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Annals of Behavioral Medicine
Erschienen in: Annals of Behavioral Medicine 2/2015

01.04.2015 | Original Article

Psychological Distress, Emotional Stability, and Emotion Regulation Moderate Dynamics of Herpes Simplex Virus Type 2 Recurrence

verfasst von: Erin E. Horn, MA, Eric Turkheimer, PhD, Eric Strachan, PhD

Erschienen in: Annals of Behavioral Medicine | Ausgabe 2/2015

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Abstract

Background

Herpes simplex virus type 2 (HSV-2) genital lesion recurrence is modulated by psychological factors, but no such link with viral shedding (and thus asymptomatic transmission) has been observed in humans.

Purpose

The moderating effects of average psychological distress, emotional stability, and emotion regulation on HSV-2 recurrence were tested.

Methods

Nineteen HSV-2 seropositive women were followed over 22 weeks. Daily measures of HSV-2 recurrence and psychological distress were collected. HSV-2 lesions and viral shedding were modeled as linear oscillator systems, with psychological distress moderating the periodicity of each process.

Results

High levels of distress, more labile moods, and less ability to regulate emotional states were associated with fewer days elapsed between the onset of lesion episodes. Viral shedding showed the same pattern.

Conclusions

Results are consistent with research indicating that psychological distress suppresses immune system functioning, and provide new evidence that genital HSV-2 viral shedding is related to, and regulated by, psychological distress.
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Fußnoten
1
Note that after standardization, low z-scores for emotion regulation in fact reflect better regulation, because oscillation is faster at more negative values.
 
