Introduction
Bulimia nervosa
Mortality in BN
Aim of the study
Methods
Setting and study design
Inclusion criteria
Primary outcome
Covariates
Statistical analysis
Ethical approval
Results
Descriptive statistics
Age group (years old) | Number (% in rows) | |||
---|---|---|---|---|
Deaths | SUD | AD | PD | |
10–14 (n = 38) | 0 (0.00%) | 1 (2.63%) | 5 (13.16%) | 4 (10.43%) |
15–19 (n = 211) | 0 (0.00%) | 7 (3.32%) | 42 (19.91%) | 27 (12.80%) |
20–24 (n = 338) | 6 (1.78%) | 16 (4.73%) | 40 (11.83%) | 27 (7.99%) |
25–29 (n = 390) | 3 (0.77%) | 9 (2.31%) | 56 (14.36%) | 32 (8.21%) |
30–34 (n = 223) | 1 (0.45%) | 8 (3.59%) | 32 (14.35%) | 13 (5.83%) |
35–39 (n = 117) | 1 (0.85%) | 4 (3.42%) | 24 (20.51%) | 9 (7.69%) |
40–44 (n = 75) | 2 (2.67%) | 5 (6.67%) | 17 (22.67%) | 6 (8.00%) |
45–49 (n = 49) | 3 (6.12%) | 5 (10.20%) | 8 (16.33%) | 6 (12.24%) |
50–54 (n = 37) | 1 (2.70%) | 5 (13.51%) | 9 (24.32%) | 1 (2.71%) |
55–59 (n = 17) | 0 (0.00%) | 0 (0.00%) | 7 (41.18%) | 5 (29.41%) |
60–64 (n = 6) | 1 (16.67%) | 1 (16.67%) | 2 (33.33%) | 1 (16.67%) |
Variables | Mean ± SD/numbers (% in column) | Number of deaths (% in row) | Crude hazard ratio (95% CI) | p value |
---|---|---|---|---|
Age (years old) | 28.54 ± 9.48 | – | 1.06 (1.02, 1.10) | 0.005 |
Gender
| ||||
Female | 1417 (94.40%) | 14 (0.99%) | Ref | |
Male | 84 (5.60%) | 4 (4.76%) | 5.41 (1.78, 16.46) | 0.003 |
Marital status
| ||||
Single | 1070 (71.29%) | 13 (1.21%) | Ref | |
Married/partner | 197 (13.12%) | 0 (0.00%) | 0.00 | 1.000 |
Divorced/separated | 51 (3.40%) | 1 (1.96%) | 1.36 (1.18, 10.40) | 0.768 |
Others | 183 (12.19%) | 4 (2.19%) | 1.33 (0.43, 4.12) | 0.616 |
Borough
| ||||
Lambeth | 362 (24.12%) | 5 (1.38%) | Ref | |
Croydon | 183 (12.19%) | 2 (1.09%) | 0.73 (0.14, 3.75) | 0.704 |
Lewisham | 213 (14.19%) | 4 (1.88%) | 1.28 (0.35, 4.79) | 0.709 |
Southwark | 240 (15.99%) | 1 (0.42%) | 0.29 (0.03, 2.46) | 0.256 |
Bromley | 165 (10.99%) | 2 (1.21%) | 0.91 (0.18, 4.74) | 0.920 |
Bexley | 85 (5.66%) | 0 (0.00%) | – | – |
Greenwich | 99 (6.60%) | 0 (0.00%) | – | – |
Others | 154 (10.26%) | 4 (2.60%) | 1.45 (0.39, 5.42) | 0.579 |
Ethnicity
| ||||
White | 1165 (77.61%) | 11 (0.94%) | Ref | |
Black | 88 (5.86%) | 3 (3.41%) | 3.41 (0.95, 12.21) | 0.060 |
Others/mixed | 248 (16.52%) | 4 (1.61%) | 1.76 (0.56, 5.52) | 0.335 |
Deprivation score
| ||||
1.56–21.03 | 494 (32.91%) | 5 (1.01%) | Ref | |
21.04–30.70 | 494 (32.91%) | 6 (1.21%) | 1.20 (0.37, 3.92) | 0.766 |
30.71–100 | 496 (33.04%) | 6 (1.21%) | 1.24 (0.38, 4.07) | 0.720 |
Missing | 17 (1.13%) | 1 (5.88%) | 6.22 (0.73, 53.32) | 0.095 |
Substance use disorder
| ||||
No | 1440 (95.94%) | 15 (1.04%) | Ref | |
Yes | 61 (4.06%) | 3 (4.92%) | 4.01 (1.16, 13.85) | 0.028 |
Affective disorders
| ||||
No | 1259 (83.88%) | 11 (0.87%) | Ref | |
Yes | 242 (16.12%) | 7 (2.89%) | 3.30 (1.28, 8.51) | 0.014 |
Personality disorder
| ||||
No | 1370 (91.27%) | 13 (0.95%) | Ref | |
Yes | 131 (8.73%) | 5 (3.82%) | 3.88 (1.38, 10.89) | 0.010 |
Standardised mortality ratio (SMR)
Univariate analysis by Cox regressions
Multivariable analyses
Comorbidity | Adjusted hazard ratio (95% CI) | p value |
---|---|---|
Affective disorder | 2.47 (0.90, 6.78) | 0.08 |
Substance use disorder | 3.12 (0.81, 12.08) | 0.10 |
Personality disorder | 3.36 (1.05, 10.73) | 0.04 |