Skip to main content
Erschienen in:

21.01.2022 | Research article

Protective effect of cinnamon on diabetic cardiomyopathy in nicotinamide-streptozotocin induced diabetic rat model

verfasst von: Chekkilla Uday Kumar, Singareddy Sreenivasa Reddy, Palla Suryanarayana, Madhoosudan A. Patil, Periketi Madhusudana Chary, Putcha Uday Kumar, Geereddy Bhanuprakash Reddy

Erschienen in: Journal of Diabetes & Metabolic Disorders | Ausgabe 1/2022

Einloggen, um Zugang zu erhalten

Abstract

There is an increase in the incidence and prevalence of type-2 diabetes and obesity which leads to the structural and functional changes in myocardium leading to a lethal complication called diabetic cardiomyopathy (DCM). In the present study, we investigated the preventive effect of cinnamon (3% of Cinnamomum zeylanicum bark powder in AIN-93 diet for 3 months) feeding on DCM and the concerned mechanisms in a rodent model. Experimental diabetes was induced by a single intraperitoneal injection of 40 mg/kg b.w streptozotocin (STZ), 15 min after the ip administration of 60 mg/kg b.w of nicotinamide (NA) in Wistar-NIN (WNIN) male rats. The oxidative stress parameters were investigated by assessing superoxide dismutase (SOD), glutathione-s-transferase (GST) enzyme activity, protein carbonyls and malondialdehyde (MDA) levels. The histopathology of myocardium was analyzed by H&E and Masson’s trichrome staining, and scanning electron microscopy. The changes in diabetic rat heart involved the altered left ventricular parietal pericardium, structural changes in myocardial cells, enhanced oxidative stress. Masson’s trichrome and H&E staining have shown increased fibrosis, and perinuclear vacuolization in NA-STZ induced diabetic rat myocardium. Cinnamon feeding prevented the oxidative stress and myocardial alterations in the heart of diabetic rats. Taken together, these results suggest that cinnamon can effectively prevent the metabolic and structural changes in NA-STZ induced diabetic cardiomyopathy.
Literatur
1.
Zurück zum Zitat IDF (2019) International Diabetes Federation DIABETES ATLAS 9th edition; 2019. IDF (2019) International Diabetes Federation DIABETES ATLAS 9th edition; 2019.
2.
Zurück zum Zitat Einarson TR, Acs A, Ludwig C, Panton UH. Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007–2017. Cardiovasc Diabetol. 2018;17(1):83.PubMedPubMedCentralCrossRef Einarson TR, Acs A, Ludwig C, Panton UH. Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007–2017. Cardiovasc Diabetol. 2018;17(1):83.PubMedPubMedCentralCrossRef
4.
Zurück zum Zitat Andersen AR, Christiansen JS, Andersen JK, Kreiner S, Deckert T. Diabetic nephropathy in Type 1 (insulin-dependent) diabetes: an epidemiological study. Diabetologia. 1983;25(6):496–501.PubMedCrossRef Andersen AR, Christiansen JS, Andersen JK, Kreiner S, Deckert T. Diabetic nephropathy in Type 1 (insulin-dependent) diabetes: an epidemiological study. Diabetologia. 1983;25(6):496–501.PubMedCrossRef
5.
Zurück zum Zitat Barnes JA, Eid MA, Creager MA, Goodney PP. Epidemiology and Risk of Amputation in Patients With Diabetes Mellitus and Peripheral Artery Disease. Arterioscler Thromb Vasc Biol. 2020;40(8):1808–17.PubMedPubMedCentralCrossRef Barnes JA, Eid MA, Creager MA, Goodney PP. Epidemiology and Risk of Amputation in Patients With Diabetes Mellitus and Peripheral Artery Disease. Arterioscler Thromb Vasc Biol. 2020;40(8):1808–17.PubMedPubMedCentralCrossRef
6.
Zurück zum Zitat Stegenga ME, et al. Hyperglycemia stimulates coagulation, whereas hyperinsulinemia impairs fibrinolysis in healthy humans. Diabetes. 2006;55(6):1807–12.PubMedCrossRef Stegenga ME, et al. Hyperglycemia stimulates coagulation, whereas hyperinsulinemia impairs fibrinolysis in healthy humans. Diabetes. 2006;55(6):1807–12.PubMedCrossRef