2
This is the case when η 1 and/or ζ 1 are positive; the reverse occurs when these estimates are negative.
 
Literatur
1.
Centers for Disease Control and Prevention (CDC). Seroprevalence of herpes simplex virus type 2 among persons aged 14–49 years—United States, 2005–2008. Morb Mortal Wkly Rep. 2010; 59: 456-459.
2.
3.
Schiffer JT, Corey L. Herpes simplex virus. In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas, and Bennett’s Principles and Practices of Infectious Diseases. 7th ed. Philadelphia: Churchill Livingstone; 2009: 1943-1962.
4.
Benedetti JK, Zeh J, Corey L. Clinical reactivation of genital herpes simplex virus infection decreases in frequency over time. Ann Intern Med. 1999; 131: 14-20.CrossRefPubMed
5.
Corey L, Wald A, Celum CL, Quinn TC. The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: A review of two overlapping epidemics. J Acquir Immune Defic Syndr. 2004; 35: 435-445.CrossRefPubMed
6.
Wald A, Link K. Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: A meta-analysis. J Infect Dis. 2002; 185: 45-52.CrossRefPubMed
7.
VanderPlate C, Aral SO. Psychosocial aspects of genital herpes virus infection. Health Psychol. 1987; 6: 57-72.CrossRefPubMed
8.
Swanson JM, Remy L, Chenitz C, et al. Illicit drug use among young adults with genital herpes. Public Health Nurs. 1993; 10: 197-203.CrossRefPubMed
9.
Chida Y, Mao X. Does psychosocial stress predict symptomatic herpes simplex virus recurrence? A meta-analytic investigation on prospective studies. Brain Behav Immun. 2009; 23: 917-925.CrossRefPubMed
10.
Strachan E, Saracino M, Selke S, Magaret A, Buchwald D, Wald A. The effects of daily distress and personality on genital HSV shedding and lesions in a randomized, double-blind, placebo-controlled, crossover trial of acyclovir in HSV-2 seropositive women. Brain Behav Immun. 2011; 25: 1475-1481.CrossRefPubMedCentralPubMed
11.
Blondeau JM, Aoki FY, Glavin GB. Stress-induced reactivation of latent herpes simplex virus infection in rat lumbar dorsal root ganglia. J Psychosom Res. 1993; 37: 843-849.CrossRefPubMed
12.
Freeman ML, Sheridan BS, Bonneau RH, Hendricks RL. Psychological stress compromises CD8+ T cell control of latent herpes simplex virus type 1 infections. J Immunol. 2007; 179: 322-328.CrossRefPubMedCentralPubMed
13.
Padgett DA, Sheridan JF, Dorne J, Berntson GG, Candelora J, Glaser R. Social stress and the reactivation of latent herpes simplex virus type 1. PNAS. 1998; 95: 7231-7235.CrossRefPubMedCentralPubMed
14.
Schmidt DD, Schmidt PM, Crabtree BF, Hyun J, Anderson P, Smith C. The temporal relationship of psychosocial stress to cellular immunity and herpes labialis recurrences. Fam Med. 1991; 23: 594-599.PubMed
15.
Glaser R, Kiecolt-Glaser JK. Chronic stress modulates the virus-specific immune response to latent herpes simplex virus type I. Ann Behav Med. 1997; 19: 78-82.CrossRefPubMed
16.
Glaser R, Kiecolt-Glaser JK, Speicher CE, Holliday JE. Stress, loneliness, and changes in herpesvirus latency. J Behav Med. 1985; 8: 249-260.CrossRefPubMed
17.
Tronstein E, Johnston C, Huang M-L, et al. Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection. JAMA. 2011; 305: 1441-1449.CrossRefPubMedCentralPubMed
18.
Dalkvist J, Whalin T-BR, Bartsch E, Forsbeck M. Herpes simplex and mood: A prospective study. Psychosom Med. 1995; 57: 127-137.CrossRefPubMed
19.
McLarnon LD, Kaloupek GG. Psychological investigation of genital herpes recurrence: Prospective assessment and cognitive-behavioral intervention for a chronic physical disorder. Health Psychol. 1988; 7: 231-249.CrossRefPubMed
20.
Rand KH, Hoon EF, Massey JK, Johnson JH. Daily stress and recurrence of genital herpes simplex. Arch Intern Med. 1990; 150: 1889-1893.CrossRefPubMed
21.
Schiffer JT, Abu-Raddad L, Mark KE, et al. Frequent release of low amounts of herpes simplex virus from neurons: Results of a mathematical model. Sci Transl Med. 2009; 1: 1-9.
22.
