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27.02.2019 | Original Article

Prognostic value of phase analysis on gated single photon emission computed tomography in patients with cardiac sarcoidosis

Zeitschrift:
Journal of Nuclear Cardiology
Autoren:
MD Kazuhiro Koyanagawa, MD, PhD Masanao Naya, MD, PhD Tadao Aikawa, MD, PhD Osamu Manabe, MD Masato Kuzume, Hiroshi Ohira, MD, PhD Ichizo Tsujino, MD, PhD Nagara Tamaki, MD, PhD Toshihisa Anzai
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s12350-019-01660-9) contains supplementary material, which is available to authorized users.
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Abstract

Background

We aimed to determine the correlation between phase analysis, reflecting the heterogeneity of perfusion defects, and the dyssynchrony of the left ventricle wall motion, and adverse cardiac events in cardiac sarcoidosis (CS) patients.

Methods

Fifty-seven consecutive patients with diagnosed CS (64 [IQR 55–71] years old, 14 males), who underwent 18F-FDG PET/CT and ECG-gated SPECT, were studied. FDG PET was analysed to measure cardiac metabolic volume (CMV), and total lesion glycolysis (TLG). The SPECT findings, such as LVEF, Summed Rest Score (SRS), bandwidth (BW) were evaluated.

Results

The median of BW was 56° (IQR 40–95). BW showed a strong inverse correlation with LVEF (r = − 0.60, P < 0.0001), and positive correlation with SRS (r = 0.82, P < 0.0001). However, there were no significant correlations between BW and CMV or TLG. The Kaplan–Meier curves revealed a significantly higher rate of MACE in the high BW group (BW > 56°) than the low BW group (BW ≤ 56°) (15.1%/years vs. 4.4%/years, P = 0.025). In multivariable analysis, BW was a significant independent predictor of MACE (P = 0.015).

Conclusion

Phase analysis on gated SPECT was a significant and independent predictor of MACE in patients with CS.

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Zusatzmaterial
Supplementary material 1 (DOCX 16 kb)
12350_2019_1660_MOESM1_ESM.docx
Supplementary material 2 (DOCX 76 kb)
12350_2019_1660_MOESM2_ESM.docx
Supplementary material 3 (DOCX 13 kb)
12350_2019_1660_MOESM3_ESM.docx
Supplement Figure 1 The rate of MACE in the patients with and without steroid therapy. Event-free rate of MACE is stratified into the patients with and without steroid therapy. Supplementary material 4 (JPEG 38 kb)
12350_2019_1660_MOESM4_ESM.jpg
Supplementary material 5 (PPTX 1290 kb)
12350_2019_1660_MOESM5_ESM.pptx
Literatur
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