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Pathology & Oncology Research

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11.06.2019 | Original Article

Prognostic Value of Accumulative Expression of COX-2 and p53 in Small and Diffuse Large B Cell Lymphoma

verfasst von: Amen H. Zaky, Dalia Elsers, Rania Bakry, Mostafa Abdelwanis, Ola Nabih, Rania Hafez, Mahmoud Rezk

Erschienen in: Pathology & Oncology Research | Ausgabe 2/2020

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Abstract

Cyclooxygenase-2 (COX-2) plays an important role in carcinogenesis, which catalyzes the conversion of arachidonic acid into prostaglandins. P53 is a tumor suppressor gene that contributes to apoptosis and cell cycle control. There is functional interaction between p53 and COX-2, which lead to abrogation of apoptosis and progression of malignancy. To assess the relationship between COX-2, p53 expression and the clinicopathololgic features in SLL and DLBCL. We immunohistochemically examined the expression of COX-2 and p53 in non-neoplastic lymphoid cells, lymph nodal low-grade (50 cases of SLL), intermediate and high-grade lymphomas (100 cases of DLBCL) and their corresponding bone marrow specimens. The expression of COX-2 and p53 was absent in the in non-neoplastic lymphoid cells. In contrast, their expression values increased progressively with the advancing grade of lymphoma (p < 0.001). COX-2 expression was significantly associated with advanced disease stage, high-grade lymphomas, and disease relapse and p53 expression. The p53was detected in 64.5% in patients positive for COX-2. The expressions of COX-2 and p53 proteins, were significantly associated with shorter overall-survival and progression free survival. Here we report up-regulation of COX-2and p53 protein expression in SLL and DLBCL indicating their interactive involvement in the pathogenesis of lymphoma. Our data provide a rationale for further investigation of COX-2 expression in lymphomas for potential prognostic, chemopreventive and chemotherapeutic purposes.

Jelic S, Jovanovic V, Milanovic N et al (1997) Richter syndrome with emphasis on large-cell non-Hodgkin lymphoma in previously unrecognized subclinical chronic lymphocytic leukemia. Neoplasma. 44:63–68PubMed

Matolcsy A, Casali P, Knowles DM (1995) Different clonal origin of B cell populations of chronic lymphocytic leukemia and large-cell lymphoma in Richter’s syndrome. Ann N Y Acad Sci 764:496–503PubMedCrossRef

Traweek ST, Liu J, Johnson RM, Winberg CD, Rappaport H (1993) High-grade transformation of chronic lymphocytic leukemia and low-grade non-Hodgkin’s lymphoma. Genotypic confirmation of clonal identity. Am J Clin Pathol 100:519–526PubMedCrossRef

Brynes RK, McCourty A, Sun NC, Koo CH (1995) Trisomy 12 in Richter’s transformation of chronic lymphocytic leukemia. Am J Clin Pathol 104:199–203PubMedCrossRef

Bea S, Lopez-Guillermo A, Ribas M et al (2002) Genetic imbalances in progressed B cell chronic lymphocytic leukemia and transformed large-cell lymphoma (Richter’s syndrome). Am J Pathol 161:957–968PubMedPubMedCentralCrossRef

d’Amore ES, Wick MR, Geisinger KR, Frizzera G (1990) Primary malignant lymphoma arising in postmastectomy lymphedema. Another facet of the Stewart-Treves syndrome. Am J Surg Pathol 14:456–463PubMedCrossRef

Copie-Bergman C, Niedobitek G, Mangham DC et al (1997) Epstein-Barr virus in B cell lymphomas associated with chronic suppurative inflammation. J Pathol 183:287–292PubMedCrossRef

Aozasa K, Takakuwa T, Nakatsuka S (2005) Pyothorax-associated lymphoma: a lymphoma developing in chronic inflammation. Adv Anat Pathol 12:324–331PubMedCrossRef

Sehn LH, Scott DW, Chhanabhai M et al (2011) Impact of concordant and discordant bone marrow involvement on outcome in diffuse large B cell lymphoma treated with R-CHOP. J Clin Oncol Off J Am Soc Clin Oncol 29:1452–1457CrossRef

10.

