Skip to main content
Erschienen in: Journal of NeuroVirology 4/2019

08.05.2019 | Case Report

Progressive multifocal leukoencephalopathy in a renal transplant patient

verfasst von: Tsu-Chen Lin, Mei-Yi Wu, Hui-Tzung Luh, Shiou-Fu Lin, Chien-Min Lin, Ying-Chi Tseng, Yung-Ching Liu, Mai-Szu Wu

Erschienen in: Journal of NeuroVirology | Ausgabe 4/2019

Einloggen, um Zugang zu erhalten

Abstract

End-stage renal disease (ESRD) has a major impact on health and affects more than 600,000 people in the USA. The current mainstay treatments include dialysis and kidney transplantation (KT), and patients who have received KT have a higher quality of life and a lower mortality risk than those on chronic dialysis. Therefore, KT is considered the more preferred treatment modality for patients with ESRD. However, even though KT results in a higher long-term survival rate, the use of immunosuppressants is associated with various complications, including opportunistic infections and malignancies, which may lead to a higher risk of death in the first year after transplantation. Progressive multifocal leukoencephalopathy (PML) is a rare complication following KT, with an incidence of 0.027% in KT recipients. We present a case of PML following immunosuppressant therapy in a patient who received KT.
Literatur
Zurück zum Zitat Astrom KE, Mancall EL, Richardson EP Jr (1958) Progressive multifocal leuko-encephalopathy; a hitherto unrecognized complication of chronic lymphatic leukaemia and Hodgkin’s disease. Brain 81:93–111CrossRefPubMed Astrom KE, Mancall EL, Richardson EP Jr (1958) Progressive multifocal leuko-encephalopathy; a hitherto unrecognized complication of chronic lymphatic leukaemia and Hodgkin’s disease. Brain 81:93–111CrossRefPubMed
Zurück zum Zitat Berger JR, Aksamit AJ, Clifford DB, Davis L, Koralnik IJ, Sejvar JJ, Bartt R, Major EO, Nath A (2013) PML diagnostic criteria: consensus statement from the AAN neuroinfectious disease section. Neurology 80:1430–1438CrossRefPubMedPubMedCentral Berger JR, Aksamit AJ, Clifford DB, Davis L, Koralnik IJ, Sejvar JJ, Bartt R, Major EO, Nath A (2013) PML diagnostic criteria: consensus statement from the AAN neuroinfectious disease section. Neurology 80:1430–1438CrossRefPubMedPubMedCentral
Zurück zum Zitat Brew BJ, Davies NW, Cinque P, Clifford DB, Nath A (2010) Progressive multifocal leukoencephalopathy and other forms of JC virus disease. Nat Rev Neurol 6:667–679CrossRefPubMed Brew BJ, Davies NW, Cinque P, Clifford DB, Nath A (2010) Progressive multifocal leukoencephalopathy and other forms of JC virus disease. Nat Rev Neurol 6:667–679CrossRefPubMed
Zurück zum Zitat Misbah SA (2017) Progressive multi-focal leucoencephalopathy - driven from rarity to clinical mainstream by iatrogenic immunodeficiency. Clin Exp Immunol 188:342–352CrossRefPubMedPubMedCentral Misbah SA (2017) Progressive multi-focal leucoencephalopathy - driven from rarity to clinical mainstream by iatrogenic immunodeficiency. Clin Exp Immunol 188:342–352CrossRefPubMedPubMedCentral
Zurück zum Zitat Neff RT, Hurst FP, Falta EM, Bohen EM, Lentine KL, Dharnidharka VR, Agodoa LY, Jindal RM, Yuan CM, Abbott KC (2008) Progressive multifocal leukoencephalopathy and use of mycophenolate mofetil after kidney transplantation. Transplantation 86:1474–1478CrossRefPubMed Neff RT, Hurst FP, Falta EM, Bohen EM, Lentine KL, Dharnidharka VR, Agodoa LY, Jindal RM, Yuan CM, Abbott KC (2008) Progressive multifocal leukoencephalopathy and use of mycophenolate mofetil after kidney transplantation. Transplantation 86:1474–1478CrossRefPubMed
Zurück zum Zitat Ohara H, Kataoka H, Nakamichi K, Saijo M, Ueno S (2014) Favorable outcome after withdrawal of immunosuppressant therapy in progressive multifocal leukoencephalopathy after renal transplantation: case report and literature review. J Neurol Sci 341:144–146CrossRefPubMed Ohara H, Kataoka H, Nakamichi K, Saijo M, Ueno S (2014) Favorable outcome after withdrawal of immunosuppressant therapy in progressive multifocal leukoencephalopathy after renal transplantation: case report and literature review. J Neurol Sci 341:144–146CrossRefPubMed
Zurück zum Zitat Padgett BL, Walker DL, ZuRhein GM, Eckroade RJ, Dessel BH (1971) Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy. Lancet 1:1257–1260CrossRefPubMed Padgett BL, Walker DL, ZuRhein GM, Eckroade RJ, Dessel BH (1971) Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy. Lancet 1:1257–1260CrossRefPubMed
Zurück zum Zitat Pavlovic D, Patera AC, Nyberg F, Gerber M, Liu M (2015) Progressive multifocal leukoencephalopathy: current treatment options and future perspectives. Ther Adv Neurol Disord 8:255–273CrossRefPubMedPubMedCentral Pavlovic D, Patera AC, Nyberg F, Gerber M, Liu M (2015) Progressive multifocal leukoencephalopathy: current treatment options and future perspectives. Ther Adv Neurol Disord 8:255–273CrossRefPubMedPubMedCentral
Zurück zum Zitat Shah R, Bag AK, Chapman PR, Cure JK (2010) Imaging manifestations of progressive multifocal leukoencephalopathy. Clin Radiol 65:431–439CrossRefPubMed Shah R, Bag AK, Chapman PR, Cure JK (2010) Imaging manifestations of progressive multifocal leukoencephalopathy. Clin Radiol 65:431–439CrossRefPubMed
Zurück zum Zitat Shitrit D, Lev N, Bar-Gil-Shitrit A, Kramer MR (2005) Progressive multifocal leukoencephalopathy in transplant recipients. Transpl Int 17:658–665CrossRefPubMed Shitrit D, Lev N, Bar-Gil-Shitrit A, Kramer MR (2005) Progressive multifocal leukoencephalopathy in transplant recipients. Transpl Int 17:658–665CrossRefPubMed
Zurück zum Zitat Wollebo HS, White MK, Gordon J, Berger JR, Khalili K (2015) Persistence and pathogenesis of the neurotropic polyomavirus JC. Ann Neurol 77:560–570CrossRefPubMedPubMedCentral Wollebo HS, White MK, Gordon J, Berger JR, Khalili K (2015) Persistence and pathogenesis of the neurotropic polyomavirus JC. Ann Neurol 77:560–570CrossRefPubMedPubMedCentral
Metadaten
Titel
Progressive multifocal leukoencephalopathy in a renal transplant patient
verfasst von
Tsu-Chen Lin
Mei-Yi Wu
Hui-Tzung Luh
Shiou-Fu Lin
Chien-Min Lin
Ying-Chi Tseng
Yung-Ching Liu
Mai-Szu Wu
Publikationsdatum
08.05.2019
Verlag
Springer International Publishing
Erschienen in
Journal of NeuroVirology / Ausgabe 4/2019
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI
https://doi.org/10.1007/s13365-019-00749-8

Weitere Artikel der Ausgabe 4/2019

Journal of NeuroVirology 4/2019 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Neu im Fachgebiet Neurologie

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.