There is still controversy regarding whether Quadriceps-sparing (QS) approach for total knee arthroplasty (TKA) lead to better earlier recovery as well as compromising low limb alignment and prosthesis position compared with conventional medial parapatellar (MP) approach. To overcome the shortcomings and inaccuracies of single studies, the clinical outcomes and radiographic assessments of QS approach and MP approach were evaluated through meta-analysis.
Methods
We performed this meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. A literature search was conducted in the PubMed, EMBase, Cochrane Collaboration Library and Web of Science databases. Our search strategy followed the requirements of the Cochrane Library Handbook. The study selection, data extraction and assessment of methodological quality were independently completed by four authors. And subgroup analysis and publication bias were also performed in the study.
Results
Eight prospective randomized controlled trials (RCTs) and eight retrospective studies were identified. Overall meta-analysis and subgroup meta-analysis of RCTs identified the QS approach mainly was associated with increased Knee Society function score beyond 24 months postoperatively (weighted mean difference [WMD] 1.78, P = 0.0004) (WMD 1.86, P = 0.0002), and improved range of motion 1–2 weeks postoperatively (WMD 5.84, P < 0.00001) (WMD 4.87, P = 0.002). Besides, lower visual analogue scale on postoperative day 1 (WMD -0.91, P = 0.02), shorter hospital stay (WMD -0.88, P = 0.02) and shorter incision (extension) (WMD -4.62, P < 0.00001) were indicated in overall meta-analysis. However, surgical and tourniquet time was significantly longer in QS group by both overall and subgroup meta-analysis.
Conclusions
QS approach may accelerate early recovery without increasing the risk of malalignment of low limb and malposition of prosthesis.
Preferred Reporting Items for Systematic Reviews and Meta-analysis
QS TKA
Quadriceps-sparing total knee arthroplasty
RCT
Randomized controlled trial
ROM
Range of motion
SLR
Straight leg raising
TKA
Total knee arthroplasty
VAS
Visual analog scale
WMD
Weighted mean difference
Background
Total knee arthroplasty (TKA) was first performed in 1968 [1]. It is widely used in patients with symptomatic, end-stage knee arthritis [2‐4] and is the most successful surgical procedure for relieving pain and improving poor function in patients with advanced arthritis [5, 6]. The conventional medial parapatellar (MP) approach has been established as the gold standard technique for TKA [7‐11]. However, since the first quadriceps-sparing (QS) approach was performed in 2002 [12], it has become one of the most common alternatives to the MP approach and, theoretically, provides a faster recovery of muscle. By avoiding violation of the extensor mechanism and suprapatellar pouch and everting the patella, the QS approach aims to produce less discomfort, provide a faster recovery and reduce the extent of patellar devascularization that can lead to patellar subluxation, dislocation, avascular necrosis, fracture, patellar component loosening, and anterior knee pain [13]. Currently, numerous well-designed studies have compared the outcomes of the QS and MP approaches. However, the conclusions from studies are still controversial. Some studies have found no significant differences between the two approaches [14, 15], whereas others have supported either the QS [16‐23] or the MP approach [24‐26]. Therefore, we designed this meta-analysis to quantitatively compare the efficacy and safety of the QS versus the MP approach for TKA.
Methods
Our meta-analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement that established procedures for rigorous performance and reporting of meta-analyses [27, 28].
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Search strategy
Two authors independently carried out a systematic search (last update 4 August 2018) of the PubMed, EMBase, Cochrane Collaboration Library and Web of Science databases, without restrictions on regions, publication types, or languages. The following search strategies were used in the search: #1. (knee arthroplasty) OR knee replacement; #2. (((((quadriceps-sparing) OR quadriceps sparing) OR quad-sparing) OR quad sparing) OR minimally invasive) OR mini-incision; #3. #1 AND #2. Furthermore, the references from all accessed papers were also searched for any undetected studies. The results of our database search were imported into EndNote X7 and duplicates were eliminated using the duplicate removal function. Then, two authors screened all entries by title and abstract, and the remaining studies underwent full text review.
