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Erschienen in: BMC Infectious Diseases 3/2014

Open Access 01.05.2014 | Poster presentation

Protective role of Mannose binding Lectin (MBL2) promoter haplotypes on TB infection in South Indian HIV-1 patients

verfasst von: Kalaimani Pandian, Stalinraja Maruthamuthu, Suresh Madasamy, Jayalakshmi Mariakuttikan

Erschienen in: BMC Infectious Diseases | Sonderheft 3/2014

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Background

Mannose binding Lectin (MBL) mediates protection against infections by activating the complement system, but certain microorganisms may increase infectivity by exploiting this host defence system. Hence, the purpose of this study is to evaluate MBL genetic variants with the development of TB infection caused by Mycobacterium tuberculosis among HIV patients.

Methods

Blood samples from TB+ART+ and TB-ART+ (n=30) were collected. Genomic DNA was extracted from Peripheral Blood Mononuclear Cells (PBMC) using salting out procedure. MBL promoter haplotypes of -550 H/L and -221Y/X associated with high, medium and low (HY, LY and LX) secretion was assessed by PCR-SSP.

Results

The Promoter haplotype (LY/LX) associated with deficient MBL levels conferred a protective role to TB in our study population with a significant difference (Chi-square (X 2 ) =4.00; p<0.05).

Conclusion

In this study, we could observe MBL2 promoter haplotypes with low MBL secretion may play a protective role to intracellular mycobacterium infections like TB in HIV seropositive individuals.
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
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Metadaten
Titel
Protective role of Mannose binding Lectin (MBL2) promoter haplotypes on TB infection in South Indian HIV-1 patients
verfasst von
Kalaimani Pandian
Stalinraja Maruthamuthu
Suresh Madasamy
Jayalakshmi Mariakuttikan
Publikationsdatum
01.05.2014
Verlag
BioMed Central
Erschienen in
BMC Infectious Diseases / Ausgabe Sonderheft 3/2014
Elektronische ISSN: 1471-2334
DOI
https://doi.org/10.1186/1471-2334-14-S3-P37

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