Skip to main content
Erschienen in: Clinical and Translational Oncology 11/2017

24.05.2017 | Research Article

Prognostic value of maximum standardized uptake value measured by pretreatment 18F-FDG PET/CT in locally advanced head and neck squamous cell carcinoma

verfasst von: J. Cacicedo, I. Fernandez, O. del Hoyo, A. Navarro, A. Gomez-Iturriaga, J. Ignacio Pijoan, L. Martinez-Indart, J. Escudero, J. Gomez-Suarez, R. Ortiz de Zarate, J. Fernando Perez, P. Bilbao, D. Rades

Erschienen in: Clinical and Translational Oncology | Ausgabe 11/2017

Einloggen, um Zugang zu erhalten

Abstract

Purpose/objectives

To evaluate the prognostic impact of maximum standardized uptake value (SUVmax) in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) undergoing pretreatment [F-18] fluoro-d-glucose-positron emission tomography/computed tomography (FDG PET/CT) imaging.

Materials/methods

Fifty-eight patients undergoing FDG PET/CT before radical treatment with definitive radiotherapy (±concomitant chemotherapy) or surgery + postoperative (chemo)radiation were analyzed. The effects of clinicopathological factors (age, gender, tumor location, stage, Karnofsky Performance Status (KPS), and treatment strategy) including primary tumor SUVmax and nodal SUVmax on overall survival (OS), disease-free survival (DFS), locoregional control (LRC), and distant metastasis-free survival (DMFS) were evaluated. Kaplan–Meier survival curves were generated and compared with the log-rank test.

Results

Median follow-up for the whole population was 31 months (range 2.3–53.5). Two-year OS, LRC, DFS and DMFS, for the entire cohort were 62.1, 78.3, 55.2 and 67.2%, respectively. Median pretreatment SUVmax for the primary tumor and lymph nodes was 11.85 and 5.4, respectively. According to univariate analysis, patients with KPS < 80% (p < 0.001), AJCC stage IVa or IVb vs III (p = 0.037) and patients undergoing radiotherapy vs surgery (p = 0.042) were significantly associated with worse OS. Patients with KPS < 80% (p = 0.003) or age ≥65 years (p = 0.007) had worse LRC. The KPS < 80% was the only factor associated with decreased DFS (p = 0.001). SUVmax of the primary tumor or the lymph nodes were not associated with OS, DFS or LRC. The KPS < 80% (p = 0.002), tumor location (p = 0.047) and AJCC stage (p = 0.025) were associated with worse cancer-specific survival (CSS). According to Cox regression analysis, on multivariate analysis KPS < 80% was the only independent parameter determining worse OS, DFS, CSS. Regarding LRC only patients with IK < 80% (p = 0.01) and ≥65 years (p = 0.01) remained statistically significant. Nodal SUVmax was the only factor associated with decreased DMFS. Patients with a nodal SUVmax > 5.4 presented an increased risk for distant metastases (HR, 3.3; 95% CI 1.17–9.25; p = 0.023).

