Skip to main content
main-content
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 9/2012

01.09.2012 | Retinal Disorders

Pulse-wave analysis of optic nerve head circulation is significantly correlated with brachial–ankle pulse-wave velocity, carotid intima–media thickness, and age

verfasst von: Tomoaki Shiba, Mao Takahashi, Yuichi Hori, Takatoshi Maeno

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 9/2012

Einloggen, um Zugang zu erhalten

Abstract

Background

To determine whether there is a significant correlation between the pulse-wave analysis in the optic nerve head circulation determined by laser speckle flowgraphy (LSFG), and brachial–ankle pulse wave velocity (baPVW), carotid intima–media thickness (IMT), and age.

Methods

Thirty-three patients who visited the Vascular Function Section in our hospital were included. Age was 57.3 ± 12.6 years, with a range from 29 to 80 years. baPVW, carotid IMT, and pulse wave analysis in optic nerve head circulation using LSFG were conducted on subjects, and this parameter is named blowout time (BOT). The following items were analyzed as other systemic parameters: age, blood pressure, pulse pressure, heart rate, body mass index, and mean arterial blood pressure; other ocular parameters were intraocular pressure and ocular perfusion pressure. Pearson’s correlation coefficients were used to determine the relationship between the BOT, baPWV, IMT, age, and other parameters. In addition, multiple regression analysis was used to determine independent factors for age.

Results

BOT was significantly correlated with age (r = −0.85, P <0.0001), pulse pressure (r = −0.36, P = 0.04), baPWV (r = −0.72, P <0.0001), and IMT (r = −0.64, P < 0.0001). The result of multiple regression analysis showed that baPWV (odds ratio = 0.93, 95% confidence interval = 0.03–1.82 P = 0.04) and BOT (−2.26, −3.27  to −1.26, <0.0001) were independent contribution factors to age.

