Programmed Sports Therapy (PST) in People with Haemophilia (PwH) “Sports Therapy Model for Rare Diseases”

From the sports medicine perspective, we distinguish between five different basic motoric skills: strength, coordination, endurance, flexibility and speed. Except for the last one, all these elements are of main importance in respect of physical health, and partly also psychological health. Whereas strength and coordination, together with flexibility, have a main role in inter- and intraarticular joint play, endurance has a further overall physical effect, not least, because it improves cardiovascular [4, 5], metabolic [6], as well as immunological function [7]. These important motoric skills for every human being are restricted in PwH, if bleedings were present in the history of the patients, but sometimes also in patients without reminded bleedings. In this case, this could be due to unknown silent bleedings and/or inactivity.

In an older study, we could show, that muscle strength is attenuated in the lower limp of adult PwH [8], whereas Falk et al. had published the same findings in children with haemophilia [9]. This is of main importance because the M. quadriceps is a main shock absorber for the knee as well as the hip joint. In their cross sectional study, Baker et al. revealed that quadriceps muscle weakness has a close relationship to knee osteoarthritis in nearly all compartments [10]. The quadrizeps together with sufficient ischiocrural muscles strength are mainly responsible for a solid joint play of the knee. Brunner et al. could show that there exists a difference in quadriceps strength of approximately 30% between adult subjects with or without haemophilia [11]. This difference becomes more prominent in the older age, e.g. 40–49 years - 35-36%; 50–70 years - 53-61%, but is also present in the younger groups (18–29 years - 10-13%; 30–39 years - 20-23%). The definite reason for the widening of this gap is not clear; it still is a mixture of progression of arthropathy as well as reduced utilization of the muscles. Although the extension of the impact of muscle weakness on the development of haemophilic arthropathy has not been clearly investigated yet, the data from osteoarthritis studies support the hypothesis, that muscle weakness lead to a faster progression in destructive joint disease and therefore should be avoided in PwH, as good as possible. Beside the destructive mechanisms induced by blood components such as iron as well as inflammatory cytokines in the joint [12, 13], the necessary immobilization after joint bleeding indeed includes negative consequences for the affected muscles, particularly if the time space of immobilization is too long.

The effects of disuse have been comprehensively investigated by de Boer et al. [14, 15] and Narici et al. [16]. The authors used a unilateral lower-limb suspension model in young healthy men, where the “dominant leg was kept in slightly flexed position by use of straps, suspending the foot of the dominant leg above the ground while walking with crutches” for a period of 14 and/or 23 days. The torque of the knee extensor was reduced by 15% after 14, and 21% after 23 days [14]. In addition to the functional loss, the suspension also resulted in a distinct reduction in the muscle anatomical cross sectional area by approximately 5% after 14 and 10% after 23 days [14]. Investigations of the metabolic muscle situation after disuse show a reduction in myofibrillar protein synthesis, tendon collagen synthesis accompanied by a decreased phosphorylation of FAK (focal adhesion kinase), a cell signalling molecule, which is associated with mechanotransduction. The PKB-P70-mTOR protein anabolic pathway, however, remained unaffected [15]. The last one is probably downregulated in animal models during disuse atrophy [17]. Sufficient resistance training after this suspension is able to compensate a lot of these disuse effects as shown by Brocca et al. [18]. Therefore, the main problem in PwH is not a single necessary immobilization over a short but sufficient time period, but an insufficient rehabilitation and false immobilization afterwards and/or repeated bleeding with recurrent periods of immobilization. That is why immobilization should be adapted to the needs and is not equal to absolute disuse. Whereas weight-bearing to the vulnerable joint after bleeding counteracted the rehabilitation process, isometric exercises and/or CPM (continuous passive motion) or CAM (continuous active motion) devices can be very useful in this early process of rehabilitation. The consequences of weight-bearing on cartilage during the vulnerable phase after joint bleeding have been addressed in animal models by Hooiveld et al. [19] and Ravanbod et al. [20]. On the other hand, consequences of muscle atrophy could be shown by Brunner et al. [11]. Muscle weakness in one limp is associated with higher risk of inter-extremity difference (IED), and this asymmetry between the two limps, distinctly increases during aging [11]. In addition, this IED of strength is based on a protection of the more affected limp but de facto often goes along with an overload of the contralateral limp [21]. This explains the clinical picture of contralateral more affected joints in many PwH, e.g. knee left, ankle right or otherwise. Therefore, physio- and sports therapy should focus on IED to guarantee a balanced weight load. In the other case, the process of muscle weakness and IED is accompanied by an increased fluctuation as shown by Gonzales et al. [22] and Brunner et al. [23], which results in lower steadiness during voluntary contraction. The consequences of this in PwH should be addressed by future studies. However, Carville et al. [24] underpinned that elderly, who tend to fall, show a lower isometric contraction steadiness of the quadriceps muscle, compared to young subjects as well as elderly, without the tendency to fall. Not least, also the neuromuscular innervation is influenced by processes in the development of haemophilic arthropathy.