Conclusions

The pretreatment nodal SUVmax in patients with locally advanced HNSCC is prognostic for DMFS. However, according to our results primary tumor SUVmax and nodal SUVmax were not significantly related to OS, DFS or LRC. Patients presenting KPS < 80% had worse OS, DFS, CSS and LRC.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Chiesa F, Mauri S, Tradati N, Calabrese L, Giugliano G, Ansarin M, et al. Surfing prognostic factors in head and neck cancer at the millennium. Oral Oncol. 1999;35(6):590–6.CrossRefPubMed Chiesa F, Mauri S, Tradati N, Calabrese L, Giugliano G, Ansarin M, et al. Surfing prognostic factors in head and neck cancer at the millennium. Oral Oncol. 1999;35(6):590–6.CrossRefPubMed
2.
Zurück zum Zitat Haberkorn U, Strauss LG, Reisser C, Haag D, Dimitrakopoulou A, Ziegler S, et al. Glucose uptake, perfusion, and cell proliferation in head and neck tumors: relation of positron emission tomography to flow cytometry. J Nucl Med Off Publ Soc Nucl Med. 1991;32(8):1548–55. Haberkorn U, Strauss LG, Reisser C, Haag D, Dimitrakopoulou A, Ziegler S, et al. Glucose uptake, perfusion, and cell proliferation in head and neck tumors: relation of positron emission tomography to flow cytometry. J Nucl Med Off Publ Soc Nucl Med. 1991;32(8):1548–55.
3.
Zurück zum Zitat Minn H, Clavo AC, Grénman R, Wahl RL. In vitro comparison of cell proliferation kinetics and uptake of tritiated fluorodeoxyglucose and l-methionine in squamous-cell carcinoma of the head and neck. J Nucl Med Off Publ Soc Nucl Med. 1995;36(2):252–8. Minn H, Clavo AC, Grénman R, Wahl RL. In vitro comparison of cell proliferation kinetics and uptake of tritiated fluorodeoxyglucose and l-methionine in squamous-cell carcinoma of the head and neck. J Nucl Med Off Publ Soc Nucl Med. 1995;36(2):252–8.
4.
Zurück zum Zitat Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med. 2003;349(22):2091–8.CrossRefPubMed Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med. 2003;349(22):2091–8.CrossRefPubMed
5.
Zurück zum Zitat Bonner JA, Harari PM, Giralt J, Cohen RB, Jones CU, Sur RK, et al. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 2010;11(1):21–8.CrossRefPubMed Bonner JA, Harari PM, Giralt J, Cohen RB, Jones CU, Sur RK, et al. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 2010;11(1):21–8.CrossRefPubMed
6.
Zurück zum Zitat Pignon J-P, le Maître A, Maillard E, Bourhis J. MACH-NC Collaborative Group. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients. Radiother Oncol J Eur Soc Ther Radiol Oncol. 2009;92(1):4–14.CrossRef Pignon J-P, le Maître A, Maillard E, Bourhis J. MACH-NC Collaborative Group. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients. Radiother Oncol J Eur Soc Ther Radiol Oncol. 2009;92(1):4–14.CrossRef
7.
Zurück zum Zitat Bourhis J, Lapeyre M, Tortochaux J, Rives M, Aghili M, Bourdin S, et al. Phase III randomized trial of very accelerated radiation therapy compared with conventional radiation therapy in squamous cell head and neck cancer: a GORTEC trial. J Clin Oncol Off J Am Soc Clin Oncol. 2006;24(18):2873–8.CrossRef Bourhis J, Lapeyre M, Tortochaux J, Rives M, Aghili M, Bourdin S, et al. Phase III randomized trial of very accelerated radiation therapy compared with conventional radiation therapy in squamous cell head and neck cancer: a GORTEC trial. J Clin Oncol Off J Am Soc Clin Oncol. 2006;24(18):2873–8.CrossRef
8.
