Skip to main content
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases 3/2019

24.01.2019 | Original Article

Prognostic roles of time to positivity of blood culture in children with Streptococcus pneumoniae bacteremia

verfasst von: Qinyuan Li, Yuanyuan Li, Qian Yi, Fengtao Suo, Yuan Tang, Siying Luo, Xiaoyin Tian, Guangli Zhang, Dapeng Chen, Zhengxiu Luo

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 3/2019

Einloggen, um Zugang zu erhalten

Abstract

We aimed to investigate the relationship between time to positivity (TTP) of blood cultures and clinical outcomes in children with S. pneumoniae bacteremia. Children with S. pneumoniae bacteremia hospitalized in Children’s Hospital of Chongqing Medical University from May 2011 to December 2017 were enrolled retrospectively. Overall, 136 children with S. pneumoniae bacteremia were enrolled. The standard cutoff TTP was 12 h. We stated that in-hospital mortality is significantly higher in the early TTP (≤ 12 h) group than that in the late TTP (> 12 h) group (41.70% vs 8.00%, P < 0.001). Septic shock occurred in 58.30% of patients with early TTP and in 21.00% of patients with late TTP (P < 0.001). Independent risk factors of in-hospital mortality and septic shock in children with S. pneumoniae bacteremia included early TTP, need for invasive mechanical ventilation, and PRISM III score ≥ 10. Overall, TTP ≤ 12 h appeared to associate with the worse outcomes for children with S. pneumoniae bacteremia.
Literatur
2.
Zurück zum Zitat Isaacman DJ, McIntosh ED, Reinert RR (2010) Burden of invasive pneumococcal disease and serotype distribution among Streptococcus pneumoniae isolates in young children in Europe: impact of the 7-valent pneumococcal conjugate vaccine and considerations for future conjugate vaccines. Int J Infect Dis 14(3):e197–e209. https://doi.org/10.1016/j.ijid.2009.05.010 CrossRefPubMed Isaacman DJ, McIntosh ED, Reinert RR (2010) Burden of invasive pneumococcal disease and serotype distribution among Streptococcus pneumoniae isolates in young children in Europe: impact of the 7-valent pneumococcal conjugate vaccine and considerations for future conjugate vaccines. Int J Infect Dis 14(3):e197–e209. https://​doi.​org/​10.​1016/​j.​ijid.​2009.​05.​010 CrossRefPubMed
11.
Zurück zum Zitat Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, Rochwerg B, Rubenfeld GD, Angus DC, Annane D, Beale RJ, Bellinghan GJ, Bernard GR, Chiche JD, Coopersmith C, De Backer DP, French CJ, Fujishima S, Gerlach H, Hidalgo JL, Hollenberg SM, Jones AE, Karnad DR, Kleinpell RM, Koh Y, Lisboa TC, Machado FR, Marini JJ, Marshall JC, Mazuski JE, McIntyre LA, McLean AS, Mehta S, Moreno RP, Myburgh J, Navalesi P, Nishida O, Osborn TM, Perner A, Plunkett CM, Ranieri M, Schorr CA, Seckel MA, Seymour CW, Shieh L, Shukri KA, Simpson SQ, Singer M, Thompson BT, Townsend SR, Van der Poll T, Vincent JL, Wiersinga WJ, Zimmerman JL, Dellinger RP (2017) Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med 43(3):304–377. https://doi.org/10.1007/s00134-017-4683-6 CrossRef Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, Rochwerg B, Rubenfeld GD, Angus DC, Annane D, Beale RJ, Bellinghan GJ, Bernard GR, Chiche JD, Coopersmith C, De Backer DP, French CJ, Fujishima S, Gerlach H, Hidalgo JL, Hollenberg SM, Jones AE, Karnad DR, Kleinpell RM, Koh Y, Lisboa TC, Machado FR, Marini JJ, Marshall JC, Mazuski JE, McIntyre LA, McLean AS, Mehta S, Moreno RP, Myburgh J, Navalesi P, Nishida O, Osborn TM, Perner A, Plunkett CM, Ranieri M, Schorr CA, Seckel MA, Seymour CW, Shieh L, Shukri KA, Simpson SQ, Singer M, Thompson BT, Townsend SR, Van der Poll T, Vincent JL, Wiersinga WJ, Zimmerman JL, Dellinger RP (2017) Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med 43(3):304–377. https://​doi.​org/​10.​1007/​s00134-017-4683-6 CrossRef
12.
Zurück zum Zitat Pollack MM, Patel KM, Ruttimann UE (1996) PRISM III: an updated Pediatric Risk of Mortality score. Crit Care Med 24(5):743–752CrossRefPubMed Pollack MM, Patel KM, Ruttimann UE (1996) PRISM III: an updated Pediatric Risk of Mortality score. Crit Care Med 24(5):743–752CrossRefPubMed