EMG studies initiated by Kurz et al. confirm that neuromuscular innervation measured by surface EMG is influenced in parts in relation to the extent of haemophilic arthropathy in PwH [25‐27]. These processes influence inter- and intramuscular coordination, too [21]. The fact that coordination is decreased in PwH has been investigated, for instance, in 2001 [8] as well as by Gallach et al. [28] by different methods. Interestingly, Gallach et al. demonstrated that PwH without haemophilic arthropathy also had a worse balance unlike controls in a posturographic analysis [28]. Therefore, the rehabilitation process should not only focus on the muscle atrophy after bleeding, but also on the potentiation of disuse and aging processes. This is due to the fact that aging alone can lead to the process of sarcopenia in older ages. Since PwH become older especially in the industrial world, this will be of more and more importance now and in the near future [29, 30]. In many studies it could be seen that flexibility, as another relevant factor is often reduced, particularly in adult PwH [8] but also in children with haemophilia [31].

Flexibility is not only necessary for normal daily activities but also a protection for the joint chain and the joint play. Reduced flexibility leads to a higher stress, not only for the affected, but also the adjacent joints. At least, endurance is also influenced by presence of haemophilia. This is not relevant to every PwH, but if immobilization had been necessary previously or physical inactivity is still present, it influences endurance performance as well. In an earlier study we could depict that maximal as well as submaximal endurance performance was depressed in a group of young to middle aged (range 16–44, mean 32 years) PwH [32], whereas data from Falk et al. confirm the same in children with haemophilia [9]. Since life expectancy in PwH has increased due to better treatment options, endurance capacity becomes more important, too. Endurance capacity is closely related to the prevention of metabolic as well as cardiovascular-related mortality risk. A clear reduction in total, as well as in cardiovascular-related mortality risk due to primary prevention by physical exercise, has been described in people without haemophilia [5]. Data in PwH are still lacking. Although these deficits of motoric skills are clearly present in adult PwH, Seuser et al. could show in a comprehensive study that also in children with haemophilia some deficits are present. The authors studied sport-specific motor performance in 285 PwH between 8 and 25 years and underpinned lower abilities in the one leg-stand test, the mobility of the lower extremity, the strength ratio of chest and back muscles as well as in the endurance test in comparison to a control group without haemophilia. However, some parts of the results were better in the PwH group than in healthy peers [33].

In conclusion, all the data mentioned above confirm that changes in the motoric skills still not only exist in adult PwH, which are in these cases very often directly visible, but also in children with haemophilia, where the diagnostic needs to be more sensitive. Therefore, for a higher sensitivity, other diagnostic tools such as gate or motion analysis seemed to be helpful [31, 34]. For both groups, adults and children, sports therapy will be of advantage.

Since the term of “Sports Therapy” is not common in every country and sometimes ambiguous in use, it is important to firstly present a definition: “Sports therapy is an exercise therapy - based on the motoric skills - which is prescribed by a physician including behavior-orientated components, planned and dosed by sports therapists, but controlled together with physicians and performed - supervised by therapists - by the patient alone or in a group” (adapted from Hilberg in Astermark et al. [38]). Sports therapy doesn’t stand in contrast to physiotherapy; it rather works hand in hand together in this field of work, helping to amplify or potentiate physiotherapeutic effects. Whereas physiotherapy is a medical necessity in the acute phase after bleedings, sports therapy is to take into consideration after the acute phase of bleeding has ended. Especially, but not only, in regions where physiotherapists are not nearby, sports therapy is helpful for PwH to improve the situation and the mobility in the post-acute or chronic phase, whether e.g. weight-bearing is possible again. For the therapeutic approach, we have developed a model with central elements focused by sports therapy. The cogwheel model as a central approach is shown in Fig. 1 (adapted from Hilberg in Astermark et al. [38]). This model comprises six segments which individually count on their own, but are also working together. The first one is “body awareness” in combination with “coordination” to better kinesthesia and reducing false movements as a basis for training the other components. Improving “joint mobilization” and activation of the “joint metabolism” are important steps, which can be trained by a well instructed and supervised PwH, also by himself alone. Regulation of “muscle tone” is important, because Kurz et al. described an increased “muscle tone” in knee extensor muscles in PwH with affected joints [26]. An enhancement of “muscle strength and coordination” should be additional central steps followed or accompanied by an “endurance training” in general.

