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01.03.2012 | Nuclear Medicine

Prospective evaluation of ⁶⁸Ga-DOTA-NOC PET-CT in phaeochromocytoma and paraganglioma: preliminary results from a single centre study

verfasst von: Niraj Naswa, Punit Sharma, Aftab Hasan Nazar, Krishan Kant Agarwal, Rakesh Kumar, Ariachery C. Ammini, Arun Malhotra, Chandrasekhar Bal

Erschienen in: European Radiology | Ausgabe 3/2012

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Abstract

Objective

To evaluate the role of ⁶⁸Ga-labelled [1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid]-1-NaI³-Octreotide (⁶⁸Ga-DOTA-NOC) whole body positron emission tomography-computed tomography (PET-CT) as a functional imaging approach for phaeochromocytoma and paraganglioma.

Methods

Thirty-five unrelated patients (Median age-34.4 years; range: 15–71) were evaluated in this prospective study. PET-CT was performed after injection of 132–222 MBq of ⁶⁸Ga-DOTA-NOC. Images were evaluated by two experienced nuclear medicine physicians both qualitatively as well as quantitatively (standardised uptake value-SUVmax). In addition we compared the findings with ¹³¹I Metaiodobenzylguanidine (MIBG) scintigraphy, which was available for 25 patients. Histopathology and/or conventional imaging with biochemical markers were taken as the reference standard.

Results

44 lesions were detected on ⁶⁸Ga-DOTA-NOC PET-CT imaging with an additional detection of 12 lesions not previously known, leading to a change in management of 6 patients. Sensitivity, specificity and accuracy were 100%, 85.7%, and 97.1% on a per patient basis and 100%, 85.7% and 98% on per lesion basis, respectively.¹³¹I MIBG scintigraphy was concordant with ⁶⁸Ga-DOTA-NOC PET-CT in 16 patients and false negative in 9 patients.

Conclusion

⁶⁸Ga-DOTA-NOC PET-CT is highly sensitive and specific for the detection of phaeochromoctyomas and paragangliomas. It seems better than ¹³¹I MIBG scintigraphy for this purpose.

Key Points

• ⁶⁸ Ga-DOTA-NOC PET-CT seems useful in patients with phaeochromocytoma and paraganglioma.

• This prospective single centre study showed that it has high diagnostic accuracy.

• ⁶⁸ Ga-DOTA-NOC PET-CT seems superior to ¹³¹ I-MIBG in these patients.

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Titel: Prospective evaluation of 68Ga-DOTA-NOC PET-CT in phaeochromocytoma and paraganglioma: preliminary results from a single centre study
verfasst von: Niraj Naswa
Punit Sharma
Aftab Hasan Nazar
Krishan Kant Agarwal
Rakesh Kumar
Ariachery C. Ammini
Arun Malhotra
Chandrasekhar Bal
Publikationsdatum: 01.03.2012
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 3/2012
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-011-2289-x

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Prospective evaluation of ⁶⁸Ga-DOTA-NOC PET-CT in phaeochromocytoma and paraganglioma: preliminary results from a single centre study

Abstract

Objective

Methods

Results

Conclusion

Key Points

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Objective

Methods

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Conclusion

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