Zurück zum Zitat Higgins KA, Hoang JK, Roach MC, Chino J, Yoo DS, Turkington TG, et al. Analysis of pretreatment FDG PET SUV parameters in head-and-neck cancer: tumor SUV mean has superior prognostic value. Int J Radiat Oncol Biol Phys. 2012;82(2):548–53.CrossRefPubMed Higgins KA, Hoang JK, Roach MC, Chino J, Yoo DS, Turkington TG, et al. Analysis of pretreatment FDG PET SUV parameters in head-and-neck cancer: tumor SUV mean has superior prognostic value. Int J Radiat Oncol Biol Phys. 2012;82(2):548–53.CrossRefPubMed
9.
Zurück zum Zitat Romesser PB, Lim R, Spratt DE, Setton J, Riaz N, Lok B, et al. The relative prognostic utility of standardized uptake value, gross tumor volume, and metabolic tumor volume in oropharyngeal cancer patients treated with platinum based concurrent chemoradiation with a pre-treatment [(18)F] fluorodeoxyglucose positron emission tomography scan. Oral Oncol. 2014;50(9):802–8.CrossRefPubMedPubMedCentral Romesser PB, Lim R, Spratt DE, Setton J, Riaz N, Lok B, et al. The relative prognostic utility of standardized uptake value, gross tumor volume, and metabolic tumor volume in oropharyngeal cancer patients treated with platinum based concurrent chemoradiation with a pre-treatment [(18)F] fluorodeoxyglucose positron emission tomography scan. Oral Oncol. 2014;50(9):802–8.CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Kitajima K, Suenaga Y, Kanda T, Miyawaki D, Yoshida K, Ejima Y, et al. Prognostic value of FDG PET imaging in patients with laryngeal cancer. PLoS One. 2014;9(5):e96999.CrossRefPubMedPubMedCentral Kitajima K, Suenaga Y, Kanda T, Miyawaki D, Yoshida K, Ejima Y, et al. Prognostic value of FDG PET imaging in patients with laryngeal cancer. PLoS One. 2014;9(5):e96999.CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat Cacicedo J, Navarro A, Del Hoyo O, Gomez-Iturriaga A, Alongi F, Medina JA, et al. Role of fluorine-18 fluorodeoxyglucose PET/CT in head and neck oncology: the point of view of the radiation oncologist. Br J Radiol. 2016;89(1067):20160217.CrossRefPubMed Cacicedo J, Navarro A, Del Hoyo O, Gomez-Iturriaga A, Alongi F, Medina JA, et al. Role of fluorine-18 fluorodeoxyglucose PET/CT in head and neck oncology: the point of view of the radiation oncologist. Br J Radiol. 2016;89(1067):20160217.CrossRefPubMed
12.
Zurück zum Zitat Cacicedo J, Fernandez I, Del Hoyo O, Dolado A, Gómez-Suarez J, Hortelano E, et al. Should PET/CT be implemented in the routine imaging work-up of locally advanced head and neck squamous cell carcinoma? A prospective analysis. Eur J Nucl Med Mol Imaging. 2015;42(9):1378–89.CrossRefPubMed Cacicedo J, Fernandez I, Del Hoyo O, Dolado A, Gómez-Suarez J, Hortelano E, et al. Should PET/CT be implemented in the routine imaging work-up of locally advanced head and neck squamous cell carcinoma? A prospective analysis. Eur J Nucl Med Mol Imaging. 2015;42(9):1378–89.CrossRefPubMed
13.
Zurück zum Zitat Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17(6):1471–4.CrossRefPubMed Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17(6):1471–4.CrossRefPubMed
15.
Zurück zum Zitat Peters LJ, Goepfert H, Ang KK, Byers RM, Maor MH, Guillamondegui O, et al. Evaluation of the dose for postoperative radiation therapy of head and neck cancer: first report of a prospective randomized trial. Int J Radiat Oncol Biol Phys. 1993;26(1):3–11.CrossRefPubMed Peters LJ, Goepfert H, Ang KK, Byers RM, Maor MH, Guillamondegui O, et al. Evaluation of the dose for postoperative radiation therapy of head and neck cancer: first report of a prospective randomized trial. Int J Radiat Oncol Biol Phys. 1993;26(1):3–11.CrossRefPubMed
16.
Zurück zum Zitat Ang KK, Trotti A, Brown BW, Garden AS, Foote RL, Morrison WH, et al. Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2001;51(3):571–8.CrossRefPubMed Ang KK, Trotti A, Brown BW, Garden AS, Foote RL, Morrison WH, et al. Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2001;51(3):571–8.CrossRefPubMed
