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09.12.2015 | Original Article

Protocols for massive blood transfusion: when and why, and potential complications

verfasst von: E. Guerado, A. Medina, M. I. Mata, J. M. Galvan, M. L. Bertrand

Erschienen in: European Journal of Trauma and Emergency Surgery | Ausgabe 3/2016

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Abstract

Purpose

An update paper on massive bleeding after major trauma. A review of protocols to address massive bleeding, and its possible complications, including coagulation abnormalities, complications related to blood storage, immunosuppression and infection, lung injury associated with transfusion, and hypothermia is carried out.

Methods

Literature review and discussion with authors’ experience.

Results

Massive bleeding is an acute life-threatening complication of major trauma, and consequently its prompt diagnosis and treatment is of overwhelming importance. Treatment requires rapid surgical management together with the massive infusion of colloid and blood.

Conclusions

Since massive transfusion provokes further problems in patients who are already severely traumatized and anaemic, once this course of action has been decided upon, a profound knowledge of its potential complications, careful monitoring and proper follow-up are all essential. To diagnose this bleeding, most authors favour, as the main first choice tool, a full-body CT scan (head to pelvis), in non-critical severe trauma cases. In addition, focused abdominal sonography for trauma (FAST, an acronym that highlights the necessity of rapid performance) is a very important diagnostic test for abdominal and thoracic bleeding. Furthermore, urgent surgical intervention should be undertaken for patients with significant free intraabdominal fluid and haemodynamic instability. Although the clinical situation and the blood haemoglobin concentration are the key factors considered in this rapid decision-making context, laboratory markers should not be based on a single haematocrit value, as its sensitivity to significant bleeding may be very low. Serum lactate and base deficit are very sensitive markers for detecting and monitoring the extent of bleeding and shock, in conjunction with repeated combined measurements of prothrombin time, activated partial thromboplastin time, fibrinogen and platelets.
Literatur
2.
Zurück zum Zitat Pham HP, Shaz BH. Update on massive transfusion. Br J Anaesth. 2013;111(S1):71–82.CrossRef Pham HP, Shaz BH. Update on massive transfusion. Br J Anaesth. 2013;111(S1):71–82.CrossRef
3.
Zurück zum Zitat Kautza BC, Cohen MJ, Cuschieri J, Minei JP, Brackenridge SC, Maier RV, Harbrecht BG, Moore EE, Billiar TR, Peitzman AB, Sperry JL. Changes in massive transfusion over time: an early shift in the right direction? Inflammation and the host response to injury investigators. J Trauma Acute Care Surg. 2012;72:106–11.CrossRefPubMedPubMedCentral Kautza BC, Cohen MJ, Cuschieri J, Minei JP, Brackenridge SC, Maier RV, Harbrecht BG, Moore EE, Billiar TR, Peitzman AB, Sperry JL. Changes in massive transfusion over time: an early shift in the right direction? Inflammation and the host response to injury investigators. J Trauma Acute Care Surg. 2012;72:106–11.CrossRefPubMedPubMedCentral
4.
Zurück zum Zitat Probst C, Pape HC, Hildebrand F, Regel G, Mahlke L, Giannoudis P, Krettek C, Grotz MR. 30 years of polytrauma care: an analysis of the change in strategies and results of 4849 cases treated at a single institution. Injury. 2009;40:77–83.CrossRefPubMed Probst C, Pape HC, Hildebrand F, Regel G, Mahlke L, Giannoudis P, Krettek C, Grotz MR. 30 years of polytrauma care: an analysis of the change in strategies and results of 4849 cases treated at a single institution. Injury. 2009;40:77–83.CrossRefPubMed
6.
Zurück zum Zitat Huber-Wagner S, Lefering R, Qvick LM, Körner M, Kay MV, Pfeifer KJ, Reiser M, Mutschler W, Kanz KG, Working Group on Polytrauma of the German Trauma Society. Effect of whole-body CT during trauma resuscitation on survival: a retrospective, multicentre study. Lancet. 2009;25(373):1455–61.CrossRef Huber-Wagner S, Lefering R, Qvick LM, Körner M, Kay MV, Pfeifer KJ, Reiser M, Mutschler W, Kanz KG, Working Group on Polytrauma of the German Trauma Society. Effect of whole-body CT during trauma resuscitation on survival: a retrospective, multicentre study. Lancet. 2009;25(373):1455–61.CrossRef
7.
Zurück zum Zitat Sierink JC, Saltzherr TP, Reitsma JB, Van Delden OM, Luitse JS, Goslings JC. Systematic review and meta-analysis of immediate total-body computed tomography compared with selective radiological imaging of injured patients. Br J Surg. 2012;99(Suppl 1):52–8.CrossRefPubMed Sierink JC, Saltzherr TP, Reitsma JB, Van Delden OM, Luitse JS, Goslings JC. Systematic review and meta-analysis of immediate total-body computed tomography compared with selective radiological imaging of injured patients. Br J Surg. 2012;99(Suppl 1):52–8.CrossRefPubMed
8.
Zurück zum Zitat Spahn DR, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernández-Mondéjar E, Filipescu D, Hunt BJ, Komadina R, Nardi G, Neugebauer E, Ozier Y, Riddez L, Schultz A, Vincent JL, Rossaint R. Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care. 2013;17(R76):1–45. Spahn DR, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernández-Mondéjar E, Filipescu D, Hunt BJ, Komadina R, Nardi G, Neugebauer E, Ozier Y, Riddez L, Schultz A, Vincent JL, Rossaint R. Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care. 2013;17(R76):1–45.
9.