Inclusion and exclusion criteria
Studies were selected on the basis of the following criteria: (1) study design: randomized controlled trials (RCTs), and retrospective comparative studies (both cohort and case-control studies); (2) study population: adult patients who underwent primary TKA; (3) intervention: including both QS TKA and MP TKA; (4) available mean and standard deviation (SD) or proportion (or ability to estimate SD using data range). Review articles, case reports, editorials, letters to the editor, animal experimental studies and cadaver studies were excluded.
Data extraction and methodological quality assessment
Data were extracted using a predesigned sheet that included authors, publication data, specific interventions, main participant characteristics and results by three authors. Unreported data needed for this meta-analysis were obtained by communicating with the author though e-mail. For methodological quality evaluation of RCTs, recommendations issued by the Cochrane Handbook for Systematic Reviews were utilized in the meta-analysis [29]. The methodological quality of the included nonRCTs were evaluated with the modified Newcastle-Ottawa Scale (NOS), a simple tool used for the assessment of case controlled and cohort studies [30] that has been recommended by Cochrane collaboration [29]. NOS consists of three factors: patient selection, comparability of the study group and assessment of outcomes. According to NOS, a study can be awarded 0–9 stars.
Statistical analysis
This meta-analysis was performed with Review Manager 5.3 (Cochrane Collaboration, Oxford, UK). The level of significance was set at P < 0.05. For dichotomous outcomes, the odds ratio (OR) and 95% confidence interval (95% CI) were calculated. For continuous outcomes, weighted mean difference (WMD) and the 95% CI were calculated. Statistical heterogeneity was tested with the I2 statistic and the Chi-squared(χ2)test. A P > 0.1 and an I2 ≤ 50% were considered to represent the absence of statistical heterogeneity. If significant heterogeneity (I2 > 50%) was found in the meta-analysis, a random effects model was used, otherwise, a fixed effects model was employed [29]. Certain studies in this meta-analysis provided data ranges (maximum and minimum values) rather than SDs. In these instances, SD was estimated as the difference between the maximum and minimum values divided by four [31], which serves as a conservative estimate of SD. Sensitivity analyses were conducted on the different types of study designs and the different participants enrolled in studies. Funnel plots were used to screen for potential publication bias.
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Results
Literature search
The details of identifying relevant studies are shown in a flow chart of the study selection process (Fig. 1). The initial search identified 2038 potentially relevant citations from PubMed, EMBase, Cochrane Collaboration Library and Web of Science. After the duplicates were removed, 1903 studies were identified. A total of 1824 records were excluded based on a review of abstracts, leaving 79 articles for full-text review. Following full-text review, 16 citations were finally included consisting of eight RCTs [15, 16, 21, 24, 25, 32‐34] and eight non-RCTs [14, 17‐20, 23, 26, 35].
Fig. 1
PRISMA flow chart of literature screening
×
The characteristics of included studies
Table 1 summarizes the key characteristics of the included studies. There was a total of 1112 patients with 1439 TKAs in the included studies. The mean age of the included patients ranged from 42 to 88 years, the mean BMI ranged from 17.9 to 49 kg/m2, and the mean follow-up duration ranged from 0 days to more than five years. Seven studies favored the QS approach results, while nine studies favored the MP approach results.