Cabanillas F, Velasquez WS, Hagemeister FB, McLaughlin P, Redman JR (1992) Clinical, biologic, and histologic features of late relapses in diffuse large cell lymphoma. Blood. 79:1024–1028PubMedCrossRef

11.

Hodges GF, Lenhardt TM, Cotelingam JD (1994) Bone marrow involvement in large-cell lymphoma. Prognostic implications of discordant disease. Am J Clin Pathol 101:305–311PubMedCrossRef

12.

Robertson LE, Redman JR, Butler JJ et al (1991) Discordant bone marrow involvement in diffuse large-cell lymphoma: a distinct clinical-pathologic entity associated with a continuous risk of relapse. J Clin Oncol Off J Am Soc Clin Oncol 9:236–242CrossRef

13.

Barisik NO, Bozkurt S, Gumus M et al (2010) Expression and prognostic significance of Cox-2 and p-53 in Hodgkin lymphomas: a retrospective study. Diagn Pathol 5:19PubMedPubMedCentralCrossRef

14.

Ohsawa M, Fukushima H, Ikura Y et al (2006) Expression of cyclooxygenase-2 in Hodgkin’s lymphoma: its role in cell proliferation and angiogenesis. Leuk Lymphoma 47:1863–1871PubMedCrossRef

15.

Zhi H, Wang L, Zhang J et al (2006) Significance of COX-2 expression in human esophageal squamous cell carcinoma. Carcinogenesis. 27:1214–1221PubMedCrossRef

16.

Romero M, Artigiani R, Costa H, Oshima CT, Miszputen S, Franco M (2008) Evaluation of the immunoexpression of COX-1, COX-2 and p53 in Crohn’s disease. Arq Gastroenterol 45:295–300PubMedCrossRef

17.

Asproni P, Vignoli M, Cancedda S, Millanta F, Terragni R, Poli A (2014) Immunohistochemical expression of cyclooxygenase-2 in normal, hyperplastic and neoplastic canine lymphoid tissues. J Comp Pathol 151:35–41PubMedCrossRef

18.

Konturek PC, Konturek SJ, Pierzchalski P et al (2002) Gastric MALT-lymphoma, gastrin and cyclooxygenases. Acta Gastro-Enterol Belg 65:17–23

19.

Al-Salam S, Awwad A, Sudhadevi M et al (2013) Epstein-Barr virus infection correlates with the expression of COX-2, p16(INK4A) and p53 in classic Hodgkin lymphoma. Int J Clin Exp Pathol 6:2765–2777PubMedPubMedCentral

20.

Paul AG, Sharma-Walia N, Chandran B (2011) Targeting KSHV/HHV-8 latency with COX-2 selective inhibitor nimesulide: a potential chemotherapeutic modality for primary effusion lymphoma. PLoS One 6:e24379PubMedCrossRef

21.

Paydas S, Ergin M, Erdogan S, Seydaoglu G (2007) Cyclooxygenase-2 expression in non-Hodgkin’s lymphomas. Leuk Lymphoma 48(2):389–395PubMedCrossRef

22.

Mestre F, Gutierrez A, Ramos R et al (2012) Expression of COX-2 on Reed-Sternberg cells is an independent unfavorable prognostic factor in Hodgkin lymphoma treated with ABVD. Blood. 119:6072–6079PubMedCrossRef

23.

Hsum YW, Yew WT, Hong PL et al (2011) Cancer chemopreventive activity of maslinic acid: suppression of COX-2 expression and inhibition of NF-kappaB and AP-1 activation in Raji cells. Planta Med 77:152–157PubMedCrossRef

24.

Paydas S, Ergin M, Seydaoglu G, Erdogan S, Yavuz S (2009) Prognostic [corrected] significance of angiogenic/lymphangiogenic, anti-apoptotic, inflammatory and viral factors in 88 cases with diffuse large B cell lymphoma and review of the literature. Leuk Res 33(12)

25.

Wun T, McKnight H, Tuscano JM (2004) Increased cyclooxygenase-2 (COX-2): a potential role in the pathogenesis of lymphoma. Leuk Res 28:179–190PubMedCrossRef

26.

Bernard MP, Bancos S, Sime PJ, Phipps RP (2008) Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise. Curr Pharm Des 14:2051–2060PubMedPubMedCentralCrossRef

27.