Conclusions

Our results confirmed measurements of BOT in the optic nerve head can be a useful method for determinin g whether early atherosclerotic changes are present in the optic nerve head circulation.
Literatur
2.
Zurück zum Zitat Mitchell P, Smith W, Chang A (1996) Prevalence and associations of retinal vein occlusion in Australia. The Blue Mountains Eye Study. Arch Ophthalmol 114:1243–1247 PubMedCrossRef Mitchell P, Smith W, Chang A (1996) Prevalence and associations of retinal vein occlusion in Australia. The Blue Mountains Eye Study. Arch Ophthalmol 114:1243–1247 PubMedCrossRef
3.
Zurück zum Zitat Yasuda M, Kiyohara Y, Arakawa S, Hata Y, Yonemoto K, Doi Y, Iida M, Ishibashi T (2010) Prevalence and systemic risk factors for retinal vein occlusion in a general Japanese population: the Hisayama study. Invest Ophthalmol Vis Sci 51:3205–3209 PubMedCrossRef Yasuda M, Kiyohara Y, Arakawa S, Hata Y, Yonemoto K, Doi Y, Iida M, Ishibashi T (2010) Prevalence and systemic risk factors for retinal vein occlusion in a general Japanese population: the Hisayama study. Invest Ophthalmol Vis Sci 51:3205–3209 PubMedCrossRef
4.
Zurück zum Zitat Hayreh SS, Zimmerman MB, Podhajsky P (1994) Incidence of various types of retinal vein occlusion and their recurrence and demographic characteristics. Am J Ophthalmol 117:429–441 PubMed Hayreh SS, Zimmerman MB, Podhajsky P (1994) Incidence of various types of retinal vein occlusion and their recurrence and demographic characteristics. Am J Ophthalmol 117:429–441 PubMed
5.
Zurück zum Zitat Miyazaki M, Nakamura H, Kubo M, Kiyohara Y, Oshima Y, Ishibashi T, Nose Y (2003) Risk factors for age related maculopathy in a Japanese population: the Hisayama study. Br J Ophthalmol 87:469–472 PubMedCrossRef Miyazaki M, Nakamura H, Kubo M, Kiyohara Y, Oshima Y, Ishibashi T, Nose Y (2003) Risk factors for age related maculopathy in a Japanese population: the Hisayama study. Br J Ophthalmol 87:469–472 PubMedCrossRef
6.
Zurück zum Zitat Miyazaki M, Kiyohara Y, Yoshida A, Iida M, Nose Y, Ishibashi T (2005) The 5-year incidence and risk factors for age-related maculopathy in a general Japanese population: the Hisayama study. Invest Ophthalmol Vis Sci 46:1907–1910 PubMedCrossRef Miyazaki M, Kiyohara Y, Yoshida A, Iida M, Nose Y, Ishibashi T (2005) The 5-year incidence and risk factors for age-related maculopathy in a general Japanese population: the Hisayama study. Invest Ophthalmol Vis Sci 46:1907–1910 PubMedCrossRef
7.
Zurück zum Zitat Kaderli AA, Kaderli B, Gullulu S, Avci R (2010) Impaired aortic stiffness and pulse wave velocity in patients with branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 248:369–374 PubMedCrossRef Kaderli AA, Kaderli B, Gullulu S, Avci R (2010) Impaired aortic stiffness and pulse wave velocity in patients with branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 248:369–374 PubMedCrossRef
8.
Zurück zum Zitat Sato E, Feke GT, Appelbaum EY, Menke MN, Trempe CL, McMeel JW (2006) Association between systemic arterial stiffness and age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 244:963–971 PubMedCrossRef Sato E, Feke GT, Appelbaum EY, Menke MN, Trempe CL, McMeel JW (2006) Association between systemic arterial stiffness and age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 244:963–971 PubMedCrossRef
9.
Zurück zum Zitat Klein R, Klein BE, Knudtson MD, Cotch MF, Wong TY, Liu K, Burke GL, Saad MF, Jacobs DR Jr, Sharrett AR (2007) Subclinical atherosclerotic cardiovascular disease and early age-related macular degeneration in a multiracial cohort: the Multiethnic Study of Atherosclerosis. Arch Ophthalmol 125:534–543 PubMedCrossRef Klein R, Klein BE, Knudtson MD, Cotch MF, Wong TY, Liu K, Burke GL, Saad MF, Jacobs DR Jr, Sharrett AR (2007) Subclinical atherosclerotic cardiovascular disease and early age-related macular degeneration in a multiracial cohort: the Multiethnic Study of Atherosclerosis. Arch Ophthalmol 125:534–543 PubMedCrossRef
10.
Zurück zum Zitat Lehmann ED (1999) Clinical value of aortic pulse-wave velocity measurement. Lancet 354:528–529 PubMedCrossRef Lehmann ED (1999) Clinical value of aortic pulse-wave velocity measurement. Lancet 354:528–529 PubMedCrossRef
11.
Zurück zum Zitat Asmar R, Benetos A, Topouchian J, Laurent P, Pannier B, Brisac AM, Target R, Levy BI (1995) Assessment of arterial distensibility by automatic pulse wave velocity measurement. Validation and clinical application studies. Hypertension 26:485–490 PubMedCrossRef Asmar R, Benetos A, Topouchian J, Laurent P, Pannier B, Brisac AM, Target R, Levy BI (1995) Assessment of arterial distensibility by automatic pulse wave velocity measurement. Validation and clinical application studies. Hypertension 26:485–490 PubMedCrossRef