Table 1
Characteristics of included studies
Study/Year
Country
Recruitment period
Group
Patients (male/female)
Number of TKAs
Age (year)
BMI (kg/m2)
Follow-up (months)
Results Favor
Huang 2016
China
2005–2007
QS
2/29
31
69.3 ± 7.9
26.9 ± 3.3
65 ± 3.8
QS
MP
2/28
30
71.2 ± 5.8
26.7 ± 2.8
68 ± 5.4
Qi 2016
China
2005–2007
QS
2/26
30
65.3 ± 6.9
26.5 ± 3.0
74.8
QS
MP
2/24
28
64.0 ± 5.7
28.1 ± 4.1
74.8
Lin 2013
Taiwan
2007–2008
QS
5/30
35
67.7 (60, 78)
26.3 (21.2, 29.7)
24
MP
MP
5/30
35
68.5 (55, 77)
25.9 (20, 29.5)
24
Xu 2013
China
2009–2010
QS
7/19
35
63.5 ± 8.7
25.2 ± 3.4
24
QS
MP
11/18
35
64.2 ± 9.3
25.2 ± 2.3
24
Chiang 2012
Taiwan
2005
QS
3/27
38
69.7 ± 5.3
28.6 ± 3.8
24
MP
MP
3/27
37
69.8 ± 5.4
29.6 ± 3.5
24
Matsumoto 2011
Japan
2005–2007
QS
0/25
25
73.8 ± 1.7
Unclear
0
MP
MP
0/25
25
73.7 ± 1.4
Unclear
0
Yang 2010
Korea
2006–2007
QS
1/14
24
66.7 ± 6.9
Unclear
24
MP
MP
2/14
23
68 ± 6.8
Unclear
24
Karpman 2009
USA
2004–2005
QS
8/12
20
73 ± 7.4
28 ± 4.4
6
QS
MP
9/10
19
73 ± 5.1
29 ± 4.6
6
Chotanaphuti 2008
Thailand
2004–2005
QS
3/17
20
68.4 (58, 78)
Unclear
0.25
QS
MP
4/16
20
67.5 (56, 80)
Unclear
0.25
Shen 2007
China
2005–2006
QS
Unclear
26
Unclear
Unclear
17
QS
MP
Unclear
33
Unclear
Unclear
17
Huang 2007
Taiwan
2004–2005
QS
6/26
32
63 (56, 72)
Unclear
24
MP
MP
7/28
35
65 (59, 75)
Unclear
24
King 2007
USA
2003–2005
QS
48/52
100
67 (44, 84)
30 (22, 43)
1.5
QS
MP
17/28
45
66 (42, 85)
32 (20, 49)
1.5
Kim 2007
Korea
2004–2005
QS
27/93
120
65.4 (43, 88)
28.1 (19, 36)
21.5
MP
MP
27/93
120
65.4 (43, 88)
28.1 (19, 36)
21.5
Chin 2007
Singapore
2004
QS
6/24
30
69.0 (57, 80)
27.53 (18.6, 34.2)
Unclear
MP
MP
3/27
30
63.4 (47, 80)
29.44 (22.7, 40)
Unclear
Chen 2006
USA
Prior to 2002
QS
11/17
32
70 (50, 86)
28.5 (17.9, 39.9)
33
MP
MP
11/18
38
67 (42, 81)
28.7 (21.6, 40.1)
40
Kim 2006
Korea
2003
QS
7/65
144
68.6 (57, 85)
27.2
13.6
MP
MP
8/64
144
67.4 (58, 84)
28.1
13.6
TKA total knee arthroplasty, BMI body mass index, QS quadriceps-sparing, MP medial parapatellar
Methodological quality assessment
The quality assessment of the included studies is shown in Table 2, and methodological quality was regarded as high. All eight RCTs were randomized, of which three RCTs utilized allocation concealment, four were blinded to participants and personnel, and five were blinded to outcome assessment. All the studies had incomplete data outcomes, and three selectively reported data. Observational studies achieving stars ranged from seven to eight points according to the Newcastle-Ottawa Scale, the total being nine points.
Table 2
Quality assessment of included studies
Study/Year
Random Sequence Generation
Allocation Concealment
Blinding of Participants and Personnel
Blinding of Outcome Assessment
Incomplete Outcome Data
Selective Reporting
Other Bias
Lin 2013*
Yes
Sealed envelope
Unclear
Yes
Yes
Unclear
Unclear
Xu 2013*
Yes
Sealed envelope
Unclear
Unclear
Yes
Unclear
Unclear
Chiang 2012*
Yes
Unclear
Yes
Yes
Yes
Yes
Unclear
Matsumoto 2011*
Yes
Unclear
Yes
Unclear
Yes
Unclear
Unclear
Yang 2010*
Yes
Unclear
Unclear
Yes
Yes
Yes
Unclear
Karpman 2009*
Yes
Unclear
Yes
Yes
Yes
Unclear
Unclear
Kim 2007*
Yes
Unclear
Unclear
Yes
Yes
Unclear
Unclear
Chin 2007*
Yes
Sealed envelope
Yes
Yes
Yes
Yes
Unclear
Selection
Comparability
Outcomes
Total score
Huang 2016†
2
2
3
7
Qi 2016†
3
2
2
7
Chotanaphuti 2008†
3
2
3
8
Shen 2007†
3
2
3
8
Huang 2007†
2
2
3
7
King 2007†
3
2
3
8
Chen 2006†
3
2
2
7
Kim 2006†
3
2
3
8
*The risk of bias was assessed independently using the Cochrane Handbook for Systematic Reviews of Interventions; †Methodological quality of the included studies was assessed according to Newcastle-Ottawa Scale
Quantitative data synthesis
There were 16 studies included for meta-analysis in which there were eight RCTs [15, 16, 21, 24, 25, 32‐34] and eight non-RCTs [14, 17‐20, 23, 26, 35].
