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01.03.2013 | Original Paper | Ausgabe 1/2013

Medical Oncology 1/2013

Prognostic significance of BRCA1 expression in gastric cancer

Zeitschrift:
Medical Oncology > Ausgabe 1/2013
Autoren:
Wenjiao Chen, Jian Wang, Xiao Li, Jingying Li, Li Zhou, Tianzhu Qiu, Meiling Zhang, Ping Liu
Wichtige Hinweise
Wenjiao Chen and Jian Wang offer the equal contributions to this study.

Abstract

The breast and ovarian cancer susceptibility gene 1 (BRCA1) is a well-known tumor suppressor gene implicated in the predisposition of early-onset breast and ovarian cancer. The aim of this study is to identify the prognostic significance of BRCA1 in patients with gastric cancer undergoing surgery and platinum-based adjuvant chemotherapy. BRCA1 protein expression profiles were evaluated by immunohistochemistry (IHC) on surgical specimens of 637 gastric cancer patients. The relationships between BRCA1 expression and existing prognostic factors, platinum-based adjuvant chemotherapy, disease-free survival, and overall survival were analyzed. There were 637 stage II/III patients, of which 219 samples (34 %) were evaluated as BRCA1 IHC positive. BRCA1 expression had statistically significant association only with tumor differentiation (p = 0.004). The patients with BRCA1-positive expression had significantly prolonged overall survival (p = 0.049). The patients received platinum-based adjuvant chemotherapy showed a better prognosis (p = 0.017). The patients with BRCA1-negative expression benefited more from platinum-based adjuvant chemotherapy (p = 0.024). Multivariate analysis demonstrated that tumor size, T category, N category, vascular or nerves invasion, and platinum-based adjuvant chemotherapy were good prognostic factors for overall survival (p < 0.05). BRCA1 expression was not significantly related to overall survival (p = 0.127). The positive correlation between BRCA1 expression and overall survival suggests that patients with BRCA1 expression have a better prognosis in gastric cancer. Patients without BRCA1 expression can benefit from platinum-based adjuvant chemotherapy. However, BRCA1 expression might not be a good prognostic factor.

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