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Erschienen in: Der Hautarzt 6/2016

01.06.2016 | Psoriasis vulgaris | Leitthema

Pustulöse Psoriasis

verfasst von: P. Weisenseel, D. Wilsmann-Theis, C. Kahl, K. Reich, PD Dr. R. Mössner

Erschienen in: Die Dermatologie | Ausgabe 6/2016

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Zusammenfassung

Eine Reihe pustulöser Hauterkrankungen teilen klinische, pathogenetische und epidemiologische Aspekte mit der Psoriasis vulgaris, und ihre Einordung als eigene klinische Entitäten oder Unterformen der Psoriasis ist weiterhin umstritten, was sich auch in der Vielzahl ihrer Bezeichnungen widerspiegelt. Hierzu gehören die generalisierte pustulöse Psoriasis mit ihren Sonderformen, die Acrodermatitis continua suppurativa, die akute Pustulosis palmoplantaris, die Psoriasis pustulosa palmoplantaris sowie pustulöse Varianten der vorwiegend durch TNF-Blocker getriggerten paradoxen psoriasiformen Dermatitis. In diesem Beitrag werden Erkenntnisse zu Epidemiologie, klinischem Bild, Pathogenese, Genetik und Therapie dieser pustulösen Hauterkrankungen dargestellt.
Literatur
1.
Zurück zum Zitat Capon F (2013) IL36RN mutations in generalized pustular psoriasis: just the tip of the iceberg? J Invest Dermatol 133:2503–2504CrossRefPubMed Capon F (2013) IL36RN mutations in generalized pustular psoriasis: just the tip of the iceberg? J Invest Dermatol 133:2503–2504CrossRefPubMed
2.
Zurück zum Zitat Korber A, Mossner R, Renner R et al (2013) Mutations in IL36RN in patients with generalized pustular psoriasis. J Invest Dermatol 133(11):2634–2637CrossRefPubMed Korber A, Mossner R, Renner R et al (2013) Mutations in IL36RN in patients with generalized pustular psoriasis. J Invest Dermatol 133(11):2634–2637CrossRefPubMed
3.
Zurück zum Zitat Marrakchi S, Guigue P, Renshaw BR et al (2011) Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis. N Engl J Med 365:620–628CrossRefPubMed Marrakchi S, Guigue P, Renshaw BR et al (2011) Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis. N Engl J Med 365:620–628CrossRefPubMed
4.
Zurück zum Zitat Berki DM, Liu L, Choon SE et al (2015) Activating CARD14 mutations are associated with generalized pustular psoriasis but rarely account for familial recurrence in psoriasis Vulgaris. J Invest Dermatol 135:2964–2970CrossRefPubMed Berki DM, Liu L, Choon SE et al (2015) Activating CARD14 mutations are associated with generalized pustular psoriasis but rarely account for familial recurrence in psoriasis Vulgaris. J Invest Dermatol 135:2964–2970CrossRefPubMed
5.
Zurück zum Zitat Brenner M, Molin S, Ruebsam K, Weisenseel P, Ruzicka T, Prinz JC (2009) Generalized pustular psoriasis induced by systemic glucocorticosteroids: four cases and recommendations for treatment. Br J Dermatol 161:964–966 Brenner M, Molin S, Ruebsam K, Weisenseel P, Ruzicka T, Prinz JC (2009) Generalized pustular psoriasis induced by systemic glucocorticosteroids: four cases and recommendations for treatment. Br J Dermatol 161:964–966
6.
Zurück zum Zitat Weisenseel P, Reich K (2013) Paradoxical skin reactions under therapy with TNF-alpha antagonists. Z Rheumatol 72:423–428CrossRefPubMed Weisenseel P, Reich K (2013) Paradoxical skin reactions under therapy with TNF-alpha antagonists. Z Rheumatol 72:423–428CrossRefPubMed
7.
Zurück zum Zitat Robinson A, Van Voorhees AS, Hsu S, Korman NJ, Lebwohl MG, Bebo BF, Jr., Kalb RE (2012) Treatment of pustular psoriasis: from the Medical Board of the National Psoriasis Foundation. J Am Acad Dermatol 67:279-288 (2012) Robinson A, Van Voorhees AS, Hsu S, Korman NJ, Lebwohl MG, Bebo BF, Jr., Kalb RE (2012) Treatment of pustular psoriasis: from the Medical Board of the National Psoriasis Foundation. J Am Acad Dermatol 67:279-288 (2012)
8.
Zurück zum Zitat Imafuku S, Honma M, Okubo Y et al (2016) Efficacy and safety of secukinumab in patients with generalized pustular psoriasis: A 52-week analysis from phase III open-label multicenter Japanese study. J Dermatol : doi:/10.1111/1346-8138.13306 Imafuku S, Honma M, Okubo Y et al (2016) Efficacy and safety of secukinumab in patients with generalized pustular psoriasis: A 52-week analysis from phase III open-label multicenter Japanese study. J Dermatol : doi:/10.1111/1346-8138.13306
9.