17.
Zurück zum Zitat Lee N, Mechalakos J, Puri DR, Hunt M. Choosing an intensity-modulated radiation therapy technique in the treatment of head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2007;68(5):1299–309.CrossRefPubMed Lee N, Mechalakos J, Puri DR, Hunt M. Choosing an intensity-modulated radiation therapy technique in the treatment of head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2007;68(5):1299–309.CrossRefPubMed
18.
Zurück zum Zitat Grégoire V, Ang K, Budach W, Grau C, Hamoir M, Langendijk JA, et al. Delineation of the neck node levels for head and neck tumors: a 2013 update. DAHANCA, EORTC, HKNPCSG, NCIC CTG, NCRI, RTOG, TROG consensus guidelines. Radiother Oncol J Eur Soc Ther Radiol Oncol. 2014;110(1):172–81.CrossRef Grégoire V, Ang K, Budach W, Grau C, Hamoir M, Langendijk JA, et al. Delineation of the neck node levels for head and neck tumors: a 2013 update. DAHANCA, EORTC, HKNPCSG, NCIC CTG, NCRI, RTOG, TROG consensus guidelines. Radiother Oncol J Eur Soc Ther Radiol Oncol. 2014;110(1):172–81.CrossRef
19.
Zurück zum Zitat Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefèbvre J-L, Greiner RH, et al. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med. 2004;350(19):1945–52.CrossRefPubMed Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefèbvre J-L, Greiner RH, et al. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med. 2004;350(19):1945–52.CrossRefPubMed
20.
Zurück zum Zitat Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med. 2004;350(19):1937–44.CrossRefPubMed Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med. 2004;350(19):1937–44.CrossRefPubMed
21.
Zurück zum Zitat Bernier J, Vermorken JB, Koch WM. Adjuvant therapy in patients with resected poor-risk head and neck cancer. J Clin Oncol Off J Am Soc Clin Oncol. 2006;24(17):2629–35.CrossRef Bernier J, Vermorken JB, Koch WM. Adjuvant therapy in patients with resected poor-risk head and neck cancer. J Clin Oncol Off J Am Soc Clin Oncol. 2006;24(17):2629–35.CrossRef
22.
Zurück zum Zitat Allal AS, Slosman DO, Kebdani T, Allaoua M, Lehmann W, Dulguerov P. Prediction of outcome in head-and-neck cancer patients using the standardized uptake value of 2-[18F]fluoro-2-deoxy-d-glucose. Int J Radiat Oncol Biol Phys. 2004;59(5):1295–300.CrossRefPubMed Allal AS, Slosman DO, Kebdani T, Allaoua M, Lehmann W, Dulguerov P. Prediction of outcome in head-and-neck cancer patients using the standardized uptake value of 2-[18F]fluoro-2-deoxy-d-glucose. Int J Radiat Oncol Biol Phys. 2004;59(5):1295–300.CrossRefPubMed
23.
Zurück zum Zitat Romesser PB, Qureshi MM, Shah BA, Chatburn LT, Jalisi S, Devaiah AK, et al. Superior prognostic utility of gross and metabolic tumor volume compared to standardized uptake value using PET/CT in head and neck squamous cell carcinoma patients treated with intensity-modulated radiotherapy. Ann Nucl Med. 2012;26(7):527–34.CrossRefPubMedPubMedCentral Romesser PB, Qureshi MM, Shah BA, Chatburn LT, Jalisi S, Devaiah AK, et al. Superior prognostic utility of gross and metabolic tumor volume compared to standardized uptake value using PET/CT in head and neck squamous cell carcinoma patients treated with intensity-modulated radiotherapy. Ann Nucl Med. 2012;26(7):527–34.CrossRefPubMedPubMedCentral
24.
Zurück zum Zitat Castelli J, De Bari B, Depeursinge A, Simon A, Devillers A, Roman Jimenez G, et al. Overview of the predictive value of quantitative 18 FDG PET in head and neck cancer treated with chemoradiotherapy. Crit Rev Oncol Hematol. 2016;108:40–51.CrossRefPubMed Castelli J, De Bari B, Depeursinge A, Simon A, Devillers A, Roman Jimenez G, et al. Overview of the predictive value of quantitative 18 FDG PET in head and neck cancer treated with chemoradiotherapy. Crit Rev Oncol Hematol. 2016;108:40–51.CrossRefPubMed
