Skip to main content
Erschienen in: Der Onkologe 10/2017

14.09.2017 | Ovarialkarzinom | Psychoonkologie

Psychoneuroimmunologie und Krebs

Neuere Forschungsergebnisse zu Katecholaminen, β‑Blockern und klinischen Implikationen

verfasst von: Dr. med. Jochen Hefner, Professor Dr. med. Herbert Csef

Erschienen in: Die Onkologie | Ausgabe 10/2017

Einloggen, um Zugang zu erhalten

Zusammenfassung

Es verdichten sich die Hinweise, dass psychische Belastungen (Distress) den Verlauf von Krebserkrankungen beeinflussen können. Bei der Aufklärung möglicher Pathomechanismen hat die Erforschung des autonomen Nervensystems mit dem Fokus auf Katecholamine und β‑Blocker die bisher wichtigsten Ergebnisse erbracht. In diesem Beitrag sollen die Entwicklung psychoneuroimmunologischer Arbeitsmodelle nachvollzogen, aktuelle Forschungsschwerpunkte skizziert und klinische Implikationen diskutiert werden.
Literatur
1.
Zurück zum Zitat Ader R, Cohen N (1975) Behaviorally conditioned immunosuppression. Psychosom Med 37:333–340CrossRefPubMed Ader R, Cohen N (1975) Behaviorally conditioned immunosuppression. Psychosom Med 37:333–340CrossRefPubMed
2.
Zurück zum Zitat Armaiz-Pena GN, Gonzalez-Villasana V, Nagaraja AS et al (2015) Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth. Oncotarget 6:4266–4273CrossRefPubMed Armaiz-Pena GN, Gonzalez-Villasana V, Nagaraja AS et al (2015) Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth. Oncotarget 6:4266–4273CrossRefPubMed
3.
Zurück zum Zitat Battacharyya GS, Babu KG, Bondarde SA et al (2015) Effect of coadministered beta blocker and COX-2 inhibitors to patients with pancreatic cancer prior to receiving albumin-bound paclitaxel. American Society of Clinical Oncology 12th Annual Gastrointestinal (GI) Cancers Symposium, San Francisco. Battacharyya GS, Babu KG, Bondarde SA et al (2015) Effect of coadministered beta blocker and COX-2 inhibitors to patients with pancreatic cancer prior to receiving albumin-bound paclitaxel. American Society of Clinical Oncology 12th Annual Gastrointestinal (GI) Cancers Symposium, San Francisco.
4.
Zurück zum Zitat Batty GD, Russ TC, Stamatakis E et al (2017) Psychological distress in relation to site specific cancer mortality: pooling of unpublished data from 16 prospective cohort studies. BMJ 356:j108CrossRefPubMedPubMedCentral Batty GD, Russ TC, Stamatakis E et al (2017) Psychological distress in relation to site specific cancer mortality: pooling of unpublished data from 16 prospective cohort studies. BMJ 356:j108CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Ben-Eliyahu S, Shakhar G, Rosenne E et al (1999) Hypothermia in barbiturate-anesthetized rats suppresses natural killer cell activity and compromises resistance to tumor metastasis: a role for adrenergic mechanisms. Anesthesiology 91:732–740CrossRefPubMed Ben-Eliyahu S, Shakhar G, Rosenne E et al (1999) Hypothermia in barbiturate-anesthetized rats suppresses natural killer cell activity and compromises resistance to tumor metastasis: a role for adrenergic mechanisms. Anesthesiology 91:732–740CrossRefPubMed
6.
Zurück zum Zitat Bharati SJ, Chowdhury T, Bergese SD et al (2016) Anesthetics impact on cancer recurrence: what do we know? J Cancer Res Ther 12:464–468CrossRefPubMed Bharati SJ, Chowdhury T, Bergese SD et al (2016) Anesthetics impact on cancer recurrence: what do we know? J Cancer Res Ther 12:464–468CrossRefPubMed
7.
