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Erschienen in: Annals of Nuclear Medicine 1/2023

12.11.2022 | Original Article

Prognostic value of textural features obtained from F-fluorodeoxyglucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) in patients with locally advanced cervical cancer undergoing concurrent chemoradiotherapy

verfasst von: Hyun-Woong Cho, Eun Seong Lee, Jae Kwan Lee, Jae Seon Eo, Sungeun Kim, Jin Hwa Hong

Erschienen in: Annals of Nuclear Medicine | Ausgabe 1/2023

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Abstract

Objective

To evaluate whether textural features obtained from F-18 FDG PET/CT offer clinical value that can predict the outcome of patients with locally advanced cervical cancer (LACC) receiving concurrent chemoradiotherapy (CCRT).

Methods

We reviewed the records of 68 patients with stage IIB–IVA LACC who underwent PET/CT before CCRT. Conventional metabolic parameters, shape indices, and textural features of the primary tumor were measured on PET/CT. A Cox regression model was used to examine the effects of variables on overall survival (OS) and progression-free survival (PFS).

Results

The patients included in this study were classified into two groups based on median value of PET/CT parameters. The high group of GLNU derived from GLRLM is only independent prognostic factor for PFS (HR 7.142; 95% CI 1.656–30.802; p = 0.008) and OS (HR 9,780; 95% CI 1.222–78.286; p = 0.031). In addition, GLNU derived from GLRLM (AUC 0.846, 95% CI 0.738–0.923) was the best predictor for recurrence among clinical prognostic factors and PET/CT parameters.

Conclusion

Our results demonstrated that high GLNU from GLRLM on pretreatment F-18 FDG PET/CT images, were significant prognostic factors for recurrence and death in patients with LACC receiving CCRT.
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Metadaten
Titel
Prognostic value of textural features obtained from F-fluorodeoxyglucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) in patients with locally advanced cervical cancer undergoing concurrent chemoradiotherapy
verfasst von
Hyun-Woong Cho
Eun Seong Lee
Jae Kwan Lee
Jae Seon Eo
Sungeun Kim
Jin Hwa Hong
Publikationsdatum
12.11.2022
Verlag
Springer Nature Singapore
Erschienen in
Annals of Nuclear Medicine / Ausgabe 1/2023
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-022-01802-z

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