25.
Zurück zum Zitat La TH, Filion EJ, Turnbull BB, Chu JN, Lee P, Nguyen K, et al. Metabolic tumor volume predicts for recurrence and death in head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2009;74(5):1335–41.CrossRefPubMedPubMedCentral La TH, Filion EJ, Turnbull BB, Chu JN, Lee P, Nguyen K, et al. Metabolic tumor volume predicts for recurrence and death in head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2009;74(5):1335–41.CrossRefPubMedPubMedCentral
26.
Zurück zum Zitat Chung MK, Jeong H-S, Park SG, Jang JY, Son Y-I, Choi JY, et al. Metabolic tumor volume of [18F]-fluorodeoxyglucose positron emission tomography/computed tomography predicts short-term outcome to radiotherapy with or without chemotherapy in pharyngeal cancer. Clin Cancer Res Off J Am Assoc Cancer Res. 2009;15(18):5861–8.CrossRef Chung MK, Jeong H-S, Park SG, Jang JY, Son Y-I, Choi JY, et al. Metabolic tumor volume of [18F]-fluorodeoxyglucose positron emission tomography/computed tomography predicts short-term outcome to radiotherapy with or without chemotherapy in pharyngeal cancer. Clin Cancer Res Off J Am Assoc Cancer Res. 2009;15(18):5861–8.CrossRef
27.
Zurück zum Zitat Kubicek GJ, Champ C, Fogh S, Wang F, Reddy E, Intenzo C, et al. FDG PET staging and importance of lymph node SUV in head and neck cancer. Head Neck Oncol. 2010;16(2):19.CrossRef Kubicek GJ, Champ C, Fogh S, Wang F, Reddy E, Intenzo C, et al. FDG PET staging and importance of lymph node SUV in head and neck cancer. Head Neck Oncol. 2010;16(2):19.CrossRef
28.
Zurück zum Zitat Inokuchi H, Kodaira T, Tachibana H, Nakamura T, Tomita N, Nakahara R, et al. Clinical usefulness of [18F] fluoro-2-deoxy-d-glucose uptake in 178 head-and-neck cancer patients with nodal metastasis treated with definitive chemoradiotherapy: consideration of its prognostic value and ability to provide guidance for optimal selection of patients for planned neck dissection. Int J Radiat Oncol Biol Phys. 2011;79(3):747–55.CrossRefPubMed Inokuchi H, Kodaira T, Tachibana H, Nakamura T, Tomita N, Nakahara R, et al. Clinical usefulness of [18F] fluoro-2-deoxy-d-glucose uptake in 178 head-and-neck cancer patients with nodal metastasis treated with definitive chemoradiotherapy: consideration of its prognostic value and ability to provide guidance for optimal selection of patients for planned neck dissection. Int J Radiat Oncol Biol Phys. 2011;79(3):747–55.CrossRefPubMed
29.
Zurück zum Zitat Lim R, Eaton A, Lee NY, Setton J, Ohri N, Rao S, et al. 18F-FDG PET/CT metabolic tumor volume and total lesion glycolysis predict outcome in oropharyngeal squamous cell carcinoma. J Nucl Med Off Publ Soc Nucl Med. 2012;53(10):1506–13. Lim R, Eaton A, Lee NY, Setton J, Ohri N, Rao S, et al. 18F-FDG PET/CT metabolic tumor volume and total lesion glycolysis predict outcome in oropharyngeal squamous cell carcinoma. J Nucl Med Off Publ Soc Nucl Med. 2012;53(10):1506–13.
30.
Zurück zum Zitat Lee SJ, Choi JY, Lee HJ, Baek C-H, Son Y-I, Hyun SH, et al. Prognostic value of volume-based 18 F-fluorodeoxyglucose PET/CT parameters in patients with clinically node-negative oral tongue squamous cell carcinoma. Korean J Radiol. 2012;13(6):752.CrossRefPubMedPubMedCentral Lee SJ, Choi JY, Lee HJ, Baek C-H, Son Y-I, Hyun SH, et al. Prognostic value of volume-based 18 F-fluorodeoxyglucose PET/CT parameters in patients with clinically node-negative oral tongue squamous cell carcinoma. Korean J Radiol. 2012;13(6):752.CrossRefPubMedPubMedCentral
