The authors declare that they have no competing interests.
SH, CJCF, CJ and RS designed the study; SH, BD, FG, JLA, LFP and LTKM reviewed all the charts of the patients followed in the service to identify those that met the inclusion criteria and collected clinical and hemodynamic data; DJ and CF reviewed all CT scans; SH, CJCF, CJ and RS analyzed all the data and drafted the first version of the manuscript. All authors revised the manuscript and have given approval of the current version.
Schistosomiasis associated pulmonary arterial hypertension (Sch-PAH) might represent the most prevalent form of PAH worldwide. In Sch-PAH, the presence of aneurismal dilation of the pulmonary artery has been described, although it is still a matter of debate whether on average the pulmonary artery is more enlarged in Sc-PAH than IPAH.
We retrospectively evaluated patients with IPAH (n = 25) and Sch-PAH (n = 22) who underwent computed tomography pulmonary angiogram and right heart catheterization.
Sch-PAH patients were older and presented less severe hemodynamic profiles. Main pulmonary artery diameter (MPAD) was greater in Sch-PAH than IPAH (4.5 ± 1.8 vs 3.7 ± 1.1 cm, p = 0.018). For the same level of mean pulmonary artery pressure, the MPAD in Sch-PAH was 0.89 cm larger than in IPAH (Covariance model p = 0.02).
This study demonstrated that pulmonary artery enlargement is more pronounced in Sch-PAH than IPAH, independently of mean pulmonary artery pressure level, suggesting that this is more likely a feature of Sch-PAH.
Fernandes C, Jardim C, Hovnanian A, Hoette S, Dias B, Souza S, et al., Survival in Schistosomiasis-Associated Pulmonary Arterial Hypertension. J Am Coll Cardiol, 2010. 56(9): p. 715–720. CrossRef
Gavilanes, F. Jr, J.L., Fernandes C., Prada L.F., Jardim, C.V., Morinaga, L.T., et al., Left ventricular dysfunction in patients with suspected pulmonary arterial hypertension. J Bras Pneumol, 2014. 40(6): p. 609-16.
Humbert M, Morrell NW, Archer SL, Stenmark KR, MacLean MR, Lang IM, et al., Cellular and molecular pathobiology of pulmonary arterial hypertension. J Am Coll Cardiol, 2004. 43(12 Suppl S):p. 13S–24S.
- Pulmonary artery enlargement in schistosomiasis associated pulmonary arterial hypertension
Jose Leonidas Alves-Jr
Luis Felipe Prada
Luciana Tamie Kato Morinaga
Caio Julio Cesar Fernandes
- BioMed Central
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