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Comparative Clinical Pathology

Erschienen in:

23.11.2015 | Review Article

Prognostic value and clinical significance of TCR rearrangements for MRD monitoring in ALL patients

verfasst von: Maria Kavianpur, Mohammad Shahjahani, Kaveh Jaseb, Siddha Kasar, Najmaldin Saki

Erschienen in: Comparative Clinical Pathology | Ausgabe 2/2017

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Abstract

Acute lymphoblastic leukemia is a hematological malignancy of lymphoid progenitor cells associated with excessive proliferation of lymphocytes, and lymphocyte markers can be used for the diagnosis and assessment of disease. Cell surface receptors, including T cell receptor and immunoglobulin (on T and B cells, respectively), are among the most important lymphocyte markers. Gene segment variation, i.e., involvement of several genes in the expression of each receptor, is effective on extensive rearrangement of cell surface receptors. These receptors can be observed in both T-acute lymphoblastic leukemia (ALL) and precursor B-ALL cells. In this study, we have discussed T cell receptor (TCR) gene rearrangements in ALL. As leukemia cell proliferation originates from a unique clone, clone-specific rearrangement can be very helpful in diagnosis and detection of remaining malignant cells from among normal cells for minimal residual disease. On the other hand, each of the TCR genes is associated with translocation in ALL types, and the result of gene rearrangements can be used as prognosis markers.

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Titel: Prognostic value and clinical significance of TCR rearrangements for MRD monitoring in ALL patients
verfasst von: Maria Kavianpur
Mohammad Shahjahani
Kaveh Jaseb
Siddha Kasar
Najmaldin Saki
Publikationsdatum: 23.11.2015
Verlag: Springer London
Erschienen in: Comparative Clinical Pathology / Ausgabe 2/2017
Print ISSN: 1618-5641
Elektronische ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-015-2207-8

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Prognostic value and clinical significance of TCR rearrangements for MRD monitoring in ALL patients

Abstract

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