Primary outcomes
The overall meta-analysis results (Table 3) were in favor of the QS approach based on long-term Knee Society (KS) function score (WMD 1.78, 95% CI 0.80 to 2.76, P = 0.0004, I2 = 0%). Furthermore, the results showed that there were no significant differences between the QS and MP approaches in the KS Knee Score beyond 24 months postoperatively (WMD -0.02, 95% CI -0.69 to 0.65, P = 0.95, I2 = 0%), in range of motion (ROM) beyond 16 months postoperatively (WMD 0.08, 95% CI -1.40 to 1.57, P = 0.91, I2 = 4%), or complications (OR 0.87, 95% CI 0.49 to 1.54, P = 0.63, I2 = 9%), infections (OR 1.53, 95% CI 0.69 to 3.39, P = 0.29, I2 = 0%), mechanical axis outliers (OR 1.05, 95% CI 0.65 to 1.72, P = 0.83, I2 = 27%), femoral component coronal angle outliers (OR 2.30, 95% CI 0.35 to 15.24 P = 0.39, I2 = 65%), tibial component coronal angle outliers (OR 0.73, 95% CI 0.40 to 1.33, P = 0.30, I2 = 40%), mechanical axis (WMD 0.35, 95% CI -0.02 to 0.73, P = 0.07, I2 = 0%), femoral component coronal angle (WMD 0.23, 95% CI -0.90 to 1.35, P = 0.69, I2 = 92%), tibial component coronal angle (WMD -0.40, 95% CI -1.29 to 0.49, P = 0.38, I2 = 92%), lateral patellar tilt (WMD -1.25, 95% CI -3.36 to 0.85, P = 0.24, I2 = 78%) or lateral patellar displacement (WMD -1.47, 95% CI -4.59 to 1.66, P = 0.36, I2 = 90%).
Table 3
Primary outcomes of meta-analysis results
Outcomes of Demographics
Number of Contributing Studies
Number of QS TKAs
Number of MP TKAs
WMD or OR (95% CI)
P - Value
Heterogeneity
KS Knee Score beyond 24 months
4
330
329
-0.02 (− 0.69, 0.65)
0.95
0%
KS Function Score beyond 24 months
3
186
185
1.78 (0.80, 2.76)
0.0004
0%
ROM beyond 16 months
6
400
404
0.08 (−1.40, 1.57)
0.91
4%
Complications
10
464
430
0.87 (0.49, 1.54)
0.63
9%
Infections
10
503
515
1.53 (0.69, 3.39)
0.29
0%
Mechanical axis outliers
5
257
266
1.05 (0.65, 1.72)
0.83
27%
Femoral component coronal angle outliers
4
237
235
2.30 (0.35, 15.24)
0.39
65%
Tibial component coronal angle outliers
5
337
280
0.73 (0.40, 1.33)
0.30
40%
Mechanical axis
5
149
147
0.35 (−0.02, 0.73)
0.07
0%
Femoral component coronal angle
6
395
395
0.23 (− 0.90, 1.35)
0.69
92%
Tibial component coronal angle
7
495
445
-0.40 (−1.29, 0.49)
0.38
92%
Lateral patellar tilt
5
418
363
-1.25 (−3.36, 0.85)
0.24
78%
Lateral patellar displacement
2
131
75
-1.47 (−4.59, 1.66)
0.36
90%
TKA total knee arthroplasty, BMI body mass index, QS quadriceps-sparing, MP medial parapatellar, WMD weighted mean difference, OR odds ratio, CI confidence interval, KS knee society, ROM range of motion
Secondary outcomes
Meta-analysis showed that, when compared with the MP approach, the QS approach significantly improved ROM 1–2 weeks postoperatively (WMD 5.84, 95% CI 3.84 to 7.83, P < 0.00001, I2 = 21%), shortened length of stay (WMD -0.88, 95% CI -1.62 to − 0.15, P = 0.02, I2 = 94%) and reduced the length of incision in extension (WMD -4.62, 95% CI -6.35 to − 2.90, P < 0.00001, I2 = 99%). However, the QS approach significantly increased surgical time (WMD 12.02, 95% CI 4.06 to 19.98, P = 0.003, I2 = 95%) and tourniquet time (WMD 27.19, 95% CI 9.17 to 45.22, P = 0.003, I2 = 99%). Although the meta-analysis demonstrated significant differences in visual analogue scale (VAS) on postoperative day 1 (WMD -0.91, 95% CI -1.68 to − 0.41, P = 0.02, I2 = 81%). No other significant differences were found for secondary outcomes as shown in Table 4.