7.
Zurück zum Zitat Dal Canto E, et al. Diabetes as a cardiovascular risk factor: An overview of global trends of macro and micro vascular complications. Eur J Prev Cardiol. 2019;26(2_suppl):25–32.CrossRef Dal Canto E, et al. Diabetes as a cardiovascular risk factor: An overview of global trends of macro and micro vascular complications. Eur J Prev Cardiol. 2019;26(2_suppl):25–32.CrossRef
8.
Zurück zum Zitat Movahed MR, Hashemzadeh M, Jamal MM. Diabetes mellitus is a strong, independent risk for atrial fibrillation and flutter in addition to other cardiovascular disease. Int J Cardiol. 2005;105(3):315–8.PubMedCrossRef Movahed MR, Hashemzadeh M, Jamal MM. Diabetes mellitus is a strong, independent risk for atrial fibrillation and flutter in addition to other cardiovascular disease. Int J Cardiol. 2005;105(3):315–8.PubMedCrossRef
9.
Zurück zum Zitat Patel HP, Gandhi A, Trivedi S, Patel S. Prevalence and risk factors of cardiac autonomic neuropathy in diabetes mellitus. J Assoc Phys India. 2020;68(5):54. Patel HP, Gandhi A, Trivedi S, Patel S. Prevalence and risk factors of cardiac autonomic neuropathy in diabetes mellitus. J Assoc Phys India. 2020;68(5):54.
10.
Zurück zum Zitat Pinti MV, et al. Mitochondrial dysfunction in type 2 diabetes mellitus: an organ-based analysis. Am J Physiol Endocrinol Metab. 2019;316(2):E268–85.PubMedPubMedCentralCrossRef Pinti MV, et al. Mitochondrial dysfunction in type 2 diabetes mellitus: an organ-based analysis. Am J Physiol Endocrinol Metab. 2019;316(2):E268–85.PubMedPubMedCentralCrossRef
11.
Zurück zum Zitat Modesti A, et al. Hyperglycemia activates JAK2 signaling pathway in human failing myocytes via angiotensin II-mediated oxidative stress. Diabetes. 2005;54(2):394–401.PubMedCrossRef Modesti A, et al. Hyperglycemia activates JAK2 signaling pathway in human failing myocytes via angiotensin II-mediated oxidative stress. Diabetes. 2005;54(2):394–401.PubMedCrossRef
13.
Zurück zum Zitat Ceylan-Isik AF, et al. Cardiac overexpression of metallothionein rescues cardiac contractile dysfunction and endoplasmic reticulum stress but not autophagy in sepsis. J Mol Cell Cardiol. 2010;48(2):367–78.PubMedCrossRef Ceylan-Isik AF, et al. Cardiac overexpression of metallothionein rescues cardiac contractile dysfunction and endoplasmic reticulum stress but not autophagy in sepsis. J Mol Cell Cardiol. 2010;48(2):367–78.PubMedCrossRef
14.
Zurück zum Zitat Zhang C, Yu H, Yang H, Liu B. Activation of PI3K/PKB/GSK-3beta signaling by sciadopitysin protects cardiomyocytes against high glucose-induced oxidative stress and apoptosis. J Biochem Mol Toxicol. 2021;e22887. Zhang C, Yu H, Yang H, Liu B. Activation of PI3K/PKB/GSK-3beta signaling by sciadopitysin protects cardiomyocytes against high glucose-induced oxidative stress and apoptosis. J Biochem Mol Toxicol. 2021;e22887.
15.
Zurück zum Zitat Kowluru RA, et al. Beneficial effects of the nutritional supplements on the development of diabetic retinopathy. Nutr Metab. 2014;11(1):8.CrossRef Kowluru RA, et al. Beneficial effects of the nutritional supplements on the development of diabetic retinopathy. Nutr Metab. 2014;11(1):8.CrossRef
16.
Zurück zum Zitat Kommula SR, et al. Cinnamon attenuated long-term IGT-induced retinal abnormalities via regulation of glucose homeostasis in neonatal streptozotocin induced rat model. Indian J Clin Biochem. 2020;35(4):442–50.PubMedCrossRef Kommula SR, et al. Cinnamon attenuated long-term IGT-induced retinal abnormalities via regulation of glucose homeostasis in neonatal streptozotocin induced rat model. Indian J Clin Biochem. 2020;35(4):442–50.PubMedCrossRef