Hussein MR, Haemel AK, Wood GS (2003) p53-related pathways and the molecular pathogenesis of melanoma. Eur J Cancer Prev 12:93–100PubMedCrossRef

28.

Hussein MR, Al-Sabae TM, Georgis MN (2004) Analysis of Bcl-2 and p53 protein expression in non-Hodgkin’s lymphoma. Ann Oncol 15:1849–1850PubMedCrossRef

29.

Hussein MR, Al-Sabae TM, Georgis MN (2005) Analysis of the Bcl-2 and p53 protein expression in the lymphoproliferative lesions in the upper Egypt. Cancer Biol Ther 4:324–328PubMedCrossRef

30.

Li HL, Sun BZ, Ma FC (2004) Expression of COX-2, iNOS, p53 and Ki-67 in gastric mucosa-associated lymphoid tissue lymphoma. World J Gastroenterol 10:1862–1866PubMedPubMedCentralCrossRef

31.

Holmila R, Cyr D, Luce D et al (2008) COX-2 and p53 in human sinonasal cancer: COX-2 expression is associated with adenocarcinoma histology and wood-dust exposure. Mutat Res 122:2154–2159

32.

Kardosh A, Wang W, Uddin J et al (2005) Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt’s lymphoma in vitro and in vivo. Cancer Biology & Therapy 4:571–582CrossRef

33.

Witkowska M, Smolewski P (2013) Helicobacter pylori infection, chronic inflammation, and genomic transformations in gastric MALT lymphoma. Mediat Inflamm 2013:523170CrossRef

34.

Loong F, Chan AC, Ho BC et al (2010) Diffuse large B cell lymphoma associated with chronic inflammation as an incidental finding and new clinical scenarios. Cancer Biol Ther 23:493–501

35.

Valli R, Froio E, Alvarez de Celis MI, Mandato VD, Piana S (2014) Diffuse large B cell lymphoma occurring in an ovarian cystic teratoma: expanding the spectrum of large B cell lymphoma associated with chronic inflammation. Hum Pathol 45:2507–2511PubMedCrossRef

36.

Sagaert X, Van Cutsem E, De Hertogh G, Geboes K, Tousseyn T (2010) Gastric MALT lymphoma: a model of chronic inflammation-induced tumor development. Nat Rev Gastroenterol Hepatol 7:336–346PubMedCrossRef

37.

Baecklund E, Iliadou A, Askling J et al (2006) Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis. Arthritis Rheum 54:692–701PubMedCrossRef

38.

Valli R, Piana S, Capodanno I, Cavazza A (2011) Diffuse large B cell lymphoma associated with chronic inflammation arising in a renal pseudocyst. Int J Surg Pathol 19:117–119PubMedCrossRef

39.

Hoeft B, Becker N, Deeg E, Beckmann L, Nieters A (2008) Joint effect between regular use of non-steroidal anti-inflammatory drugs, variants in inflammatory genes and risk of lymphoma. Cancer Causes Control 19(2):163–173PubMedCrossRef

40.

Katkoori VR, Manne K, Vital-Reyes VS et al (2013) Selective COX-2 inhibitor (celecoxib) decreases cellular growth in prostate cancer cell lines independent of p53. Biotechnic & Histochemistry: Int J Surg Pathol 88:38–46

41.

Piplani H, Vaish V, Rana C, Sanyal SN (2013) Up-regulation of p53 and mitochondrial signaling pathway in apoptosis by a combination of COX-2 inhibitor, Celecoxib and Dolastatin 15, a marine mollusk linear peptide in experimental colon carcinogenesis. Mol Carcinog 52:845–858PubMedCrossRef

42.

Hazar B, Ergin M, Seyrek E, Erdogan S, Tuncer I, Hakverdi S (2004) Cyclooxygenase-2 (Cox-2) expression in lymphomas. Leuk Lymphoma 45:1395–1399PubMedCrossRef

43.

Zweifel BS, Davis TW, Ornberg RL, Masferrer JL (2002) Direct evidence for a role of cyclooxygenase 2-derived prostaglandin E2 in human head and neck xenograft tumors. Cancer Res 62:6706–6711PubMed

44.