Zurück zum Zitat Blomberg BB, Alvarez JP, Diaz A et al (2009) Psychosocial adaptation and cellular immunity in breast cancer patients in the weeks after surgery: an exploratory study. J Psychosom Res 67:369–376CrossRefPubMedPubMedCentral Blomberg BB, Alvarez JP, Diaz A et al (2009) Psychosocial adaptation and cellular immunity in breast cancer patients in the weeks after surgery: an exploratory study. J Psychosom Res 67:369–376CrossRefPubMedPubMedCentral
9.
10.
Zurück zum Zitat Choi MJ, Cho KH, Lee S et al (2015) hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness. Oncogene 34:3402–3412CrossRefPubMed Choi MJ, Cho KH, Lee S et al (2015) hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness. Oncogene 34:3402–3412CrossRefPubMed
11.
Zurück zum Zitat Choy C, Raytis JL, Smith DD et al (2016) Inhibition of beta2-adrenergic receptor reduces triple-negative breast cancer brain metastases: the potential benefit of perioperative beta-blockade. Oncol Rep 35:3135–3142CrossRefPubMedPubMedCentral Choy C, Raytis JL, Smith DD et al (2016) Inhibition of beta2-adrenergic receptor reduces triple-negative breast cancer brain metastases: the potential benefit of perioperative beta-blockade. Oncol Rep 35:3135–3142CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Cole SW, Nagaraja AS, Lutgendorf SK et al (2015) Sympathetic nervous system regulation of the tumour microenvironment. Nat Rev Cancer 15:563–572CrossRefPubMedPubMedCentral Cole SW, Nagaraja AS, Lutgendorf SK et al (2015) Sympathetic nervous system regulation of the tumour microenvironment. Nat Rev Cancer 15:563–572CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Eskander R, Bessonova L, Chiu C (2012) Beta blocker use and ovarian cancer survival: a retrospective cohort study. Gynecol Oncol 127(1):S21 Eskander R, Bessonova L, Chiu C (2012) Beta blocker use and ovarian cancer survival: a retrospective cohort study. Gynecol Oncol 127(1):S21
19.
Zurück zum Zitat Forget P, Machiels JP, Coulie PG et al (2013) Neutrophil:lymphocyte ratio and intraoperative use of ketorolac or diclofenac are prognostic factors in different cohorts of patients undergoing breast, lung, and kidney cancer surgery. Ann Surg Oncol 20(Suppl 3):S650–S660CrossRefPubMed Forget P, Machiels JP, Coulie PG et al (2013) Neutrophil:lymphocyte ratio and intraoperative use of ketorolac or diclofenac are prognostic factors in different cohorts of patients undergoing breast, lung, and kidney cancer surgery. Ann Surg Oncol 20(Suppl 3):S650–S660CrossRefPubMed
20.
Zurück zum Zitat Gotlieb N, Rosenne E, Matzner P et al (2015) The misleading nature of in vitro and ex vivo findings in studying the impact of stress hormones on NK cell cytotoxicity. Brain Behav Immun 45:277–286CrossRefPubMed Gotlieb N, Rosenne E, Matzner P et al (2015) The misleading nature of in vitro and ex vivo findings in studying the impact of stress hormones on NK cell cytotoxicity. Brain Behav Immun 45:277–286CrossRefPubMed
21.
Zurück zum Zitat Hadden JW, Hadden EM, Middleton E Jr. (1970) Lymphocyte blast transformation. I. Demonstration of adrenergic receptors in human peripheral lymphocytes. Cell Immunol 1:583–595CrossRefPubMed Hadden JW, Hadden EM, Middleton E Jr. (1970) Lymphocyte blast transformation. I. Demonstration of adrenergic receptors in human peripheral lymphocytes. Cell Immunol 1:583–595CrossRefPubMed
22.
Zurück zum Zitat Hefner J, Csef H (2016) The clinical relevance of beta blockers in ovarian carcinoma: a systematic review. Geburtshilfe Frauenheilkd 76:1050–1056CrossRefPubMedPubMedCentral Hefner J, Csef H (2016) The clinical relevance of beta blockers in ovarian carcinoma: a systematic review. Geburtshilfe Frauenheilkd 76:1050–1056CrossRefPubMedPubMedCentral
23.