31.
Zurück zum Zitat Tang C, Murphy JD, Khong B, La TH, Kong C, Fischbein NJ, et al. Validation that metabolic tumor volume predicts outcome in head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2012;83(5):1514–20.CrossRefPubMedPubMedCentral Tang C, Murphy JD, Khong B, La TH, Kong C, Fischbein NJ, et al. Validation that metabolic tumor volume predicts outcome in head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2012;83(5):1514–20.CrossRefPubMedPubMedCentral
32.
Zurück zum Zitat Moon SH, Choi JY, Lee HJ, Son Y-I, Baek C-H, Ahn YC, et al. Prognostic value of 18F-FDG PET/CT in patients with squamous cell carcinoma of the tonsil: comparisons of volume-based metabolic parameters. Head Neck. 2013;35(1):15–22.CrossRefPubMed Moon SH, Choi JY, Lee HJ, Son Y-I, Baek C-H, Ahn YC, et al. Prognostic value of 18F-FDG PET/CT in patients with squamous cell carcinoma of the tonsil: comparisons of volume-based metabolic parameters. Head Neck. 2013;35(1):15–22.CrossRefPubMed
33.
Zurück zum Zitat Abd El-Hafez YG, Moustafa HM, Khalil HF, Liao C-T, Yen T-C. Total lesion glycolysis: a possible new prognostic parameter in oral cavity squamous cell carcinoma. Oral Oncol. 2013;49(3):261–8.CrossRefPubMed Abd El-Hafez YG, Moustafa HM, Khalil HF, Liao C-T, Yen T-C. Total lesion glycolysis: a possible new prognostic parameter in oral cavity squamous cell carcinoma. Oral Oncol. 2013;49(3):261–8.CrossRefPubMed
34.
Zurück zum Zitat Garsa AA, Chang AJ, Dewees T, Spencer CR, Adkins DR, Dehdashti F, et al. Prognostic value of (18)F-FDG PET metabolic parameters in oropharyngeal squamous cell carcinoma. J Radiat Oncol. 2013;2(1):27–34.CrossRefPubMedPubMedCentral Garsa AA, Chang AJ, Dewees T, Spencer CR, Adkins DR, Dehdashti F, et al. Prognostic value of (18)F-FDG PET metabolic parameters in oropharyngeal squamous cell carcinoma. J Radiat Oncol. 2013;2(1):27–34.CrossRefPubMedPubMedCentral
35.
Zurück zum Zitat Schwartz DL, Harris J, Yao M, Rosenthal DI, Opanowski A, Levering A, et al. Metabolic tumor volume as a prognostic imaging-based biomarker for head-and-neck cancer: pilot results from Radiation Therapy Oncology Group protocol 0522. Int J Radiat Oncol Biol Phys. 2015;91(4):721–9.CrossRefPubMedPubMedCentral Schwartz DL, Harris J, Yao M, Rosenthal DI, Opanowski A, Levering A, et al. Metabolic tumor volume as a prognostic imaging-based biomarker for head-and-neck cancer: pilot results from Radiation Therapy Oncology Group protocol 0522. Int J Radiat Oncol Biol Phys. 2015;91(4):721–9.CrossRefPubMedPubMedCentral
36.
Zurück zum Zitat Ju J, Wang J, Ma C, Li Y, Zhao Z, Gao T, et al. Nomograms predicting long-term overall survival and cancer-specific survival in head and neck squamous cell carcinoma patients. Oncotarget. 2016;7(32):51059–68.CrossRefPubMedPubMedCentral Ju J, Wang J, Ma C, Li Y, Zhao Z, Gao T, et al. Nomograms predicting long-term overall survival and cancer-specific survival in head and neck squamous cell carcinoma patients. Oncotarget. 2016;7(32):51059–68.CrossRefPubMedPubMedCentral
37.
Zurück zum Zitat Käsmann L, Janssen S, Schild SE, Rades D. karnosky performance score and radiation dose predict survival of patients re-irradiated for a locoregional recurrence of small cell lung cancer. Anticancer Res. 2016;36(2):803–5.PubMed Käsmann L, Janssen S, Schild SE, Rades D. karnosky performance score and radiation dose predict survival of patients re-irradiated for a locoregional recurrence of small cell lung cancer. Anticancer Res. 2016;36(2):803–5.PubMed
38.
