02.05.2023 | Correspondence
Prospective role of liquid biopsy for early screening in laryngeal cancer
verfasst von:
Xiao-yang Gong, Hai-bing Chen, Zhao-yi Lu, Chan Zhu, Dong-sheng Chen, Xi Chen
Erschienen in:
Investigational New Drugs
|
Ausgabe 3/2023
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Excerpt
Laryngeal cancer (LC) is a common malignant tumour of the head and neck, with a significantly higher incidence in males (3.6/100,000) [
1]. The 5-year survival rate for advanced LC is 30–40% [
2]. Unfortunately, most patients with advanced LC are only eligible for total laryngectomy, leading to a loss of speech and sense of smell [
3,
4]. Consequently, early detection and management of LC are vital for improving the survival rate and quality of life [
5]. However, over 40% of patients with LC are diagnosed at an advanced stage [
6]. Although endoscopy is one of the most effective diagnostic tools for identifying precancerous lesions and early benign and malignant tumours of the larynx, narrow-band imaging outperforms white light laryngoscope in identifying superficial mucosal lesions [
7]. Nevertheless, endoscopy is a complex procedure that requires specialised doctors, making it unsuitable for general population screening. …
