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01.12.2012 | Research | Ausgabe 1/2012 Open Access

World Journal of Surgical Oncology 1/2012

Prognostic value of expression of molecular markers in adenoid cystic cancer of the salivary glands compared with lymph node metastasis: a retrospective study

Zeitschrift:
World Journal of Surgical Oncology > Ausgabe 1/2012
Autoren:
Seok Ki Lee, Min Su Kwon, Yoon Se Lee, Seung-Ho Choi, Sang Yoon Kim, Kyoung Ja Cho, Soon Yuhl Nam
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-10-266) contains supplementary material, which is available to authorized users.

Competing interests

All authors have no competing interests.

Authors’ contributions

SKL, MSK, and SYN participated in the design of the study, carried out the extraction and analysis of data, and wrote the manuscript. KJC reviewed pathology of the enrolled slides. YSL and SYN performed the critical review of the literature. KJC and SYK assisted in the collection of the clinical data and in reviewing the manuscript. SYN assisted in reviewing the manuscript. All authors have read and approved the final manuscript.

Abstract

Background

Adenoid cystic cancer arising in the salivary glands has distinctive features such as perineural invasion, distant metastasis, and a variable prognosis. In salivary gland cancer, c-kit, EGFR, and VEGF are representative molecular markers that may predict remnant and recurrent tumors. In this study, the expression of c-kit, EGFR, and VEGF in adenoid cystic cancer was evaluated, and the relationships between the expression of these markers and the clinical findings were investigated.

Methods

The medical records of 48 patients who were treated for parotid adenoid cystic cancer from January 1990 to January 2006 were reviewed. The tumor location, size, histological subtypes, perineural invasion, the resected margin status, and lymph node metastasis were assessed. Immunohistochemical staining and semiquantitative analysis of c-kit, EGFR and VEGF were performed. The relationship between the expression of each marker and the clinicopathological factors were analyzed.

Results

Positive c-kit immunostaining was present in 45 patients (94%), with weak positivity (+1) in 23, moderate positivity (+2) in 19 and strong positivity (+3) in three. Positive EGFR immunostaining was observed in 27 (56%), with weak positivity (+1) in 19 and moderate positivity (+2) in eight with no strong positive staining. Positive VEGF immunostaining was present in 42 patients (88%) with weak positivity (+1) in 12, moderate positivity (+2) in 17, and strong positivity (+3) in 13. Only the expression of VEGF was significantly higher in parotid gland tumors than in any other gland (P = 0.032). Marginal involvement was associated with strong VEGF expression (P = 0.02). No marker was significantly correlated with recurrence or the survival rate. Lymph node status was related to the survival rate.

Conclusions

The expression of c-kit, EGRF, and VEGF had no predictive value for recurrence or the prognosis of adenoid cystic cancer. Only the lymph node status was related to the prognosis.
Zusatzmaterial
Authors’ original file for figure 1
12957_2012_1201_MOESM1_ESM.tiff
Authors’ original file for figure 2
12957_2012_1201_MOESM2_ESM.pdf
Literatur
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