Pain, especially present in PwH with affected joints, hinders the therapy success and should be addressed by a sufficient therapy [39]. Bank et al. substantiate in their excellent review the negative consequences of limb pain for muscle activity, strength and proprioception [40]. The changed redistribution of activity within and between muscles leads to an altered distribution of load, movement and variability as shown by Hodges et al. [41] and with it increases the impact on joints with consequences for the cogwheel model.

Following this model, different studies have shown that this therapy is successful. In an early cohort study - published in 2003 - we were able to demonstrate that muscle strength in PwH can be improved by sports therapy although patients are limited by haemophilic arthropathy [42]. This study result is in accordance with other studies of different research groups and also in line with us, that a sufficient training seemed to be able to improve muscular strength also in patients in different ages and with or without obvious haemophilic arthropathy [43‐46]. However, most of these studies were cohort studies/case reports or studies in children and criticized, due to the fact, that this kind of studies has almost always the possible bias that the active group is more motivated, which can possibly influence the study results. For handling this critic, we initiated a randomized controlled study which has been published just recently [47]. In this study, it could be shown that the results of the cohort studies could be clearly confirmed in adult PwH also at the highest possible study design. It is important to point out the necessity of a well-trained therapist, which has the ability to teach, control and supervise the sports therapy training. A combination of strength with coordination training is relevant and the study results demonstrate the feasibility and improvement [47]. The major importance of strength and coordination in the context of prevention of falling is addressed by Forsyth et al. [48], and falling and fall risks become more and more a topic in PwH [49]. Although some studies indicate changes in flexibility, this is directly dependent on the situation of the affected joint. The outcome will be less, whether contraction is fixed, so that the best range of motion (ROM) should be maintained as good as possible. Blamey et al. have also claimed to address any ROM limitations after a bleeding episode has resolved [50]. Sports therapy as well as physiotherapy are often helpful, but if conservative treatments fail, other treatments such as radiosynoviorthesis or joint surgery are unavoidable [51]. However, also in the case of e.g. total knee arthroplasty the clinical outcome is influenced by the preconditions, because the outcome is lowered, e.g. in PwH, with stiff knees [52] and hospitalization is prolonged. At least, it could also be underpinned that endurance is also enhanced after sports therapy treatment. In this direct context, just for once the musculoskeletal system doesn’t stand in the center of interest. Especially in the industrial world, PwH have the same life expectancy as people without haemophilia and, therefore, also other diseases such as metabolic and cardiovascular diseases will be more present in PwH. The reduction of metabolic and cardiovascular diseases by the improvement of endurance performance is confirmed by sufficient studies. In addition, we know that physical endurance exercise can modulate the immunological function, but it is still unclear if this is also helpful in the context of HIV and/or Hepatitis infection, which are present in some PwH. Today it is undoubted that sports therapy is helpful to reduce deficits in the motoric skills in PwH. This could be shown by measuring objective as well as subjective physical performance parameters. The latter are not unimportant because the subjective physical performance is quite different to the objective physical performance in many cases and sometimes give a better overview of the personal reflexion concerning individual physical performance [53]. This should be taken into consideration in respect of measuring physical performance. Not only qualities of performance are influenced by sports therapy, but also the quality of life in parts could be improved by a sports therapy program, as Runkel et al. revealed, too [54]. Many therapists agree that advising physical activity is not enough, now it is “time to prescribe” as Lobet et al. title their publication [55]. However, one central question is how to train PwH. In cardiovascular diseases with a higher prevalence it seemed to be easier because sports therapy groups or similar therapeutic options are more common in every bigger city.