Prostatic utricles without external genital anomalies in children: our experience, literature review, and pooling analysis

The prostatic utricle is an enlarged diverticulum in the posterior urethra, which result from incomplete degradation of the Müllerian ducts or decreased androgenic stimulation of the urogenital sinus [1]. Prostatic utricle is an uncommon congenital anomalies, with 1% incidence in autopsy findings and clinical prevalence of 5% in urologic patients [2]. Prostatic utricles are seen in young men commonly in the first and second decades and are associated with hypospadias, cryptorchidism, and pseudohermaphroditism/intersex disorders [3]. It is dived into grade 0-III according to the present feature based on voiding cystourethrogram (grade 0 - confined to the verumontanum; grade 1 - below the bladder neck; grade 2 - extend over the bladder neck; grade 3- opening distal to the external sphincter). The majority of prostatic utricles are asymptomatic. Symptomatic prostatic utricles may present with var. ious complaints including recurrent urinary tract infection, post-voiding dribbling, urethral discharge and epididymitis [4]. In particular, the presence of prostatic utricles in male patients with normal external genitalia has been reported but is exceedingly rare. Because these utricles are very rare, with few symptoms and no specific symptoms, a correct diagnosis is difficult to establish. Since no single series has been amassed for analysis, the clinical features, symptoms and signs of these patients, and how to deal with them have not been well characterized. Therefore, we combined the previously reported 19 cases with our own 3 cases for analysis to better clarify their clinical features and treatment management.

All cases of prostatic utricles published in English from PubMed were reviewed, the closing date was June 30, 2018. All patients included in our study were children (age ≤ 18 years). Four cases were excluded due to the lack of required clinical data, and the remaining 19 cases (No. 4–22) and our own 3 cases (No. 1–3) constituted the subjects of this study [1, 4‐20]. Clinical data of the case was reviewed with special attention to the patient’s clinical manifestations, diagnostic methods, therapeutic methods, pathological diagnosis and follow-up results.

The prostatic utricle is a rudimentary structure in the posterior urethra of males. After careful embryological investigation, the researchers believe that the cranial portion of the prostatic utricle is derived from the Müllerian ducts and the caudal segment has a mixed origin from the Müllerian ducts and Wolffian ducts and the urogenital sinus [13]. In males, the Müllerian ducts regress respond to Müllerian inhibiting factor (MIF) produced by the fetal testis, leaving them as a vestige. The urogenital sinus, which continues to form the distal third of the vagina in female, does not respond to MIF but instead masculinizes by closing off in response to testosterone in males [21]. Therefore, it is not surprising that the utricles were lined with squamous epithelium (Müllerian ducts), cuboidal epithelium and transitional epithelium (Wolffian ducts and urogenital sinus) in our reported histological examination. We also found that 32% of the cases show an association of unilateral renal agenesis, this may be due to the metanephric bud and renal blastema are in contiguity during the stage of prostatic utricle embryogenesis (7 to 8 weeks) [7].

The differential diagnosis need to be considered include Müllerian duct cyst, bladder diverticulum, urachal cyst, or a seminal vesicle cyst [22]. Among the diseases that need to be identified, Müllerian duct cysts are the most difficult to distinguish from embryology, clinical and imaging with the prostatic utricles because both of them are median intraprostatic cysts. Some researchers believe that the Müllerian duct cyst originates from the mesoderm, while the prostatic utricles originate from the endoderm [7]. Müllerian duct cysts are generally not connected to the prostatic urethra. They are round in shape and are often found in adults (20-40y) with normal external genitalia. Prostate utricles are tubular or vesicular in shape and most commonly seen in children (<20y) with hypospadias, cryptorchidism and gender dysplasia, usually communicating with the prostatic urethra [19]. Our patient is rare and unusual because all the features are in favor of a utricle that presented in the first or second period and communicated with the urethra but at the same time our patient had normal external genitalia. Two reasons are considered for the low number of reported cases. One is that the majority of prostatic utricles are asymptomatic, especially when small, thus symptomatic prostatic utricles are easily misdiagnosed or never diagnosed. Another is that symptoms of the prostatic utricle are varied and nonspecific, and outpatients are often treated symptomatically without further examination to determine the underlying disease. When large, the clinical presentation includes recurrent urinary tract infection, urethral discharge, post void urine dribbling, urinary retention, epididymitis, calculi formation and in rare cases malignant transformation [4].

The diagnosis is suspected when there is clinical manifestation and the mass is felt on the digital rectal examination. A pelvic ultrasound, a transrectal ultrasound or a perineal ultrasound can show cavity filled with fluid and its relationship with adjacent anatomical structures such as the prostate and urethra [23]. In VCUG or RUG, the utricles may have different sizes, showing an opacified cystic structure posterior to the prostatic urethra. However, it is worth noting that the identification of the prostate utricle by VCUG or RUG is often missed because the utricle is not fully filled, and the small prostate utricle is not easily detected by ultrasound. Fortunately, small prostate utricle (grade 0 and I) are often asymptomatic, and only need to be monitored without treatment. Enlarged prostatic utricles (grade II and III), which often requires surgical intervention, are easily detected by ultrasound, RUG and VCUG [24]. Using CT to detect these utricles is more accurate but it does not provide more help than ultrasound, RUG or VCUG. An MRI with an endorectal coil is particularly useful to delineate the utricle from the other pelvic structures due to their high resolution and multiplanar capability [25]. Certainly, the most useful investigation for a prostatic utricle is the urethrocystoscopy to identify the utricular orifice in the posterior urethra. Catheterization of the utricle with injection of contrast agent can be implemented to delineate the pouch more clearly [10]. Surgical treatment can also be performed with the aid of cystourethroscope.

Appropriate surgical procedures have been described to treat symptomatic and enlarged prostatic utricle. The first is endoscopic utricle orifice dilation, catheterization and aspiration, and resection of utricle roof. These methods have the advantage of less invasive, but also have a relatively high risk of recurrence [26]. We treated 2 of our patient with endoscopic utricle catheterization and aspiration. The reason for choosing this option was because the symptoms of the child were first seen, and also to avoid impotency and infertility caused by surgery. There was no recurrence by the adequate drainage of the wide mouthed diverticulum into the urethra. Surgical resection is recommended for utricles with recurrent symptoms and further neoplastic changes. Many open surgical approaches have been proposed to excise prostate utricle such as posterior pararectal [15]. Traditional open surgical approaches require high operational skills and may damage adjacent tissues [26]. Laparoscopic excision of prostatic utricle is suitable for surgeons who are skilled in advanced laparoscopic techniques. This technique reduces intrusion to the retrovesical space, provides a clear vision, and reduces the time required for recovery [26]. We have successfully applied laparoscopic techniques to a child with recurrent symptoms. Recently robot-assisted laparoscopy was considered as an advantageous technique for the treatment of prostatic utricle [20].

The presence of a prostatic utricle in the absence of hypospadias, cryptorchidism or pseudohermaphroditism/intersex disorders is a rare finding. A combination of clinical signs and findings on physical examination guide diagnosis. Imaging test and urethrocystoscope can not only diagnose the prostatic utricle but also investigate its anatomical relationship. In general, small, asymptomatic, accidentally diagnosed prostatic utricles can be followed up without treatment. Complicated and large utricles need to be cured by surgery.