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Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 9/2018

06.06.2018 | Glaucoma

Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake: a comparative study between habitual and non-habitual groups

verfasst von: Aishah Ismail, Mehwish S. Bhatti, Ibrahima Faye, Cheng Kai Lu, Augustinus Laude, Tong Boon Tang

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 9/2018

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Abstract

Purpose

To evaluate and compare the temporal changes in pulse waveform parameters of ocular blood flow (OBF) between non-habitual and habitual groups due to caffeine intake.

Method

This study was conducted on 19 healthy subjects (non-habitual 8; habitual 11), non-smoking and between 21 and 30 years of age. Using laser speckle flowgraphy (LSFG), three areas of optical nerve head were analyzed which are vessel, tissue, and overall, each with ten pulse waveform parameters, namely mean blur rate (MBR), fluctuation, skew, blowout score (BOS), blowout time (BOT), rising rate, falling rate, flow acceleration index (FAI), acceleration time index (ATI), and resistive index (RI). Two-way mixed ANOVA was used to determine the difference between every two groups where p < 0.05 is considered significant.

Result

There were significant differences between the two groups in several ocular pulse waveform parameters, namely MBR (overall, vessel, tissue), BOT (overall), rising rate (overall), and falling rate (vessel), all with p < 0.05. In addition, the ocular pulse waveform parameters, i.e., MBR (overall), skew (tissue), and BOT (tissue) showed significant temporal changes within the non-habitual group, but not within the habitual group. The temporal changes in parameters MBR (vessel, tissue), skew (overall, vessel), BOT (overall, vessel), rising rate (overall), falling rate (overall, vessel), and FAI (tissue) were significant for both groups (habitual and non-habitual) in response to caffeine intake.

Conclusion

The experiment results demonstrated caffeine does modulate OBF significantly and response differently in non-habitual and habitual groups. Among all ten parameters, MBR and BOT were identified as the suitable biomarkers to differentiate between the two groups.
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Literatur
2.
Zurück zum Zitat Okuno T, Sugiyama T, Tominaga M, Kojima S, Ikeda T (2002) Effects of caffeine on microcirculation of the human ocular fundus. Jpn J Ophthalmol 46(2):170–176CrossRefPubMed Okuno T, Sugiyama T, Tominaga M, Kojima S, Ikeda T (2002) Effects of caffeine on microcirculation of the human ocular fundus. Jpn J Ophthalmol 46(2):170–176CrossRefPubMed
20.
Zurück zum Zitat Chandrasekaran S, Rochtchina E, Mitchell P (2005) Effects of caffeine on intraocular pressure: the Blue Mountains Eye Study. J Glaucoma 14(6):504–507CrossRefPubMed Chandrasekaran S, Rochtchina E, Mitchell P (2005) Effects of caffeine on intraocular pressure: the Blue Mountains Eye Study. J Glaucoma 14(6):504–507CrossRefPubMed
Metadaten
Titel
Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake: a comparative study between habitual and non-habitual groups
verfasst von
Aishah Ismail
Mehwish S. Bhatti
Ibrahima Faye
Cheng Kai Lu
Augustinus Laude
Tong Boon Tang
Publikationsdatum
06.06.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 9/2018
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-018-4030-9

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