Skip to main content
Erschienen in: Targeted Oncology 1/2014

01.03.2014 | Day-to-Day Practice

Prolonged efficacy of mTOR inhibitors in papillary renal cell carcinoma: progression-free survival lasting for over 3 years, a case report and review of the literature

verfasst von: Amaury Daste, Marine Gross-Goupil, Sophie Roca, Jean-Christophe Bernhard, Alain Ravaud

Erschienen in: Targeted Oncology | Ausgabe 1/2014

Einloggen, um Zugang zu erhalten

Abstract

Treatment of metastatic renal cell carcinoma has radically changed during the last decade with the approval of new drugs, antiangiogenic agents and mammalian targets of rapamycin (m-TOR) inhibitors. The outcome of metastatic clear-cell carcinoma has been significantly improved, while other entities such as metastatic papillary renal cell carcinoma are still associated with a poor prognosis. To date, there is no standard guideline for metastatic non clear cell carcinoma. We report the case of a 68-year-old patient with a pulmonary metastatic evolution of a papillary kidney cancer who has had more than 3 years disease progression-free survival and is under ongoing treatment with m-TOR inhibitors.
Literatur
1.
Zurück zum Zitat Linehan WM, Pinto PA, Srinivasan R et al (2007) Identification of the genes for kidney cancer: opportunity for disease-specific targeted therapeutics. Clin Cancer Res 13:671s–679sPubMedCrossRef Linehan WM, Pinto PA, Srinivasan R et al (2007) Identification of the genes for kidney cancer: opportunity for disease-specific targeted therapeutics. Clin Cancer Res 13:671s–679sPubMedCrossRef
2.
Zurück zum Zitat Ronnen EA, Kondagunta GV, Ishill N et al (2006) Treatment outcome for metastatic papillary renal cell carcinoma patients. Cancer 107:2617–2621PubMedCrossRef Ronnen EA, Kondagunta GV, Ishill N et al (2006) Treatment outcome for metastatic papillary renal cell carcinoma patients. Cancer 107:2617–2621PubMedCrossRef
3.
Zurück zum Zitat Steffens S, Janssen M, Roos FC et al (2012) Incidence and long-term prognosis of papillary compared to clear cell renal cell carcinoma—a multicentre study. Eur J Cancer 48:2347–2352PubMedCrossRef Steffens S, Janssen M, Roos FC et al (2012) Incidence and long-term prognosis of papillary compared to clear cell renal cell carcinoma—a multicentre study. Eur J Cancer 48:2347–2352PubMedCrossRef
4.
Zurück zum Zitat Motzer RJ, Bacik J, Mariani T et al (2002) Treatment outcome and survival associated with metastatic renal cell carcinoma of non-clear-cell histology. J Clin Oncol 20:2376–2381PubMedCrossRef Motzer RJ, Bacik J, Mariani T et al (2002) Treatment outcome and survival associated with metastatic renal cell carcinoma of non-clear-cell histology. J Clin Oncol 20:2376–2381PubMedCrossRef
5.
Zurück zum Zitat Motzer RJ, Escudier B, Oudard S et al (2008) Efficacy of everolimus in advanced renal cell carcinoma:a double-blind, randomised, placebo-controlled phase III trial. Lancet 372:449–456PubMedCrossRef Motzer RJ, Escudier B, Oudard S et al (2008) Efficacy of everolimus in advanced renal cell carcinoma:a double-blind, randomised, placebo-controlled phase III trial. Lancet 372:449–456PubMedCrossRef
6.
Zurück zum Zitat Motzer RJ, Hutson TE, Tomczak P et al (2007) Sunitinib versus interferon alfa in metastatic renal cell carcinoma. N Engl J Med 356:115–124PubMedCrossRef Motzer RJ, Hutson TE, Tomczak P et al (2007) Sunitinib versus interferon alfa in metastatic renal cell carcinoma. N Engl J Med 356:115–124PubMedCrossRef
7.
Zurück zum Zitat Escudier B, Pluzanska A, Korlewski P et al (2007) Bevacizumab plusinterferon alfa-2a for treatment of metastatic renal cell carcinoma:a randomised, double-blind phase III trial. Lancet 370:2103–2111PubMedCrossRef Escudier B, Pluzanska A, Korlewski P et al (2007) Bevacizumab plusinterferon alfa-2a for treatment of metastatic renal cell carcinoma:a randomised, double-blind phase III trial. Lancet 370:2103–2111PubMedCrossRef
8.
Zurück zum Zitat Hudes G, Carducci M, Tomczak P et al (2007) Temsirolimus, interferon alfa, or both for advanced renal cell carcinoma. N Engl J Med 356:2271–2281PubMedCrossRef Hudes G, Carducci M, Tomczak P et al (2007) Temsirolimus, interferon alfa, or both for advanced renal cell carcinoma. N Engl J Med 356:2271–2281PubMedCrossRef
9.
