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10.06.2020 | Original Article

Proteomic Analysis of the Acid-Insoluble Fraction of Whole Saliva from Patients Affected by Different Forms of Non-histaminergic Angioedema

verfasst von: Davide Firinu, Morena Arba, Federica Vincenzoni, Federica Iavarone, Giulia Costanzo, Tiziana Cabras, Massimo Castagnola, Irene Messana, Stefano R. Del Giacco, Maria T. Sanna

Erschienen in: Journal of Clinical Immunology | Ausgabe 6/2020

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Abstract

We analyzed by bidimensional electrophoresis the acid-insoluble fraction of saliva from three classes of angioedema patients and a healthy control group, highlighting significant variations of several normalized spot volumes. Characterization of the corresponding proteins was performed by in-gel tryptic digestion of the spots, followed by high-resolution HPLC-ESI-MS/MS analysis of tryptic mixtures. By this strategy, 16 differentially-expressed proteins among two or more groups were identified. We found higher concentration of proteins involved in immune response (interleukin-1 receptor antagonist and annexin A1), and of moonlighting proteins acting as plasminogen receptors (glyceraldehyde-3-phosphate dehydrogenase, α-enolase, and annexin A2) in patients affected by the idiopathic non-histaminergic or hereditary angioedema with unknown origin with respect to healthy controls. These data provide new information on the molecular basis of these less characterized types of angioedema.

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Titel: Proteomic Analysis of the Acid-Insoluble Fraction of Whole Saliva from Patients Affected by Different Forms of Non-histaminergic Angioedema
verfasst von: Davide Firinu
Morena Arba
Federica Vincenzoni
Federica Iavarone
Giulia Costanzo
Tiziana Cabras
Massimo Castagnola
Irene Messana
Stefano R. Del Giacco
Maria T. Sanna
Publikationsdatum: 10.06.2020
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 6/2020
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-020-00802-w

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Proteomic Analysis of the Acid-Insoluble Fraction of Whole Saliva from Patients Affected by Different Forms of Non-histaminergic Angioedema

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