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Tumor Biology

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10.12.2015 | Review

Pseudogene-expressed RNAs: a new frontier in cancers

verfasst von: Xuefei Shi, Fengqi Nie, Zhaoxia Wang, Ming Sun

Erschienen in: Tumor Biology | Ausgabe 2/2016

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Abstract

Over the past decade, the importance of non-protein-coding functional elements in the human genome has emerged from the water and been identified as a key revelation in post-genomic biology. Since the completion of the ENCODE (Encyclopedia of DNA Elements) and FANTOM (Functional Annotation of Mammals) project, tens of thousands of pseudogenes as well as numerous long non-coding RNA (lncRNA) genes were identified. However, while pseudogenes were initially regarded as non-functional relics littering the human genome during evolution, recent studies have revealed that they play critical roles at multiple levels in diverse physiological and pathological processes, especially in cancer through parental-gene-dependent or parental-gene-independent regulation. Herein, we review the current knowledge of pseudogenes and synthesize the nascent evidence for functional properties and regulatory modalities exerted by pseudogene-transcribed RNAs in human cancers and prospect the potential as molecular signatures in cancer reclassification and tailored therapy.

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Titel: Pseudogene-expressed RNAs: a new frontier in cancers
verfasst von: Xuefei Shi
Fengqi Nie
Zhaoxia Wang
Ming Sun
Publikationsdatum: 10.12.2015
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 2/2016
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-015-4482-z

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Pseudogene-expressed RNAs: a new frontier in cancers

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