Table 4
Secondary outcomes of meta-analysis results
Outcomes of Demographics
Number of Contributing Studies
Number of QS TKAs
Number of MP TKAs
WMD or OR (95% CI)
P - Value
Heterogeneity
KS Knee Score 1.5–3 months
4
204
212
1.27 (− 0.57, 3.11)
0.18
57%
KS Function Score 1.5–3 months
4
204
212
−0.09 (−3.98, 3.81)
0.97
73%
ROM 1–2 weeks
5
148
162
5.84 (3.84, 7.83)
< 0.00001
21%
ROM 4–8 weeks
7
283
247
0.51 (−1.90, 2.91)
0.68
61%
ROM 3 months
2
152
158
−0.60 (−2.32, 1.12)
0.50
47%
ROM 12 months
2
58
68
4.00 (−5.80, 13.80)
0.42
90%
VAS 1 day
6
183
197
−0.91 (−1.68, − 0.41)
0.02
81%
VAS 3 days
2
64
70
−0.93 (−2.01, 0.14)
0.09
82%
VAS 4–8 weeks
3
84
89
−0.26 (−1.13, 0.61)
0.56
77%
Surgical time (min)
8
507
450
12.02 (4.06, 19.98)
0.003
95%
Tourniquet time (min)
8
447
462
27.19 (9.17, 45.22)
0.003
99%
Intraoperative blood loss (ml)
4
334
339
1.99 (−14.28, 18.25)
0.81
0%
Total blood loss (ml)
5
255
254
−42.94 (−150.57, 64.70)
0.43
90%
Incision, extension (cm)
7
276
284
−4.62 (−6.35, −2.90)
< 0.00001
99%
Incision, flexion (cm)
3
193
192
−1.90 (−3.99, 0.19)
0.07
99%
Length of stay (days)
8
433
441
−0.88 (−1.62, −0.15)
0.02
94%
SLR at 24 h (% of patients)
3
105
107
3.05 (0.89, 10.53)
0.08
75%
VAS, visual analogue scale; SLR, straight leg rising
Subgroup analysis
A pooling of the RCTs is summarized in Table 5. The QS approach extended the surgical time (WMD 18.86, 95% CI 8.81 to 28.91, P = 0.0002, I2 = 94%) and tourniquet time (WMD 24.39, 95% CI 3.19 to 45.60, P = 0.02, I2 = 99%). However, the QS approach significantly improved ROM 1–2 weeks postoperatively (WMD 4.87, 95% CI 1.78 to 9.76, P = 0.002, I2 = 0%) and shortened the incision scar in extension (WMD -3.76, 95% CI -6.79 to − 0.73, P = 0.02, I2 = 99%). Furthermore, the meta-analysis of RCTs also showed that the QS approach was associated with a higher KS Function Score beyond 24 months postoperatively (WMD 1.86, 95% CI 0.86 to 2.85, P = 0.0002, I2 = 0%).