Boker SM, Neale MC, Rausch JR. Latent differential equation modeling with multivariate multi-occasion indicators. In: van Montfort HOK, Satorra A, eds. Recent Developments on Structural Equation Models: Theory and Applications. Amsterdam: Kluwer; 2004: 151-174.CrossRef
23.
Wald A, Zeh J, Barnum G, Davis LG, Corey L. Suppression of sub-clinical shedding of herpes simplex virus type 2 with acyclovir. Ann Intern Med. 1996; 124: 8-15.CrossRefPubMed
24.
Ahearn EP. The use of visual analog scales in mood disorders: A critical review. J Psychiatr Res. 1997; 31: 569-579.CrossRefPubMed
25.
Lesage F-X, Berjot S, Deschamps F. Clinical stress assessment using a visual analogue scale. Occup Med (Lond). 2012; 62: 600-605.CrossRef
26.
Williams VSL, Morlock RJ, Feltner D. Psychometric evaluation of a visual analog scale for the assessment of anxiety. Health Qual Life Outcome. 2010; 8: 57.CrossRef
27.
Cohen F, Kemeny ME, Kearney KA, Zegans LS, Neuhaus JM, Conant MA. Persistent stress as a predictor of genital herpes recurrence. Arch Intern Med. 1999; 159: 2430-2436.CrossRefPubMed
28.
29.
R: A Language and Environment for Statistical Computing [computer program]. Version 2.15.2. Vienna, Austria: R Foundation for Statistical Computing; 2012.
30.
Newman DA. Longitudinal modeling with randomly and systematically missing data: A simulation of ad hoc, maximum likelihood, and multiple imputation techniques. Organ Res Methods. 2003; 6: 238-362.CrossRef
31.
Schlomer GL, Bauman S, Card NA. Best practices for missing data management in counseling psychology. J Couns Psychol. 2010; 57: 1-10.CrossRefPubMed
32.
Boker SM, Montpetit MA, Hunter MD, Bergeman CS. Modeling resilience with differential equations. In: Molenaar P, Newell K, eds. Learning and Development: Individual Pathways of Change. Washington, DC: American Psychological Association; 2010: 183-206.CrossRef
33.
Boker SM, Nesselroade JR. A method for modeling the intrinsic dynamics of intraindividual variability: Recovering the parameters of simulated oscillators in multi-wave panel data. Multivar Behav Res. 2002; 37: 127-160.CrossRef
34.
35.
Staples AD, Boker SM, Bergeman CS. Moderated latent differential equations. Multivar Behav Res. [under review].
36.
Noakes L. The Takens embedding theorem. Int J Bifurc Chaos. 1991; 1: 867-872.CrossRef
37.
Ram N, Brose A, Molenaar PCM. Dynamic factor analysis: Modeling person-specific process. In: Little TD, ed. The Oxford Handbook of Quantitative Methods in Psychology: Vol. 2: Statistical Analysis. New York: Oxford University Press; 2013: 441-457.
38.
Hu Y. Dynamic Process for Ordinal Data: Simulation and Application [doctoral dissertation]. Charlottesville, VA: University of Virginia; 2013.
39.
Box GEP, Jenkins GM, Reinsel GC. Time Series Analysis: Forecasting and Control. 4th ed. Hoboken, NJ: Wiley; 2008.CrossRef
40.
Boker SM, Deboeck PR, Edler C, Keel PK. Generalized local linear approximation of derivatives from time series. In: Chow SM, Ferrar E, eds. Statistical Methods for Modeling Human Dynamics: An Interdisciplinary Dialogue. Boca Raton, FL: Taylor & Francis; 2009: 161-178.
41.
Deboeck PR, Boker SM, Bergeman C. Modeling individual damped linear oscillator processes with differential equations: Using surrogate data analysis to estimate the smoothing parameter. Multivar Behav Res. 2008; 43: 497-523.CrossRef
42.
Soetaert K, Petzoldt T, Setzer RW. Solving differential equations in R: Package deSolve. J Stat Soft. 2010; 33: 1-25.
43.
Mostad SB, Kreiss JK, Ryncarz A, et al. Cervical shedding of herpes simplex virus and cytomegalovirus throughout the menstrual cycle in women infected with human immunodeficiency virus type 1. Am J Obstet Gynecol. 2000; 183: 948-955.CrossRefPubMed
44.
Segerstrom SC, Miller GE. Psychological stress and the human immune system: A meta-analytic study of 30 years of inquiry. Psychol Bull. 2004; 130: 601-630.CrossRefPubMedCentralPubMed
45.
Mbopi-Kéou F-X, Bélec L, Dalessio J, et al. Cervicovaginal neutralizing antibodies to herpes simplex virus (HSV) in women seropositive for HSV types 1 and 2. Clin Diagn Lab Immunol. 2003; 10: 388-393.PubMedCentralPubMed
46.
