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European Radiology

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14.06.2018 | Urogenital

Prostate artery embolisation for benign prostatic hyperplasia: a systematic review and meta-analysis

verfasst von: B. Malling, M. A. Røder, K. Brasso, J. Forman, M. Taudorf, L. Lönn

Erschienen in: European Radiology | Ausgabe 1/2019

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Abstract

Objectives

Prostate artery embolisation (PAE) is a new minimally invasive treatment for lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH). The purpose of this study was to review the efficacy and safety of PAE in the treatment of BPH with LUTS.

Methods

A systematic review performed according to the PRISMA guidelines with a pre-specified search strategy for PubMed, Web of Science, Cochrane Library and Embase databases protocol (PROSPERO ID: CRD42017059196). Trials studying the efficacy of prostate artery embolisation to treat LUTS with more than ten participants and follow-up longer than 6 months were included by two independent authors. Outcomes investigated were International Prostate Symptom Score (IPSS), quality of life (QoL), International Index of Erectile Function (IIEF-5), prostate volume (PV), prostate-specific antigen (PSA), peak void flow (Qmax), post-void residual (PVR) and complications. To summarise mean change from baseline, a meta-analysis was done using the random-effects model.

Results

The search returned 210 references, of which 13 studies met the inclusion criteria, representing 1,254 patients. Patients in the included studies with data available for meta-analysis had moderate to severe LUTS and a mean IPSS of 23.5. Statistically significant (p value < 0.05) improvements of all investigated outcomes were seen at 12-month follow-up. Major complications were reported in 0.3% of the cases.

Conclusions

Our findings suggest that PAE can reduce moderate to severe LUTS in men with BPH with a low risk of complications.

Key Points

• Prostate artery embolisation (PAE) improved International Prostate Symptom Score (IPSS) by 67%.

• Major complications after PAE are very rare.

• Use of cone-beam CT may reduce risk of non-target embolisation.

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Titel: Prostate artery embolisation for benign prostatic hyperplasia: a systematic review and meta-analysis
verfasst von: B. Malling
M. A. Røder
K. Brasso
J. Forman
M. Taudorf
L. Lönn
Publikationsdatum: 14.06.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 1/2019
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-018-5564-2

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Prostate artery embolisation for benign prostatic hyperplasia: a systematic review and meta-analysis

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

Objectives

Methods

Results

Conclusions

Key Points

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