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Erschienen in: Abdominal Radiology 1/2017

02.08.2016

Prostate cancer bone metastases on staging prostate MRI: prevalence and clinical features associated with their diagnosis

verfasst von: Hebert Alberto Vargas, Rachel Schor-Bardach, Niamh Long, Anna N. Kirzner, Jane D. Cunningham, Debra A. Goldman, Chaya S. Moskowitz, Ramon E. Sosa, Evis Sala, David M. Panicek, Hedvig Hricak

Erschienen in: Abdominal Radiology | Ausgabe 1/2017

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Abstract

Purpose

Bone lesions on prostate MRI often raise concern about metastases. This study aimed to evaluate the prevalence of bone metastases on staging prostate MRI and evaluate associations between their MRI features and clinical/pathologic characteristics.

Methods

Retrospective, IRB-approved study of 3765 patients undergoing prostate MRI for newly diagnosed PCa between 2000 and 2014. The reference standard to calculate the prevalence of bone metastases was bone biopsy and/or ≥1-year follow-up after MRI. In a subsample of 228 patients, the MRI characteristics of bone lesions were recorded by two radiologists independently. Associations between MRI and clinical/pathologic findings, including National Comprehensive Cancer Network (NCCN) risk categories, were calculated.

Results

57/3765 patients (1.5%, 95% CI 1.2–2.0%) had bone metastases. No patient with NCCN low-risk PCa (Gleason < 7, PSA < 10 ng/mL, cT1-2a) had bone metastases. In the subsample, ≥1 bone lesion was present on MRI in 74% (95% CI 0.67–0.79) and 72% (95% CI 0.66–0.78) of patients (R1 and R2). Larger lesion diameter (OR 1.33/1.19; p < 0.001 for both readers) and the absence of intralesional fat (OR 0.07/0.11; p = 0.004/0.002 for R1/R2) were significantly associated with bone metastases.

Conclusion

Bone lesions are common in prostate MRI, but only rarely represent metastases. MRI should be interpreted in the context of clinical features that influence the likelihood of metastatic disease.
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Metadaten
Titel
Prostate cancer bone metastases on staging prostate MRI: prevalence and clinical features associated with their diagnosis
verfasst von
Hebert Alberto Vargas
Rachel Schor-Bardach
Niamh Long
Anna N. Kirzner
Jane D. Cunningham
Debra A. Goldman
Chaya S. Moskowitz
Ramon E. Sosa
Evis Sala
David M. Panicek
Hedvig Hricak
Publikationsdatum
02.08.2016
Verlag
Springer US
Erschienen in
Abdominal Radiology / Ausgabe 1/2017
Print ISSN: 2366-004X
Elektronische ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-016-0851-3

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