Zurück zum Zitat Jansen JO, Thomas R, Loudon MA, Brooks A. Damage control resuscitation for patients with major trauma. BMJ. 2009;338(b1778):1–12. Jansen JO, Thomas R, Loudon MA, Brooks A. Damage control resuscitation for patients with major trauma. BMJ. 2009;338(b1778):1–12.
10.
Zurück zum Zitat Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg. 2007;245:812–8.CrossRefPubMedPubMedCentral Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg. 2007;245:812–8.CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, Pittet JF. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma. 2008;64:1211–7.CrossRefPubMed Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, Pittet JF. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma. 2008;64:1211–7.CrossRefPubMed
12.
Zurück zum Zitat Rugeri L, Levrat A, David JS, Delecroix E, Floccard B, Gros A, Allaouchiche B, Negrier C. Diagnosis of early coagulation abnormalities in trauma patients by rotation thromboelastography. J Thromb Haemost. 2007;5:289–95.CrossRefPubMed Rugeri L, Levrat A, David JS, Delecroix E, Floccard B, Gros A, Allaouchiche B, Negrier C. Diagnosis of early coagulation abnormalities in trauma patients by rotation thromboelastography. J Thromb Haemost. 2007;5:289–95.CrossRefPubMed
14.
Zurück zum Zitat Spahn DR, Rossaint R. Coagulopathy and blood component transfusion in trauma. Br J Anaesth. 2005;95:130–9.CrossRefPubMed Spahn DR, Rossaint R. Coagulopathy and blood component transfusion in trauma. Br J Anaesth. 2005;95:130–9.CrossRefPubMed
15.
Zurück zum Zitat Hussmann B, Lefering R, Waydhas C, Touma A, Kauther MD, Ruchholtz S, Lendemans S, Trauma Registry of the German Society for Trauma Surgery. Does increased prehospital replacement volume lead to a poor clinical course and an increased mortality? A matched-pair analysis of 1896 patients of the Trauma Registry of the German Society for Trauma Surgery who were managed by an emergency doctor at the accident site. Injury. 2013;44:611–7.CrossRefPubMed Hussmann B, Lefering R, Waydhas C, Touma A, Kauther MD, Ruchholtz S, Lendemans S, Trauma Registry of the German Society for Trauma Surgery. Does increased prehospital replacement volume lead to a poor clinical course and an increased mortality? A matched-pair analysis of 1896 patients of the Trauma Registry of the German Society for Trauma Surgery who were managed by an emergency doctor at the accident site. Injury. 2013;44:611–7.CrossRefPubMed
16.
Zurück zum Zitat Cap AP, Spinella PC. Severity of head injury is associated with increased risk of coagulopathy in combat casualties. J Trauma. 2011;71(1 Suppl):S78–81.CrossRefPubMed Cap AP, Spinella PC. Severity of head injury is associated with increased risk of coagulopathy in combat casualties. J Trauma. 2011;71(1 Suppl):S78–81.CrossRefPubMed
17.
Zurück zum Zitat Frith D, Davenport R, Brohi K. Acute traumatic coagulopathy. Curr Opin Anaesthesiol. 2012;25:229–34.CrossRefPubMed Frith D, Davenport R, Brohi K. Acute traumatic coagulopathy. Curr Opin Anaesthesiol. 2012;25:229–34.CrossRefPubMed
18.
Zurück zum Zitat Spivey M, Parr MJ. Therapeutic approaches in trauma-induced coagulopathy. Minerva Anestesiol. 2005;71:281–9.PubMed Spivey M, Parr MJ. Therapeutic approaches in trauma-induced coagulopathy. Minerva Anestesiol. 2005;71:281–9.PubMed
19.
Zurück zum Zitat Hess JR, Lawson JH. The coagulopathy of trauma versus disseminated intravascular coagulation. J Trauma. 2006;60(6 Suppl):S12–9.CrossRefPubMed Hess JR, Lawson JH. The coagulopathy of trauma versus disseminated intravascular coagulation. J Trauma. 2006;60(6 Suppl):S12–9.CrossRefPubMed
20.
Zurück zum Zitat Gaillard M, Hervé C, Mandin L, Raynaud P. Mortality prognostic factors in chest injury. J Trauma. 1990;30:93–6.CrossRefPubMed Gaillard M, Hervé C, Mandin L, Raynaud P. Mortality prognostic factors in chest injury. J Trauma. 1990;30:93–6.CrossRefPubMed
21.
Zurück zum Zitat Bottlang M, Simpson T, Sigg J, Krieg JC, Madey SM, Long WB. Noninvasive reduction of open-book pelvic fractures by circumferential compression. J Orthop Trauma. 2002;16:367–73.CrossRefPubMed Bottlang M, Simpson T, Sigg J, Krieg JC, Madey SM, Long WB. Noninvasive reduction of open-book pelvic fractures by circumferential compression. J Orthop Trauma. 2002;16:367–73.CrossRefPubMed
22.
Zurück zum Zitat Knops SP, Van Lieshout EM, Spanjersberg WR, Patka P, Schipper IB. Randomised clinical trial comparing pressure characteristics of pelvic circumferential compression devices in healthy volunteers. Injury. 2011;42:1020–6.CrossRefPubMed Knops SP, Van Lieshout EM, Spanjersberg WR, Patka P, Schipper IB. Randomised clinical trial comparing pressure characteristics of pelvic circumferential compression devices in healthy volunteers. Injury. 2011;42:1020–6.CrossRefPubMed
23.
