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01.12.2012 | Research | Ausgabe 1/2012 Open Access

World Journal of Surgical Oncology 1/2012

Prognostic significance of solitary lymph node metastasis in patients with squamous cell carcinoma of middle thoracic esophagus

Zeitschrift:
World Journal of Surgical Oncology > Ausgabe 1/2012
Autoren:
Jie Wu, Qi-Xun Chen, Xing-Ming Zhou, Wei-Ming Mao, Mark J. Krasna, Li-Song Teng
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-10-210) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

JW conceived this study, collected data, performed analysis and drafted the manuscript. QXC participated in study design, literature search and coordination. JW, QXC, XMZ and WMM participated in the treatment of these patients. MJK performed data analysis and helped to draft the manuscript. LST participated in study design and helped to draft the manuscript. All authors read and approve the final manuscript.

Abstract

Background

The aim of this study is to compare clinical outcomes between patients with solitary lymph node metastasis and node-negative (N0) patients in squamous cell carcinoma of the middle thoracic esophagus.

Methods

A series of 135 patients with squamous cell carcinoma of the middle thoracic esophagus were retrospectively investigated. There were 33 patients with solitary lymph node metastasis and 102 N0 patients. Skip metastasis in 33 patients with solitary lymph node metastasis was defined according to three criteria: Japanese Society for Esophageal Disease (JSED), American Joint Commission on Cancer (AJCC), and the anatomical compartment.

Results

In 33 patients with solitary lymph node metastasis, skip metastasis was shown in 13, 23, and 8 patients according JSED, AJCC and anatomical compartment respectively. The 5-year survival rates for N0 patients and patients with solitary lymph node metastasis were 58% and 32% respectively (P =0.008). Multivariate analysis revealed that skip metastasis was not an independent prognostic factor.

Conclusions

For patients with middle thoracic esophageal squamous cell carcinoma, solitary lymph node metastasis has a negative impact on survival compared with N0 disease; skip metastasis, however, is comparable to N0 diseases in predicting prognosis.
Zusatzmaterial
Authors’ original file for figure 1
12957_2012_1157_MOESM1_ESM.pdf
Authors’ original file for figure 2
12957_2012_1157_MOESM2_ESM.pdf
Literatur
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