Electronic supplementary material
Presentation of the hypothesis
What are the most highly prognostic factors for foot ulceration in people with diabetes (symptoms signs, diagnostic tests and elements from the patient history) based on IPD analysis?
Can the data from each study be adjusted for a consistent set of adjustment factors?
Does the model accuracy change when patient populations are stratified according to demographic or clinical characteristics?
Testing the hypothesis and Implications of the hypothesis
Types of Participants
Types of exposure variables
Type of outcome variable
Types of studies
Data extraction and quality assessment
Validation of the dataset
Handling missing data
Specifying variables for analysis
Supplying the data
Ethics and governance
Investigators of each of the original studies obtained local ethical committee approval and written, informed patient consent prior for each of the cohorts included in the IPD review.
The project seeks anonymised data from which the individuals recruited to the original study cannot be identified .