Zurück zum Zitat Saeki H, Nakagawa H, Ishii T et al (2015) Efficacy and safety of open-label ixekizumab treatment in Japanese patients with moderate-to-severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis. J Eur Acad Dermatol Venereol 29:1148–1155CrossRefPubMed Saeki H, Nakagawa H, Ishii T et al (2015) Efficacy and safety of open-label ixekizumab treatment in Japanese patients with moderate-to-severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis. J Eur Acad Dermatol Venereol 29:1148–1155CrossRefPubMed
10.
Zurück zum Zitat Fujisawa T, Suzuki S, Mizutani Y et al (2015) Granulocyte and monocyte adsorption Apheresis for generalized pustular psoriasis: therapeutic outcomes in three refractory patients. Ther Apher Dial 19:336–341CrossRefPubMed Fujisawa T, Suzuki S, Mizutani Y et al (2015) Granulocyte and monocyte adsorption Apheresis for generalized pustular psoriasis: therapeutic outcomes in three refractory patients. Ther Apher Dial 19:336–341CrossRefPubMed
11.
Zurück zum Zitat Huffmeier U, Watzold M, Mohr J et al (2014) Successful therapy with anakinra in a patient with generalized pustular psoriasis carrying IL36RN mutations. Br J Dermatol 170:202–204CrossRefPubMed Huffmeier U, Watzold M, Mohr J et al (2014) Successful therapy with anakinra in a patient with generalized pustular psoriasis carrying IL36RN mutations. Br J Dermatol 170:202–204CrossRefPubMed
12.
Zurück zum Zitat Gao QQ, Xi MR, Yao Q (2013) Impetigo Herpetiformis during pregnancy: a case report and literature review. Dermatology 226:35–40CrossRefPubMed Gao QQ, Xi MR, Yao Q (2013) Impetigo Herpetiformis during pregnancy: a case report and literature review. Dermatology 226:35–40CrossRefPubMed
13.
Zurück zum Zitat Sugiura K, Oiso N, Iinuma S et al (2014) IL36RN mutations underlie impetigo herpetiformis. J Invest Dermatol 134:2472–2474CrossRefPubMed Sugiura K, Oiso N, Iinuma S et al (2014) IL36RN mutations underlie impetigo herpetiformis. J Invest Dermatol 134:2472–2474CrossRefPubMed
14.
Zurück zum Zitat Liao PB, Rubinson R, Howard R et al (2002) Annular pustular psoriasis–most common form of pustular psoriasis in children: report of three cases and review of the literature. Pediatr Dermatol 19:19–25CrossRefPubMed Liao PB, Rubinson R, Howard R et al (2002) Annular pustular psoriasis–most common form of pustular psoriasis in children: report of three cases and review of the literature. Pediatr Dermatol 19:19–25CrossRefPubMed
15.
Zurück zum Zitat Albert A, Hein R, Ring J et al (2007) Erythema annulare centrifugum-like psoriasis cum pustulatione. Hautarzt 58:769–773CrossRefPubMed Albert A, Hein R, Ring J et al (2007) Erythema annulare centrifugum-like psoriasis cum pustulatione. Hautarzt 58:769–773CrossRefPubMed
16.
Zurück zum Zitat Stadler R, Orfanos CE (1981) Erythema anulare centrifugum with pustulation. Successful oral retinoid therapy. Hautarzt 32:564–566PubMed Stadler R, Orfanos CE (1981) Erythema anulare centrifugum with pustulation. Successful oral retinoid therapy. Hautarzt 32:564–566PubMed
17.
Zurück zum Zitat Vocks E, Worret WI, Ring J (2003) Erythema annulare centrifugum-type psoriasis: a particular variant of acute-eruptive psoriasis. J Eur Acad Dermatol Venereol 17:446–448CrossRefPubMed Vocks E, Worret WI, Ring J (2003) Erythema annulare centrifugum-type psoriasis: a particular variant of acute-eruptive psoriasis. J Eur Acad Dermatol Venereol 17:446–448CrossRefPubMed
18.
Zurück zum Zitat Lo SA, Brancaccio G, Puca RV et al (2012) Etanercept in the treatment of generalized annular pustular psoriasis. Ann Dermatol 24:233–234CrossRef Lo SA, Brancaccio G, Puca RV et al (2012) Etanercept in the treatment of generalized annular pustular psoriasis. Ann Dermatol 24:233–234CrossRef
19.
Zurück zum Zitat Setta-Kaffetzi N, Simpson MA, Navarini AA et al (2014) AP1S3 mutations are associated with pustular psoriasis and impaired Toll-like receptor 3 trafficking. Am J Hum Genet 94:790–797CrossRefPubMedPubMedCentral Setta-Kaffetzi N, Simpson MA, Navarini AA et al (2014) AP1S3 mutations are associated with pustular psoriasis and impaired Toll-like receptor 3 trafficking. Am J Hum Genet 94:790–797CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Wilsmann-Theis D, Hagemann T, Dederer H et al (2004) Successful treatment of acrodermatitis continua suppurativa with topical tacrolimus 0.1 % ointment. Br J Dermatol 150:1194–1197CrossRefPubMed Wilsmann-Theis D, Hagemann T, Dederer H et al (2004) Successful treatment of acrodermatitis continua suppurativa with topical tacrolimus 0.1 % ointment. Br J Dermatol 150:1194–1197CrossRefPubMed
21.