12.
Zurück zum Zitat Suzuki E, Kashiwagi A, Nishio Y, Egawa K, Shimizu S, Maegawa H, Haneda M, Yasuda H, Morikawa S, Inubushi T, Kikkawa R (2001) Increased arterial wall stiffness limits flow volume in the lower extremities in type 2 diabetic patients. Diabetes Care 24:2107–2114 PubMedCrossRef Suzuki E, Kashiwagi A, Nishio Y, Egawa K, Shimizu S, Maegawa H, Haneda M, Yasuda H, Morikawa S, Inubushi T, Kikkawa R (2001) Increased arterial wall stiffness limits flow volume in the lower extremities in type 2 diabetic patients. Diabetes Care 24:2107–2114 PubMedCrossRef
13.
Zurück zum Zitat Yamashina A, Tomiyama H, Takeda K, Tsuda H, Arai T, Hirose K, Koji Y, Hori S, Yamamoto Y (2002) Validity, reproducibility, and clinical significance of noninvasive brachial–ankle pulse wave velocity measurement. Hypertens Res 25:359–364 PubMedCrossRef Yamashina A, Tomiyama H, Takeda K, Tsuda H, Arai T, Hirose K, Koji Y, Hori S, Yamamoto Y (2002) Validity, reproducibility, and clinical significance of noninvasive brachial–ankle pulse wave velocity measurement. Hypertens Res 25:359–364 PubMedCrossRef
14.
Zurück zum Zitat Matsushima Y, Kawano H, Koide Y, Baba T, Toda G, Seto S, Yano K (2004) Relationship of carotid intima–media thickness, pulse wave velocity, and ankle brachial index to the severity of coronary artery atherosclerosis. Clin Cardiol 27:629–634 PubMedCrossRef Matsushima Y, Kawano H, Koide Y, Baba T, Toda G, Seto S, Yano K (2004) Relationship of carotid intima–media thickness, pulse wave velocity, and ankle brachial index to the severity of coronary artery atherosclerosis. Clin Cardiol 27:629–634 PubMedCrossRef
15.
Zurück zum Zitat Wofford JL, Kahl FR, Howard GR, McKinney WM, Toole JF, Crouse JR 3rd (1991) Relation of extent of extracranial carotid artery atherosclerosis as measured by B-mode ultrasound to the extent of coronary atherosclerosis. Arterioscler Thromb 11:1786–1794 PubMedCrossRef Wofford JL, Kahl FR, Howard GR, McKinney WM, Toole JF, Crouse JR 3rd (1991) Relation of extent of extracranial carotid artery atherosclerosis as measured by B-mode ultrasound to the extent of coronary atherosclerosis. Arterioscler Thromb 11:1786–1794 PubMedCrossRef
16.
Zurück zum Zitat Craven TE, Ryu JE, Espeland MA, Kahl FR, McKinney WM, Toole JF, McMahan MR, Thompson CJ, Heiss G, Crouse JR 3rd (1990) Evaluation of the associations between carotid artery atherosclerosis and coronary artery stenosis. A case-control study. Circulation 82:1230–1242 PubMedCrossRef Craven TE, Ryu JE, Espeland MA, Kahl FR, McKinney WM, Toole JF, McMahan MR, Thompson CJ, Heiss G, Crouse JR 3rd (1990) Evaluation of the associations between carotid artery atherosclerosis and coronary artery stenosis. A case-control study. Circulation 82:1230–1242 PubMedCrossRef
17.
Zurück zum Zitat Tomiyama H, Yamashina A, Arai T, Hirose K, Koji Y, Chikamori T, Hori S, Yamamoto Y, Doba N, Hinohara S (2003) Influences of age and gender on results of noninvasive brachial–ankle pulse wave velocity measurement—a survey of 12517 subjects. Atherosclerosis 166:303–309 PubMedCrossRef Tomiyama H, Yamashina A, Arai T, Hirose K, Koji Y, Chikamori T, Hori S, Yamamoto Y, Doba N, Hinohara S (2003) Influences of age and gender on results of noninvasive brachial–ankle pulse wave velocity measurement—a survey of 12517 subjects. Atherosclerosis 166:303–309 PubMedCrossRef
18.
Zurück zum Zitat Sun Y, Lin CH, Lu CJ, Yip PK, Chen RC (2002) Carotid atherosclerosis, intima media thickness and risk factors—an analysis of 1781 asymptomatic subjects in Taiwan. Atherosclerosis 164:89–94 PubMedCrossRef Sun Y, Lin CH, Lu CJ, Yip PK, Chen RC (2002) Carotid atherosclerosis, intima media thickness and risk factors—an analysis of 1781 asymptomatic subjects in Taiwan. Atherosclerosis 164:89–94 PubMedCrossRef
19.
Zurück zum Zitat Tamaki Y, Araie M, Kawamoto E, Eguchi S, Fujii H (1995) Non-contact, two-dimensional measurement of tissue circulation in choroid and optic nerve head using laser speckle phenomenon. Exp Eye Res 60:373–383 PubMedCrossRef Tamaki Y, Araie M, Kawamoto E, Eguchi S, Fujii H (1995) Non-contact, two-dimensional measurement of tissue circulation in choroid and optic nerve head using laser speckle phenomenon. Exp Eye Res 60:373–383 PubMedCrossRef
20.