Zurück zum Zitat Roh J-L, Pae KH, Choi S-H, Kim JS, Lee S, Kim S-B, et al. 2-[18F]-Fluoro-2-deoxy-D-glucose positron emission tomography as guidance for primary treatment in patients with advanced-stage resectable squamous cell carcinoma of the larynx and hypopharynx. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2007;33(6):790–5. Roh J-L, Pae KH, Choi S-H, Kim JS, Lee S, Kim S-B, et al. 2-[18F]-Fluoro-2-deoxy-D-glucose positron emission tomography as guidance for primary treatment in patients with advanced-stage resectable squamous cell carcinoma of the larynx and hypopharynx. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2007;33(6):790–5.
39.
Zurück zum Zitat Mehanna H, Wong W-L, McConkey CC, Rahman JK, Robinson M, Hartley AGJ, et al. PET-CT surveillance versus neck dissection in advanced head and neck cancer. N Engl J Med. 2016;374(15):1444–54.CrossRefPubMed Mehanna H, Wong W-L, McConkey CC, Rahman JK, Robinson M, Hartley AGJ, et al. PET-CT surveillance versus neck dissection in advanced head and neck cancer. N Engl J Med. 2016;374(15):1444–54.CrossRefPubMed
40.
Zurück zum Zitat Wong KH, Panek R, Welsh LC, Mcquaid D, Dunlop A, Riddell A, et al. The predictive value of early assessment after one cycle of induction chemotherapy with 18F-FDG PET/CT and DW-MRI for response to radical chemoradiotherapy in head and neck squamous cell carcinoma. J Nucl Med Off Publ Soc Nucl Med. 2016;57(12):1843–50. Wong KH, Panek R, Welsh LC, Mcquaid D, Dunlop A, Riddell A, et al. The predictive value of early assessment after one cycle of induction chemotherapy with 18F-FDG PET/CT and DW-MRI for response to radical chemoradiotherapy in head and neck squamous cell carcinoma. J Nucl Med Off Publ Soc Nucl Med. 2016;57(12):1843–50.
41.
Zurück zum Zitat Pak K, Cheon GJ, Nam H-Y, Kim S-J, Kang KW, Chung J-K, et al. Prognostic value of metabolic tumor volume and total lesion glycolysis in head and neck cancer: a systematic review and meta-analysis. J Nucl Med Off Publ Soc Nucl Med. 2014;55(6):884–90. Pak K, Cheon GJ, Nam H-Y, Kim S-J, Kang KW, Chung J-K, et al. Prognostic value of metabolic tumor volume and total lesion glycolysis in head and neck cancer: a systematic review and meta-analysis. J Nucl Med Off Publ Soc Nucl Med. 2014;55(6):884–90.
42.
Zurück zum Zitat Castelli J, Depeursinge A, de Bari B, Devillers A, de Crevoisier R, Bourhis J, et al. Metabolic tumor volume and total lesion glycolysis in oropharyngeal cancer treated with definitive radiotherapy: which threshold is the best predictor of local control? Clin Nucl Med. 2017;42(6):e281–e285CrossRefPubMed Castelli J, Depeursinge A, de Bari B, Devillers A, de Crevoisier R, Bourhis J, et al. Metabolic tumor volume and total lesion glycolysis in oropharyngeal cancer treated with definitive radiotherapy: which threshold is the best predictor of local control? Clin Nucl Med. 2017;42(6):e281–e285CrossRefPubMed
Metadaten
Titel
Prognostic value of maximum standardized uptake value measured by pretreatment 18F-FDG PET/CT in locally advanced head and neck squamous cell carcinoma
verfasst von
J. Cacicedo
I. Fernandez
O. del Hoyo
A. Navarro
A. Gomez-Iturriaga
J. Ignacio Pijoan
L. Martinez-Indart
J. Escudero
J. Gomez-Suarez
R. Ortiz de Zarate
J. Fernando Perez
P. Bilbao
D. Rades
Publikationsdatum
24.05.2017
Verlag
Springer International Publishing
Erschienen in
Clinical and Translational Oncology / Ausgabe 11/2017
Print ISSN: 1699-048X
Elektronische ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-017-1674-6

Weitere Artikel der Ausgabe 11/2017

Clinical and Translational Oncology 11/2017 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.