Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Heart Failure Reviews
Erschienen in: Heart Failure Reviews 1/2018

25.09.2017

Protective molecular mechanisms of clusterin against apoptosis in cardiomyocytes

verfasst von: Rodrigo Martins Pereira, Rania A. Mekary, Kellen Cristina da Cruz Rodrigues, Chadi Pellegrini Anaruma, Eduardo Rochete Ropelle, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, José Rodrigo Pauli, Leandro Pereira de Moura

Erschienen in: Heart Failure Reviews | Ausgabe 1/2018

Einloggen, um Zugang zu erhalten

Abstract

Loss of cardiomyocytes occurs with aging and contributes to cardiovascular complications. In the present study, we highlighted the role of clusterin, a protein that has recently been associated with the protection of cardiomyocytes from apoptosis. Clusterin protects cardiac cells against damage from myocardial infarction, transplant, or myocarditis. Clusterin can act directly or indirectly on apoptosis by regulating several intracellular pathways. These pathways include (1) the oxidant and inflammatory program, (2) insulin growth factor 1 (IGF-1) pathway, (3) KU70 / BCL-2-associated X protein (BAX) pathway, (4) tumor necrosis factor alpha (TNF-α) pathway, (5) BCL-2 antagonist of cell death (BAD) pathway, and (6) mitogen-activated protein kinase (MAPK) pathway. Given the key role of clusterin in preventing loss of cardiac tissue, modulating the expression and function of this protein carries the potential of improving cardiovascular care in the future.
Literatur
1.
Kostin S (2011) Types of cardiomyocyte death and clinical outcomes in patients with heart failure. J Am Coll Cardiol 57:1532–1534CrossRefPubMed
2.
Chiong M, Wang ZV, Pedrozo Z, Cao DJ, Troncoso R, Ibacache M, Criollo A, Nemchenko A, Hill JA, Lavandero S (2011) Cardiomyocyte death: mechanisms and translational implications. Cell Death Dis 2:e244CrossRefPubMedPubMedCentral
3.
Lee Y, Gustafsson ÅB (2009) Role of apoptosis in cardiovascular disease. Apoptosis 14:536–548CrossRefPubMed
4.
5.
Gladyshev VN (2016) Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes. Aging Cell 15:594–602CrossRefPubMedPubMedCentral
6.
Trougakos IP, Gonos ES (2002) Clusterin/apolipoprotein J in human aging and cancer. Int J Biochem Cell Biol 34:1430–1448CrossRefPubMed
7.
Rizzi F, Coletta M, Bettuzzi S (2009) Clusterin (CLU): from one gene and two transcripts to many proteins. Adv Cancer Res 104:9–23CrossRefPubMed
8.
Watari H, Ohta Y, Hassan MK, Xiong Y, Tanaka S, Sakuragi N (2008) Clusterin expression predicts survival of invasive cervical cancer patients treated with radical hysterectomy and systematic lymphadenectomy. Gynecol Oncol 108:527–532CrossRefPubMed
9.
Ma Y, Kong L, Nan K, Qi S, Ru L, Ding C, Wang D (2015) Apolipoprotein-J prevents angiotensin II-induced apoptosis in neonatal rat ventricular cells. Lipids Health Dis 14:114CrossRefPubMedPubMedCentral
10.
Jun H-O, Kim D, Lee S-W, Lee HS, Seo JH, Kim JH, Kim JH, Yu YS, Min BH, Kim K-W (2011) Clusterin protects H9c2 cardiomyocytes from oxidative stress-induced apoptosis via Akt/GSK-3β signaling pathway. Exp Mol Med 43:53–61CrossRefPubMed
11.
Hollander Z, Lazárová M, Lam KKY et al (2014) Proteomic biomarkers of recovered heart function. Eur J Heart Fail 16:551–559CrossRefPubMed
12.
Goldspink DF, Burniston JG, Tan L (2003) Cardiomyocyte death and the ageing and failing heart
