Background
Methods
Study population
Data collection
Study 1 (N=142) | Study 2 (N=113) | Study 3 (N=123) | Study 4 (N=153) | |
---|---|---|---|---|
Gender | x | x | x | x |
Age | x | x | x | x |
Disease duration | x | x | x | |
Education level | x | x | x | x |
Living arrangement | x | x | x | x |
Symptomatology (PANSS) | x | x | x | x |
Depression (CDSS) | x | x | x | |
Quality of life (S-QoL18) | x | x | x | x |
Insight (SUMD) | x | x | x | x |
Statistical analysis
Two scoring models
Validation
Results
Sample characteristics
Overall sample | Study 1 (N=142) | Study 2 (N=113) | Study 3 (N=123) | Study 4 (N=153) | ||
---|---|---|---|---|---|---|
n (%) or M ± SD | ||||||
Gender (Male) | 360 (67.8) | 101 (71.1) | 79 (69.9) | 84 (68.3) | 96 (62.7) | |
Age (in years) | 38.2 ± 11.7 | 36.2 ± 12.7 | 38.5 ± 10.8 | 40.8 ± 11.5 | 37.6 ± 11.3 | |
Disease duration (in years) | 14.4 ± 9.6 | 12.3 ± 10.1 | 13.9 ± 8.1 | 17.1 ± 9.6 | ||
Education Level (University level) | 206 (38.8) | 67 (55.8) | 51 (45.1) | 27 (22.0) | 61 (43.0) | |
Living arrangement (Alone) | 185 (34.8) | 44 (37.9) | 46 (40.7) | 50 (41.3) | 45 (36.3) | |
PANSS | Total score | 69.2 ± 20.5 | 70.3 ± 19.9 | 63.9 ± 18.0 | 63.1 ± 21.6 | 77.3 ± 19.2 |
Positive scale score | 14.9 ± 6.1 | 14.5 ± 5.5 | 14.6 ± 6.2 | 12.9 ± 5.9 | 17.1 ± 6.0 | |
Negative scale score | 17.8 ± 6.6 | 19.5 ± 7.3 | 15.8 ± 5.6 | 15.6 ± 6.3 | 19.4 ± 6.0 | |
General psychopathology score | 36.6 ± 10.9 | 36.3 ± 10.1 | 33.5 ± 9.8 | 34.6 ± 11.5 | 40.8 ± 10.6 | |
G12 | 2.8 ± 1.5 | 3.1 ± 1.5 | 2.7 ± 1.4 | 2.4 ± 1.4 | 2.6 ± 1.1 | |
CDSS | Total | 4.2 ± 4.1 | 4.0 ± 4.2 | 4.1 ± 4.5 | 4.5 ± 3.6 | |
S-QoL18 | Index | 58.0 ± 18.9 | 57.7 ± 17.9 | 59.4 ± 19.4 | 55.0 ± 17.0 | 58.8 ± 20.4 |
Validity of model 1 scoring: ‘not applicable’ = ‘0’
Construct validity and reliability
Dimension/index (number of items) | M (SD) | Missing values % | Item-internal consistency (min-max) | Item discriminant validity (min-max) | Floor % | Ceiling % | Alpha* | INFIT** (min-max) |
---|---|---|---|---|---|---|---|---|
Model 1 scoring: ‘not applicable’ = ‘0’
| ||||||||
Awareness of disease (3) | 55.3 (22.1) | 0.13 | 0.81–0.90 | 0.32–0.44 | 4.5 | 17.1 | 0.83 | 0.86–1.15 |
Awareness of positive symptoms (3) | 47.2 (27.2) | 0.70 | 0.79–0.85 | 0.37–0.48 | 22.3 | 15.3 | 0.76 | 0.88–1.09 |
Awareness of negative symptoms (3) | 47.5 (25.4) | 0.53 | 0.81–0.87 | 0.31–0.44 | 16.8 | 11.3 | 0.80 | 0.87–1.12 |
Index (9) | 50.0 (20.0) | 0.45 | NA*** | NA*** | NA*** | NA*** | 0.85 | NA*** |
Model 2 scoring: ‘not applicable’ = missing data
| ||||||||
Awareness of disease (3) | 56.20 (22.0) | 1.6 | 0.82–0.93 | 0.43–0.70 | 48.2 | 17.1 | 0.87 | 0.73–1.39 |
Awareness of positive symptoms (3) | 59.83 (19.6) | 23.0 | 0.82–0.88 | 0.52–0.68 | 28.5 | 15.3 | 0.82 | 0.93–1.10 |
