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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Musculoskeletal Disorders 1/2015

Quadriceps muscle strength, radiographic knee osteoarthritis and knee pain: the ROAD study

BMC Musculoskeletal Disorders > Ausgabe 1/2015
Shigeyuki Muraki, Toru Akune, Masatoshi Teraguchi, Ryohei Kagotani, Yoshiki Asai, Munehito Yoshida, Fumiaki Tokimura, Sakae Tanaka, Hiroyuki Oka, Hiroshi Kawaguchi, Kozo Nakamura, Noriko Yoshimura
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​s12891-015-0737-5) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

SM, TA and NY conceptualized and designed the study, drafted the initial manuscript, and carried out the initial analyses. MY, FT, ST, HK and KN reviewed and revised the manuscript. MT, RK, YA and HO designed the data collection instruments, and coordinated and supervised data collection, critically reviewed the manuscript. All authors read and approved the final manuscript.

Authors' information

Not Applicable.



The objective of this study was to clarify the association of quadriceps muscle strength with knee pain using a large-scale, population-based cohort of the Research on Osteoarthritis/osteoporosis Against Disability (ROAD) study.


From the 2566 subjects at the third visit of the ROAD study, the present study analyzed 2152 subjects who completed radiographic examinations and measurements of muscle strength and mass (690 men and 1462 women; mean age, 71.6 ± 12.2 years). Knee pain was assessed by an experienced orthopedist. Knee osteoarthritis (OA) was defined according to Kellgren-Lawrence (KL) grade. Quadriceps muscle strength and muscle mass at the lower limbs were measured by the Quadriceps Training Machine (QTM-05F, Alcare Co., Ltd. Tokyo, Japan) and the Body Composition Analyzer MC-190 (Tanita Corp., Tokyo, Japan), respectively.


Quadriceps muscle strength and weight bearing index (WBI: quadriceps muscle strength by weight) were significantly associated with knee pain after adjustment for age and body mass index, whereas grip strength and muscle mass at the lower limbs were not. The significant association of quadriceps muscle strength with knee pain was independent of radiographic knee OA.


The present cross-sectional study showed an independent association of quadriceps muscle strength with knee pain.
Additional file 1: Figure S1. Quadriceps muscle strength by age strata (PPT 188 kb)
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