Zurück zum Zitat Knops SP, Schep NW, Spoor CW, van Riel MP, Spanjersberg WR, Kleinrensink GJ, van Lieshout EM, Patka P, Schipper IB. Comparison of three different pelvic circumferential compression devices: a biomechanical cadaver study. J Bone Joint Surg Am. 2011;93:230–40.CrossRefPubMed Knops SP, Schep NW, Spoor CW, van Riel MP, Spanjersberg WR, Kleinrensink GJ, van Lieshout EM, Patka P, Schipper IB. Comparison of three different pelvic circumferential compression devices: a biomechanical cadaver study. J Bone Joint Surg Am. 2011;93:230–40.CrossRefPubMed
24.
Zurück zum Zitat Osborn PM, Smith WR, Moore EE, Cothren CC, Morgan SJ, Williams AE, Stahel PF. Direct retroperitoneal pelvic packing versus pelvic angiography: a comparison of two management protocols for haemodynamically unstable pelvic fractures. Injury. 2009;40:54–60.CrossRefPubMed Osborn PM, Smith WR, Moore EE, Cothren CC, Morgan SJ, Williams AE, Stahel PF. Direct retroperitoneal pelvic packing versus pelvic angiography: a comparison of two management protocols for haemodynamically unstable pelvic fractures. Injury. 2009;40:54–60.CrossRefPubMed
25.
Zurück zum Zitat Papakostidis C, Giannoudis PV. Pelvic ring injuries with haemodynamic instability: efficacy of pelvic packing, a systematic review. Injury. 2009;40(Suppl 4):S53–61.CrossRefPubMed Papakostidis C, Giannoudis PV. Pelvic ring injuries with haemodynamic instability: efficacy of pelvic packing, a systematic review. Injury. 2009;40(Suppl 4):S53–61.CrossRefPubMed
26.
Zurück zum Zitat Steinhausen E, Lefering R, Tjardes T, Neugebauer EA, Bouillon B, Rixen D, Committee on Emergency Medicine, Intensive and Trauma Care (Sektion NIS) of the German Society for Trauma Surgery (DGU). A risk-adapted approach is beneficial in the management of bilateral femoral shaft fractures in multiple trauma patients: an analysis based on the trauma registry of the German Trauma Society. J Trauma Acute Care Surg. 2014;76:1288–93.CrossRefPubMed Steinhausen E, Lefering R, Tjardes T, Neugebauer EA, Bouillon B, Rixen D, Committee on Emergency Medicine, Intensive and Trauma Care (Sektion NIS) of the German Society for Trauma Surgery (DGU). A risk-adapted approach is beneficial in the management of bilateral femoral shaft fractures in multiple trauma patients: an analysis based on the trauma registry of the German Trauma Society. J Trauma Acute Care Surg. 2014;76:1288–93.CrossRefPubMed
27.
Zurück zum Zitat Nahm NJ, Vallier HA. Timing of definitive treatment of femoral shaft fractures in patients with multiple injuries: a systematic review of randomized and nonrandomized trials. J Trauma Acute Care Surg. 2012;73:1046–63.CrossRefPubMed Nahm NJ, Vallier HA. Timing of definitive treatment of femoral shaft fractures in patients with multiple injuries: a systematic review of randomized and nonrandomized trials. J Trauma Acute Care Surg. 2012;73:1046–63.CrossRefPubMed
28.
Zurück zum Zitat Cotton BA, Au BK, Nunez TC, Gunter OL, Robertson AM, Young PP. Predefined massive transfusion protocols are associated with a reduction in organ failure and post injury complications. J Trauma. 2009;66:41–8.CrossRefPubMed Cotton BA, Au BK, Nunez TC, Gunter OL, Robertson AM, Young PP. Predefined massive transfusion protocols are associated with a reduction in organ failure and post injury complications. J Trauma. 2009;66:41–8.CrossRefPubMed
29.
Zurück zum Zitat Hoyt DB, Dutton RP, Hauser CJ, Hess JR, Holcomb JB, Kluger Y, Mackway-Jones K, Parr MJ, Rizoli SB, Yukioka T, Bouillon B. Management of coagulopathy in the patients with multiple injuries: results from an international survey of clinical practice. J Trauma. 2008;65:755–64.CrossRefPubMed Hoyt DB, Dutton RP, Hauser CJ, Hess JR, Holcomb JB, Kluger Y, Mackway-Jones K, Parr MJ, Rizoli SB, Yukioka T, Bouillon B. Management of coagulopathy in the patients with multiple injuries: results from an international survey of clinical practice. J Trauma. 2008;65:755–64.CrossRefPubMed
30.
31.
Zurück zum Zitat Nunez TC, Voskresensky IV, Dossett LA, Shinall R, Dutton WD, Cotton BA. Early prediction of massive transfusion in trauma: simple as ABC (assessment of blood consumption)? J Trauma. 2009;2:346–52.CrossRef Nunez TC, Voskresensky IV, Dossett LA, Shinall R, Dutton WD, Cotton BA. Early prediction of massive transfusion in trauma: simple as ABC (assessment of blood consumption)? J Trauma. 2009;2:346–52.CrossRef
32.
Zurück zum Zitat Yucel N, Lefering R, Maegele M, Vorweg M, Tjardes T, Ruchholtz S, Neugebauer E, Wappler F, Bouillon B, Rixen D, Polytrauma Study Group of the German Trauma Society. Trauma Associated Severe Haemorrhage (TASH)-Score: probability of mass transfusion as surrogate for life threatening haemorrhage after multiple trauma. J Trauma. 2006;60:1228–37.CrossRefPubMed Yucel N, Lefering R, Maegele M, Vorweg M, Tjardes T, Ruchholtz S, Neugebauer E, Wappler F, Bouillon B, Rixen D, Polytrauma Study Group of the German Trauma Society. Trauma Associated Severe Haemorrhage (TASH)-Score: probability of mass transfusion as surrogate for life threatening haemorrhage after multiple trauma. J Trauma. 2006;60:1228–37.CrossRefPubMed
33.
