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28.02.2017 | ORIGINAL ARTICLE

Progranulin Protects Against Osteonecrosis of the Femoral Head by Activating ERK1/2 Pathway

verfasst von: Yingguang Han, Meng Si, Yunpeng Zhao, Yi Liu, Kaiyuan Cheng, Yuedong Zhang, Jialin Jia, Jingkun Li, Lin Nie

Erschienen in: Inflammation | Ausgabe 3/2017

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Abstract

The aim of this study was to investigate progranulin (PGRN) expression and its effect in cartilage degradation and in the pathogenesis of osteonecrosis of the femoral head (ONFH). Cartilage specimens were obtained from ONFH and FNF patients and PGRN expression was analyzed by immunohistochemistry, western blot analysis, and RT-PCR. Peripheral blood PGRN level was detected by ELISA. Additionally, primary chondrocytes were cultured and treated with PGRN. Next, the expression of aggrecan and collagen II and the activation of ERK1/2 were detected. We observed that the expression of PGRN was significantly upregulated in ONFH patients’ articular cartilage, and recombinant PGRN could promote expression of aggrecan and collagen II and the activation of ERK1/2. Collectively, PGRN can improve chondrocyte anabolism and perform a therapeutic role in the pathogenesis of ONFH. This study helps to elucidate the pathogenesis of ONFH and presents PGRN as a potential target for the treatment of ONFH.

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Titel: Progranulin Protects Against Osteonecrosis of the Femoral Head by Activating ERK1/2 Pathway
verfasst von: Yingguang Han
Meng Si
Yunpeng Zhao
Yi Liu
Kaiyuan Cheng
Yuedong Zhang
Jialin Jia
Jingkun Li
Lin Nie
Publikationsdatum: 28.02.2017
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 3/2017
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-017-0539-z

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Progranulin Protects Against Osteonecrosis of the Femoral Head by Activating ERK1/2 Pathway

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