Zurück zum Zitat Escudier B, Kataja V (2010) Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up on behalf of the ESMO Guidelines Working Group. Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 21(suppl 5):v137–9PubMedCrossRef Escudier B, Kataja V (2010) Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up on behalf of the ESMO Guidelines Working Group. Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 21(suppl 5):v137–9PubMedCrossRef
10.
Zurück zum Zitat Motzer RJ, Escudier B, Oudard S (2010) Phase 3 trial of everolimus for metastatic renal cell carcinoma: final results and analysis of prognostic factors. Cancer 15:116 Motzer RJ, Escudier B, Oudard S (2010) Phase 3 trial of everolimus for metastatic renal cell carcinoma: final results and analysis of prognostic factors. Cancer 15:116
11.
Zurück zum Zitat Motzer RJ, Bacik J, Schwartz LH et al (2004) Prognostic factors for survival in previously treated patients with metastatic renal cell carcinoma. J Clin Oncol 22:454–463PubMedCrossRef Motzer RJ, Bacik J, Schwartz LH et al (2004) Prognostic factors for survival in previously treated patients with metastatic renal cell carcinoma. J Clin Oncol 22:454–463PubMedCrossRef
12.
Zurück zum Zitat Choueri T, Plantade A, Elson P et al (2008) Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma. J Clin Oncol 26:127–131CrossRef Choueri T, Plantade A, Elson P et al (2008) Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma. J Clin Oncol 26:127–131CrossRef
13.
Zurück zum Zitat Dutcher JP, de Souza P, McDermott D et al (2009) Effect of temsirolimus versus interferon-a on outcome of patients with advanced renal cell carcinoma of different tumor histologies. Med Oncol 26:202–209PubMedCrossRef Dutcher JP, de Souza P, McDermott D et al (2009) Effect of temsirolimus versus interferon-a on outcome of patients with advanced renal cell carcinoma of different tumor histologies. Med Oncol 26:202–209PubMedCrossRef
14.
Zurück zum Zitat Escudier B, Bracarda S, Maroto JP et al (2012) Open-label phaseII trial of first-line everolimus monotherapy in patients with advanced papillary renal cell carcinoma: raptor interim analysis. Ann Oncol 23:9s, ix264 Escudier B, Bracarda S, Maroto JP et al (2012) Open-label phaseII trial of first-line everolimus monotherapy in patients with advanced papillary renal cell carcinoma: raptor interim analysis. Ann Oncol 23:9s, ix264
15.
Zurück zum Zitat Ravaud A, Oudard S, De-Fromont M et al (2012) First-line sunitinib in type I and II papillary renal cell carcinoma (PRCC): SUPAP, a phase II study of the French Genito-Urinary Group (GETUG) and the Group of Early Phase trials (GEP). Ann Oncol 23:9s, ix263CrossRef Ravaud A, Oudard S, De-Fromont M et al (2012) First-line sunitinib in type I and II papillary renal cell carcinoma (PRCC): SUPAP, a phase II study of the French Genito-Urinary Group (GETUG) and the Group of Early Phase trials (GEP). Ann Oncol 23:9s, ix263CrossRef
18.
Zurück zum Zitat Chaux A, Schultz L, Albadine R et al (2012) Immunoexpression status and prognostic value of mammalian target of rapamycin and hypoxia-induced pathway members in papillary cell renal cell carcinomas. Hum Pathol 43:2129–37PubMedCrossRef Chaux A, Schultz L, Albadine R et al (2012) Immunoexpression status and prognostic value of mammalian target of rapamycin and hypoxia-induced pathway members in papillary cell renal cell carcinomas. Hum Pathol 43:2129–37PubMedCrossRef
19.
Zurück zum Zitat Srinivasan R, Linehan WM, Vaishampayan U et al (2009) A phase II study of two dosing regimens of GSK 1363089 (GSK089), a dual MET/VEGFR2 inhibitor, in patients (pts) with papillary renal carcinoma (PRC). J Clin Oncol 27:15s, suppl,abstr 5103CrossRef Srinivasan R, Linehan WM, Vaishampayan U et al (2009) A phase II study of two dosing regimens of GSK 1363089 (GSK089), a dual MET/VEGFR2 inhibitor, in patients (pts) with papillary renal carcinoma (PRC). J Clin Oncol 27:15s, suppl,abstr 5103CrossRef
Metadaten
Titel
Prolonged efficacy of mTOR inhibitors in papillary renal cell carcinoma: progression-free survival lasting for over 3 years, a case report and review of the literature
verfasst von
Amaury Daste
Marine Gross-Goupil
Sophie Roca
Jean-Christophe Bernhard
Alain Ravaud
Publikationsdatum
01.03.2014
Verlag
Springer International Publishing
Erschienen in
Targeted Oncology / Ausgabe 1/2014
Print ISSN: 1776-2596
Elektronische ISSN: 1776-260X
DOI
https://doi.org/10.1007/s11523-012-0245-6

Weitere Artikel der Ausgabe 1/2014

Targeted Oncology 1/2014 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.