Zurück zum Zitat Isono H, Kishi S, Kimura Y, Hagiwara N, Konishi N, Fujii H (2003) Observation of choroidal circulation using index of erythrocytic velocity. Arch Ophthalmol 121:225–231 PubMedCrossRef Isono H, Kishi S, Kimura Y, Hagiwara N, Konishi N, Fujii H (2003) Observation of choroidal circulation using index of erythrocytic velocity. Arch Ophthalmol 121:225–231 PubMedCrossRef
21.
Zurück zum Zitat Fujii H (1994) Visualisation of retinal blood flow by laser speckle flowgraphy. Med Biol Eng Comput 32:302–304 PubMedCrossRef Fujii H (1994) Visualisation of retinal blood flow by laser speckle flowgraphy. Med Biol Eng Comput 32:302–304 PubMedCrossRef
22.
Zurück zum Zitat Shirai K, Utino J, Otsuka K, Takata M (2006) A novel blood pressure-independent arterial wall stiffness parameter; cardio–ankle vascular index (CAVI). J Atheroscler Thromb 13:101–107 PubMedCrossRef Shirai K, Utino J, Otsuka K, Takata M (2006) A novel blood pressure-independent arterial wall stiffness parameter; cardio–ankle vascular index (CAVI). J Atheroscler Thromb 13:101–107 PubMedCrossRef
23.
Zurück zum Zitat Takiuchi S, Kamide K, Miwa Y, Tomiyama M, Yoshii M, Matayoshi T, Horio T, Kawano Y (2004) Diagnostic value of carotid intima–media thickness and plaque score for predicting target organ damage in patients with essential hypertension. J Hum Hypertens 18:17–23 PubMedCrossRef Takiuchi S, Kamide K, Miwa Y, Tomiyama M, Yoshii M, Matayoshi T, Horio T, Kawano Y (2004) Diagnostic value of carotid intima–media thickness and plaque score for predicting target organ damage in patients with essential hypertension. J Hum Hypertens 18:17–23 PubMedCrossRef
24.
Zurück zum Zitat O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr (1999) Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 340:14–22 PubMedCrossRef O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr (1999) Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 340:14–22 PubMedCrossRef
25.
Zurück zum Zitat Ishikawa T, Hashimoto J, Morito RH, Hanazawa T, Aikawa T, Hara A, Shintani Y, Metoki H, Inoue R, Asayama K, Kikuya M, Ohkubo T, Totsune K, Hoshi H, Satoh H, Imai Y (2008) Association of microalbuminuria with brachial–ankle pulse wave velocity: the Ohasama study. Am J Hypertens 21:413–418 PubMedCrossRef Ishikawa T, Hashimoto J, Morito RH, Hanazawa T, Aikawa T, Hara A, Shintani Y, Metoki H, Inoue R, Asayama K, Kikuya M, Ohkubo T, Totsune K, Hoshi H, Satoh H, Imai Y (2008) Association of microalbuminuria with brachial–ankle pulse wave velocity: the Ohasama study. Am J Hypertens 21:413–418 PubMedCrossRef
26.
Zurück zum Zitat Sugiyama T, Araie M, Riva CE, Schmetterer L, Orgul S (2010) Use of laser speckle flowgraphy in ocular blood flow research. Acta Ophthalmol 88:723–729 PubMedCrossRef Sugiyama T, Araie M, Riva CE, Schmetterer L, Orgul S (2010) Use of laser speckle flowgraphy in ocular blood flow research. Acta Ophthalmol 88:723–729 PubMedCrossRef
27.
Zurück zum Zitat Nagaoka T, Sato E, Takahashi A, Sogawa K, Yokota H, Yoshida A (2009) Effect of aging on retinal circulation in normotensive healthy subjects. Exp Eye Res 89:887–891 PubMedCrossRef Nagaoka T, Sato E, Takahashi A, Sogawa K, Yokota H, Yoshida A (2009) Effect of aging on retinal circulation in normotensive healthy subjects. Exp Eye Res 89:887–891 PubMedCrossRef
28.
Zurück zum Zitat Nagaoka T, Ishii Y, Takeuchi T, Takahashi A, Sato E, Yoshida A (2005) Relationship between the parameters of retinal circulation measured by laser Doppler velocimetry and a marker of early systemic atherosclerosis. Invest Ophthalmol Vis Sci 46:720–725 PubMedCrossRef Nagaoka T, Ishii Y, Takeuchi T, Takahashi A, Sato E, Yoshida A (2005) Relationship between the parameters of retinal circulation measured by laser Doppler velocimetry and a marker of early systemic atherosclerosis. Invest Ophthalmol Vis Sci 46:720–725 PubMedCrossRef
29.
Zurück zum Zitat Yambe M, Tomiyama H, Hirayama Y, Gulniza Z, Takata Y, Koji Y, Motobe K, Yamashina A (2004) Arterial stiffening as a possible risk factor for both atherosclerosis and diastolic heart failure. Hypertens Res 27:625–631 PubMedCrossRef Yambe M, Tomiyama H, Hirayama Y, Gulniza Z, Takata Y, Koji Y, Motobe K, Yamashina A (2004) Arterial stiffening as a possible risk factor for both atherosclerosis and diastolic heart failure. Hypertens Res 27:625–631 PubMedCrossRef
Metadaten
Titel
Pulse-wave analysis of optic nerve head circulation is significantly correlated with brachial–ankle pulse-wave velocity, carotid intima–media thickness, and age
verfasst von
Tomoaki Shiba
Mao Takahashi
Yuichi Hori
Takatoshi Maeno
Publikationsdatum
01.09.2012
Verlag
Springer-Verlag
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 9/2012
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-012-1952-5