Table 5
Meta-analysis results of RCTs
Outcomes of Demographics
Number of Contributing Studies
Number of QS TKAs
Number of MP TKAs
WMD or OR (95% CI)
P - Value
Heterogeneity
KS Knee Score beyond 24 months
2
155
155
−0.18 (−1.13, 0.77)
0.71
25%
KS Function Score beyond 24 months
2
155
155
1.86 (0.86, 2.85)
0.0002
0%
ROM beyond 16 months
3
193
192
−0.41 (−2.18, 1.37)
0.65
0%
Complications
5
243
244
1.49 (0.68, 3.27)
0.32
1%
Infections
7
301
300
1.95 (0.75, 5.10)
0.17
0%
Mechanical axis outliers
2
55
54
3.80 (0.61, 23.57)
0.15
25%
Femoral component coronal angle outliers
3
93
91
5.24 (0.80, 34.28)
0.08
20%
Tibial component coronal angle outliers
3
93
91
4.14 (0.87, 19.75)
0.07
0%
Mechanical axis
3
88
89
0.34 (−0.37, 1.05)
0.35
15%
Femoral component coronal angle
5
251
251
0.07 (−1.30, 1.44)
0.92
93%
Tibial component coronal angle
5
251
251
−0.31 (− 1.58, 0.97)
0.64
93%
Lateral patellar tilt
2
143
144
0.73 (−0.30, 1.76)
0.16
0%
KS Knee Score 1.5–3 months
3
178
179
1.01 (−0.74, 2.76)
0.26
61%
KS Function Score 1.5–3 months
3
178
179
−0.67 (−5.45, 4.10)
0.78
82%
ROM 1–2 weeks
2
58
56
4.87 (1.78, 7.96)
0.002
0%
ROM 4–8 weeks
3
93
91
1.68 (−2.16, 5.51)
0.39
60%
VAS 1 day
3
93
91
−0.07 (−0.49, 0.35)
0.74
0%
VAS 4–8 weeks
2
58
56
−0.46 (−2.31, 1.40)
0.63
87%
Surgical time (min)
5
243
241
18.86 (8.81, 28.91)
0.0002
94%
Tourniquet time (min)
3
193
192
24.39 (3.19, 45.60)
0.02
99%
Intraoperative blood loss (ml)
2
158
157
3.10 (−24.89, 31.09)
0.83
0%
Total blood loss (ml)
4
111
110
4.24 (−56.29, 64.77)
0.89
48%
Incision, extension (cm)
4
188
188
−3.76 (−6.79, −0.73)
0.02
99%
Incision, flexion (cm)
3
193
192
−1.90 (−3.99, 0.19)
0.07
99%
Length of stay (days)
4
205
204
−0.34 (−1.02, 0.34)
0.33
71%
SLR at 24 h (% of patients)
2
73
72
1.62 (0.79, 3.30)
0.19
0%
TKA total knee arthroplasty, QS quadriceps-sparing, MP medial parapatellar, WMD weighted mean difference, OR odds ratio, CI confidence interval, KS knee society, ROM range of motion, VAS visual analogue scale, SLR straight leg rising
Publication bias
Figure 2 shows a funnel plot of the studies included in this meta-analysis that reported infections. All studies lie inside the 95% CIs, with an even distribution around the vertical, indicating no obvious publication bias.
Fig. 2
Funnel plot illustrating meta-analysis of infections
×
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Discussion
The results suggest that QS approach may be associated with higher KS function score beyond 24 months postoperatively, could improve ROM 1–2 weeks postoperatively, and shorten incision (extension) with significantly longer surgical and tourniquet time in both overall and subgroup meta-analysis.
According to both the subgroup meta-analysis of RCTs and the overall meta-analysis, results showed that the QS approach was favored in terms of the KS function score beyond 24 months postoperatively which was a primary outcome with a WMD 1.78 and 1.86, respectively. However, we cautiously thought that QS approach could not be confirmed as superior because Lee et al. [36] found that a minimal clinically important difference (MCID) in the KS function score was between 6.1 and 6.4. Besides, QS approach significantly improved ROM 1–2 week postoperatively and shortened the incision length in extension. Longer surgical time and tourniquet time were needed in QS group without increasing complications and infections. Based on these results of the secondary outcomes, we identified that the QS approach may accelerate early recovery to some extent and improved cosmesis which may make patients to be more satisfied with their surgery without increasing the risk of surgery. But it is undeniable that a longer surgery time may lead to increased hospital costs.
