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Erschienen in: The International Journal of Cardiovascular Imaging 12/2017

29.06.2017 | Original Paper

Prognostic value of a faster, low-radiation myocardial perfusion SPECT protocol in a CZT camera

verfasst von: Ronaldo S. L. Lima, Thaís R. Peclat, Ana Carolina A. H. Souza, Aline M. K. Nakamoto, Felipe M. Neves, Victor F. Souza, Letícia B. Glerian, Andrea De Lorenzo

Erschienen in: The International Journal of Cardiovascular Imaging | Ausgabe 12/2017

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Abstract

To determine the prognostic value of a new, ultrafast, low dose myocardial perfusion SPECT (MPS) protocol in a cadmium-zinc telluride (CZT) camera. CZT cameras have introduced significant progress in MPS imaging, offering high-quality images despite lower doses and scan time. Yet, it is unknown if, with such protocol changes, the prognostic value of MPS is preserved. Patients had a 1-day 99 m-Tc-sestamibi protocol, starting with the rest (185–222 MBq) followed by stress (666–740 MBq). Acquisition times were 6 and 3 min, respectively. MPS were classified as normal or abnormal perfusion scans and summed scores of stress, rest, and difference (SSS, SRS and SDS), calculated. Patients were followed with 6-month phone calls. Hard events were defined as death or nonfatal myocardial infarction. Late revascularization was that occurring after 60 days of MPS. 2930 patients (age 64.0 ± 12.1 years, 53.3% male) were followed for 30.7 ± 7.5 months. Mean dosimetry was 6 mSv and mean total study time, 48 ± 13 min. The annual hard event and late revascularization rate were higher in patients with greater extension of defect and ischemia. SSS was higher in patients with hard events compared to those without events (2.6 ± 4.9 vs. 5.0 ± 6.3, p < 0.001), as well as the SDS (0.7 ± 1.9 vs. 1.7 ± 3.4, p < 0.00). The same was true for patients with or without late revascularization (SSS: 2.5 ± 4.7 vs. 6.6 ± 7.1; SDS: 0.6 ± 1.7 vs. 2.9 ± 3.8, p < 0.01). A new, faster, low-radiation, MPS protocol in a CZT camera maintain the ability to stratify patients with increased risk of events, showing that, in the presence of greater extension of defect or ischemia, patients presented higher rates of hard events and late revascularization.
Literatur
1.
Zurück zum Zitat Verberne HJ, Acampa W, Anagnostopoulos C, Ballinger J, Bengel F, De Bondt P et al (2015) EANM procedural guidelines for radionuclide myocardial perfusion imaging with SPECT and SPECT/CT: 2015 revision. Eur J Nucl Med Mol Imaging 42(12):1929–1940CrossRefPubMedPubMedCentral Verberne HJ, Acampa W, Anagnostopoulos C, Ballinger J, Bengel F, De Bondt P et al (2015) EANM procedural guidelines for radionuclide myocardial perfusion imaging with SPECT and SPECT/CT: 2015 revision. Eur J Nucl Med Mol Imaging 42(12):1929–1940CrossRefPubMedPubMedCentral
2.
Zurück zum Zitat Hansen CL, Goldstein RA, Akinboboye OO, Berman DS, Botvinick EH, Churchwell KB et al (2007) Myocardial perfusion and function: single photon emission computed tomography. J Nucl Cardiol 14(6):e39–e60CrossRefPubMed Hansen CL, Goldstein RA, Akinboboye OO, Berman DS, Botvinick EH, Churchwell KB et al (2007) Myocardial perfusion and function: single photon emission computed tomography. J Nucl Cardiol 14(6):e39–e60CrossRefPubMed
3.
Zurück zum Zitat Oddstig J, Hedeer F, Jögi J, Carlsson M, Hindorf C, Engblom H (2013) Reduced administered activity, reduced acquisition time, and preserved image quality for the new CZT camera. J Nucl Cardiol 20(1):38–44CrossRefPubMed Oddstig J, Hedeer F, Jögi J, Carlsson M, Hindorf C, Engblom H (2013) Reduced administered activity, reduced acquisition time, and preserved image quality for the new CZT camera. J Nucl Cardiol 20(1):38–44CrossRefPubMed
