Skip to main content
Erschienen in: Rheumatology International 1/2013

01.01.2013 | Original Article

PTU-induced ANCA-positive vasculitis: an innocent or a life-threatening adverse effect?

verfasst von: N. Şule Yaşar Bilge, Timuçin Kaşifoğlu, Cengiz Korkmaz

Erschienen in: Rheumatology International | Ausgabe 1/2013

Einloggen, um Zugang zu erhalten

Abstract

Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides are rare, but they can be triggered by chemicals, infections and drugs; among them, antithyroid drugs are common. Autoimmune disorders, such as vasculitis, are unusual, but serious complications of antithyroid therapy. Both propylthiouracil (PTU) and methimazole may induce ANCA-associated vasculitis. PTU-induced vasculitides may have different organ involvement patterns. Herein, we report four cases with ANCA-associated vasculitis with different clinical manifestations.
Literatur
2.
Zurück zum Zitat Yazisiz V, Öngüt G, Terzioğlu E, Karayalçin Ü (2010) Clinical importance of antineutrophil cytoplasmic antibody positivity during propylthiouracil treatment. Int J Clin Pract 64(1):19–24PubMedCrossRef Yazisiz V, Öngüt G, Terzioğlu E, Karayalçin Ü (2010) Clinical importance of antineutrophil cytoplasmic antibody positivity during propylthiouracil treatment. Int J Clin Pract 64(1):19–24PubMedCrossRef
3.
Zurück zum Zitat Cin OM, Gursoy A, Morris Y, Aydıntuğ OT, Kamel N, Gullu S (2009) Prevalence and clinical significance of antineutrophil cytoplasmic antibody in Graves’ patients treated with propylthiouracil. Int J Clin Pract 63(2):299–302PubMedCrossRef Cin OM, Gursoy A, Morris Y, Aydıntuğ OT, Kamel N, Gullu S (2009) Prevalence and clinical significance of antineutrophil cytoplasmic antibody in Graves’ patients treated with propylthiouracil. Int J Clin Pract 63(2):299–302PubMedCrossRef
4.
Zurück zum Zitat Reumaux D, Duthilleul P, Roos D (2004) Pathogenesis of diseases associated with antineutrophil cytoplasmic antibodies. Hum Immunol 65:1–12PubMedCrossRef Reumaux D, Duthilleul P, Roos D (2004) Pathogenesis of diseases associated with antineutrophil cytoplasmic antibodies. Hum Immunol 65:1–12PubMedCrossRef
5.
Zurück zum Zitat Savage COS, Harper L, Holland M (2002) New findings in pathogenesis of antineutrophil cytoplasm antibody-associated vasculitis. Curr Opinion in Rheum 14:15–22CrossRef Savage COS, Harper L, Holland M (2002) New findings in pathogenesis of antineutrophil cytoplasm antibody-associated vasculitis. Curr Opinion in Rheum 14:15–22CrossRef
6.
Zurück zum Zitat Gao Y, Zhao MH (2009) Review article: drug-induced anti-neutrophil cytoplasmic antibody-associated vasculitis. Nephrology 14:33–41PubMedCrossRef Gao Y, Zhao MH (2009) Review article: drug-induced anti-neutrophil cytoplasmic antibody-associated vasculitis. Nephrology 14:33–41PubMedCrossRef
7.
Zurück zum Zitat Bonaci-Nikolic B, Nikolic MM, Andrejevic S, Zoric S, Bukilica M (2005) Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitis. Arhtritis Res Ther 7:1072–1081CrossRef Bonaci-Nikolic B, Nikolic MM, Andrejevic S, Zoric S, Bukilica M (2005) Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitis. Arhtritis Res Ther 7:1072–1081CrossRef
8.
