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Erschienen in: Clinical Rheumatology 2/2021

08.07.2020 | Original Article

Pulmonary artery involvement in Takayasu arteritis: a retrospective study in Chinese population

verfasst von: Xin Xi, Juan Du, Jiayi Liu, Guangfa Zhu, Guanming Qi, Lili Pan

Erschienen in: Clinical Rheumatology | Ausgabe 2/2021

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Abstract

Background

Takayasu’s arteritis (TA) may involve the pulmonary artery, which signifies a poor prognosis. This study investigated the features of TA patients with pulmonary artery involvement.

Methods

One hundred and twenty-six inpatients diagnosed with TA were retrospectively studied. The clinical data of TA patients with and without pulmonary artery involvement were compared. The imaging features of pulmonary artery lesions in TA patients were evaluated. The treatment responses of pulmonary artery lesions were described, and the drug regimens in different treatment response groups were compared.

Results

Among the patients with TA, 15.9% showed associated pulmonary artery involvement. The disease durations were significantly longer in patients with pulmonary artery involvement than in those without (108.0 months (53.5, 222.0) vs. 36.0 months (12.0, 120.0); p = 0.038). Hemoptysis was more common in TA patients with pulmonary artery involvement than in those without (15.0%, 3 cases vs. 0.0%; p < 0.001). TA patients with disease duration longer than 5 years showed a 3.42-fold higher odds of pulmonary artery involvement than those with a disease duration of less than 5 years (adjusted odds ratio, 3.42 (95% confidence interval, 1.20–9.76); p = 0.02). The most common imaging manifestations of pulmonary artery involvement were stenosis and occlusion. Among the six patients who had good response to treatment of pulmonary artery lesions, five were treated with the interleukin-6 receptor antagonist tocilizumab.

Conclusions

TA patients with pulmonary artery involvement have a longer course of disease and more symptoms of hemoptysis. TA-related pulmonary artery lesions more commonly manifested as stenosis and occlusion. Tocilizumab may be effective for TA-related pulmonary vascular disease.
Key Points
Disease duration longer than 5 years is associated with pulmonary artery involvement in TA.
• Hemoptysis is a characteristic clinical symptom of TA with pulmonary artery involvement.
• Tocilizumab may be more effective for pulmonary artery lesions of TA.
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Metadaten
Titel
Pulmonary artery involvement in Takayasu arteritis: a retrospective study in Chinese population
verfasst von
Xin Xi
Juan Du
Jiayi Liu
Guangfa Zhu
Guanming Qi
Lili Pan
Publikationsdatum
08.07.2020
Verlag
Springer International Publishing
Erschienen in
Clinical Rheumatology / Ausgabe 2/2021
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-020-05271-5

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