13.
Armstrong L, Al-Aama J, Stojkovic M, Lako M (2014) The epigenetic contribution to stem cell ageing—can we rejuvenate our older cells? Stem Cells 1–10
14.
Marchi S, Giorgi C, Suski JM et al (2012) Mitochondria-Ros crosstalk in the control of cell death and aging. J Signal Transduct 2012:1–17CrossRef
15.
16.
Sudhir R, Sukhodub A, Du Q, Jovanović S, Jovanović A (2011) Ageing-induced decline in physical endurance in mice is associated with decrease in cardiac SUR2A and increase in cardiac susceptibility to metabolic stress: therapeutic prospects for up-regulation of SUR2A. Biogerontology 12:147–155CrossRefPubMed
17.
Corbi G, Conti V, Russomanno G, Rengo G, Vitulli P, Ciccarelli AL, Filippelli A, Ferrara N (2012) Is physical activity able to modify oxidative damage in cardiovascular aging? Oxidative Med Cell Longev 2012:728547
18.
Li Q, Liu X, Wei J (2014) Ageing related periostin expression increase from cardiac fibroblasts promotes cardiomyocytes senescent. Biochem Biophys Res Commun 452:497–502CrossRefPubMed
19.
Norris RA, Damon B, Mironov V et al (2007) Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues. J Cell Biochem 101:695–711CrossRefPubMedPubMedCentral
20.
Litvin J, Blagg A, Mu A, Matiwala S, Montgomery M, Berretta R, Houser S, Margulies K (2006) Periostin and periostin-like factor in the human heart: possible therapeutic targets. Cardiovasc Pathol 15:24–32CrossRefPubMed
21.
22.
23.
Izuhara K, Arima K, Ohta S, Suzuki S, Inamitsu M, Yamamoto K-I (2014) Periostin in allergic inflammation. Allergol Int 0:1–9
24.
Rao UNM, Hood BL, Jones-Laughner JM, Sun M, Conrads TP (2013) Distinct profiles of oxidative stress-related and matrix proteins in adult bone and soft tissue osteosarcoma and desmoid tumors: a proteomics study. Hum Pathol 44:725–733CrossRefPubMed
25.
26.
Lai C-H, Ho T-J, Kuo W-W, Day C-H, Pai P-Y, Chung L-C, Liao P-H, Lin F-H, Wu E-T, Huang C-Y (2014) Exercise training enhanced SIRT1 longevity signaling replaces the IGF1 survival pathway to attenuate aging-induced rat heart apoptosis. Age (Dordr) 36:9706CrossRef
27.
Kumar D, Lou H, Singal PK (2002) Oxidative stress and apoptosis in heart dysfunction. Herz 27:662–668CrossRefPubMed
28.
Blaschuk O, Burdzy K, Fritz IB (1983) Purification and characterization of a cell-aggregating factor (clusterin), the major glycoprotein in ram rete testis fluid. J Biol Chem 258:7714–7720PubMed
29.
Park S, Mathis KW, Lee IK (2014) The physiological roles of apolipoprotein J/clusterin in metabolic and cardiovascular diseases. Rev Endocr Metab Disord 15:45–53CrossRefPubMed
30.
31.
Trougakos IP (2013) The molecular chaperone apolipoprotein J/clusterin as a sensor of oxidative stress: implications in therapeutic approaches—a mini-review. Gerontology 59:514–523CrossRefPubMed
32.
Li Y, Sagar MB, Wassler M, Shelat H, Geng YJ (2007) Apolipoprotein-J prevention of fetal cardiac myoblast apoptosis induced by ethanol. Biochem Biophys Res Commun 357:157–161CrossRefPubMedPubMedCentral
33.
Li S, Guan Q, Chen Z, Gleave ME, Nguan CYC, Du C (2011) Reduction of cold ischemia-reperfusion injury by graft-expressing clusterin in heart transplantation. J Hear Lung Transplant 30:819–826CrossRef
34.