Zurück zum Zitat Maegele M, Lefering R, Wafaisade A, Theodorou P, Wutzler S, Fischer P, Bouillon B, Paffrath T, Trauma Registry of the Deutsche Gesellschaft für Unfallchirurgie (TR-DGU). Revalidation and update of the TASH-Score: a scoring system to predict the probability for massive transfusion as a surrogate for life-threatening haemorrhage after severe injury. Vox Sang. 2011;100:231–8.CrossRefPubMed Maegele M, Lefering R, Wafaisade A, Theodorou P, Wutzler S, Fischer P, Bouillon B, Paffrath T, Trauma Registry of the Deutsche Gesellschaft für Unfallchirurgie (TR-DGU). Revalidation and update of the TASH-Score: a scoring system to predict the probability for massive transfusion as a surrogate for life-threatening haemorrhage after severe injury. Vox Sang. 2011;100:231–8.CrossRefPubMed
34.
Zurück zum Zitat Rainer TH, Ho AMH, Yeung JHH, Cheung NK, Wong RSM, Tang N, Ng SK, Wong GKC, Lai PBS, Graham CA. Early risk stratification of patients with major trauma requiring massive blood transfusion. Resuscitation. 2011;82:724–9.CrossRefPubMed Rainer TH, Ho AMH, Yeung JHH, Cheung NK, Wong RSM, Tang N, Ng SK, Wong GKC, Lai PBS, Graham CA. Early risk stratification of patients with major trauma requiring massive blood transfusion. Resuscitation. 2011;82:724–9.CrossRefPubMed
35.
Zurück zum Zitat Vandromme MJ, Griffin RL, McGwin G Jr, Weinberg JA, Rue LW 3rd, Kerby JD. Prospective identification of patients at risk for massive transfusion. Am Surg. 2011;77:155–61.PubMed Vandromme MJ, Griffin RL, McGwin G Jr, Weinberg JA, Rue LW 3rd, Kerby JD. Prospective identification of patients at risk for massive transfusion. Am Surg. 2011;77:155–61.PubMed
36.
Zurück zum Zitat Baker JB, Korn CS, Robinson K, Chan L, Henderson SO. Type and crossmatch of the trauma patient. J Trauma. 2001;50:878–81.CrossRefPubMed Baker JB, Korn CS, Robinson K, Chan L, Henderson SO. Type and crossmatch of the trauma patient. J Trauma. 2001;50:878–81.CrossRefPubMed
37.
Zurück zum Zitat Ruchholtz S, Pehle B, Lewan U, Lefering R, Müller N, Oberbeck R, Waydhas C. The emergency room transfusion score (ETS): prediction of blood transfusion requirement in initial resuscitation after sever trauma. Transfusion Med. 2006;16:49–56.CrossRef Ruchholtz S, Pehle B, Lewan U, Lefering R, Müller N, Oberbeck R, Waydhas C. The emergency room transfusion score (ETS): prediction of blood transfusion requirement in initial resuscitation after sever trauma. Transfusion Med. 2006;16:49–56.CrossRef
38.
Zurück zum Zitat Kühne C, Zettl RP, Fischbacher M, Lefering R, Ruchholtz S. Emergency Transfusion Score (ETS): a useful instrument for prediction of blood transfusion requirement in severely injured patients. World J Surg. 2006;32:1183–8.CrossRef Kühne C, Zettl RP, Fischbacher M, Lefering R, Ruchholtz S. Emergency Transfusion Score (ETS): a useful instrument for prediction of blood transfusion requirement in severely injured patients. World J Surg. 2006;32:1183–8.CrossRef
39.
Zurück zum Zitat Callcut RA, Johannigman JA, Kadon KS, Hanseman DJ, Robinson BRH. All massive transfusion criteria are not created equal: defining the predictive value of individual transfusion triggers to better determine who benefits from blood. J Trauma. 2011;70:794–801.CrossRefPubMed Callcut RA, Johannigman JA, Kadon KS, Hanseman DJ, Robinson BRH. All massive transfusion criteria are not created equal: defining the predictive value of individual transfusion triggers to better determine who benefits from blood. J Trauma. 2011;70:794–801.CrossRefPubMed
40.
Zurück zum Zitat Maegele M, Brockamp T, Nienaber U, Probst C, Schoechl H, Görlinger K, Spinella P. Predictive models and algorithms for the need of transfusion including massive transfusion in severely injured patients. Transfus Med Hemother. 2012;39:85–97.CrossRefPubMedPubMedCentral Maegele M, Brockamp T, Nienaber U, Probst C, Schoechl H, Görlinger K, Spinella P. Predictive models and algorithms for the need of transfusion including massive transfusion in severely injured patients. Transfus Med Hemother. 2012;39:85–97.CrossRefPubMedPubMedCentral
41.
Zurück zum Zitat Schreiber MA, Perkins J, Kiraly L, Underwood S, Wade C, Holcomb JB. Early predictors of massive transfusion in combat casualties. J Am Coll Surg. 2007;205:541–5.CrossRefPubMed Schreiber MA, Perkins J, Kiraly L, Underwood S, Wade C, Holcomb JB. Early predictors of massive transfusion in combat casualties. J Am Coll Surg. 2007;205:541–5.CrossRefPubMed
42.