Awareness of negative symptoms (3) | 57.45 (19.4) | 15.5 | 0.85-0.90 | 0.43–0.67 | 35.2 | 11.4 | 0.85 | 0.81–1.14 |
Index (9) | 57.83 (17.8) | 13.4 | NA*** | NA*** | NA*** | NA*** | 0.85 | NA*** |
External validity
Awareness of disease | Awareness of positive symptoms | Awareness of negative symptoms | Index | ||
---|---|---|---|---|---|
Model 1 scoring: ‘not applicable’ = ‘0’
| |||||
PANSS | Total score |
0.395**
|
0.482**
|
0.436**
|
0.550**
|
Positive score |
0.261**
|
0.437**
|
0.251**
|
0.402**
| |
Negative score |
0.373**
|
0.348**
|
0.440**
|
0.483**
| |
General psychopathology score |
0.373**
|
0.454**
|
0.415**
|
0.521**
| |
G12 |
0.677**
|
0.471**
|
0.333**
|
0.592**
| |
CDSS total score | −0,019 | 0.098 |
0.139**
| 0.095 | |
S-QoL18 Index | 0.009 | −0.091 |
−0.180*
|
−0.115*
| |
Age |
0,132**
|
0.149**
|
0.134**
|
0.173**
| |
Disease duration | 0,032 |
0.112*
|
0.116*
| 0.109 | |
Gender | Male | 55.79 (22.2) | 46.47 (27.7) | 46.80 (25.2) | 49.68 (19.9) |
Female | 54.13 (22.0) | 48.70 (26.1) | 48.86 (25.8) | 50.56 (20.2) | |
p-value | 0.419 | 0.377 | 0.382 | 0.634 | |
Education level | University level | 53.45 (21.9) | 43.07 (27.2) | 42.98 (25.5) | 46.50 (20.1) |
High school/primary school level | 55.61 (21.9) | 49.89 (26.7) | 50.63 (24.9) | 52.04 (19.7) | |
p-value | 0.278 |
0.006
|
0.001
|
0.002
| |
Living arrangement | Alone | 55.62 (21.3) | 50.87 (27.7) | 47.33 (25.8) | 51.27 (20.4) |
Not alone | 53.96 (22.1) | 43.91 (26.7) | 46.49 (25.8) | 48.11 (19.7) | |
p-value | 0.420 |
0.007
| 0.731 | 0.094 | |
Model 2 scoring: ‘not applicable’ = missing data
| |||||
PANSS | Total score |
0.389**
|
0.465**
|
0.365**
|
0.465**
|
Positive score |
0.260**
|
0.355**
|
0.290**
|
0.344**
| |
Negative score |
0.370**
|
0.428**
|
0.382**
|
0.450**
| |
General psychopathology score |
0.364**
|
0.420**
|
0.296**
|
0.413**
| |
G12 |
0.676**
|
0.682**
|
0.501**
|
0.697**
| |
CDSS total score | −0.007 | 0.045 | −0.058 | −0.007 | |
S-QoL18 Index | 0.001 | 0.001 | 0.010 | 0.005 | |
Age |
0.124**
|
0.112**
|
0.162**
|
0.152**
| |
Disease duration | 0.035 | −0.002 | 0.074 | 0.039 | |
Gender | Male | 56.87 (22.0) | 60.49 (19.6) | 57.42 (19.0) | 58.26 (17.4) |
Female | 54.81 (22.1) | 58.45 (19.6) | 57.50 (20.5) | 56.92 (18.5) | |
p-value | 0.315 | 0.264 | 0.962 | 0.419 | |
Education level | University level | 54.34 (22.3) | 58.03 (19.8) | 54.52 (18.7) | 55.63 (17.8) |
High/Primary school level | 56.66 (21.6) | 60.56 (19.4) | 59.25 (19.3) | 58.82 (17.6) | |
p-value | 0.244 | 0.156 |
0.007
|
0.047
| |
Living arrangement | Alone | 56.94 (21.1) | 62.17 (19.8) | 59.06 (18.8) | 59.39 (17.4) |
Not alone | 54.73 (22.3) | 57.82 (19.4) | 56.52 (19.6) | 56.36 (17.8) | |
p-value | 0.283 |
0.018
| 0.164 | 0.069 |