Zurück zum Zitat Hefner J, Csef H (2011) Psychoneuroimmunologie und Krebs. Neue Ergebnisse zu psychosozialen Einflüssen auf Tumorerkrankungen. Onkologe 17:839–850CrossRef Hefner J, Csef H (2011) Psychoneuroimmunologie und Krebs. Neue Ergebnisse zu psychosozialen Einflüssen auf Tumorerkrankungen. Onkologe 17:839–850CrossRef
24.
Zurück zum Zitat Hefner J, Csef H, Kunzmann V (2014) Stress and pancreatic carcinoma—beta-adrenergic signaling and tumor biology. Dtsch Med Wochenschr 139:334–338CrossRefPubMed Hefner J, Csef H, Kunzmann V (2014) Stress and pancreatic carcinoma—beta-adrenergic signaling and tumor biology. Dtsch Med Wochenschr 139:334–338CrossRefPubMed
25.
Zurück zum Zitat Hefner J, Schwarz E, Zentis A et al The effect of pre-transplant distress on immune reconstitution among myeloma patients undergoing first autologous hematopoietic cell transplantation. Bone Marrow Transplantation, in Vorbereitung Hefner J, Schwarz E, Zentis A et al The effect of pre-transplant distress on immune reconstitution among myeloma patients undergoing first autologous hematopoietic cell transplantation. Bone Marrow Transplantation, in Vorbereitung
26.
Zurück zum Zitat Hobfoll SE, Gerhart JI, Zalta AK et al (2015) Posttraumatic stress symptoms predict impaired neutrophil recovery in stem cell transplant recipients. Psychooncology 24:1529–1535CrossRefPubMedPubMedCentral Hobfoll SE, Gerhart JI, Zalta AK et al (2015) Posttraumatic stress symptoms predict impaired neutrophil recovery in stem cell transplant recipients. Psychooncology 24:1529–1535CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Horowitz M, Neeman E, Sharon E et al (2015) Exploiting the critical perioperative period to improve long-term cancer outcomes. Nat Rev Clin Oncol 12:213–226CrossRefPubMedPubMedCentral Horowitz M, Neeman E, Sharon E et al (2015) Exploiting the critical perioperative period to improve long-term cancer outcomes. Nat Rev Clin Oncol 12:213–226CrossRefPubMedPubMedCentral
28.
Zurück zum Zitat Katayama Y, Battista M, Kao WM et al (2006) Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell 124:407–421CrossRefPubMed Katayama Y, Battista M, Kao WM et al (2006) Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell 124:407–421CrossRefPubMed
29.
Zurück zum Zitat Knight JM, Moynihan JA, Lyness JM et al (2014) Peri-transplant psychosocial factors and neutrophil recovery following hematopoietic stem cell transplantation. PLOS ONE 9:e99778CrossRefPubMedPubMedCentral Knight JM, Moynihan JA, Lyness JM et al (2014) Peri-transplant psychosocial factors and neutrophil recovery following hematopoietic stem cell transplantation. PLOS ONE 9:e99778CrossRefPubMedPubMedCentral
31.
Zurück zum Zitat Lutgendorf SK, Andersen BL (2015) Biobehavioral approaches to cancer progression and survival: mechanisms and interventions. Am Psychol 70:186–197CrossRefPubMedPubMedCentral Lutgendorf SK, Andersen BL (2015) Biobehavioral approaches to cancer progression and survival: mechanisms and interventions. Am Psychol 70:186–197CrossRefPubMedPubMedCentral
32.
Zurück zum Zitat Lutgendorf SK, Degeest K, Sung CY et al (2009) Depression, social support, and beta-adrenergic transcription control in human ovarian cancer. Brain Behav Immun 23:176–183CrossRefPubMed Lutgendorf SK, Degeest K, Sung CY et al (2009) Depression, social support, and beta-adrenergic transcription control in human ovarian cancer. Brain Behav Immun 23:176–183CrossRefPubMed
33.
Zurück zum Zitat Lutgendorf SK, Johnsen EL, Cooper B et al (2002) Vascular endothelial growth factor and social support in patients with ovarian carcinoma. Cancer 95:808–815CrossRefPubMed Lutgendorf SK, Johnsen EL, Cooper B et al (2002) Vascular endothelial growth factor and social support in patients with ovarian carcinoma. Cancer 95:808–815CrossRefPubMed
