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European Journal of Nuclear Medicine and Molecular Imaging

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21.08.2017 | Original Article

Prognostic value of lymph node-to-primary tumor standardized uptake value ratio in endometrioid endometrial carcinoma

verfasst von: Hyun Hoon Chung, Gi Jeong Cheon, Jae-Weon Kim, Noh-Hyun Park, Yong Sang Song

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 1/2018

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Abstract

Purpose

To determine whether the relative metabolic activity of pelvic or para-aortic LN compared with that of primary tumor measured by preoperative [¹⁸F]FDG PET/CT scan has prognostic value in patients with endometrioid endometrial carcinoma.

Methods

We retrospectively reviewed patients with endometrioid endometrial carcinoma who underwent preoperative [¹⁸F]FDG PET/CT scans. Prognostic values of PET/CT-derived metabolic variables such as maximum standardized uptake value (SUV) of the primary endometrial carcinoma (SUV_Tumor) and LN (SUV_LN), and the LN-to-endometrial carcinoma SUV ratio (SUV_LN / SUV_Tumor) were assessed.

Results

Clinico-pathological data, imaging data, and treatment results were reviewed for 107 eligible patients. Median post-surgical follow-up was 23 months (range, 6–60), and 7 (6.5%) patients experienced recurrence. Regression analysis showed that SUV_LN / SUV_Tumor (P < 0.001), SUV_LN (P = 0.003), International Federation of Gynecology and Obstetrics (FIGO) stage (P = 0.006), and tumor grade (P = 0.011) were risk factors of recurrence. Multivariate regression analysis revealed that FIGO stage (P = 0.034) was the independent risk factor of recurrence. SUV_LN / SUV_Tumor showed significant correlation with FIGO stage (P < 0.001), LN metastasis (P < 0.001), lymphovascular space invasion (P < 0.001), recurrence (P = 0.001), tumor grade (P < 0.001), and deep myometrial invasion of tumor (P = 0.022). Patient groups categorized by SUV_LN / SUV_Tumor showed significant difference in progression-free survival (Log-rank test, P = 0.001).

Conclusions

Preoperative SUV_LN / SUV_Tumor measured by [¹⁸F]FDG PET/CT was significantly associated with recurrence, and may become a novel prognostic factor in patients with endometrioid endometrial carcinoma.

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Titel: Prognostic value of lymph node-to-primary tumor standardized uptake value ratio in endometrioid endometrial carcinoma
verfasst von: Hyun Hoon Chung
Gi Jeong Cheon
Jae-Weon Kim
Noh-Hyun Park
Yong Sang Song
Publikationsdatum: 21.08.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 1/2018
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-017-3805-2

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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