Reeves WC, Corey L, Adams HG, Vonter LA, Holmes KK. Risk of recurrence after first episodes of genital herpes: Relation to HSV type and antibody response. N Engl J Med. 1981; 305: 315-319.CrossRefPubMed
47.
Schiffer JT. Mucosal HSV-2 specific CD8+ T-cells represent containment of prior viral shedding rather than a correlate of future protection. Front Immunol. 2013; 4: 209.CrossRefPubMedCentralPubMed
48.
Wald A, Zeh J, Selke S, Warren T, Ashley R, Corey L. Genital shedding of herpes simplex virus among men. J Infect Dis. 2002; 186(Suppl 1): S34-S39.CrossRefPubMed
49.
Benedetti J, Corey L, Ashley R. Recurrence rates in genital herpes after symptomatic first-episode infection. Ann Intern Med. 1994; 121: 847-854.CrossRefPubMed
50.
Nolan-Hoeksema S. Gender differences in depression. Curr Dir Psychol Sci. 2001; 10: 173-176.CrossRef
51.
Armstrong KA, Khawaja NG. Gender differences in anxiety: An investigation of the symptoms, cognitions, and sensitivity towards anxiety in a nonclinical population. Behav Cogn Psychother. 2002; 30: 227-231.CrossRef
52.
Matud MP. Gender differences in stress and coping styles. Personal Individ Differ. 2004; 37: 1401-1415.CrossRef
53.
Wald A, Zeh J, Selke S, Ashley R, Corey L. Virologic characteristics of subclinical and symptomatic genital herpes infections. N Engl J Med. 1995; 333: 770-775.CrossRefPubMed
54.
Burns VE, Drayson M, Ring C, Carroll D. Perceived stress and psychological well-being are associated with antibody status after meningitis C conjugate vaccination. Psychosom Med. 2002; 64: 963-970.PubMed
55.
Taylor SE, Kemeny ME, Reed GM, Bower JE, Gruenewald TL. Psychological resources, positive illusions, and health. Am Psychol. 2000; 55: 99-109.CrossRefPubMed
56.
van Eck M, Berkhof H, Nicolson N, Sulon J. The effects of perceived stress, traits, mood states, and stressful daily events on salivary control. Psychosom Med. 1996; 58: 447-458.CrossRefPubMed
57.
Cohen S, Tyrrel DAJ, Smith AP. Negative life events, perceived stress, negative affect, and susceptibility to the common cold. J Pers Soc Psychol. 1993; 64: 131-140.CrossRefPubMed
58.
Mark KE, Wald A, Magaret AS, et al. Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults. J Infect Dis. 2008; 198: 1141-1149.CrossRefPubMedCentralPubMed
59.
Rymkiewisz PD, Heng YX, Vasudev A, Larbi A. The immune system in the aging human. Immunol Res. 2012; 53: 235-250.CrossRef
60.
Boker SM, Laurenceau JP. Coupled dynamics and mutually adaptive context. In: Little TD, Bovaird JA, Card NA, eds. Modeling Ecological and Contextual Effects in Longitudinal Studies of Human Development. Mahwah, NJ: Lawrence Erlbaum; 2007: 299-324.
61.
Cruess S, Antoni M, Cruess D, et al. Reductions in herpes simplex virus type 2 antibody titers after cognitive behavioral stress management and relationships with neuroendocrine function, relaxation skills, and social support in HIV-positive men. Psychosom Med. 2000; 62: 828-837.CrossRefPubMed
62.
Longo DJ, Clum GA, Yaeger NJ. Psychosocial treatment for genital herpes. J Consult Clin Psychol. 1988; 56: 61-66.CrossRefPubMed
63.
Lutgendorf SK, Antoni MH, Ironson G, et al. Cognitive-behavioral stress management decreases dysphoric mood and herpes simplex virus-type 2 antibody titers in symptomatic HIV-positive gay men. J Consult Clin Psychol. 1997; 65: 31-43.CrossRefPubMed
64.
McLarnon LD, Kaloupek DG. Psychological investigation of genital herpes recurrence: Prospective assessment and cognitive-behavioral intervention for a chronic disorder. Health Psychol. 1988; 7: 231-249.CrossRefPubMed
Metadaten
Titel
Psychological Distress, Emotional Stability, and Emotion Regulation Moderate Dynamics of Herpes Simplex Virus Type 2 Recurrence
verfasst von
Erin E. Horn, MA
Eric Turkheimer, PhD
Eric Strachan, PhD
Publikationsdatum
01.04.2015
Verlag
Springer US
Erschienen in
Annals of Behavioral Medicine / Ausgabe 2/2015
Print ISSN: 0883-6612
Elektronische ISSN: 1532-4796
DOI
https://doi.org/10.1007/s12160-014-9640-9

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