34.
Zurück zum Zitat Martin LA, Davies GL, Weigel MT et al (2010) Pre-surgical study of the biological effects of the selective cyclo-oxygenase-2 inhibitor celecoxib in patients with primary breast cancer. Breast Cancer Res Treat 123:829–836CrossRefPubMed Martin LA, Davies GL, Weigel MT et al (2010) Pre-surgical study of the biological effects of the selective cyclo-oxygenase-2 inhibitor celecoxib in patients with primary breast cancer. Breast Cancer Res Treat 123:829–836CrossRefPubMed
35.
Zurück zum Zitat Mcgregor BA, Syrjala KL, Dolan ED et al (2013) The effect of pre-transplant distress on immune reconstitution among adult autologous hematopoietic cell transplantation patients. Brain Behav Immun 30(Suppl):S142–S148CrossRefPubMed Mcgregor BA, Syrjala KL, Dolan ED et al (2013) The effect of pre-transplant distress on immune reconstitution among adult autologous hematopoietic cell transplantation patients. Brain Behav Immun 30(Suppl):S142–S148CrossRefPubMed
36.
Zurück zum Zitat Nagaraja AS, Sadaoui NC, Lutgendorf SK et al (2013) beta-blockers: a new role in cancer chemotherapy? Expert Opin Investig Drugs 22:1359–1363CrossRefPubMedPubMedCentral Nagaraja AS, Sadaoui NC, Lutgendorf SK et al (2013) beta-blockers: a new role in cancer chemotherapy? Expert Opin Investig Drugs 22:1359–1363CrossRefPubMedPubMedCentral
37.
Zurück zum Zitat Rangarajan S, Enserink JM, Kuiperij HB et al (2003) Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2‑adrenergic receptor. J Cell Biol 160:487–493CrossRefPubMedPubMedCentral Rangarajan S, Enserink JM, Kuiperij HB et al (2003) Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2‑adrenergic receptor. J Cell Biol 160:487–493CrossRefPubMedPubMedCentral
38.
Zurück zum Zitat Schmidt SA, Schmidt M (2016) Beta-blockers and improved survival from ovarian cancer: new miracle treatment or another case of immortal person-time bias? Cancer 122:324–325CrossRefPubMed Schmidt SA, Schmidt M (2016) Beta-blockers and improved survival from ovarian cancer: new miracle treatment or another case of immortal person-time bias? Cancer 122:324–325CrossRefPubMed
39.
Zurück zum Zitat Sephton SE, Dhabhar FS, Keuroghlian AS et al (2009) Depression, cortisol, and suppressed cell-mediated immunity in metastatic breast cancer. Brain Behav Immun 23:1148–1155CrossRefPubMed Sephton SE, Dhabhar FS, Keuroghlian AS et al (2009) Depression, cortisol, and suppressed cell-mediated immunity in metastatic breast cancer. Brain Behav Immun 23:1148–1155CrossRefPubMed
40.
Zurück zum Zitat Shaashua L, Shabat-Simon M, Haldar R et al (2017) Perioperative COX-2 and beta-adrenergic blockade improves metastatic biomarkers in breast cancer patients in a phase-II randomized trial. Clin Cancer Res 3:4651–4661CrossRef Shaashua L, Shabat-Simon M, Haldar R et al (2017) Perioperative COX-2 and beta-adrenergic blockade improves metastatic biomarkers in breast cancer patients in a phase-II randomized trial. Clin Cancer Res 3:4651–4661CrossRef
41.
Zurück zum Zitat Sood AK, Armaiz-Pena GN, Halder J et al (2010) Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis. J Clin Invest 120:1515–1523CrossRefPubMedPubMedCentral Sood AK, Armaiz-Pena GN, Halder J et al (2010) Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis. J Clin Invest 120:1515–1523CrossRefPubMedPubMedCentral
43.
Zurück zum Zitat Sooriakumaran P, Coley HM, Fox SB et al (2009) A randomized controlled trial investigating the effects of celecoxib in patients with localized prostate cancer. Anticancer Res 29:1483–1488PubMed Sooriakumaran P, Coley HM, Fox SB et al (2009) A randomized controlled trial investigating the effects of celecoxib in patients with localized prostate cancer. Anticancer Res 29:1483–1488PubMed