In our overall meta-analysis, the QS approach had significant advantages over the MP approach on VAS 1 day postoperatively and length of stay, which were not identified in the subgroup meta-analysis of RCTs. Although the WMD was statistically significant, it falls below the threshold for clinical significance according to the MCID of VAS [37]. Therefore, the possibility that QS approach may accelerate early recovery was supported to a limited extent.
Meanwhile, we observed that the QS approach was not associated with a higher risk of malalignment of low limb and poor position of prosthesis, which was demonstrated in both overall and subgroup meta-analysis. The importance of accurate lower limb alignment and prothesis position after TKA and the greater risk of implant failure with malalignment have been well recognized [38, 39]. Owing to the importance of those factors, we should pay attention to this situation even though meta-analysis did not identify this issue. As arthroplasty surgeons know, the QS approach can easily be extended or converted to the MP approach during the surgery. Therefore, if a surgeon is not sufficiently skilled in the TKA procedure, the QS approach should be appropriately extended to ensure good bone resection and prosthesis installation.
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The findings from our meta-analysis are in partial disagreement with the results and conclusions of two recent meta-analyses by Peng et al. [40] and Kazarian et al. [41]. The disagreements are not only due to differences in the concluded articles and the extraction and selection of data; they are also due to differences in the included articles of RCTs. In our view, the meta-analysis by Peng et al. included three studies that did not meet the inclusion criteria and excluded two articles that met the inclusion criteria. In the included studies of Peng et al., Shen et al. [18] was a cohort study, Tasker et al. [42] compared the mini-midvastus or subvastus approach to the MP approach and Lin et al. [43] compared the QS approach to the mini-MP approach. In addition, Peng et al. did not include two studies [15, 21] that met the inclusion criteria of the meta-analysis. For the meta-analysis by Kazarian et al., we considered that an article by Yang et al. [15] met the inclusion criteria even though it was not included and a study comparing the QS approach with the mini-MP approach by Lin et al. [43] was enrolled. Because these deviations could potentially affect some of the results, they might provide an explanation for the partial disagreement between our meta-analyses.
The inclusion of both RCTs and retrospective comparative studies enhanced the sample size and robustness of the estimates when compared with previous studies [40, 41]. Although a meta-analysis of RCTs only would be ideal, the limited number of RCTs and their size limits the scope of this review and prevents its findings from being conclusive.
Between-study heterogeneity was found to exist with some outcomes. Included studies adopted different research objects, research designs, and measurement of results, differences, all of which may contribute to the significant between-study heterogeneity. After careful analysis of these documents, we found that design and objects were also potential contributors to heterogeneity. Therefore, we conducted a subgroup meta-analysis pooling only RCTs to increase the reference value of the results. It is well known that RCTs standardize the research process through randomization, blinding, strict quality control, etc. to obtain reliable research results. In addition, if heterogeneity persisted, we adopted random-effects model to potentially reduce, but not abolish, the effect of heterogeneity. The limitation is that the duration of follow-up of these studies is still not long enough. A follow-up period of more than ten years is required to evaluate and confirm outcomes, especially regarding relationships between the mechanical axis, prosthesis position and functional scores.
Conclusions
In summary, the use of QS approach in patients undergoing TKAs appears to be effective in improving ROM 1–2 postoperatively and reducing the length of incision in knee extension. In addition, the overall meta-analysis illustrated that QS approach may shorten the length of stay. However, the QS approach also significantly increases surgical and tourniquet time. Apart from this, the two surgical techniques appear to be equivalent in other aspects such as mechanical axis, prosthesis position, complications, infections and so on. On the basis of these findings, we are optimistic about the QS approach to some extent.
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Acknowledgements
This work was supported by the National Key R&D Program of China (2017YFB1303001). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funding
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The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
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Competing interests
The authors declare that they have no competing interests regarding the publication of this paper.
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