Zurück zum Zitat Sehgal VN, Verma P, Sharma S et al (2011) Acrodermatitis continua of Hallopeau: evolution of treatment options. Int J Dermatol 50:1195–1211CrossRefPubMed Sehgal VN, Verma P, Sharma S et al (2011) Acrodermatitis continua of Hallopeau: evolution of treatment options. Int J Dermatol 50:1195–1211CrossRefPubMed
22.
Zurück zum Zitat Bacharach-Buhles M, el-Gammal S, Altmeyer P (1993) The pustular bacterid (Andrews). Are there clinical criteria for differentiating from psoriasis pustulosa palmaris et plantaris? Hautarzt 44:221–224PubMed Bacharach-Buhles M, el-Gammal S, Altmeyer P (1993) The pustular bacterid (Andrews). Are there clinical criteria for differentiating from psoriasis pustulosa palmaris et plantaris? Hautarzt 44:221–224PubMed
23.
24.
Zurück zum Zitat Hellgren L, Mobacken H (1971) Pustulosis palmaris et plantaris. Prevalence, clinical observations and prognosis. Acta Derm Venereol 51:284–288PubMed Hellgren L, Mobacken H (1971) Pustulosis palmaris et plantaris. Prevalence, clinical observations and prognosis. Acta Derm Venereol 51:284–288PubMed
25.
Zurück zum Zitat O’Doherty CJ, MacIntyre C (1985) Palmoplantar pustulosis and smoking. Br Med J (Clin Res Ed) 291:861–864CrossRef O’Doherty CJ, MacIntyre C (1985) Palmoplantar pustulosis and smoking. Br Med J (Clin Res Ed) 291:861–864CrossRef
26.
Zurück zum Zitat Enfors W, Molin L (1971) Pustulosis palmaris et plantaris. A follow-up study of a ten-year material. Acta Derm Venereol 51:289–294PubMed Enfors W, Molin L (1971) Pustulosis palmaris et plantaris. A follow-up study of a ten-year material. Acta Derm Venereol 51:289–294PubMed
27.
Zurück zum Zitat Becher G, Jamieson L, Leman J (2015) Palmoplantar pustulosis–a retrospective review of comorbid conditions. J Eur Acad Dermatol Venereol 29:1854–1856CrossRefPubMed Becher G, Jamieson L, Leman J (2015) Palmoplantar pustulosis–a retrospective review of comorbid conditions. J Eur Acad Dermatol Venereol 29:1854–1856CrossRefPubMed
28.
Zurück zum Zitat Brunasso AM, Puntoni M, Aberer W et al (2013) Clinical and epidemiological comparison of patients affected by palmoplantar plaque psoriasis and palmoplantar pustulosis: a case series study. Br J Dermatol 168:1243–1251CrossRefPubMed Brunasso AM, Puntoni M, Aberer W et al (2013) Clinical and epidemiological comparison of patients affected by palmoplantar plaque psoriasis and palmoplantar pustulosis: a case series study. Br J Dermatol 168:1243–1251CrossRefPubMed
29.
Zurück zum Zitat Farley E, Masrour S, McKey J et al (2009) Palmoplantar psoriasis: a phenotypical and clinical review with introduction of a new quality-of-life assessment tool. J Am Acad Dermatol 60:1024–1031CrossRefPubMed Farley E, Masrour S, McKey J et al (2009) Palmoplantar psoriasis: a phenotypical and clinical review with introduction of a new quality-of-life assessment tool. J Am Acad Dermatol 60:1024–1031CrossRefPubMed
30.
Zurück zum Zitat Michaelsson G, Kristjansson G, Pihl LI et al (2007) Palmoplantar pustulosis and gluten sensitivity: a study of serum antibodies against gliadin and tissue transglutaminase, the duodenal mucosa and effects of gluten-free diet. Br J Dermatol 156:659–666CrossRefPubMed Michaelsson G, Kristjansson G, Pihl LI et al (2007) Palmoplantar pustulosis and gluten sensitivity: a study of serum antibodies against gliadin and tissue transglutaminase, the duodenal mucosa and effects of gluten-free diet. Br J Dermatol 156:659–666CrossRefPubMed
31.
Zurück zum Zitat Benhamou CL, Chamot AM, Kahn MF (1988) Synovitis-acne-pustulosis hyperostosis-osteomyelitis syndrome (SAPHO). A new syndrome among the spondyloarthropathies? Clin Exp Rheumatol 6:109–112PubMed Benhamou CL, Chamot AM, Kahn MF (1988) Synovitis-acne-pustulosis hyperostosis-osteomyelitis syndrome (SAPHO). A new syndrome among the spondyloarthropathies? Clin Exp Rheumatol 6:109–112PubMed
32.
Zurück zum Zitat Nguyen MT, Borchers A, Selmi C et al (2012) The SAPHO syndrome. Semin Arthritis Rheum 42:254–265CrossRefPubMed Nguyen MT, Borchers A, Selmi C et al (2012) The SAPHO syndrome. Semin Arthritis Rheum 42:254–265CrossRefPubMed
33.