Zurück zum Zitat Quax RAM, Swaak AJG, Baggen MGA (2009) Churg-Strauss Syndrome following PTU treatment. Int J Rheumatol 2009:504105. Epub 2009 Mar 8 Quax RAM, Swaak AJG, Baggen MGA (2009) Churg-Strauss Syndrome following PTU treatment. Int J Rheumatol 2009:504105. Epub 2009 Mar 8
9.
Zurück zum Zitat Sato H, Hattori M, Fujieda M, Sugihara S, Inomata H, Hoshi M, Mıyamoto S (2000) High prevalence of antineutrophil cytoplasmic antibody positivity in childhood onset Graves’ disease treated with propylthiouracil. J Clin Endoctinol Metab 85:4270–4273CrossRef Sato H, Hattori M, Fujieda M, Sugihara S, Inomata H, Hoshi M, Mıyamoto S (2000) High prevalence of antineutrophil cytoplasmic antibody positivity in childhood onset Graves’ disease treated with propylthiouracil. J Clin Endoctinol Metab 85:4270–4273CrossRef
10.
Zurück zum Zitat Mathieu E, Fain O, Sitbon M, Thomas M (1999) Systemic adverse effect of antithyroid drugs. Clin Rheumatol 18:66–68PubMedCrossRef Mathieu E, Fain O, Sitbon M, Thomas M (1999) Systemic adverse effect of antithyroid drugs. Clin Rheumatol 18:66–68PubMedCrossRef
11.
Zurück zum Zitat Ozkok A, Salman S, Agan M et al (2009) Propylthiouracil induced anti-neutrophil cytoplasmic antibody-associated vasculitis with bone marrow plasmocytosis and granulocytopenia. Chin Med J 122(9):1112–1114PubMed Ozkok A, Salman S, Agan M et al (2009) Propylthiouracil induced anti-neutrophil cytoplasmic antibody-associated vasculitis with bone marrow plasmocytosis and granulocytopenia. Chin Med J 122(9):1112–1114PubMed
12.
Zurück zum Zitat Pietszkowski NC, Carvalho GA, Souza HN, Werka CR Jr, Borazo LA, Graf H, Carvalho M (2007) Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune disease induced by propylthiouracil. Arq Bras Endocrinol Metabol 51(1):136–141PubMedCrossRef Pietszkowski NC, Carvalho GA, Souza HN, Werka CR Jr, Borazo LA, Graf H, Carvalho M (2007) Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune disease induced by propylthiouracil. Arq Bras Endocrinol Metabol 51(1):136–141PubMedCrossRef
13.
Zurück zum Zitat Guma M, Salinas I, Reverter JL et al (2003) Frequency of antineutrophil cytoplasmic antibody in Graves’ disease patients treated with methimazole. J Clin Endocrinol Metab 88:2141–2146PubMedCrossRef Guma M, Salinas I, Reverter JL et al (2003) Frequency of antineutrophil cytoplasmic antibody in Graves’ disease patients treated with methimazole. J Clin Endocrinol Metab 88:2141–2146PubMedCrossRef
14.
Zurück zum Zitat Yu F, Chen M, Gao Y, Wang S, Zou W, Zhao M, Wang H (2007) Clinical and pathological features of renal involvement in propylthiouracil—associated ANCA—positive vasculitis. Am J Kid Disvol 49(5):607–614CrossRef Yu F, Chen M, Gao Y, Wang S, Zou W, Zhao M, Wang H (2007) Clinical and pathological features of renal involvement in propylthiouracil—associated ANCA—positive vasculitis. Am J Kid Disvol 49(5):607–614CrossRef
Metadaten
Titel
PTU-induced ANCA-positive vasculitis: an innocent or a life-threatening adverse effect?
verfasst von
N. Şule Yaşar Bilge
Timuçin Kaşifoğlu
Cengiz Korkmaz
Publikationsdatum
01.01.2013
Verlag
Springer-Verlag
Erschienen in
Rheumatology International / Ausgabe 1/2013
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-011-2280-5

Weitere Artikel der Ausgabe 1/2013

Rheumatology International 1/2013 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.