The online version of this article (doi:10.1186/1752-1947-6-40) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
MS conceptualized the case study, gathered the data and wrote the manuscript. IK interpreted the data, performed the radiology and revised the manuscript. KZ and AA performed the histological evaluation and interpretation of the data. SK and FS acquired the data. BA, MB, ST and MCB gave final approval for publication. All authors read and approved the final manuscript.
Tracheobronchial amyloidosis is an uncommon localized form of amyloidosis that can simulate a tracheal tumor. Clinical signs are not specific and the diagnosis is rarely given before performing a bronchoscopy with multiples biopsies.
We report the case of a 60-year-old Moroccan woman, complaining of dyspnea and wheezing for three years, who was treated at our institution for management of severe asthma. A bronchoscopy revealed a tumor formation of her trachea; multiples biopsies were performed and a diagnosis made of amyloid light-chain amyloidosis. She successfully received an endoscopic resection.
This case highlights the importance of routinely carrying out an endoscopy in any patient complaining of atypical bronchial symptoms or with uncontrolled asthma. Tracheal amyloidosis is a rare disease, confirmed by histological examination of bronchial biopsies, and the treatment of choice is based on the bronchoscopic resection.
Pepys MB: Amyloidosis. Oxford Textbook of Medicine. Edited by: Weatherall DJ, Ledingham JGG, Warrell DA. 1995, Oxford, UK: Oxford University Press, 1512-1524.
Tattersfield AE, Gillmore JD: Amyloidosis and the respiratory tract. Thorax. 1999, 54: 444-451. 10.1136/thx.54.5.444. CrossRef
Lesser A: Ein Fall von Enchondroma osteoides mixtum der Lunge mit partieller Amyloidentartung. Virchows Arch (Path Anat). 69: 404-409. 1877
Hui AN, Koss MN, Hochholzer L: Amyloidosis presenting in the lower respiratory tract. Arch Pathol Lab Med. 1986, 110: 212-218. PubMed
Cordier JF, Loire R, Brune J: Amyloidosis of the tracheobronchial tree. N Engl J Med. 1962, 266: 587-591. 10.1056/NEJM196203222661204. CrossRef
Petermann W, Barth J, Schluter E: Localized amyloidosis of central airways. Eur J Respir Dis. 1987, 71: 210-212. PubMed
Puchtler H, Sweat F: On the binding of Congo red by amyloid. J Histochem Cytochem. 1962, 10: 355-364. 10.1177/10.3.355. CrossRef
Weismann RE, Clagett OT, McDonald JR: Amyloid disease of the lung treated by pneumonectomy. J Thorac Cardiovasc Surg. 1947, 16: 269-281.
O'Regan , Fenlon HM, Beamis JF: Tracheobronchial amyloidosis: the Boston University experience from 1984 to 1999. Medicine (Baltimore). 2000, 79: 69-79. 10.1097/00005792-200003000-00001. CrossRef
Pecora JL, Sambursky JS, Vargha F: Radiation therapy in amyloidosis of the eyelid and conjunctiva: a case report. Ann Ophtalmol. 1982, 14: 194-196.
Kurrus JA, Hayes JK, Hoidal JR: Radiation therapy for tracheobronchial amyloidosis. 1998, 114: 1489-1492.
- Pseudotumoral tracheobronchial amyloidosis mimicking asthma: a case report
Mohammed El Biaze
Mohammed Chakib Benjelloun
- BioMed Central