Zurück zum Zitat McLaughlin DF, Niles S, Salinas J, Perkins JG, Cox ED, Wade C, Holcomb JB. A predictive model for massive transfusion in combat casualty patients. J Trauma. 2008;64(2 suppl):S57–63.CrossRefPubMed McLaughlin DF, Niles S, Salinas J, Perkins JG, Cox ED, Wade C, Holcomb JB. A predictive model for massive transfusion in combat casualty patients. J Trauma. 2008;64(2 suppl):S57–63.CrossRefPubMed
43.
Zurück zum Zitat Cancio LC, Wade C, West SA, Holcomb JB. Prediction of mortality and of the need for massive transfusion in casualties arriving at combat support hospitals in Iraq. J Trauma. 2008;64(2 suppl):S51–5.CrossRefPubMed Cancio LC, Wade C, West SA, Holcomb JB. Prediction of mortality and of the need for massive transfusion in casualties arriving at combat support hospitals in Iraq. J Trauma. 2008;64(2 suppl):S51–5.CrossRefPubMed
44.
Zurück zum Zitat Larson CR, White CE, Spinella PC, Jones JA, Holcomb JB, Blackbourne LH, Wade CE. Association of shock, coagulopathy, and initial vital signs with massive transfusion in combat casualties. J Trauma. 2010;69(suppl 1):S26–32.CrossRefPubMed Larson CR, White CE, Spinella PC, Jones JA, Holcomb JB, Blackbourne LH, Wade CE. Association of shock, coagulopathy, and initial vital signs with massive transfusion in combat casualties. J Trauma. 2010;69(suppl 1):S26–32.CrossRefPubMed
45.
Zurück zum Zitat Turan A, Yang D, Bonilla A, Shiba A, Sessler DI, Saager L, Kurz A. Morbidity and mortality after massive transfusion in patients undergoing non-cardiac surgery. Can J Anaesth. 2013;60:761–70.CrossRefPubMed Turan A, Yang D, Bonilla A, Shiba A, Sessler DI, Saager L, Kurz A. Morbidity and mortality after massive transfusion in patients undergoing non-cardiac surgery. Can J Anaesth. 2013;60:761–70.CrossRefPubMed
46.
Zurück zum Zitat McDaniel LM, Etchill EW, Raval JS, Neal MD. State of the art: massive transfusion. Transfus Med. 2014;24:138–44.CrossRefPubMed McDaniel LM, Etchill EW, Raval JS, Neal MD. State of the art: massive transfusion. Transfus Med. 2014;24:138–44.CrossRefPubMed
47.
Zurück zum Zitat Hardy JF, De Moerloose P, Samama M, Groupe d’intérêt en Hémostase Périopératoire. Massive transfusion and coagulopathy: pathophysiology and implications for clinical management. Can J Anaesth. 2004;51:293–310.CrossRefPubMed Hardy JF, De Moerloose P, Samama M, Groupe d’intérêt en Hémostase Périopératoire. Massive transfusion and coagulopathy: pathophysiology and implications for clinical management. Can J Anaesth. 2004;51:293–310.CrossRefPubMed
48.
Zurück zum Zitat Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care. 2007;13:680–5.CrossRefPubMed Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care. 2007;13:680–5.CrossRefPubMed
49.
Zurück zum Zitat Lal DS, Shaz BH. Massive transfusion: blood component ratios. Curr Opin Hematol. 2013;20:521–5.CrossRefPubMed Lal DS, Shaz BH. Massive transfusion: blood component ratios. Curr Opin Hematol. 2013;20:521–5.CrossRefPubMed
50.
Zurück zum Zitat Zallen G, Offner PJ, Moore EE, Blackwell J, Ciesla DJ, Gabriel J, Denny C, Silliman CC. Age of transfused blood is an independent risk factor for postinjury multiple organ failure. Am J Surg. 1999;178:570–2.CrossRefPubMed Zallen G, Offner PJ, Moore EE, Blackwell J, Ciesla DJ, Gabriel J, Denny C, Silliman CC. Age of transfused blood is an independent risk factor for postinjury multiple organ failure. Am J Surg. 1999;178:570–2.CrossRefPubMed
51.
Zurück zum Zitat Reed RL Jr, Ciavarella D, Heimbach DM, Baron L, Pavlin E, Counts RB, Carrico CJ. Prophylactic platelet administration during massive transfusion. A prospective, randomized, double-blind clinical study. Ann Surg. 1986;203:40–8.CrossRefPubMedPubMedCentral Reed RL Jr, Ciavarella D, Heimbach DM, Baron L, Pavlin E, Counts RB, Carrico CJ. Prophylactic platelet administration during massive transfusion. A prospective, randomized, double-blind clinical study. Ann Surg. 1986;203:40–8.CrossRefPubMedPubMedCentral
52.
Zurück zum Zitat Nagaprasad V, Singh M. Sequential analysis of the influence of blood storage on aggregation, deformability and shape parameters of erythrocytes. Clin Hemorheol Microcirc. 1998;18:273–84.PubMed Nagaprasad V, Singh M. Sequential analysis of the influence of blood storage on aggregation, deformability and shape parameters of erythrocytes. Clin Hemorheol Microcirc. 1998;18:273–84.PubMed
53.
Zurück zum Zitat Hovav T, Yedgar S, Manny N, Barshtein G. Alteration of red cell aggregability and shape during blood storage. Transfusion. 1999;39:277–81.CrossRefPubMed Hovav T, Yedgar S, Manny N, Barshtein G. Alteration of red cell aggregability and shape during blood storage. Transfusion. 1999;39:277–81.CrossRefPubMed
54.