44.
Zurück zum Zitat Sorski L, Melamed R, Matzner P et al (2016) Reducing liver metastases of colon cancer in the context of extensive and minor surgeries through beta-adrenoceptors blockade and COX2 inhibition. Brain Behav Immun 58:91–98CrossRefPubMed Sorski L, Melamed R, Matzner P et al (2016) Reducing liver metastases of colon cancer in the context of extensive and minor surgeries through beta-adrenoceptors blockade and COX2 inhibition. Brain Behav Immun 58:91–98CrossRefPubMed
45.
Zurück zum Zitat Thaker PH, Han LY, Kamat AA et al (2006) Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med 12:939–944CrossRefPubMed Thaker PH, Han LY, Kamat AA et al (2006) Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med 12:939–944CrossRefPubMed
46.
Zurück zum Zitat Thaker PH, Urbauer DL, Sood AK (2016) Reply to beta blockers in epithelial ovarian cancer and beta-blockers and improved survival from ovarian cancer: New miracle treatment or another case of immortal person-time bias? Cancer 122:325–326CrossRefPubMed Thaker PH, Urbauer DL, Sood AK (2016) Reply to beta blockers in epithelial ovarian cancer and beta-blockers and improved survival from ovarian cancer: New miracle treatment or another case of immortal person-time bias? Cancer 122:325–326CrossRefPubMed
47.
Zurück zum Zitat Vandewalle B, Revillion F, Lefebvre J (1990) Functional beta-adrenergic receptors in breast cancer cells. J Cancer Res Clin Oncol 116:303–306CrossRefPubMed Vandewalle B, Revillion F, Lefebvre J (1990) Functional beta-adrenergic receptors in breast cancer cells. J Cancer Res Clin Oncol 116:303–306CrossRefPubMed
49.
Zurück zum Zitat Watkins JL, Thaker PH, Nick AM et al (2015) Clinical impact of selective and nonselective beta-blockers on survival in patients with ovarian cancer. Cancer 121:3444–3451CrossRefPubMedPubMedCentral Watkins JL, Thaker PH, Nick AM et al (2015) Clinical impact of selective and nonselective beta-blockers on survival in patients with ovarian cancer. Cancer 121:3444–3451CrossRefPubMedPubMedCentral
50.
Zurück zum Zitat Zhang C, Wenger T, Mattern J et al (2007) Clinical and mechanistic aspects of glucocorticoid-induced chemotherapy resistance in the majority of solid tumors. Cancer Biol Ther 6:278–287CrossRefPubMed Zhang C, Wenger T, Mattern J et al (2007) Clinical and mechanistic aspects of glucocorticoid-induced chemotherapy resistance in the majority of solid tumors. Cancer Biol Ther 6:278–287CrossRefPubMed
51.
Zurück zum Zitat Zhang D, Ma Q, Shen S et al (2009) Inhibition of pancreatic cancer cell proliferation by propranolol occurs through apoptosis induction: the study of beta-adrenoceptor antagonist’s anticancer effect in pancreatic cancer cell. Pancreas 38:94–100CrossRefPubMed Zhang D, Ma Q, Shen S et al (2009) Inhibition of pancreatic cancer cell proliferation by propranolol occurs through apoptosis induction: the study of beta-adrenoceptor antagonist’s anticancer effect in pancreatic cancer cell. Pancreas 38:94–100CrossRefPubMed
Metadaten
Titel
Psychoneuroimmunologie und Krebs
Neuere Forschungsergebnisse zu Katecholaminen, β‑Blockern und klinischen Implikationen
verfasst von
Dr. med. Jochen Hefner
Professor Dr. med. Herbert Csef
Publikationsdatum
14.09.2017
Verlag
Springer Medizin
Erschienen in
Die Onkologie / Ausgabe 10/2017
Print ISSN: 2731-7226
Elektronische ISSN: 2731-7234
DOI
https://doi.org/10.1007/s00761-017-0294-7

Weitere Artikel der Ausgabe 10/2017

Der Onkologe 10/2017 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.