Hosomi Y, Yokose T, Hirose Y et al (2000) Increased cyclooxygenase 2 (COX-2) expression occurs frequently in precursor lesions of human adenocarcinoma of the lung. Lung Cancer 30:73–81PubMedCrossRef

45.

Miyata Y, Koga S, Kanda S, Nishikido M, Hayashi T, Kanetake H (2003) Expression of cyclooxygenase-2 in renal cell carcinoma: correlation with tumor cell proliferation, apoptosis, angiogenesis, expression of matrix metalloproteinase-2, and survival. Clinical Cancer Research: an Official Journal of the American Association for Cancer Research 9:1741–1749

46.

Kim MH, Seo SS, Song YS et al (2003) Expression of cyclooxygenase-1 and -2 associated with expression of VEGF in primary cervical cancer and at metastatic lymph nodes. Gynecol Oncol 90:83–90PubMedCrossRef

47.

Ermert L, Dierkes C, Ermert M (2003) Immunohistochemical expression of cyclooxygenase isoenzymes and downstream enzymes in human lung tumors. Clinical Cancer Research: an Official Journal of the American Association for Cancer Research 9:1604–1610

48.

Sharma S, Stolina M, Yang SC et al (2003) Tumor cyclooxygenase 2-dependent suppression of dendritic cell function. Gynecol Oncol 9:961–968

49.

Zhang H, Sun XF (2002) Overexpression of cyclooxygenase-2 correlates with advanced stages of colorectal cancer. Am J Gastroenterol 97:1037–1041PubMedCrossRef

50.

Liu X, Li P, Zhang ST, You H, Jia JD, Yu ZL (2008) COX-2 mRNA expression in esophageal squamous cell carcinoma (ESCC) and effect by NSAID. Clin Cancer Res 21:9–14

51.

Chiarugi V, Magnelli L, Gallo O (1998) Cox-2, iNOS and p53 as play-makers of tumor angiogenesis (review). Int J Mol Med 2:715–719PubMed

52.

Gallo O, Schiavone N, Papucci L et al (2003) Down-regulation of nitric oxide synthase-2 and cyclooxygenase-2 pathways by p53 in squamous cell carcinoma. Am J Pathol 163:723–732PubMedPubMedCentralCrossRef

53.

Han JA, Kim JI, Ongusaha PP et al (2002) P53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis. EMBO J 21:5635–5644PubMedPubMedCentralCrossRef

54.

Subbaramaiah K, Altorki N, Chung WJ, Mestre JR, Sampat A, Dannenberg AJ (1999) Inhibition of cyclooxygenase-2 gene expression by p53. J Biol Chem 274:10911–10,915PubMedCrossRef

55.

Choi EM, Heo JI, Oh JY et al (2005) COX-2 regulates p53 activity and inhibits DNA damage-induced apoptosis. Biochem Biophys Res Commun 328:1107–1112PubMedCrossRef

56.

de Moraes E, Dar NA, de Moura Gallo CV, Hainaut P (2007) Cross-talks between cyclooxygenase-2 and tumor suppressor protein p53: Balancing life and death during inflammatory stress and carcinogenesis. Biochem Biophys Res Commun 121:929–937

57.

Khalifeh I, Munkarah AR, Lonardo F et al (2004) Expression of Cox-2, CD34, Bcl-2, and p53 and survival in patients with primary peritoneal serous carcinoma and primary ovarian serous carcinoma. Int J Cancer 23:162–169

58.

Hussain SP, Harris CC (1999) p53 mutation spectrum and load: the generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer. Mutat Res 428:23–32PubMedCrossRef

Titel: Prognostic Value of Accumulative Expression of COX-2 and p53 in Small and Diffuse Large B Cell Lymphoma
verfasst von: Amen H. Zaky
Dalia Elsers
Rania Bakry
Mostafa Abdelwanis
Ola Nabih
Rania Hafez
Mahmoud Rezk
Publikationsdatum: 11.06.2019
Verlag: Springer Netherlands
Erschienen in: Pathology & Oncology Research / Ausgabe 2/2020
Print ISSN: 1219-4956
Elektronische ISSN: 1532-2807
DOI: https://doi.org/10.1007/s12253-019-00674-5

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Prognostic Value of Accumulative Expression of COX-2 and p53 in Small and Diffuse Large B Cell Lymphoma

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