Zurück zum Zitat D’Almeida MS, Jagger J, Duggan M, White M, Ellis C, Chin-Yee IH. A comparison of biochemical and functional alterations of rat and human erythrocytes stored in CPDA-1 for 29 days: implications for animal models of transfusion. Transfus Med. 2000;10:291–303.CrossRefPubMed D’Almeida MS, Jagger J, Duggan M, White M, Ellis C, Chin-Yee IH. A comparison of biochemical and functional alterations of rat and human erythrocytes stored in CPDA-1 for 29 days: implications for animal models of transfusion. Transfus Med. 2000;10:291–303.CrossRefPubMed
55.
Zurück zum Zitat Sollberger T, Walter R, Brand B, Contesse J, Meredith DO, Reinhart WH. Influence of prestorage leucocyte depletion and storage time on rheologic properties of erythrocyte concentrates. Vox Sang. 2002;82:191–7.CrossRefPubMed Sollberger T, Walter R, Brand B, Contesse J, Meredith DO, Reinhart WH. Influence of prestorage leucocyte depletion and storage time on rheologic properties of erythrocyte concentrates. Vox Sang. 2002;82:191–7.CrossRefPubMed
56.
Zurück zum Zitat Berezina TL, Zaets SB, Machiedo GW. Alterations of red blood cell shape in patients with severe trauma. J Trauma. 2004;57:82–7.CrossRefPubMed Berezina TL, Zaets SB, Machiedo GW. Alterations of red blood cell shape in patients with severe trauma. J Trauma. 2004;57:82–7.CrossRefPubMed
57.
Zurück zum Zitat Johnson JL, Moore EE, Gonzalez RJ, Fedel N, Partrick DA, Silliman CC. Alteration of the postinjury hyperinflammatory response by means of resuscitation with a red cell substitute. J Trauma. 2003;54:133–9.CrossRefPubMed Johnson JL, Moore EE, Gonzalez RJ, Fedel N, Partrick DA, Silliman CC. Alteration of the postinjury hyperinflammatory response by means of resuscitation with a red cell substitute. J Trauma. 2003;54:133–9.CrossRefPubMed
58.
Zurück zum Zitat Meng ZH, Wolberg AS, Monroe DM 3rd, Hoffman M. The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients. J Trauma. 2003;55:886–91.CrossRefPubMed Meng ZH, Wolberg AS, Monroe DM 3rd, Hoffman M. The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients. J Trauma. 2003;55:886–91.CrossRefPubMed
59.
Zurück zum Zitat Smith HM, Farrow SJ, Ackerman JD, Stubbs JR, Sprung J. Cardiac arrests associated with hyperkalemia during red blood cell transfusion: a case series. Anesth Analg. 2008;106:1062–9.CrossRefPubMed Smith HM, Farrow SJ, Ackerman JD, Stubbs JR, Sprung J. Cardiac arrests associated with hyperkalemia during red blood cell transfusion: a case series. Anesth Analg. 2008;106:1062–9.CrossRefPubMed
60.
Zurück zum Zitat Aboudara MC, Hurst FP, Abbott KC, Perkins RM. Hyperkalemia after packed red blood cell transfusion in trauma patients. J Trauma. 2008;64(suppl 2):S86–91.CrossRefPubMed Aboudara MC, Hurst FP, Abbott KC, Perkins RM. Hyperkalemia after packed red blood cell transfusion in trauma patients. J Trauma. 2008;64(suppl 2):S86–91.CrossRefPubMed
61.
Zurück zum Zitat Lee TL, Lun KC. Review of problems of massive blood transfusion in a surgical intensive care unit. Ann Acad Med Singap. 1985;14:175–84.PubMed Lee TL, Lun KC. Review of problems of massive blood transfusion in a surgical intensive care unit. Ann Acad Med Singap. 1985;14:175–84.PubMed
62.
Zurück zum Zitat Perkins RM, Aboudara MC, Abbott KC, Holcomb JB. Resuscitative hyperkalemia in noncrush dtrauma: a prospective, observational study. Clin J Am Soc Nephrol. 2007;2:313–9.CrossRefPubMed Perkins RM, Aboudara MC, Abbott KC, Holcomb JB. Resuscitative hyperkalemia in noncrush dtrauma: a prospective, observational study. Clin J Am Soc Nephrol. 2007;2:313–9.CrossRefPubMed
63.
Zurück zum Zitat Wilson RF. Complications of massive transfusions. Surg Rounds. 1981;4:47–54. Wilson RF. Complications of massive transfusions. Surg Rounds. 1981;4:47–54.
64.
Zurück zum Zitat Lier H, Krep H, Schroeder S, Stuber F. Preconditions of hemostasis in trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma. J Trauma. 2008;65:951–60.CrossRefPubMed Lier H, Krep H, Schroeder S, Stuber F. Preconditions of hemostasis in trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma. J Trauma. 2008;65:951–60.CrossRefPubMed
65.
Zurück zum Zitat Bunker JP, Bendixen HH, Murphy AJ. Hemodynamic effects of intravenously administered sodium citrate. N Engl J Med. 1962;266:372–7.CrossRefPubMed Bunker JP, Bendixen HH, Murphy AJ. Hemodynamic effects of intravenously administered sodium citrate. N Engl J Med. 1962;266:372–7.CrossRefPubMed
66.
Zurück zum Zitat Meikle A, Milne B. Management of prolonged QT interval during a massive transfusion: calcium, magnesium or both? Can J Anaesth. 2000;47:792–5.CrossRefPubMed Meikle A, Milne B. Management of prolonged QT interval during a massive transfusion: calcium, magnesium or both? Can J Anaesth. 2000;47:792–5.CrossRefPubMed
67.