4.
Zurück zum Zitat Duvall WL, Sweeny JM, Croft LB, Ginsberg E, Guma KA, Henzlova MJ (2012) Reduced stress dose with rapid acquisition CZT SPECT MPI in a non-obese clinical population: comparison to coronary angiography. J Nucl Cardiol 19(1):19–27CrossRefPubMed Duvall WL, Sweeny JM, Croft LB, Ginsberg E, Guma KA, Henzlova MJ (2012) Reduced stress dose with rapid acquisition CZT SPECT MPI in a non-obese clinical population: comparison to coronary angiography. J Nucl Cardiol 19(1):19–27CrossRefPubMed
5.
Zurück zum Zitat Mouden M, Timmer JR, Ottervanger JP, Reiffers S, Oostdijk AH, Knollema S et al (2012) Impact of a new ultrafast CZT SPECT camera for myocardial perfusion imaging: fewer equivocal results and lower radiation dose. Eur J Nucl Med Mol Imaging 39(6):1048–1055CrossRefPubMed Mouden M, Timmer JR, Ottervanger JP, Reiffers S, Oostdijk AH, Knollema S et al (2012) Impact of a new ultrafast CZT SPECT camera for myocardial perfusion imaging: fewer equivocal results and lower radiation dose. Eur J Nucl Med Mol Imaging 39(6):1048–1055CrossRefPubMed
6.
Zurück zum Zitat Hayes SW, De Lorenzo A, Hachamovitch R, Dhar SC, Hsu P, Cohen I et al (2003) Prognostic implications of combined prone and supine acquisitions in patients with equivocal or abnormal supine myocardial perfusion SPECT. J Nucl Med 44(10):1633–1640PubMed Hayes SW, De Lorenzo A, Hachamovitch R, Dhar SC, Hsu P, Cohen I et al (2003) Prognostic implications of combined prone and supine acquisitions in patients with equivocal or abnormal supine myocardial perfusion SPECT. J Nucl Med 44(10):1633–1640PubMed
7.
Zurück zum Zitat Burrell S, MacDonald A (2006) Artifacts and pitfalls in myocardial perfusion imaging. J Nucl Med Technol 34(4):193–211 (quiz 2–4)PubMed Burrell S, MacDonald A (2006) Artifacts and pitfalls in myocardial perfusion imaging. J Nucl Med Technol 34(4):193–211 (quiz 2–4)PubMed
8.
Zurück zum Zitat Berman DS, Kang X, Van Train KF, Lewin HC, Cohen I, Areeda J et al (1998) Comparative prognostic value of automatic quantitative analysis versus semiquantitative visual analysis of exercise myocardial perfusion single-photon emission computed tomography. J Am Coll Cardiol 32(7):1987–1995CrossRefPubMed Berman DS, Kang X, Van Train KF, Lewin HC, Cohen I, Areeda J et al (1998) Comparative prognostic value of automatic quantitative analysis versus semiquantitative visual analysis of exercise myocardial perfusion single-photon emission computed tomography. J Am Coll Cardiol 32(7):1987–1995CrossRefPubMed
9.
Zurück zum Zitat Berman DS, Hachamovitch R, Kiat H, Cohen I, Cabico JA, Wang FP et al (1995) Incremental value of prognostic testing in patients with known or suspected ischemic heart disease: a basis for optimal utilization of exercise technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography. J Am Coll Cardiol 26(3):639–647CrossRefPubMed Berman DS, Hachamovitch R, Kiat H, Cohen I, Cabico JA, Wang FP et al (1995) Incremental value of prognostic testing in patients with known or suspected ischemic heart disease: a basis for optimal utilization of exercise technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography. J Am Coll Cardiol 26(3):639–647CrossRefPubMed
10.