17.
Zurück zum Zitat Saraswat M, et al. Antiglycating potential of Zingiber officinalis and delay of diabetic cataract in rats. Mol Vis. 2010;16:1525–37.PubMedPubMedCentral Saraswat M, et al. Antiglycating potential of Zingiber officinalis and delay of diabetic cataract in rats. Mol Vis. 2010;16:1525–37.PubMedPubMedCentral
18.
Zurück zum Zitat Muthenna P, et al. Inhibition of protein glycation by procyanidin-B2 enriched fraction of cinnamon: delay of diabetic cataract in rats. IUBMB Life. 2013;65(11):941–50.PubMedCrossRef Muthenna P, et al. Inhibition of protein glycation by procyanidin-B2 enriched fraction of cinnamon: delay of diabetic cataract in rats. IUBMB Life. 2013;65(11):941–50.PubMedCrossRef
19.
Zurück zum Zitat Pradeep SR, Barman S, Srinivasan K. Attenuation of diabetic nephropathy by dietary fenugreek (Trigonella foenum-graecum) seeds and onion (Allium cepa) via suppression of glucose transporters and renin-angiotensin system. Nutrition. 2019;67–68:110543.PubMedCrossRef Pradeep SR, Barman S, Srinivasan K. Attenuation of diabetic nephropathy by dietary fenugreek (Trigonella foenum-graecum) seeds and onion (Allium cepa) via suppression of glucose transporters and renin-angiotensin system. Nutrition. 2019;67–68:110543.PubMedCrossRef
20.
Zurück zum Zitat Hasanzade F, Toliat M, Emami SA, Emamimoghaadam Z. The effect of cinnamon on glucose of type II diabetes patients. J Tradit Complement Med. 2013;3(3):171–4.PubMedPubMedCentralCrossRef Hasanzade F, Toliat M, Emami SA, Emamimoghaadam Z. The effect of cinnamon on glucose of type II diabetes patients. J Tradit Complement Med. 2013;3(3):171–4.PubMedPubMedCentralCrossRef
21.
Zurück zum Zitat Vafa M, et al. Effects of cinnamon consumption on glycemic status, lipid profile and body composition in type 2 diabetic patients. Int J Prev Med. 2012;3(8):531–6.PubMedPubMedCentral Vafa M, et al. Effects of cinnamon consumption on glycemic status, lipid profile and body composition in type 2 diabetic patients. Int J Prev Med. 2012;3(8):531–6.PubMedPubMedCentral
22.
Zurück zum Zitat Mahdavi A, Bagherniya M, Mirenayat MS, Atkin SL, Sahebkar A. Medicinal plants and phytochemicals regulating insulin resistance and glucose homeostasis in type 2 diabetic patients: a clinical review. Adv Exp Med Biol. 2021;1308:161–83.PubMedCrossRef Mahdavi A, Bagherniya M, Mirenayat MS, Atkin SL, Sahebkar A. Medicinal plants and phytochemicals regulating insulin resistance and glucose homeostasis in type 2 diabetic patients: a clinical review. Adv Exp Med Biol. 2021;1308:161–83.PubMedCrossRef
23.
Zurück zum Zitat Ardalani H, Hejazi Amiri F, Hadipanah A, Kongstad KT. Potential antidiabetic phytochemicals in plant roots: a review of in vivo studies. J Diabetes Metab Disord. 2021. Ardalani H, Hejazi Amiri F, Hadipanah A, Kongstad KT. Potential antidiabetic phytochemicals in plant roots: a review of in vivo studies. J Diabetes Metab Disord. 2021.
24.
Zurück zum Zitat Kooti W, Farokhipour M, Asadzadeh Z, Ashtary-Larky D, Asadi-Samani M. The role of medicinal plants in the treatment of diabetes: a systematic review. Electron Phys. 2016;8(1):1832–42.CrossRef Kooti W, Farokhipour M, Asadzadeh Z, Ashtary-Larky D, Asadi-Samani M. The role of medicinal plants in the treatment of diabetes: a systematic review. Electron Phys. 2016;8(1):1832–42.CrossRef
25.
Zurück zum Zitat Ziegenfuss TN, Hofheins JE, Mendel RW, Landis J, Anderson RA. Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women. J Int Soc Sports Nutr. 2006;3:45–53.PubMedPubMedCentralCrossRef Ziegenfuss TN, Hofheins JE, Mendel RW, Landis J, Anderson RA. Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women. J Int Soc Sports Nutr. 2006;3:45–53.PubMedPubMedCentralCrossRef
26.
Zurück zum Zitat Nyadjeu P, et al. Acute and chronic antihypertensive effects of Cinnamomum zeylanicum stem bark methanol extract in L-NAME-induced hypertensive rats. BMC Complement Altern Med. 2013;13:27.PubMedPubMedCentralCrossRef Nyadjeu P, et al. Acute and chronic antihypertensive effects of Cinnamomum zeylanicum stem bark methanol extract in L-NAME-induced hypertensive rats. BMC Complement Altern Med. 2013;13:27.PubMedPubMedCentralCrossRef
27.
Zurück zum Zitat Mohamed Sham Shihabudeen H, Hansi Priscilla D, Thirumurugan K. Cinnamon extract inhibits alpha-glucosidase activity and dampens postprandial glucose excursion in diabetic rats. Nutr Metab. 2011;8(1):46.CrossRef Mohamed Sham Shihabudeen H, Hansi Priscilla D, Thirumurugan K. Cinnamon extract inhibits alpha-glucosidase activity and dampens postprandial glucose excursion in diabetic rats. Nutr Metab. 2011;8(1):46.CrossRef
28.
Zurück zum Zitat Saraswat M, Reddy PY, Muthenna P, Reddy GB. Prevention of non-enzymic glycation of proteins by dietary agents: prospects for alleviating diabetic complications. Br J Nutr. 2009;101(11):1714–21.PubMedCrossRef Saraswat M, Reddy PY, Muthenna P, Reddy GB. Prevention of non-enzymic glycation of proteins by dietary agents: prospects for alleviating diabetic complications. Br J Nutr. 2009;101(11):1714–21.PubMedCrossRef
29.
Zurück zum Zitat Muthenna P, Raghu G, Kumar PA, Surekha MV, Reddy GB. Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats. Chem Biol Interact. 2014;222:68–76.PubMedCrossRef Muthenna P, Raghu G, Kumar PA, Surekha MV, Reddy GB. Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats. Chem Biol Interact. 2014;222:68–76.PubMedCrossRef
30.
Zurück zum Zitat Okuda J, Miwa I, Maeda K, Tokui K. Rapid and sensitive, colorimetric determination of the anomers of D-glucose with D-glucose oxidase, peroxidase, and mutarotase. Carbohydr Res. 1977;58(2):267–70.PubMedCrossRef Okuda J, Miwa I, Maeda K, Tokui K. Rapid and sensitive, colorimetric determination of the anomers of D-glucose with D-glucose oxidase, peroxidase, and mutarotase. Carbohydr Res. 1977;58(2):267–70.PubMedCrossRef
31.
Zurück zum Zitat Morgan Al CR. Immunoassay of insulin: two antibody system: plasma insulin levels of normal. Subdiabetic Diabetic Rats Diabetes. 1963;12(2):115–26. Morgan Al CR. Immunoassay of insulin: two antibody system: plasma insulin levels of normal. Subdiabetic Diabetic Rats Diabetes. 1963;12(2):115–26.
32.
Zurück zum Zitat Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 1974;47(3):469–74.PubMedCrossRef Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 1974;47(3):469–74.PubMedCrossRef
33.
Zurück zum Zitat Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem. 1974;249(22):7130–9.PubMedCrossRef Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem. 1974;249(22):7130–9.PubMedCrossRef
35.
Zurück zum Zitat Bhuyan KC, Bhuyan DK, Podos SM. Lipid peroxidation in cataract of the human. Life Sci. 1986;38(16):1463–71.PubMedCrossRef Bhuyan KC, Bhuyan DK, Podos SM. Lipid peroxidation in cataract of the human. Life Sci. 1986;38(16):1463–71.PubMedCrossRef
36.
Zurück zum Zitat Nimgulkar C, et al. Combination of spices and herbal extract restores macrophage foam cell migration and abrogates the athero-inflammatory signalling cascade of atherogenesis. Vascul Pharmacol. 2015;72:53–63.PubMedCrossRef Nimgulkar C, et al. Combination of spices and herbal extract restores macrophage foam cell migration and abrogates the athero-inflammatory signalling cascade of atherogenesis. Vascul Pharmacol. 2015;72:53–63.PubMedCrossRef
37.
Zurück zum Zitat Ranasinghe P, et al. Cinnamomum zeylanicum (Ceylon cinnamon) as a potential pharmaceutical agent for type-2 diabetes mellitus: study protocol for a randomized controlled trial. Trials. 2017;18(1):446.PubMedPubMedCentralCrossRef Ranasinghe P, et al. Cinnamomum zeylanicum (Ceylon cinnamon) as a potential pharmaceutical agent for type-2 diabetes mellitus: study protocol for a randomized controlled trial. Trials. 2017;18(1):446.PubMedPubMedCentralCrossRef
38.
Zurück zum Zitat Ranasinghe P, et al. Effects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model. Pharmacogn Res. 2012;4(2):73–9.CrossRef Ranasinghe P, et al. Effects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model. Pharmacogn Res. 2012;4(2):73–9.CrossRef
39.
Zurück zum Zitat Sharma S, Mandal A, Kant R, Jachak S, Jagzape M. Is cinnamon efficacious for glycaemic control in type-2 diabetes mellitus? J Pak Med Assoc. 2020;70(11):2065–9.PubMed Sharma S, Mandal A, Kant R, Jachak S, Jagzape M. Is cinnamon efficacious for glycaemic control in type-2 diabetes mellitus? J Pak Med Assoc. 2020;70(11):2065–9.PubMed
40.
Zurück zum Zitat AlizadehBehbahani B, Falah F, Lavi Arab F, Vasiee M, TabatabaeeYazdi F. Chemical Composition and Antioxidant, Antimicrobial, and Antiproliferative Activities of Cinnamomum zeylanicum Bark Essential Oil. Evid Based Complement Alternat Med. 2020;2020:5190603. AlizadehBehbahani B, Falah F, Lavi Arab F, Vasiee M, TabatabaeeYazdi F. Chemical Composition and Antioxidant, Antimicrobial, and Antiproliferative Activities of Cinnamomum zeylanicum Bark Essential Oil. Evid Based Complement Alternat Med. 2020;2020:5190603.
41.
Zurück zum Zitat Meena Vangalapati NSS, Surya Prakash DV, Sumanjali A. A Review on Pharmacological Activities and Clinical effects of Cinnamon Species. Res J Pharm Biol Chem Sci. 2012;3(1). Meena Vangalapati NSS, Surya Prakash DV, Sumanjali A. A Review on Pharmacological Activities and Clinical effects of Cinnamon Species. Res J Pharm Biol Chem Sci. 2012;3(1).
42.
Zurück zum Zitat Abdelmageed ME, Shehatou GS, Abdelsalam RA, Suddek GM, Salem HA. Cinnamaldehyde ameliorates STZ-induced rat diabetes through modulation of IRS1/PI3K/AKT2 pathway and AGEs/RAGE interaction. Naunyn Schmiedebergs Arch Pharmacol. 2019;392(2):243–58.PubMedCrossRef Abdelmageed ME, Shehatou GS, Abdelsalam RA, Suddek GM, Salem HA. Cinnamaldehyde ameliorates STZ-induced rat diabetes through modulation of IRS1/PI3K/AKT2 pathway and AGEs/RAGE interaction. Naunyn Schmiedebergs Arch Pharmacol. 2019;392(2):243–58.PubMedCrossRef
43.
Zurück zum Zitat Hosni AA, Abdel-Moneim AA, Abdel-Reheim ES, Mohamed SM, Helmy H. Cinnamaldehyde potentially attenuates gestational hyperglycemia in rats through modulation of PPARgamma, proinflammatory cytokines and oxidative stress. Biomed Pharmacother. 2017;88:52–60.PubMedCrossRef Hosni AA, Abdel-Moneim AA, Abdel-Reheim ES, Mohamed SM, Helmy H. Cinnamaldehyde potentially attenuates gestational hyperglycemia in rats through modulation of PPARgamma, proinflammatory cytokines and oxidative stress. Biomed Pharmacother. 2017;88:52–60.PubMedCrossRef
44.
Zurück zum Zitat Singh P, et al. Potential Dual Role of Eugenol in Inhibiting Advanced Glycation End Products in Diabetes: Proteomic and Mechanistic Insights. Sci Rep. 2016;6:18798.PubMedPubMedCentralCrossRef Singh P, et al. Potential Dual Role of Eugenol in Inhibiting Advanced Glycation End Products in Diabetes: Proteomic and Mechanistic Insights. Sci Rep. 2016;6:18798.PubMedPubMedCentralCrossRef
45.