Zurück zum Zitat Buddeberg F, Schimmer BB, Spahn DR. Transfusion transmissible infections and transfusion-related immunomodulation. Best Pract Res Clin Anaesthesiol. 2008;22:503–17.CrossRefPubMed Buddeberg F, Schimmer BB, Spahn DR. Transfusion transmissible infections and transfusion-related immunomodulation. Best Pract Res Clin Anaesthesiol. 2008;22:503–17.CrossRefPubMed
68.
Zurück zum Zitat Utter GH, Reed WF, Lee TH, Busch MP. Transfusion associated microchimerism. Vox Sang. 2007;93:188–95.CrossRefPubMed Utter GH, Reed WF, Lee TH, Busch MP. Transfusion associated microchimerism. Vox Sang. 2007;93:188–95.CrossRefPubMed
69.
Zurück zum Zitat Dunne JR, Malone D, Tracy JK, Gannon C, Napolitano LM. Perioperative anemia: an independent risk factor for infection, mortality, and resource utilization in surgery. J Surg Res. 2002;102:237–44.CrossRefPubMed Dunne JR, Malone D, Tracy JK, Gannon C, Napolitano LM. Perioperative anemia: an independent risk factor for infection, mortality, and resource utilization in surgery. J Surg Res. 2002;102:237–44.CrossRefPubMed
70.
Zurück zum Zitat Hill GE, Frawley WH, Griffith KE, Forestner JE, Minei JP. Allogeneic blood transfusion increases the risk of postoperative bacterial infection: a meta-analysis. J Trauma. 2003;54:908–14.CrossRefPubMed Hill GE, Frawley WH, Griffith KE, Forestner JE, Minei JP. Allogeneic blood transfusion increases the risk of postoperative bacterial infection: a meta-analysis. J Trauma. 2003;54:908–14.CrossRefPubMed
71.
Zurück zum Zitat Claridge JA, Sawyer RG, Schulman AM, McLemore EC, Young JS. Blood transfusions correlate with infections in trauma patients in a dose-dependent manner. Am Surg. 2002;68:566–72.PubMed Claridge JA, Sawyer RG, Schulman AM, McLemore EC, Young JS. Blood transfusions correlate with infections in trauma patients in a dose-dependent manner. Am Surg. 2002;68:566–72.PubMed
72.
Zurück zum Zitat Bochicchio GV, Napolitano L, Joshi M, et al. Blood product transfusion and ventilator-associated pneumonia in trauma patients. Surg Infect (Larchmt). 2008;9:415–22.CrossRef Bochicchio GV, Napolitano L, Joshi M, et al. Blood product transfusion and ventilator-associated pneumonia in trauma patients. Surg Infect (Larchmt). 2008;9:415–22.CrossRef
73.
Zurück zum Zitat Dunne JR, Riddle MS, Danko J, Hayden R, Petersen K. Blood transfusion is associated with infection and increased resource utilization in combat casualties. Am Surg. 2006;72:619–25.PubMed Dunne JR, Riddle MS, Danko J, Hayden R, Petersen K. Blood transfusion is associated with infection and increased resource utilization in combat casualties. Am Surg. 2006;72:619–25.PubMed
74.
Zurück zum Zitat Dunne JR, Malone DL, Tracy JK, Napolitano LM. Allogenic blood transfusion in the first 24 h after trauma is associated with increased systemic inflammatory response syndrome (SIRS) and death. Surg Infect (Larchmt). 2004;5:395–404.CrossRef Dunne JR, Malone DL, Tracy JK, Napolitano LM. Allogenic blood transfusion in the first 24 h after trauma is associated with increased systemic inflammatory response syndrome (SIRS) and death. Surg Infect (Larchmt). 2004;5:395–404.CrossRef
75.
Zurück zum Zitat Beale E, Zhu J, Chan L, Shulman I, Harwood R, Demetriades D. Blood transfusion in critically injured patients: a prospective study. Injury. 2006;37:455–65.CrossRefPubMed Beale E, Zhu J, Chan L, Shulman I, Harwood R, Demetriades D. Blood transfusion in critically injured patients: a prospective study. Injury. 2006;37:455–65.CrossRefPubMed
76.
Zurück zum Zitat Robinson Y, Hostmann A, Matenov A, Ertel W, Oberholzer A. Erythropoiesis in multiply injured patients. J Trauma. 2006;61:1285–91.CrossRefPubMed Robinson Y, Hostmann A, Matenov A, Ertel W, Oberholzer A. Erythropoiesis in multiply injured patients. J Trauma. 2006;61:1285–91.CrossRefPubMed
77.
Zurück zum Zitat Goldman M, Webert KE, Arnold DM, Freedman J, Hannon J, Blajchman MA, TRALI Consensus Panel. Proceedings of a consensus conference: towards an understanding of TRALI. Transfus Med Rev. 2005;19:2–31.CrossRefPubMed Goldman M, Webert KE, Arnold DM, Freedman J, Hannon J, Blajchman MA, TRALI Consensus Panel. Proceedings of a consensus conference: towards an understanding of TRALI. Transfus Med Rev. 2005;19:2–31.CrossRefPubMed
78.
Zurück zum Zitat Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, LeGall JR, Morris A, Spragg R. Report of the American-European Consensus conference on acute respiratory distress syndrome: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Consensus Committee. J Crit Care. 1994;9:72–81.CrossRefPubMed Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, LeGall JR, Morris A, Spragg R. Report of the American-European Consensus conference on acute respiratory distress syndrome: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Consensus Committee. J Crit Care. 1994;9:72–81.CrossRefPubMed
79.