Zurück zum Zitat Yamamoto T (2011) Triggering role of focal infection in the induction of extra-palmoplantar lesions and pustulotic arthro-osteitis associated with palmoplantar pustulosis. Adv Otorhinolaryngol 72:89–92PubMed Yamamoto T (2011) Triggering role of focal infection in the induction of extra-palmoplantar lesions and pustulotic arthro-osteitis associated with palmoplantar pustulosis. Adv Otorhinolaryngol 72:89–92PubMed
34.
Zurück zum Zitat Weisenseel P, Kuznetsov AV, Ruzicka T et al (2007) Palmoplantar pustulosis is not inevitably associated with antigliadin antibodies. Br J Dermatol 156:1399–1400CrossRefPubMed Weisenseel P, Kuznetsov AV, Ruzicka T et al (2007) Palmoplantar pustulosis is not inevitably associated with antigliadin antibodies. Br J Dermatol 156:1399–1400CrossRefPubMed
35.
Zurück zum Zitat Agner T, Sindrup JH, Hoier-Madsen M et al (1989) Thyroid disease in pustulosis palmoplantaris. Br J Dermatol 121:487–491CrossRefPubMed Agner T, Sindrup JH, Hoier-Madsen M et al (1989) Thyroid disease in pustulosis palmoplantaris. Br J Dermatol 121:487–491CrossRefPubMed
36.
Zurück zum Zitat Eriksson MO, Hagforsen E, Lundin IP et al (1998) Palmoplantar pustulosis: a clinical and immunohistological study. Br J Dermatol 138:390–398CrossRefPubMed Eriksson MO, Hagforsen E, Lundin IP et al (1998) Palmoplantar pustulosis: a clinical and immunohistological study. Br J Dermatol 138:390–398CrossRefPubMed
37.
Zurück zum Zitat Murakami M, Ohtake T, Horibe Y et al (2010) Acrosyringium is the main site of the vesicle/pustule formation in palmoplantar pustulosis. J Invest Dermatol 130:2010–2016CrossRefPubMed Murakami M, Ohtake T, Horibe Y et al (2010) Acrosyringium is the main site of the vesicle/pustule formation in palmoplantar pustulosis. J Invest Dermatol 130:2010–2016CrossRefPubMed
38.
Zurück zum Zitat Uehara M, Ofuji S (1974) The morphogenesis of pustulosis palmaris et plantaris. Arch Dermatol 109:518–520CrossRefPubMed Uehara M, Ofuji S (1974) The morphogenesis of pustulosis palmaris et plantaris. Arch Dermatol 109:518–520CrossRefPubMed
39.
Zurück zum Zitat Murakami M, Hagforsen E, Morhenn V et al (2011) Patients with palmoplantar pustulosis have increased IL-17 and IL-22 levels both in the lesion and serum. Exp Dermatol 20:845–847CrossRefPubMed Murakami M, Hagforsen E, Morhenn V et al (2011) Patients with palmoplantar pustulosis have increased IL-17 and IL-22 levels both in the lesion and serum. Exp Dermatol 20:845–847CrossRefPubMed
40.
Zurück zum Zitat Murakami M, Kaneko T, Nakatsuji T et al (2014) Vesicular LL-37 contributes to inflammation of the lesional skin of palmoplantar pustulosis. PLoS ONE 9:e110677CrossRefPubMedPubMedCentral Murakami M, Kaneko T, Nakatsuji T et al (2014) Vesicular LL-37 contributes to inflammation of the lesional skin of palmoplantar pustulosis. PLoS ONE 9:e110677CrossRefPubMedPubMedCentral
41.
Zurück zum Zitat Hagforsen E, Edvinsson M, Nordlind K et al (2002) Expression of nicotinic receptors in the skin of patients with palmoplantar pustulosis. Br J Dermatol 146:383–391CrossRefPubMed Hagforsen E, Edvinsson M, Nordlind K et al (2002) Expression of nicotinic receptors in the skin of patients with palmoplantar pustulosis. Br J Dermatol 146:383–391CrossRefPubMed
42.
Zurück zum Zitat Yoshizaki T, Bandoh N, Ueda S et al (2009) Up-regulation of CC chemokine receptor 6 on tonsillar T cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis palmaris et plantaris. Clin Exp Immunol 157:71–82CrossRefPubMedPubMedCentral Yoshizaki T, Bandoh N, Ueda S et al (2009) Up-regulation of CC chemokine receptor 6 on tonsillar T cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis palmaris et plantaris. Clin Exp Immunol 157:71–82CrossRefPubMedPubMedCentral
43.
Zurück zum Zitat Ueda S, Takahara M, Tohtani T et al (2010) Up-regulation of ss1 integrin on tonsillar T cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis Palmaris et Plantaris. J Clin Immunol 30:861–871CrossRefPubMed Ueda S, Takahara M, Tohtani T et al (2010) Up-regulation of ss1 integrin on tonsillar T cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis Palmaris et Plantaris. J Clin Immunol 30:861–871CrossRefPubMed
44.
