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Longitudinal studies in laryngeal cancer can provide clinicians information about short-term and long-term functional outcomes, like quality of life (QoL) and voice outcome. This information is important when counseling patients or choosing a primary treatment modality. The present study assessed long-term (2 years) QoL and voice outcome in patients with extended T1 and limited T2 glottic carcinoma treated with transoral CO2 laser microsurgery (TLM) (unilateral type III or bilateral type II resections).
Three questionnaires were administered: the Voice Handicap Index (VHI), the European Organization for Research and Treatment of Cancer (EORTC) QoL questionnaire (QLQ)-C30, the EORTC QLQ-HN35. A perceptual voice evaluation at six different time points was conducted: preoperatively, and postoperatively at 6 weeks, 3 months, 6 months, 1 year, and 2 years. Fluctuations over time were investigated.
Sixty-one patients were included in the analysis. Patients reported high-level functioning and low symptom scores 2 years postoperatively. Gender significantly affected the VHI scores at 2 years (mean VHI scores: female 8.7 vs. male, 23.9; p = 0.023). The major improvement in VHI scores was observed within the first 6 months. The tumor stage (T1a, T1b, and T2) significantly impacted the grade (mean scores at 2 years: 1.0, 1.9, and 1.7; p = 0.001). These scores stabilized at 6 months.
Patients show good long-term QoL with low symptom scores, a low voice handicap, and mild to moderate dysphonia, 2 years postoperatively. Scores stabilize at 6 months and provide a clear indication of status at 1 and 2 years.
Nederlandse Werkgroep Hoofd Halstumoren, NWHHT (2010) Richtlijn Larynxcarcinomen Kwaliteitsinstituut voor de gezondheidszorg CBO 2010. Version 3.0. http://www.medinfo.nl/Richtlijnen/Oncologie/Hoofdhalstumoren/Larynxcarcinoom.pdf. Accessed Oct 2018
Hendriksma M, Heijnen BJ, Sjögren EV (2018) Oncologic and functional outcomes of patients treated with transoral CO 2 laser microsurgery or radiotherapy for T2 glottic carcinoma. Curr Opin Otolaryngol Head Neck Surg 26:84–93. https://doi.org/10.1097/MOO.0000000000000438 CrossRefPubMed
Karlsson T, Bergstrom L, Ward E, Finizia C (2016) A prospective longitudinal study of voice characteristics and health-related quality of life outcomes following laryngeal cancer treatment with radiotherapy. Acta Oncol 55:693–699. https://doi.org/10.3109/0284186X.2016.1150604 CrossRefPubMed
van Loon Y, Hendriksma M, Heijnen BJ, van de Kamp VAH, Hakkesteegt MM, Böhringer S, Langeveld TPM, de Jong MA, Klop WMC, Baatenburg de Jong RJ, Sjögren EV (2019) Voice outcome after unilateral ELS type III or bilateral type II resections for T1–T2 glottic carcinoma: results after 1 year. Head Neck. https://doi.org/10.1002/hed.25582 PubMedCrossRefPubMedCentral
Bjordal K, Ahlner-Elmqvist M, Tollesson E et al (1994) Development of a European Organization for Research and Treatment of Cancer (EORTC) questionnaire module to be used in quality of life assessments in head and neck cancer patients. EORTC Quality of Life Study Group. Acta Oncol 33:879–885 CrossRefPubMed
Van Gogh CDL, Mahieu HF, Kuik DJ et al (2007) Voice in early glottic cancer compared to benign voice pathology. Eur Arch Oto-Rhino-Laryngol 264:1033–1038 CrossRef
Bjordal K, De G, Fayers PM, et al (2000) A 12 country field study of the EORTC QLQ-C30 (version 3.0) and the head and neck cancer specific module (EORTC QLQ-H and N35) in head and neck patients. Eur J Cancer 36:1796–1807. https://doi.org/10.1016/S0959-8049(00)00186-6 CrossRefPubMed
Osoba D, Rodrigues G, Myles J et al (1998) Interpreting the significance of changes in health-related quality-of-life scores. J Clin Oncol 16:139–144. https://doi.org/10.1200/JCO.19188.8.131.52 CrossRefPubMed
Bjordal K, Hammerlid E, Ahlner-Elmqvist M et al (1999) Quality of life in head and neck cancer patients: validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-H&N35. J Clin Oncol 17:1008–1019. https://doi.org/10.1200/JCO.19184.108.40.2068 CrossRefPubMed
Hirano M (1981) Clinical examination of voice. Springer, New York
Karlsen T, Sandvik L, Heimdal JH et al (2017) Health-related quality of life as studied by EORTC QLQ and Voice Handicap Index among various patients with laryngeal disease. J Voice 31:251.e17–251.e26. https://doi.org/10.1016/j.jvoice.2016.07.009 CrossRef
Mendelsohn AH, Matar N, Bachy V et al (2015) Longitudinal voice outcomes following advanced CO 2 laser cordectomy for glottic cancer. J Voice 29:772–775. https://doi.org/10.1016/j.jvoice.2014.12.005 CrossRefPubMed
Nunez Batalla F, Caminero Cueva MJ, Senaris Gonzalez B et al (2008) Voice quality after endoscopic laser surgery and radiotherapy for early glottic cancer: objective measurements emphasizing the Voice Handicap Index. Eur Arch Oto-Rhino-Laryngol 265:543–548. https://doi.org/10.1007/s00405-007-0512-9 CrossRef
Tan S, Duong Dinh TA, Westhofen M (2016) Evaluation of gender-specific aspects in quality-of-life in patients with larynx carcinoma. Acta Otolaryngol 136:1201–1205. https://doi.org/10.1080/00016489.2016.1211319 CrossRefPubMed
Schwarz R, Hinz a (2001) Reference data for the quality of life questionnaire EORTC QLQ-C30 in the general German population. Eur J Cancer 37:1345–1351. https://doi.org/10.1016/S0959-8049(00)00447-0 CrossRefPubMed
Van De Poll-Franse LV, Mols F, Gundy CM et al (2011) Normative data for the EORTC QLQ-C30 and EORTC-sexuality items in the general Dutch population. Eur J Cancer 47:667–675. https://doi.org/10.1016/j.ejca.2010.11.004 CrossRefPubMed
Heijnen BJ, Speyer R, Kertscher B et al (2016) Dysphagia, speech, voice, and trismus following radiotherapy and/or chemotherapy in patients with head and neck carcinoma: review of the literature. Biomed Res. Int. 2016:24 CrossRef
- Quality of life and voice outcome of patients treated with transoral CO2 laser microsurgery for early glottic carcinoma (T1–T2): a 2-year follow-up study
Yda van Loon
W. Martin C. Klop
Marieke M. Hakkesteegt
Bas J. Heijnen
Ibtissam el Hasnaoui
Martin de Jong
Ton P. M. Langeveld
Peter Paul G. van Benthem
Robert J. Baatenburg de Jong
Elisabeth V. Sjögren
- Springer Berlin Heidelberg
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