13.
Zurück zum Zitat Clinical and Laboratory Standards Institute (2014) Performance standards for antimicrobial susceptibility testing: twenty-four informational supplement. M100-S24. Wayne, PA Clinical and Laboratory Standards Institute (2014) Performance standards for antimicrobial susceptibility testing: twenty-four informational supplement. M100-S24. Wayne, PA
14.
Zurück zum Zitat Van Erkel AR, Pattynama PM (1998) Receiver operating characteristic (ROC) analysis: basic principles and applications in radiology. Eur J Radiol 27(2):88–94CrossRefPubMed Van Erkel AR, Pattynama PM (1998) Receiver operating characteristic (ROC) analysis: basic principles and applications in radiology. Eur J Radiol 27(2):88–94CrossRefPubMed
16.
Zurück zum Zitat Youden WJ (1950) Index for rating diagnostic tests. Cancer 3(1):32–35CrossRef Youden WJ (1950) Index for rating diagnostic tests. Cancer 3(1):32–35CrossRef
18.
Zurück zum Zitat Haimi-Cohen Y, Vellozzi EM, Rubin LG (2002) Initial concentration of Staphylococcus epidermidis in simulated pediatric blood cultures correlates with time to positive results with the automated, continuously monitored BACTEC blood culture system. J Clin Microbiol 40(3):898–901CrossRefPubMedPubMedCentral Haimi-Cohen Y, Vellozzi EM, Rubin LG (2002) Initial concentration of Staphylococcus epidermidis in simulated pediatric blood cultures correlates with time to positive results with the automated, continuously monitored BACTEC blood culture system. J Clin Microbiol 40(3):898–901CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat Bell LM, Alpert G, Campos JM, Plotkin SA (1985) Routine quantitative blood cultures in children with Haemophilus influenzae or Streptococcus pneumoniae bacteremia. Pediatrics 76(6):901–904PubMed Bell LM, Alpert G, Campos JM, Plotkin SA (1985) Routine quantitative blood cultures in children with Haemophilus influenzae or Streptococcus pneumoniae bacteremia. Pediatrics 76(6):901–904PubMed
20.
Zurück zum Zitat Choi KM, Ng DK, Wong SF, Kwok KL, Chow PY, Chan CH, Ho JC (2005) Assessment of the Pediatric Index of Mortality (PIM) and the Pediatric Risk of Mortality (PRISM) III score for prediction of mortality in a paediatric intensive care unit in Hong Kong. Hong Kong Med J 11(2):97–103PubMed Choi KM, Ng DK, Wong SF, Kwok KL, Chow PY, Chan CH, Ho JC (2005) Assessment of the Pediatric Index of Mortality (PIM) and the Pediatric Risk of Mortality (PRISM) III score for prediction of mortality in a paediatric intensive care unit in Hong Kong. Hong Kong Med J 11(2):97–103PubMed
22.
Zurück zum Zitat Wang JN, Wu JM, Chen YJ (2001) Validity of the updated Pediatric Risk of Mortality score (PRISM III) in predicting the probability of mortality in a pediatric intensive care unit. Acta Paediatr Taiwan 42(6):333–337PubMed Wang JN, Wu JM, Chen YJ (2001) Validity of the updated Pediatric Risk of Mortality score (PRISM III) in predicting the probability of mortality in a pediatric intensive care unit. Acta Paediatr Taiwan 42(6):333–337PubMed
26.
Zurück zum Zitat Matthias W, Ines K, Wichard V, Ingo F, Uwe M, Matthias M, Klaus S, Ingo A, Florian H, Silke P (2013) Time to positivity as prognostic tool in patients with Pseudomonas aeruginosa bloodstream infection. J Inf Secur 67(5):416–423 Matthias W, Ines K, Wichard V, Ingo F, Uwe M, Matthias M, Klaus S, Ingo A, Florian H, Silke P (2013) Time to positivity as prognostic tool in patients with Pseudomonas aeruginosa bloodstream infection. J Inf Secur 67(5):416–423
Metadaten
Titel
Prognostic roles of time to positivity of blood culture in children with Streptococcus pneumoniae bacteremia
verfasst von
Qinyuan Li
Yuanyuan Li
Qian Yi
Fengtao Suo
Yuan Tang
Siying Luo
Xiaoyin Tian
Guangli Zhang
Dapeng Chen
Zhengxiu Luo
Publikationsdatum
24.01.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 3/2019
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-018-03443-5

Weitere Artikel der Ausgabe 3/2019

European Journal of Clinical Microbiology & Infectious Diseases 3/2019 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.