Krijnen PAJ, Cillessen SAGM, Manoe R, Muller A, Visser CA, Meijer CJLM, Musters RJP, Hack CE, Aarden LA, Niessen HWM (2005) Clusterin: a protective mediator for ischemic cardiomyocytes? Am J Physiol Heart Circ Physiol 289:H2193–H2202CrossRefPubMed
35.
Van Dijk A, Vermond RA, Krijnen PAJ et al (2010) Intravenous clusterin administration reduces myocardial infarct size in rats. Eur J Clin Investig 40:893–902CrossRef
36.
Foglio E, Puddighinu G, Fasanaro P et al (2015) Exosomal clusterin, identified in the pericardial fluid, improves myocardial performance following MI through epicardial activation, enhanced arteriogenesis and reduced apoptosis. Int J Cardiol 197:333–347CrossRefPubMed
37.
Tschopp J, Chonn A, Hertig S, French LE (1993) Clusterin, the human apolipoprotein and complement inhibitor, binds to complement C7, C8 beta, and the b domain of C9. J Immunol 151:2159–2165PubMed
38.
Väkevä A, Laurila P, Meri S (1993) Co-deposition of clusterin with the complement membrane attack complex in myocardial infarction. Immunology 80:177–182PubMedPubMedCentral
39.
Silkensen JR, Hirsch AT, Lunzer MM, Chmielewski D, Manivel JC, Muellerleile MR, Rosenberg ME (1998) Temporal induction of clusterin in the peri-infarct zone after experimental myocardial infarction in the rat. J Lab Clin Med 131:28–35CrossRefPubMed
40.
McLaughlin L, Zhu G, Mistry M et al (2000) Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis. J Clin Invest 106:1105–1113CrossRefPubMedPubMedCentral
41.
Swertfeger DK, Witte DP, Stuart WD, Rockman HA, Harmony JA (1996) Apolipoprotein J/clusterin induction in myocarditis: a localized response gene to myocardial injury. Am J Pathol 148:1971–1983PubMedPubMedCentral
42.
Grivicich I, Regner A, da Rocha AB (2007) Apoptosis: programmed cell death. Rev Bras Cancerol 53:335–343
43.
44.
Beurel E, Jope RS (2006) The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Prog Neurobiol 79:173–189CrossRefPubMedPubMedCentral
45.
Kwon MJ, Ju TJ, Heo JY et al (2014) Deficiency of clusterin exacerbates high-fat diet-induced insulin resistance in male mice. Endocrinology 155:2089–2101CrossRefPubMed
46.
Ammar H, Closset JL (2008) Clusterin activates survival through the phosphatidylinositol 3-kinase/akt pathway. J Biol Chem 283:12851–12861CrossRefPubMed
47.
Li Y, Qu J, Shelat H, Gao S, Wassler M, Geng YJ (2010) Clusterin induces CXCR4 expression and migration of cardiac progenitor cells. Exp Cell Res 316:3435–3442CrossRefPubMed
48.
Ma X, Bai Y (2012) IGF-1 activates the PI3K/AKT signaling pathway via upregulation of secretory clusterin. Mol Med Rep 6:1433–1437CrossRefPubMed
49.
Zhang B, Zhang K, Liu Z, Hao F, Wang M, Li X, Yin Z, Liang H (2014) Secreted clusterin gene silencing enhances chemosensitivity of A549 cells to cisplatin through AKT and ERK1/2 pathways in vitro. Cell Physiol Biochem 33:1162–1175CrossRefPubMed
50.
Liu X, Meng L, Li J, Meng J, Teng X, Gu H, Hu S, Wei Y (2015) Secretory clusterin is upregulated in rats with pulmonary arterial hypertension induced by systemic-to-pulmonary shunts and exerts important roles in pulmonary artery smooth muscle cells. Acta Physiol 213:505–518CrossRef
51.
Zlokovic BV, Martel CL, Matsubara E, McComb JG, Zheng G, McCluskey RT, Frangione B, Ghiso J (1996) Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. Proc Natl Acad Sci U S A 93:4229–4234CrossRefPubMedPubMedCentral
52.