Zurück zum Zitat Faam MT, Sarmidi MR. A proanthocyanidin from cinnamomum zeylanicum stimulates phosphorylation of insulin receptor in 3T3–L1 adipocytes. J Teknol. 2006;44(1):53–68. Faam MT, Sarmidi MR. A proanthocyanidin from cinnamomum zeylanicum stimulates phosphorylation of insulin receptor in 3T3–L1 adipocytes. J Teknol. 2006;44(1):53–68.
46.
Zurück zum Zitat Frangogiannis NG. Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities. Mol Aspects Med. 2019;65:70–99.PubMedCrossRef Frangogiannis NG. Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities. Mol Aspects Med. 2019;65:70–99.PubMedCrossRef
48.
Zurück zum Zitat Niknezhad F, et al. Improvement in histology, enzymatic activity, and redox state of the liver following administration of Cinnamomum zeylanicum bark oil in rats with established hepatotoxicity. Anat Cell Biol. 2019;52(3):302–11.PubMedPubMedCentralCrossRef Niknezhad F, et al. Improvement in histology, enzymatic activity, and redox state of the liver following administration of Cinnamomum zeylanicum bark oil in rats with established hepatotoxicity. Anat Cell Biol. 2019;52(3):302–11.PubMedPubMedCentralCrossRef
49.
Zurück zum Zitat Manrique Franco K, Aragon Valera C, Gutierrez Medina S, Sanchez-Vilar Burdiel O, RoviraLoscos A. Acute pericarditis associated to onset of diabetes mellitus. Endocrinol Nutr. 2012;59(10):608–9.PubMedCrossRef Manrique Franco K, Aragon Valera C, Gutierrez Medina S, Sanchez-Vilar Burdiel O, RoviraLoscos A. Acute pericarditis associated to onset of diabetes mellitus. Endocrinol Nutr. 2012;59(10):608–9.PubMedCrossRef
50.
Zurück zum Zitat Shen X, Zheng S, Metreveli NS, Epstein PN. Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathy. Diabetes. 2006;55(3):798–805.PubMedCrossRef Shen X, Zheng S, Metreveli NS, Epstein PN. Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathy. Diabetes. 2006;55(3):798–805.PubMedCrossRef
51.
Zurück zum Zitat Im K, et al. Effects of the polyphenol content on the anti-diabetic activity of Cinnamomum zeylanicum extracts. Food Funct. 2014;5(9):2208–20.PubMedCrossRef Im K, et al. Effects of the polyphenol content on the anti-diabetic activity of Cinnamomum zeylanicum extracts. Food Funct. 2014;5(9):2208–20.PubMedCrossRef
52.
Zurück zum Zitat Li R, et al. Protective effect of cinnamon polyphenols against STZ-diabetic mice fed high-sugar, high-fat diet and its underlying mechanism. Food Chem Toxicol. 2013;51:419–25.PubMedCrossRef Li R, et al. Protective effect of cinnamon polyphenols against STZ-diabetic mice fed high-sugar, high-fat diet and its underlying mechanism. Food Chem Toxicol. 2013;51:419–25.PubMedCrossRef
53.
Zurück zum Zitat Han B, Baliga R, Huang H, Giannone PJ, Bauer JA. Decreased cardiac expression of vascular endothelial growth factor and redox imbalance in murine diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol. 2009;297(2):H829-835.PubMedCrossRef Han B, Baliga R, Huang H, Giannone PJ, Bauer JA. Decreased cardiac expression of vascular endothelial growth factor and redox imbalance in murine diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol. 2009;297(2):H829-835.PubMedCrossRef
Metadaten
Titel
Protective effect of cinnamon on diabetic cardiomyopathy in nicotinamide-streptozotocin induced diabetic rat model
verfasst von
Chekkilla Uday Kumar
Singareddy Sreenivasa Reddy
Palla Suryanarayana
Madhoosudan A. Patil
Periketi Madhusudana Chary
Putcha Uday Kumar
Geereddy Bhanuprakash Reddy
Publikationsdatum
21.01.2022
Verlag
Springer International Publishing
Erschienen in
Journal of Diabetes & Metabolic Disorders / Ausgabe 1/2022
Elektronische ISSN: 2251-6581
DOI
https://doi.org/10.1007/s40200-021-00948-3