Zurück zum Zitat Marik PE, Corwin HL. Acute lung injury following blood transfusion: expanding the definition. Crit Care Med. 2008;36:3080–4.CrossRefPubMed Marik PE, Corwin HL. Acute lung injury following blood transfusion: expanding the definition. Crit Care Med. 2008;36:3080–4.CrossRefPubMed
80.
Zurück zum Zitat Gazmuri RJ, Shakeri SA. Blood transfusion and the risk of nosocomial infection: an underreported complication? Crit Care Med. 2002;30:2389–91.CrossRefPubMed Gazmuri RJ, Shakeri SA. Blood transfusion and the risk of nosocomial infection: an underreported complication? Crit Care Med. 2002;30:2389–91.CrossRefPubMed
81.
Zurück zum Zitat Silliman CC, Paterson AJ, Dickey WO, Stroneck DF, Popovsky MA, Caldwell SA, Ambruso DR. The association of biologically active lipids with the development of transfusion-related acute lung injury: a retrospective study. Transfusion. 1997;37:719–26.CrossRefPubMed Silliman CC, Paterson AJ, Dickey WO, Stroneck DF, Popovsky MA, Caldwell SA, Ambruso DR. The association of biologically active lipids with the development of transfusion-related acute lung injury: a retrospective study. Transfusion. 1997;37:719–26.CrossRefPubMed
82.
Zurück zum Zitat Wallis JP, Lubenko A, Wells AW, Chapman CE. Single hospital experience of TRALI. Transfusion. 2003;43:1053–9.CrossRefPubMed Wallis JP, Lubenko A, Wells AW, Chapman CE. Single hospital experience of TRALI. Transfusion. 2003;43:1053–9.CrossRefPubMed
83.
Zurück zum Zitat Jia X, Malhotra A, Saeed M, Mark RG, Talmor D. Risk factors for ARDS in patients receiving mechanical ventilation for >48 h. Chest. 2008;133:853–61.CrossRefPubMed Jia X, Malhotra A, Saeed M, Mark RG, Talmor D. Risk factors for ARDS in patients receiving mechanical ventilation for >48 h. Chest. 2008;133:853–61.CrossRefPubMed
84.
Zurück zum Zitat Gajic O, Gropper MA, Hubmayr RD. Pulmonary edema after transfusion: how to differentiate transfusion-associated circulatory overload from transfusion-related acute lung injury. Crit Care Med. 2006;34:S109–13.CrossRefPubMed Gajic O, Gropper MA, Hubmayr RD. Pulmonary edema after transfusion: how to differentiate transfusion-associated circulatory overload from transfusion-related acute lung injury. Crit Care Med. 2006;34:S109–13.CrossRefPubMed
85.
Zurück zum Zitat Curtis BR, McFarland JG. Mechanisms of transfusion related acute lung injury (TRALI): anti-leukocyte antibodies. Crit Care Med. 2006;34(suppl 5):S118–23.CrossRefPubMed Curtis BR, McFarland JG. Mechanisms of transfusion related acute lung injury (TRALI): anti-leukocyte antibodies. Crit Care Med. 2006;34(suppl 5):S118–23.CrossRefPubMed
86.
Zurück zum Zitat Silliman CC. The two-event model of transfusion-related acute lung injury. Crit Care Med. 2006;34(suppl 5):S124–31.CrossRefPubMed Silliman CC. The two-event model of transfusion-related acute lung injury. Crit Care Med. 2006;34(suppl 5):S124–31.CrossRefPubMed
87.
Zurück zum Zitat Holcomb JB, Jenkins D, Rhee P, Johannigman J, Mahoney P, Mehta S, Cox ED, Gehrke MJ, Beilman GJ, Schreiber M, Flaherty SF, Grathwohl KW, Spinella PC, Perkins JG, Beekley AC, McMullin NR, Park MS, Gonzalez EA, Wade CE, Dubick MA, Schwab CW, Moore FA, Champion HR, Hoyt DB, Hess JR. Damage control resuscitation: directly addressing the early coagulopathy of trauma. J Trauma. 2007;62:307–10.CrossRefPubMed Holcomb JB, Jenkins D, Rhee P, Johannigman J, Mahoney P, Mehta S, Cox ED, Gehrke MJ, Beilman GJ, Schreiber M, Flaherty SF, Grathwohl KW, Spinella PC, Perkins JG, Beekley AC, McMullin NR, Park MS, Gonzalez EA, Wade CE, Dubick MA, Schwab CW, Moore FA, Champion HR, Hoyt DB, Hess JR. Damage control resuscitation: directly addressing the early coagulopathy of trauma. J Trauma. 2007;62:307–10.CrossRefPubMed
88.
Zurück zum Zitat Kermode JC, Zheng Q, Milner EP. Marked temperature dependence of the platelet calcium signal induced by human von Willebrand factor. Blood. 1999;94:199–207.PubMed Kermode JC, Zheng Q, Milner EP. Marked temperature dependence of the platelet calcium signal induced by human von Willebrand factor. Blood. 1999;94:199–207.PubMed
Metadaten
Titel
Protocols for massive blood transfusion: when and why, and potential complications
verfasst von
E. Guerado
A. Medina
M. I. Mata
J. M. Galvan
M. L. Bertrand
Publikationsdatum
09.12.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Trauma and Emergency Surgery / Ausgabe 3/2016
Print ISSN: 1863-9933
Elektronische ISSN: 1863-9941
DOI
https://doi.org/10.1007/s00068-015-0612-y

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