Zurück zum Zitat Asumalahti K, Ameen M, Suomela S et al (2003) Genetic analysis of PSORS1 distinguishes guttate psoriasis and palmoplantar pustulosis. J Invest Dermatol 120:627–632CrossRefPubMed Asumalahti K, Ameen M, Suomela S et al (2003) Genetic analysis of PSORS1 distinguishes guttate psoriasis and palmoplantar pustulosis. J Invest Dermatol 120:627–632CrossRefPubMed
45.
Zurück zum Zitat Setta-Kaffetzi N, Navarini AA, Patel VM et al (2013) Rare pathogenic variants in IL36RN underlie a spectrum of psoriasis-associated pustular phenotypes. J Invest Dermatol 133:1366–1369CrossRefPubMed Setta-Kaffetzi N, Navarini AA, Patel VM et al (2013) Rare pathogenic variants in IL36RN underlie a spectrum of psoriasis-associated pustular phenotypes. J Invest Dermatol 133:1366–1369CrossRefPubMed
46.
Zurück zum Zitat Mossner R, Frambach Y, Wilsmann-Theis D et al (2015) Palmoplantar pustular psoriasis is associated with Missense variants in CARD14, but not with loss-of-function mutations in IL36RN in european patients. J Invest Dermatol 135:2538–2541CrossRefPubMed Mossner R, Frambach Y, Wilsmann-Theis D et al (2015) Palmoplantar pustular psoriasis is associated with Missense variants in CARD14, but not with loss-of-function mutations in IL36RN in european patients. J Invest Dermatol 135:2538–2541CrossRefPubMed
47.
Zurück zum Zitat Kingo K, Mossner R, Koks S et al (2007) Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis. Br J Dermatol 156:646–652CrossRefPubMed Kingo K, Mossner R, Koks S et al (2007) Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis. Br J Dermatol 156:646–652CrossRefPubMed
48.
Zurück zum Zitat Wu W, Debbaneh M, Moslehi H et al (2014) Tonsillectomy as a treatment for psoriasis: a review. J Dermatolog Treat 25:482–486CrossRefPubMed Wu W, Debbaneh M, Moslehi H et al (2014) Tonsillectomy as a treatment for psoriasis: a review. J Dermatolog Treat 25:482–486CrossRefPubMed
49.
Zurück zum Zitat Kragballe K, Larsen FG (1991) A hydrocolloid occlusive dressing plus triamcinolone acetonide cream is superior to clobetasol cream in palmo-plantar pustulosis. Acta Derm Venereol 71:540–542PubMed Kragballe K, Larsen FG (1991) A hydrocolloid occlusive dressing plus triamcinolone acetonide cream is superior to clobetasol cream in palmo-plantar pustulosis. Acta Derm Venereol 71:540–542PubMed
50.
Zurück zum Zitat Marsland AM, Griffiths CE (2001) Treatments for chronic palmoplantar pustular psoriasis. Skin Therapy Lett 6:3–5PubMed Marsland AM, Griffiths CE (2001) Treatments for chronic palmoplantar pustular psoriasis. Skin Therapy Lett 6:3–5PubMed
51.
Zurück zum Zitat Umezawa Y, Nakagawa H, Tamaki K (2015) Phase III clinical study of maxacalcitol ointment in patients with palmoplantar pustulosis: A randomized, double-blind, placebo-controlled trial. J Dermatol 43:288CrossRefPubMed Umezawa Y, Nakagawa H, Tamaki K (2015) Phase III clinical study of maxacalcitol ointment in patients with palmoplantar pustulosis: A randomized, double-blind, placebo-controlled trial. J Dermatol 43:288CrossRefPubMed
52.
Zurück zum Zitat Muro M, Kawakami H, Matsumoto Y et al (2015) Topical combination therapy with vitamin D and corticosteroid ointment for palmoplantar pustulosis: A prospective, randomized, left-right comparison study. J Dermatolog Treat 27:51CrossRefPubMed Muro M, Kawakami H, Matsumoto Y et al (2015) Topical combination therapy with vitamin D and corticosteroid ointment for palmoplantar pustulosis: A prospective, randomized, left-right comparison study. J Dermatolog Treat 27:51CrossRefPubMed
53.
Zurück zum Zitat Sevrain M, Richard MA, Barnetche T et al (2014) Treatment for palmoplantar pustular psoriasis: systematic literature review, evidence-based recommendations and expert opinion. J Eur Acad Dermatol Venereol 28(Suppl 5):13–16CrossRefPubMed Sevrain M, Richard MA, Barnetche T et al (2014) Treatment for palmoplantar pustular psoriasis: systematic literature review, evidence-based recommendations and expert opinion. J Eur Acad Dermatol Venereol 28(Suppl 5):13–16CrossRefPubMed
54.
Zurück zum Zitat Layton AM, Sheehan-Dare R, Cunliffe WJ (1991) A double-blind, placebo-controlled trial of topical PUVA in persistent palmoplantar pustulosis. Br J Dermatol 124:581–584CrossRefPubMed Layton AM, Sheehan-Dare R, Cunliffe WJ (1991) A double-blind, placebo-controlled trial of topical PUVA in persistent palmoplantar pustulosis. Br J Dermatol 124:581–584CrossRefPubMed
55.
Zurück zum Zitat Marsland AM, Chalmers RJ, Hollis S et al (2006) Interventions for chronic palmoplantar pustulosis. Cochrane Database Syst Rev CD001433: doi:/10.1002/14651858.cd001433.pub2PubMed Marsland AM, Chalmers RJ, Hollis S et al (2006) Interventions for chronic palmoplantar pustulosis. Cochrane Database Syst Rev CD001433: doi:/10.1002/14651858.cd001433.pub2PubMed
56.
Zurück zum Zitat Lassus A, Geiger JM (1988) Acitretin and etretinate in the treatment of palmoplantar pustulosis: a double-blind comparative trial. Br J Dermatol 119:755–759CrossRefPubMed Lassus A, Geiger JM (1988) Acitretin and etretinate in the treatment of palmoplantar pustulosis: a double-blind comparative trial. Br J Dermatol 119:755–759CrossRefPubMed
57.
Zurück zum Zitat Wilken R, Sharma A, Patel F et al (2015) Successful treatment of palmoplantar pustulosis with isotretinoin. Dermatol Online J 21 Wilken R, Sharma A, Patel F et al (2015) Successful treatment of palmoplantar pustulosis with isotretinoin. Dermatol Online J 21
58.
Zurück zum Zitat Reich K, Graff O, Mehta N (2016) Oral alitretinoin treatment in patients with palmoplantar pustulosis inadequately responding to standard topical treatment: a randomised Phase II study. Br J Dermatol : doi:10.1111/bjd.14401 Reich K, Graff O, Mehta N (2016) Oral alitretinoin treatment in patients with palmoplantar pustulosis inadequately responding to standard topical treatment: a randomised Phase II study. Br J Dermatol : doi:10.1111/bjd.14401
59.
Zurück zum Zitat Irla N, Navarini AA, Yawalkar N (2012) Alitretinoin abrogates innate inflammation in palmoplantar pustular psoriasis. Br J Dermatol 167:1170–1174CrossRefPubMed Irla N, Navarini AA, Yawalkar N (2012) Alitretinoin abrogates innate inflammation in palmoplantar pustular psoriasis. Br J Dermatol 167:1170–1174CrossRefPubMed
60.
Zurück zum Zitat Adisen E, Tekin O, Gulekon A et al (2009) A retrospective analysis of treatment responses of palmoplantar psoriasis in 114 patients. J Eur Acad Dermatol Venereol 23:814–819CrossRefPubMed Adisen E, Tekin O, Gulekon A et al (2009) A retrospective analysis of treatment responses of palmoplantar psoriasis in 114 patients. J Eur Acad Dermatol Venereol 23:814–819CrossRefPubMed
61.
Zurück zum Zitat Stanford CW, Kollipara R, Melookaran AM et al (2014) Palmoplantar pustular psoriasis following initiation of a beta-blocker: disease control with low-dose methotrexate. Cutis 94:153–155PubMed Stanford CW, Kollipara R, Melookaran AM et al (2014) Palmoplantar pustular psoriasis following initiation of a beta-blocker: disease control with low-dose methotrexate. Cutis 94:153–155PubMed
62.
Zurück zum Zitat Reitamo S, Erkko P, Remitz A et al (1993) Cyclosporine in the treatment of palmoplantar pustulosis. A randomized, double-blind, placebo-controlled study. Arch Dermatol 129:1273–1279CrossRefPubMed Reitamo S, Erkko P, Remitz A et al (1993) Cyclosporine in the treatment of palmoplantar pustulosis. A randomized, double-blind, placebo-controlled study. Arch Dermatol 129:1273–1279CrossRefPubMed
63.
Zurück zum Zitat Erkko P, Granlund H, Remitz A et al (1998) Double-blind placebo-controlled study of long-term low-dose cyclosporin in the treatment of palmoplantar pustulosis. Br J Dermatol 139:997–1004CrossRefPubMed Erkko P, Granlund H, Remitz A et al (1998) Double-blind placebo-controlled study of long-term low-dose cyclosporin in the treatment of palmoplantar pustulosis. Br J Dermatol 139:997–1004CrossRefPubMed
64.
Zurück zum Zitat Stander H, Stadelmann A, Luger T et al (2003) Efficacy of fumaric acid ester monotherapy in psoriasis pustulosa palmoplantaris. Br J Dermatol 149:220–222CrossRefPubMed Stander H, Stadelmann A, Luger T et al (2003) Efficacy of fumaric acid ester monotherapy in psoriasis pustulosa palmoplantaris. Br J Dermatol 149:220–222CrossRefPubMed
65.
Zurück zum Zitat Bissonnette R, Nigen S, Langley RG et al (2014) Increased expression of IL-17 A and limited involvement of IL-23 in patients with palmo-plantar (PP) pustular psoriasis or PP pustulosis; results from a randomised controlled trial. J Eur Acad Dermatol Venereol 28:1298–1305CrossRefPubMed Bissonnette R, Nigen S, Langley RG et al (2014) Increased expression of IL-17 A and limited involvement of IL-23 in patients with palmo-plantar (PP) pustular psoriasis or PP pustulosis; results from a randomised controlled trial. J Eur Acad Dermatol Venereol 28:1298–1305CrossRefPubMed
66.
Zurück zum Zitat Robinson A, Van Voorhees AS, Hsu S et al (2012) Treatment of pustular psoriasis: from the Medical Board of the National Psoriasis Foundation. J Am Acad Dermatol 67:279–288CrossRefPubMed Robinson A, Van Voorhees AS, Hsu S et al (2012) Treatment of pustular psoriasis: from the Medical Board of the National Psoriasis Foundation. J Am Acad Dermatol 67:279–288CrossRefPubMed
67.
Zurück zum Zitat Bissonnette R, Poulin Y, Bolduc C et al (2008) Etanercept in the treatment of palmoplantar pustulosis. J Drugs Dermatol 7:940–946PubMed Bissonnette R, Poulin Y, Bolduc C et al (2008) Etanercept in the treatment of palmoplantar pustulosis. J Drugs Dermatol 7:940–946PubMed
68.
Zurück zum Zitat Au SC, Goldminz AM, Kim N et al (2013) Investigator-initiated, open-label trial of ustekinumab for the treatment of moderate-to-severe palmoplantar psoriasis. J Dermatolog Treat 24:179–187CrossRefPubMed Au SC, Goldminz AM, Kim N et al (2013) Investigator-initiated, open-label trial of ustekinumab for the treatment of moderate-to-severe palmoplantar psoriasis. J Dermatolog Treat 24:179–187CrossRefPubMed
69.
Zurück zum Zitat Tillack C, Ehmann LM, Friedrich M et al (2014) Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-gamma-expressing Th1 cells and IL-17 A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment. Gut 63:567–577CrossRefPubMed Tillack C, Ehmann LM, Friedrich M et al (2014) Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-gamma-expressing Th1 cells and IL-17 A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment. Gut 63:567–577CrossRefPubMed
70.
Zurück zum Zitat Perez-Zafrilla B, Angel DM, Carmona L (2008) Adverse reactions related to the administration of TNF inhibitors. analysis of a registry of biologic therapy. Reumatol Clin 4:90–95CrossRefPubMed Perez-Zafrilla B, Angel DM, Carmona L (2008) Adverse reactions related to the administration of TNF inhibitors. analysis of a registry of biologic therapy. Reumatol Clin 4:90–95CrossRefPubMed
71.
Zurück zum Zitat Navarro R, Dauden E (2014) Clinical management of paradoxical psoriasiform reactions during TNF- alpha therapy. Actas Dermosifiliogr 105:752–761CrossRefPubMed Navarro R, Dauden E (2014) Clinical management of paradoxical psoriasiform reactions during TNF- alpha therapy. Actas Dermosifiliogr 105:752–761CrossRefPubMed
72.
Zurück zum Zitat Collamer AN, Battafarano DF (2010) Psoriatic skin lesions induced by tumor necrosis factor antagonist therapy: clinical features and possible immunopathogenesis. Semin Arthritis Rheum 40:233–240CrossRefPubMed Collamer AN, Battafarano DF (2010) Psoriatic skin lesions induced by tumor necrosis factor antagonist therapy: clinical features and possible immunopathogenesis. Semin Arthritis Rheum 40:233–240CrossRefPubMed
73.
Zurück zum Zitat Shmidt E, Wetter DA, Ferguson SB et al (2012) Psoriasis and palmoplantar pustulosis associated with tumor necrosis factor-alpha inhibitors: the Mayo Clinic experience, 1998 to 2010. J Am Acad Dermatol 67:e179–e185CrossRefPubMed Shmidt E, Wetter DA, Ferguson SB et al (2012) Psoriasis and palmoplantar pustulosis associated with tumor necrosis factor-alpha inhibitors: the Mayo Clinic experience, 1998 to 2010. J Am Acad Dermatol 67:e179–e185CrossRefPubMed
74.
Zurück zum Zitat Palucka AK, Blanck JP, Bennett L et al (2005) Cross-regulation of TNF and IFN-alpha in autoimmune diseases. Proc Natl Acad Sci USA 102:3372–3377CrossRefPubMedPubMedCentral Palucka AK, Blanck JP, Bennett L et al (2005) Cross-regulation of TNF and IFN-alpha in autoimmune diseases. Proc Natl Acad Sci USA 102:3372–3377CrossRefPubMedPubMedCentral
75.
Zurück zum Zitat Nestle FO, Conrad C, Tun-Kyi A et al (2005) Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. J Exp Med 202:135–143CrossRefPubMedPubMedCentral Nestle FO, Conrad C, Tun-Kyi A et al (2005) Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. J Exp Med 202:135–143CrossRefPubMedPubMedCentral
76.
Zurück zum Zitat Friedrich M, Tillack C, Wollenberg A et al (2014) IL-36gamma sustains a proinflammatory self-amplifying loop with IL-17 C in anti-TNF-induced psoriasiform skin lesions of patients with Crohn’s disease. Inflamm Bowel Dis 20:1891–1901CrossRefPubMed Friedrich M, Tillack C, Wollenberg A et al (2014) IL-36gamma sustains a proinflammatory self-amplifying loop with IL-17 C in anti-TNF-induced psoriasiform skin lesions of patients with Crohn’s disease. Inflamm Bowel Dis 20:1891–1901CrossRefPubMed
77.
Zurück zum Zitat Denadai R, Teixeira FV, Steinwurz F et al (2013) Induction or exacerbation of psoriatic lesions during anti-TNF-alpha therapy for inflammatory bowel disease: a systematic literature review based on 222 cases. J Crohns Colitis 7:517–524CrossRefPubMed Denadai R, Teixeira FV, Steinwurz F et al (2013) Induction or exacerbation of psoriatic lesions during anti-TNF-alpha therapy for inflammatory bowel disease: a systematic literature review based on 222 cases. J Crohns Colitis 7:517–524CrossRefPubMed
78.
Zurück zum Zitat Gregoriou S, Kazakos C, Christofidou E et al (2011) Pustular psoriasis development after initial ustekinumab administration in chronic plaque psoriasis. Eur J Dermatol 21:104–105PubMed Gregoriou S, Kazakos C, Christofidou E et al (2011) Pustular psoriasis development after initial ustekinumab administration in chronic plaque psoriasis. Eur J Dermatol 21:104–105PubMed
79.
Zurück zum Zitat Wenk KS, Claros JM, Ehrlich A (2012) Flare of pustular psoriasis after initiating ustekinumab therapy. J Dermatolog Treat 23:212–214CrossRefPubMed Wenk KS, Claros JM, Ehrlich A (2012) Flare of pustular psoriasis after initiating ustekinumab therapy. J Dermatolog Treat 23:212–214CrossRefPubMed
80.
Zurück zum Zitat Hay RA, Pan JY (2014) Paradoxical flare of pustular psoriasis triggered by ustekinumab, which responded to adalimumab therapy. Clin Exp Dermatol 39:751–752CrossRefPubMed Hay RA, Pan JY (2014) Paradoxical flare of pustular psoriasis triggered by ustekinumab, which responded to adalimumab therapy. Clin Exp Dermatol 39:751–752CrossRefPubMed
81.
Zurück zum Zitat Laino L, DiCarlo A (2011) Palmoplantar pustular psoriasis: clinical and video thermographic evaluation before and after topical tacrolimus treatment. Arch Dermatol 147:760CrossRefPubMed Laino L, DiCarlo A (2011) Palmoplantar pustular psoriasis: clinical and video thermographic evaluation before and after topical tacrolimus treatment. Arch Dermatol 147:760CrossRefPubMed
82.
Zurück zum Zitat Hayama K, Inadomi T, Fujisawa D et al (2010) A pilot study of medium-dose cyclosporine for the treatment of palmoplantar pustulosis complicated with pustulotic arthro-osteitis. Eur J Dermatol 20:758–762PubMed Hayama K, Inadomi T, Fujisawa D et al (2010) A pilot study of medium-dose cyclosporine for the treatment of palmoplantar pustulosis complicated with pustulotic arthro-osteitis. Eur J Dermatol 20:758–762PubMed
83.
Zurück zum Zitat Wozel G, Vitez L (2008) Palmoplantar pustular psoriasis: successful therapy with efalizumab after non-response to infliximab. Acta Derm Venereol 88:169–170CrossRefPubMed Wozel G, Vitez L (2008) Palmoplantar pustular psoriasis: successful therapy with efalizumab after non-response to infliximab. Acta Derm Venereol 88:169–170CrossRefPubMed
84.
Zurück zum Zitat Morales-Munera C, Vilarrasa E, Puig L (2013) Efficacy of ustekinumab in refractory palmoplantar pustular psoriasis. Br J Dermatol 168:820–824CrossRefPubMed Morales-Munera C, Vilarrasa E, Puig L (2013) Efficacy of ustekinumab in refractory palmoplantar pustular psoriasis. Br J Dermatol 168:820–824CrossRefPubMed
85.
Zurück zum Zitat Gerdes S, Franke J, Domm S et al (2010) Ustekinumab in the treatment of palmoplantar pustulosis. Br J Dermatol 163:1116–1118CrossRefPubMed Gerdes S, Franke J, Domm S et al (2010) Ustekinumab in the treatment of palmoplantar pustulosis. Br J Dermatol 163:1116–1118CrossRefPubMed
86.
Zurück zum Zitat Bertelsen T, Kragballe K, Johansen C et al (2014) Efficacy of ustekinumab in palmoplantar pustulosis and palmoplantar pustular psoriasis. Int J Dermatol 53:e464–e466CrossRefPubMed Bertelsen T, Kragballe K, Johansen C et al (2014) Efficacy of ustekinumab in palmoplantar pustulosis and palmoplantar pustular psoriasis. Int J Dermatol 53:e464–e466CrossRefPubMed
Metadaten
Titel
Pustulöse Psoriasis
verfasst von
P. Weisenseel
D. Wilsmann-Theis
C. Kahl
K. Reich
PD Dr. R. Mössner
Publikationsdatum
01.06.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Die Dermatologie / Ausgabe 6/2016
Print ISSN: 2731-7005
Elektronische ISSN: 2731-7013
DOI
https://doi.org/10.1007/s00105-016-3804-4

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