Kompaktes Leitlinien-Wissen Innere Medizin (Link öffnet in neuem Fenster)

Mit medbee Pocketcards schnell und sicher entscheiden.
Leitlinien-Wissen kostenlos und immer griffbereit auf ihrem Desktop, Handy oder Tablet.

Neu im Fachgebiet Innere Medizin

Vorhofflimmern: Antikoagulation vor Schlaganfall von Vorteil

Erleiden Menschen mit Vorhofflimmern einen ischämischen Schlaganfall, ist dieser weniger schwer, auch sind Infarktgröße und Blutungsrisiko geringer, wenn sie zuvor orale Antikoagulanzien erhalten haben. Die Art der Antikoagulation spielt dabei keine Rolle.

Frühe CLL-Therapie: BTK-Hemmer verlängert EFS und PFS, aber nicht OS

Auch nach sechs Jahren ergibt sich kein Überlebensvorteil einer Therapie mit dem BTK-Hemmer Ibrutinib für Menschen mit frühem CLL-Stadium und erhöhtem Progressionsrisiko. Die Progressionsrate wird mit der Behandlung jedoch um über 80% gesenkt.

Mehr Cholesterin im Essen = höheres Herzinfarktrisiko

Je mehr Cholesterin man täglich über die Nahrung zu sich nimmt, desto höher ist offenbar das Herzinfarktrisiko – das legt eine Studie mit US-Veteranen zumindest für Männer nahe.

Antikoagulation bei Vorhofflimmern: Sind DOAK noch zu toppen?

Gegen Thromboembolien so wirksam wie ein DOAK, bei zugleich geringerem Blutungsrisiko – werden Faktor-XI-Hemmer als neue Antikoagulanzien dieser Erwartung gerecht? Eine aktuell publizierte Vergleichsstudie gibt darüber Aufschluss.

EKG Essentials: EKG befunden mit System (Link öffnet in neuem Fenster)

In diesem CME-Kurs können Sie Ihr Wissen zur EKG-Befundung anhand von zwölf Video-Tutorials auffrischen und 10 CME-Punkte sammeln.
Praxisnah, relevant und mit vielen Tipps & Tricks vom Profi.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.