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Erschienen in: Acta Neurologica Belgica 2/2020

28.04.2018 | Letter to the Editor

Pyridoxine-induced sensory ataxic ganglionopathy: a case report and literature review

verfasst von: Elia Malek, Hassan Doumiati, Johnny S. Salameh

Erschienen in: Acta Neurologica Belgica | Ausgabe 2/2020

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Excerpt

Vitamin-B6, a water soluble vitamin, cannot be synthesized by mammals. They consume its inactive form as pyridoxine, pyridoxal and pyridoxamine. These are converted to pyridoxal phosphate (active ingredient) [1]. Pyridoxine is unsaturable and can be absorbed excessively [2]. Vitamin B6 is involved in the synthesis of neurotransmitters, thus affecting neuronal function [1]. …
Literatur
1.
2.
Zurück zum Zitat Said HM (2011) Intestinal absorption of water-soluble vitamins in health and disease. Biochem J 437:357–372CrossRef Said HM (2011) Intestinal absorption of water-soluble vitamins in health and disease. Biochem J 437:357–372CrossRef
3.
Zurück zum Zitat Schaumburg H, Kaplan J, Windebank A, Vick N, Rasmus S, Pleasure D et al (1983) Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 309(8):445–448CrossRef Schaumburg H, Kaplan J, Windebank A, Vick N, Rasmus S, Pleasure D et al (1983) Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 309(8):445–448CrossRef
4.
Zurück zum Zitat Dalton K, Dalton MJ (1987) Characteristics of pyridoxine overdose neuropathy syndrome. Acta Neurol Scand 76(1):8–11CrossRef Dalton K, Dalton MJ (1987) Characteristics of pyridoxine overdose neuropathy syndrome. Acta Neurol Scand 76(1):8–11CrossRef
5.
Zurück zum Zitat Kulkantrakorn Kongkiat (2014) Pyridoxine-induced sensory ataxic neuronopathy and neuropathy: revisited. Neurol Sci 35:1827–1830CrossRef Kulkantrakorn Kongkiat (2014) Pyridoxine-induced sensory ataxic neuronopathy and neuropathy: revisited. Neurol Sci 35:1827–1830CrossRef
6.
Zurück zum Zitat European Food Safety Authority (EFSA), Parma, Italy (2016) Draft scientific opinion. Scientific opinion on dietary reference values for vitamin B6. EFSA panel on dietetic products, nutrition and allergies (NDA). EFSA J 43:10–11 European Food Safety Authority (EFSA), Parma, Italy (2016) Draft scientific opinion. Scientific opinion on dietary reference values for vitamin B6. EFSA panel on dietetic products, nutrition and allergies (NDA). EFSA J 43:10–11
7.
Zurück zum Zitat Perry TA, Weerasuriya A, Mouton PR, Holloway HW, Greig NH (2004) Pyridoxine-induced toxicity in rats: a stereological quantification of the sensory neuropathy. Exp Neurol 190:133–144CrossRef Perry TA, Weerasuriya A, Mouton PR, Holloway HW, Greig NH (2004) Pyridoxine-induced toxicity in rats: a stereological quantification of the sensory neuropathy. Exp Neurol 190:133–144CrossRef
8.
Zurück zum Zitat Vrolijk MF, Opperhuizen A, Jansen EHJM, Hageman GJ, Bast A, Haenen GRMM (2017) The vitamin B6 paradox: supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicol In Vitro 44:206–212CrossRef Vrolijk MF, Opperhuizen A, Jansen EHJM, Hageman GJ, Bast A, Haenen GRMM (2017) The vitamin B6 paradox: supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicol In Vitro 44:206–212CrossRef
9.
Zurück zum Zitat Potter MC, Wozniak KM, Callizot N, Slusher BS (2014) Glutamate carboxypeptidase II inhibition behaviorally and physiologically improves pyridoxine-induced neuropathy in rats. PLoS One 9(9):e102936CrossRef Potter MC, Wozniak KM, Callizot N, Slusher BS (2014) Glutamate carboxypeptidase II inhibition behaviorally and physiologically improves pyridoxine-induced neuropathy in rats. PLoS One 9(9):e102936CrossRef
10.
Zurück zum Zitat Zhang W, Murakawa Y, Wozniak KM, Slusher B, Sima AA (2006) The preventive and therapeutic effects of GCPII (NAALADase) inhibition on painful and sensory diabetic neuropathy. J Neurol Sci 247:217–223CrossRef Zhang W, Murakawa Y, Wozniak KM, Slusher B, Sima AA (2006) The preventive and therapeutic effects of GCPII (NAALADase) inhibition on painful and sensory diabetic neuropathy. J Neurol Sci 247:217–223CrossRef
Metadaten
Titel
Pyridoxine-induced sensory ataxic ganglionopathy: a case report and literature review
verfasst von
Elia Malek
Hassan Doumiati
Johnny S. Salameh
Publikationsdatum
28.04.2018
Verlag
Springer International Publishing
Erschienen in
Acta Neurologica Belgica / Ausgabe 2/2020
Print ISSN: 0300-9009
Elektronische ISSN: 2240-2993
DOI
https://doi.org/10.1007/s13760-018-0919-7

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