Trougakos IP, Lourda M, Antonelou MH, Kletsas D, Gorgoulis VG, Papassideri IS, Zou Y, Margaritis LH, Boothman DA, Gonos ES (2009) Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-bax protein complex. Clin Cancer Res 15:48–59CrossRefPubMedPubMedCentral
53.
Alibek K, Irving S, Sautbayeva Z et al (2014) Disruption of Bcl-2 and Bcl-xL by viral proteins as a possible cause of cancer. 1–13
54.
55.
Datta SR, Ranger AM, Lin MZ, Sturgill JF, Ma YC, Cowan CW, Dikkes P, Korsmeyer SJ, Greenberg ME (2002) Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev Cell 3:631–643CrossRefPubMed
56.
Cross TG, Scheel-Toellner D, Henriquez NV, Deacon E, Salmon M, Lord JM (2000) Serine/threonine protein kinases and apoptosis. Exp Cell Res 256:34–41CrossRefPubMed
57.
58.
Li J, Jia L, Zhao P, Jiang Y, Zhong S, Chen D (2012) Stable knockdown of clusterin by vectorbased RNA interference in a human breast cancer cell line inhibits tumour cell invasion and metastasis. J Int Med Res 40:545–555CrossRefPubMed
59.
Lee J, Kim H, Rho SB, Lee S (2016) eIF3f reduces tumor growth by directly interrupting clusterin with anti-apoptotic property in cancer cells. 7:
60.
Kaisman-Elbaz T, Sekler I, Fishman D, Karol N, Forberg M, Kahn N, Hershfinkel M, Silverman WF (2009) Cell death induced by zinc and cadmium is mediated by clusterin in cultured mouse seminiferous tubules. J Cell Physiol 220:222–229CrossRefPubMed
61.
Shi H, Deng J-H, Wang Z, Cao K-Y, Zhou L, Wan H (2013) Knockdown of clusterin inhibits the growth and migration of renal carcinoma cells and leads to differential gene expression. Mol Med Rep 8:35–40CrossRefPubMed
Metadaten
Titel
Protective molecular mechanisms of clusterin against apoptosis in cardiomyocytes
verfasst von
Rodrigo Martins Pereira
Rania A. Mekary
Kellen Cristina da Cruz Rodrigues
Chadi Pellegrini Anaruma
Eduardo Rochete Ropelle
Adelino Sanchez Ramos da Silva
Dennys Esper Cintra
José Rodrigo Pauli
Leandro Pereira de Moura
Publikationsdatum
25.09.2017
Verlag
Springer US
Erschienen in
Heart Failure Reviews / Ausgabe 1/2018
Print ISSN: 1382-4147
Elektronische ISSN: 1573-7322
DOI
https://doi.org/10.1007/s10741-017-9654-z

Weitere Artikel der Ausgabe 1/2018

Heart Failure Reviews 1/2018 Zur Ausgabe

ReviewPaper

Pathophysiological and therapeutic implications in patients with atrial fibrillation and heart failure

ReviewPaper

Resistance exercise enhances oxygen uptake without worsening cardiac function in patients with systolic heart failure: a systematic review and meta-analysis

ReviewPaper

Systematic review of economic burden of heart failure

ReviewPaper

Hypothalamic dysfunction in heart failure: pathogenetic mechanisms and therapeutic implications

ReviewPaper

Role of microRNAs in doxorubicin-induced cardiotoxicity: an overview of preclinical models and cancer patients

ReviewPaper

Exercise therapy and autonomic function in heart failure patients: a systematic review and meta-analysis

Neu im Fachgebiet Kardiologie

25.04.2024 | Hypotonie | Nachrichten

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 | Hypertonie | Nachrichten

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

24.04.2024 | Adipositas | Nachrichten

Adipositas-Medikament auch gegen Schlafapnoe wirksam

24.04.2024 | ACC 2024 | Nachrichten

Komplette Revaskularisation bei Infarkt: Neue Studie setzt ein Fragezeichen
weitere anzeigen

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen