The online version of this article (doi:10.1186/s12891-015-0737-5) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
SM, TA and NY conceptualized and designed the study, drafted the initial manuscript, and carried out the initial analyses. MY, FT, ST, HK and KN reviewed and revised the manuscript. MT, RK, YA and HO designed the data collection instruments, and coordinated and supervised data collection, critically reviewed the manuscript. All authors read and approved the final manuscript.
The objective of this study was to clarify the association of quadriceps muscle strength with knee pain using a large-scale, population-based cohort of the Research on Osteoarthritis/osteoporosis Against Disability (ROAD) study.
From the 2566 subjects at the third visit of the ROAD study, the present study analyzed 2152 subjects who completed radiographic examinations and measurements of muscle strength and mass (690 men and 1462 women; mean age, 71.6 ± 12.2 years). Knee pain was assessed by an experienced orthopedist. Knee osteoarthritis (OA) was defined according to Kellgren-Lawrence (KL) grade. Quadriceps muscle strength and muscle mass at the lower limbs were measured by the Quadriceps Training Machine (QTM-05F, Alcare Co., Ltd. Tokyo, Japan) and the Body Composition Analyzer MC-190 (Tanita Corp., Tokyo, Japan), respectively.
Quadriceps muscle strength and weight bearing index (WBI: quadriceps muscle strength by weight) were significantly associated with knee pain after adjustment for age and body mass index, whereas grip strength and muscle mass at the lower limbs were not. The significant association of quadriceps muscle strength with knee pain was independent of radiographic knee OA.
The present cross-sectional study showed an independent association of quadriceps muscle strength with knee pain.
Additional file 1: Figure S1. Quadriceps muscle strength by age strata (PPT 188 kb)12891_2015_737_MOESM1_ESM.ppt
Sharma L, Kapoor D. Epidemiology of osteoarthritis. In: Moskowitz RW, Altman RD, Hochberg MC, Buckwalter JA, Goldberg VM, editors. Osteoarthritis: diagnosis and medical/surgical management. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2007. p. 3–26.
Ministry of Health, Labour and Welfare. The outline of the results of National Livelihood Survey 2010. Available at http://www.mhlw.go.jp/toukei/saikin/hw/k-tyosa/k-tyosa10/index.html
Roubenoff R. Sarcopenia: a major modifiable cause of frailty in the elderly. J Nutr Health Aging. 2000;4:4140–2.
Bohannon RW. Hand-grip dynamometry predicts future outcomes in aging adults. J Geriatr Phys Ther. 2008;31:313–10.
Muraki S, Akune T, Oka H, En-yo Y, Yoshida M, Saika A, et al. Association of radiographic and symptomatic knee osteoarthritis with health-related quality of life in a population-based cohort study in Japan. ROAD Stud Osteoarthritis Cartilage. 2010;18:1227–34. CrossRef
Andrews JS, Trupin L, Schmajuk G, Barton J, Margaretten M, Yazdany J, et al. Muscle strength, muscle mass, and physical disability in women with systemic lupus erythematosus. Arthritis Care Res. 2015;67:120–7. CrossRef
Janssen I, Heymsfield SB, Baumgartner RN, Ross R. Estimation of skeletal muscle mass by bioelectrical impedance analysis. J Appl Physiol. 2000;89:465–71. PubMed
Nemoto M, Yabushita N, Kim M, Matsuo T, Seino S, Songee J, et al. Validity of the bioelectrical impedance method for assessing body composition in non-frail and pre-frail older adults. Int J Body Comps Res. 2012;10:55.
Kellgren JH, Lawrence JS, editors. The epidemiology of chronic rheumatism: atlas of standard radiographs of arthritis. Oxford: Blackwell Scientific; 1963.
Metter EJ, Conwit R, Metter B, Pacheco T, Tobin J. The relationship of peripheral motor nerve conduction velocity to age-associated loss of grip strength. Aging (Milano). 1998;10:471–8.
Goodpaster BH, Carlson CL, Visser M, Kelley DE, Scherzinger A, Harris TB, et al. Attenuation of skeletal muscle and strength in the elderly: the health ABC study. J Appl Physiol. 2001;90:2157–65. PubMed
- Quadriceps muscle strength, radiographic knee osteoarthritis and knee pain: the ROAD study
- BioMed Central
Neu im Fachgebiet Orthopädie und Unfallchirurgie
Mail Icon II