metadaten
Titel
Prognostic role of diuretic failure in determining mortality for patients hospitalized with acute decompensated heart failure
verfasst von
Salmaan Mumtaz
Mehul Sharma
Maggie P. Fu
Abhinav Sharma
Junaid Mir
Aisha Rehman
Michael N. Vranian
Publikationsdatum
18.02.2022
Verlag
Springer Japan
Erschienen in
Heart and Vessels / Ausgabe 8/2022
Print ISSN: 0910-8327
Elektronische ISSN: 1615-2573
DOI
https://doi.org/10.1007/s00380-022-02042-x

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