Zurück zum Zitat Hachamovitch R, Berman DS, Shaw LJ, Kiat H, Cohen I, Cabico JA et al (1998) Incremental prognostic value of myocardial perfusion single photon emission computed tomography for the prediction of cardiac death: differential stratification for risk of cardiac death and myocardial infarction. Circulation 97(6):535–543CrossRefPubMed Hachamovitch R, Berman DS, Shaw LJ, Kiat H, Cohen I, Cabico JA et al (1998) Incremental prognostic value of myocardial perfusion single photon emission computed tomography for the prediction of cardiac death: differential stratification for risk of cardiac death and myocardial infarction. Circulation 97(6):535–543CrossRefPubMed
11.
Zurück zum Zitat Lima R, Ronaldo L, De Lorenzo A, Andrea DL, Camargo G, Gabriel C et al (2014) Prognostic value of myocardium perfusion imaging with a new reconstruction algorithm. J Nucl Cardiol 21(1):149–157CrossRefPubMed Lima R, Ronaldo L, De Lorenzo A, Andrea DL, Camargo G, Gabriel C et al (2014) Prognostic value of myocardium perfusion imaging with a new reconstruction algorithm. J Nucl Cardiol 21(1):149–157CrossRefPubMed
12.
Zurück zum Zitat Thygesen K, Alpert JS, White HD, Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction (2007) Universal definition of myocardial infarction. J Am Coll Cardiol 50(22):2173–2195CrossRefPubMed Thygesen K, Alpert JS, White HD, Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction (2007) Universal definition of myocardial infarction. J Am Coll Cardiol 50(22):2173–2195CrossRefPubMed
13.
Zurück zum Zitat Duvall WL, Croft LB, Ginsberg ES, Einstein AJ, Guma KA, George T et al (2011) Reduced isotope dose and imaging time with a high-efficiency CZT SPECT camera. J Nucl Cardiol 18(5):847–857CrossRefPubMed Duvall WL, Croft LB, Ginsberg ES, Einstein AJ, Guma KA, George T et al (2011) Reduced isotope dose and imaging time with a high-efficiency CZT SPECT camera. J Nucl Cardiol 18(5):847–857CrossRefPubMed
14.
Zurück zum Zitat Oldan JD, Shaw LK, Hofmann P, Phelan M, Nelson J, Pagnanelli R et al (2016) Prognostic value of the cadmium-zinc-telluride camera: a comparison with a conventional (Anger) camera. J Nucl Cardiol 23(6):1280–1287CrossRefPubMed Oldan JD, Shaw LK, Hofmann P, Phelan M, Nelson J, Pagnanelli R et al (2016) Prognostic value of the cadmium-zinc-telluride camera: a comparison with a conventional (Anger) camera. J Nucl Cardiol 23(6):1280–1287CrossRefPubMed
15.
Zurück zum Zitat Hachamovitch R, Berman DS, Kiat H, Bairey CN, Cohen I, Cabico A et al (1996) Effective risk stratification using exercise myocardial perfusion SPECT in women: gender-related differences in prognostic nuclear testing. J Am Coll Cardiol 28(1):34–44CrossRefPubMed Hachamovitch R, Berman DS, Kiat H, Bairey CN, Cohen I, Cabico A et al (1996) Effective risk stratification using exercise myocardial perfusion SPECT in women: gender-related differences in prognostic nuclear testing. J Am Coll Cardiol 28(1):34–44CrossRefPubMed
16.
Zurück zum Zitat Navare SM, Mather JF, Shaw LJ, Fowler MS, Heller GV (2004) Comparison of risk stratification with pharmacologic and exercise stress myocardial perfusion imaging: a meta-analysis. J Nucl Cardiol 11(5):551–561CrossRefPubMed Navare SM, Mather JF, Shaw LJ, Fowler MS, Heller GV (2004) Comparison of risk stratification with pharmacologic and exercise stress myocardial perfusion imaging: a meta-analysis. J Nucl Cardiol 11(5):551–561CrossRefPubMed
Metadaten
Titel
Prognostic value of a faster, low-radiation myocardial perfusion SPECT protocol in a CZT camera
verfasst von
Ronaldo S. L. Lima
Thaís R. Peclat
Ana Carolina A. H. Souza
Aline M. K. Nakamoto
Felipe M. Neves
Victor F. Souza
Letícia B. Glerian
Andrea De Lorenzo
Publikationsdatum
29.06.2017
Verlag
Springer Netherlands
Erschienen in
The International Journal of Cardiovascular Imaging / Ausgabe 12/2017
Print ISSN: 1569-5794
Elektronische ISSN: 1875-8312
DOI
https://doi.org/10.1007/s10554-017-1202-3

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